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Non-gestational choriocarcinoma

MedGen UID:
211656
•Concept ID:
C1135873
•
Neoplastic Process
Synonyms: Choriocarcinoma, Non gestational; Choriocarcinoma, Non-gestational; Choriocarcinomas, Non-gestational; Non gestational Choriocarcinoma; Non-gestational Choriocarcinoma; Non-gestational Choriocarcinomas
 
Monarch Initiative: MONDO:0006871

Definition

A highly malignant choriocarcinoma derived from the non-placental origin such as the totipotent cells in the testis, the ovary, and the pineal gland. It produces high levels of chorionic gonadotropin and can metastasize widely through the bloodstream to the lungs, brain, liver, bone, and other viscera by the time of diagnosis. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-gestational choriocarcinoma

Professional guidelines

PubMed

Pulse actinomycin D as first-line treatment of low-risk post-molar non-choriocarcinoma gestational trophoblastic neoplasia.
Li L, Wan X, Feng F, Ren T, Yang J, Zhao J, Jiang F, Xiang Y
BMC Cancer 2018 May 23;18(1):585. doi: 10.1186/s12885-018-4512-5. PMID: 29792175Free PMC Article

Recent clinical studies

Etiology

Imaging in gynecological disease (22): clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors.
Moro F, Castellano LM, Franchi D, Epstein E, Fischerova D, Froyman W, Timmerman D, Zannoni GF, Scambia G, Valentin L, Testa AC, Mascilini F
Ultrasound Obstet Gynecol 2021 Jun;57(6):987-994. doi: 10.1002/uog.23529. PMID: 33142349
Choriocarcinoma in Women: Analysis of a Case Series With Genotyping.
Savage J, Adams E, Veras E, Murphy KM, Ronnett BM
Am J Surg Pathol 2017 Dec;41(12):1593-1606. doi: 10.1097/PAS.0000000000000937. PMID: 28877059
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066
Molecular genetic analyses of choriocarcinoma.
Zhao J, Xiang Y, Wan XR, Feng FZ, Cui QC, Yang XY
Placenta 2009 Sep;30(9):816-20. Epub 2009 Jul 31 doi: 10.1016/j.placenta.2009.06.011. PMID: 19647314
Primary non-gestational choriocarcinoma of the uterine cervix: a case report.
Maestá I, Michelin OC, Traiman P, Hokama P, Rudge MV
Gynecol Oncol 2005 Jul;98(1):146-50. doi: 10.1016/j.ygyno.2005.03.045. PMID: 15925400

Diagnosis

Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
Primary non-gestational mediastinal choriocarcinoma metastatic to the brainstem.
De Jesus O, Pellot Cestero JE, Gómez-González FM, Vélez R
BMJ Case Rep 2022 Apr 1;15(4) doi: 10.1136/bcr-2021-248389. PMID: 35365470Free PMC Article
Extragonadal Non-gestational Choriocarcinoma with Tonsillar Presentation.
Payne T, Di Palma S, Walker D, Dakin J, Thompson LDR
Head Neck Pathol 2021 Sep;15(3):1047-1053. Epub 2020 Oct 31 doi: 10.1007/s12105-020-01245-w. PMID: 33128732Free PMC Article
Primary non-gestational uterine choriocarcinoma mimicking leiomyoma.
Sano R, Moriya T, Suzuki S, Saito W, Shimoya K, Shiota M
Pathol Int 2019 Mar;69(3):160-164. Epub 2019 Feb 18 doi: 10.1111/pin.12763. PMID: 30775828
Primary sinonasal choriocarcinoma.
Bell DM, Porras G, Tortoledo ME, Luna MA
Ann Diagn Pathol 2009 Apr;13(2):96-100. doi: 10.1016/j.anndiagpath.2008.12.008. PMID: 19302957

Therapy

A 20-Year-Old-Man With New Onset of Melena.
Yang XY, Bégin LR, Tamaz R
Gastroenterology 2022 Jan;162(1):e14-e15. Epub 2021 Jun 17 doi: 10.1053/j.gastro.2021.05.065. PMID: 34146570
A rare case of primary rectal choriocarcinoma and review of the literature.
Telli TA, Demircan NC, Alan O, Tuylu TB, Arikan R, Ercelep O, Atıcı AE, Ergelen R, Seven IE, Babacan NA, Kaya S, Dane F, Fulden Yumuk P
J Oncol Pharm Pract 2020 Jun;26(4):989-994. Epub 2019 Sep 23 doi: 10.1177/1078155219875510. PMID: 31547751
Pure non-gestational choriocarcinoma arising in the ovary.
Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS
Eur J Gynaecol Oncol 2016 Aug;37(4):549-553. PMID: 29894083
Laparoscopic Fertility-preserving Treatment of a Pure Nongestational Choriocarcinoma of the Ovary: Case Report and Review of Current Literature.
Xin L, Beier A, Tiede S, Pfiffer T, Köhler C, Favero G
J Minim Invasive Gynecol 2015 Sep-Oct;22(6):1095-9. Epub 2015 May 1 doi: 10.1016/j.jmig.2015.04.025. PMID: 25939824
Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma.
Takahashi K, Tsukamoto S, Saito K, Ohkohchi N, Hirayama K
World J Gastroenterol 2013 Aug 21;19(31):5187-94. doi: 10.3748/wjg.v19.i31.5187. PMID: 23964157Free PMC Article

Prognosis

Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
A rare case of primary rectal choriocarcinoma and review of the literature.
Telli TA, Demircan NC, Alan O, Tuylu TB, Arikan R, Ercelep O, Atıcı AE, Ergelen R, Seven IE, Babacan NA, Kaya S, Dane F, Fulden Yumuk P
J Oncol Pharm Pract 2020 Jun;26(4):989-994. Epub 2019 Sep 23 doi: 10.1177/1078155219875510. PMID: 31547751
Pure nongestational uterine choriocarcinoma in postmenopausal women: a case report with literature review.
Wang L, Wan Y, Sun Y, Zhang X, Cheng X, Wu M, Liu G
Cancer Biol Ther 2019;20(9):1176-1182. Epub 2019 May 27 doi: 10.1080/15384047.2019.1617564. PMID: 31132027Free PMC Article
Choriocarcinoma in Women: Analysis of a Case Series With Genotyping.
Savage J, Adams E, Veras E, Murphy KM, Ronnett BM
Am J Surg Pathol 2017 Dec;41(12):1593-1606. doi: 10.1097/PAS.0000000000000937. PMID: 28877059
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066

Clinical prediction guides

Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model.
Oda Y, Niimi K, Yoshida K, Tamauchi S, Yokoi A, Yasui Y, Nishiko Y, Shibata M, Shimizu Y, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, Yamamoto E, Kajiyama H
BMC Cancer 2023 Nov 13;23(1):1103. doi: 10.1186/s12885-023-11626-3. PMID: 37957624Free PMC Article
A rare case of gestational ovarian choriocarcinoma coexistent with intrauterine pregnancy.
Sakurai S, Asano R, Furugori M, Shigeta H
Taiwan J Obstet Gynecol 2022 Jul;61(4):708-712. doi: 10.1016/j.tjog.2021.09.036. PMID: 35779927
Clinical Experience of Male Primary Choriocarcinoma at the Samsung Medical Center.
Ji YS, Park SH
Cancer Res Treat 2021 Jul;53(3):874-880. Epub 2020 Dec 7 doi: 10.4143/crt.2020.1066. PMID: 33285049Free PMC Article
Genomic profile in gestational and non-gestational choriocarcinomas.
Mello JB, Ramos Cirilo PD, Michelin OC, Custódio Domingues MA, Cunha Rudge MV, Rogatto SR, Maestá I
Placenta 2017 Feb;50:8-15. Epub 2016 Dec 7 doi: 10.1016/j.placenta.2016.12.009. PMID: 28161066
Clinical and Radiologic Features of Pediatric Basal Ganglia Germ Cell Tumors.
Zhang S, Liang G, Ju Y, You C
World Neurosurg 2016 Nov;95:516-524.e1. Epub 2016 Aug 24 doi: 10.1016/j.wneu.2016.08.072. PMID: 27567571

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