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Wasting Disease, Chronic

MedGen UID:
211688
Concept ID:
C1135993
Disease or Syndrome
Synonym: Chronic Wasting Disease

Definition

A transmissible spongiform encephalopathy (prion disease) of DEER and elk characterized by chronic weight loss leading to death. It is thought to spread by direct contact between animals or through environmental contamination with the prion protein (PRIONS). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWasting Disease, Chronic

Professional guidelines

PubMed

Hammond S, Erridge S, Mangal N, Pacchetti B, Sodergren MH
Cannabis Cannabinoid Res 2021 Dec;6(6):474-487. Epub 2021 Oct 18 doi: 10.1089/can.2021.0048. PMID: 34664988Free PMC Article
Hwang S, Greenlee JJ, Nicholson EM
PLoS One 2020;15(1):e0227487. Epub 2020 Jan 7 doi: 10.1371/journal.pone.0227487. PMID: 31910440Free PMC Article
Gray JG, Graham C, Dudas S, Paxman E, Vuong B, Czub S
J Mol Diagn 2016 May;18(3):454-467. Epub 2016 Apr 8 doi: 10.1016/j.jmoldx.2016.01.005. PMID: 27068712

Recent clinical studies

Therapy

Napper S, Schatzl HM
Front Immunol 2023;14:1156451. Epub 2023 Apr 14 doi: 10.3389/fimmu.2023.1156451. PMID: 37122761Free PMC Article
Taschuk R, Scruten E, Woodbury M, Cashman N, Potter A, Griebel P, Tikoo SK, Napper S
Prion 2017 Sep 3;11(5):368-380. doi: 10.1080/19336896.2017.1367083. PMID: 28968152Free PMC Article
Wisniewski T, Goñi F
Expert Rev Anti Infect Ther 2012 Mar;10(3):307-17. doi: 10.1586/eri.11.177. PMID: 22397565Free PMC Article
Li L, Napper S, Cashman NR
Immunotherapy 2010 Mar;2(2):269-82. doi: 10.2217/imt.10.3. PMID: 20635933
Belay ED, Schonberger LB
Annu Rev Public Health 2005;26:191-212. doi: 10.1146/annurev.publhealth.26.021304.144536. PMID: 15760286

Prognosis

Cook JD, Williams DM, Walsh DP, Hefley TJ
Sci Rep 2023 May 19;13(1):8137. doi: 10.1038/s41598-023-35177-6. PMID: 37208385Free PMC Article
Güere ME, Våge J, Tharaldsen H, Benestad SL, Vikøren T, Madslien K, Hopp P, Rolandsen CM, Røed KH, Tranulis MA
Prion 2020 Dec;14(1):1-10. doi: 10.1080/19336896.2019.1702446. PMID: 31852336Free PMC Article
Osterholm MT, Anderson CJ, Zabel MD, Scheftel JM, Moore KA, Appleby BS
mBio 2019 Jul 23;10(4) doi: 10.1128/mBio.01091-19. PMID: 31337719Free PMC Article
Chiu A, Goddard E, Parlee B
J Toxicol Environ Health A 2016;79(16-17):762-97. doi: 10.1080/15287394.2016.1174011. PMID: 27556568
Kong Q, Huang S, Zou W, Vanegas D, Wang M, Wu D, Yuan J, Zheng M, Bai H, Deng H, Chen K, Jenny AL, O'Rourke K, Belay ED, Schonberger LB, Petersen RB, Sy MS, Chen SG, Gambetti P
J Neurosci 2005 Aug 31;25(35):7944-9. doi: 10.1523/JNEUROSCI.2467-05.2005. PMID: 16135751Free PMC Article

Clinical prediction guides

Cook JD, Williams DM, Walsh DP, Hefley TJ
Sci Rep 2023 May 19;13(1):8137. doi: 10.1038/s41598-023-35177-6. PMID: 37208385Free PMC Article
Nakagawa Y, Kagohashi K, Shioya A, Kinoshita K, Tsuji H, Satoh H
Sultan Qaboos Univ Med J 2022 May;22(2):280-282. Epub 2022 May 26 doi: 10.18295/squmj.4.2021.071. PMID: 35673286Free PMC Article
Sakudo A
Curr Issues Mol Biol 2020;36:13-22. Epub 2019 Sep 9 doi: 10.21775/cimb.036.013. PMID: 31496519
Chiu A, Goddard E, Parlee B
J Toxicol Environ Health A 2016;79(16-17):762-97. doi: 10.1080/15287394.2016.1174011. PMID: 27556568
Miller MW, Williams ES
Curr Top Microbiol Immunol 2004;284:193-214. doi: 10.1007/978-3-662-08441-0_8. PMID: 15148993

Recent systematic reviews

Waddell L, Greig J, Mascarenhas M, Otten A, Corrin T, Hierlihy K
Transbound Emerg Dis 2018 Feb;65(1):37-49. Epub 2017 Jan 30 doi: 10.1111/tbed.12612. PMID: 28139079

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