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Wasting Disease, Chronic

MedGen UID:
211688
•Concept ID:
C1135993
•
Disease or Syndrome
Synonym: Chronic Wasting Disease

Definition

A transmissible spongiform encephalopathy (prion disease) of DEER and elk characterized by chronic weight loss leading to death. It is thought to spread by direct contact between animals or through environmental contamination with the prion protein (PRIONS). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWasting Disease, Chronic

Professional guidelines

PubMed

The Effect of Cannabis-Based Medicine in the Treatment of Cachexia: A Systematic Review and Meta-Analysis.
Hammond S, Erridge S, Mangal N, Pacchetti B, Sodergren MH
Cannabis Cannabinoid Res 2021 Dec;6(6):474-487. Epub 2021 Oct 18 doi: 10.1089/can.2021.0048. PMID: 34664988Free PMC Article
Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates.
Hwang S, Greenlee JJ, Nicholson EM
PLoS One 2020;15(1):e0227487. Epub 2020 Jan 7 doi: 10.1371/journal.pone.0227487. PMID: 31910440Free PMC Article
Defining and Assessing Analytical Performance Criteria for Transmissible Spongiform Encephalopathy-Detecting Amyloid Seeding Assays.
Gray JG, Graham C, Dudas S, Paxman E, Vuong B, Czub S
J Mol Diagn 2016 May;18(3):454-467. Epub 2016 Apr 8 doi: 10.1016/j.jmoldx.2016.01.005. PMID: 27068712

Recent clinical studies

Etiology

Transmission, Strain Diversity, and Zoonotic Potential of Chronic Wasting Disease.
Pritzkow S
Viruses 2022 Jun 25;14(7) doi: 10.3390/v14071390. PMID: 35891371Free PMC Article
Exposure Risk of Chronic Wasting Disease in Humans.
Nemani SK, Myskiw JL, Lamoureux L, Booth SA, Sim VL
Viruses 2020 Dec 17;12(12) doi: 10.3390/v12121454. PMID: 33348562Free PMC Article
The ecology of chronic wasting disease in wildlife.
Escobar LE, Pritzkow S, Winter SN, Grear DA, Kirchgessner MS, Dominguez-Villegas E, Machado G, Townsend Peterson A, Soto C
Biol Rev Camb Philos Soc 2020 Apr;95(2):393-408. Epub 2019 Nov 21 doi: 10.1111/brv.12568. PMID: 31750623Free PMC Article
Chronic Wasting Disease: Current Assessment of Transmissibility.
Sakudo A
Curr Issues Mol Biol 2020;36:13-22. Epub 2019 Sep 9 doi: 10.21775/cimb.036.013. PMID: 31496519
Prion Diseases.
Whitechurch BC, Welton JM, Collins SJ, Lawson VA
Adv Neurobiol 2017;15:335-364. doi: 10.1007/978-3-319-57193-5_13. PMID: 28674988

Diagnosis

Canine detection of chronic wasting disease (CWD) in laboratory and field settings.
Mallikarjun A, Swartz B, Kane SA, Gibison M, Wilson I, Collins A, Moore MB, Charendoff I, Ellis J, Murphy LA, Nichols T, Otto CM
Prion 2023 Dec;17(1):16-28. doi: 10.1080/19336896.2023.2169519. PMID: 36740856Free PMC Article
Exposure Risk of Chronic Wasting Disease in Humans.
Nemani SK, Myskiw JL, Lamoureux L, Booth SA, Sim VL
Viruses 2020 Dec 17;12(12) doi: 10.3390/v12121454. PMID: 33348562Free PMC Article
Chronic Wasting Disease: Current Assessment of Transmissibility.
Sakudo A
Curr Issues Mol Biol 2020;36:13-22. Epub 2019 Sep 9 doi: 10.21775/cimb.036.013. PMID: 31496519
Chronic wasting disease.
Gilch S, Chitoor N, Taguchi Y, Stuart M, Jewell JE, Schätzl HM
Top Curr Chem 2011;305:51-77. doi: 10.1007/128_2011_159. PMID: 21598099
Chronic wasting disease.
Prcina M, Bardon J, Kontseková E
Acta Virol 2008;52(4):209-18. PMID: 19143476

Therapy

Oral vaccination as a potential strategy to manage chronic wasting disease in wild cervid populations.
Napper S, Schatzl HM
Front Immunol 2023;14:1156451. Epub 2023 Apr 14 doi: 10.3389/fimmu.2023.1156451. PMID: 37122761Free PMC Article
Induction of PrP(Sc)-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease.
Taschuk R, Scruten E, Woodbury M, Cashman N, Potter A, Griebel P, Tikoo SK, Napper S
Prion 2017 Sep 3;11(5):368-380. doi: 10.1080/19336896.2017.1367083. PMID: 28968152Free PMC Article
Could immunomodulation be used to prevent prion diseases?
Wisniewski T, Goñi F
Expert Rev Anti Infect Ther 2012 Mar;10(3):307-17. doi: 10.1586/eri.11.177. PMID: 22397565Free PMC Article
Immunotherapy for prion diseases: opportunities and obstacles.
Li L, Napper S, Cashman NR
Immunotherapy 2010 Mar;2(2):269-82. doi: 10.2217/imt.10.3. PMID: 20635933
The public health impact of prion diseases.
Belay ED, Schonberger LB
Annu Rev Public Health 2005;26:191-212. doi: 10.1146/annurev.publhealth.26.021304.144536. PMID: 15760286

Prognosis

Bayesian forecasting of disease spread with little or no local data.
Cook JD, Williams DM, Walsh DP, Hefley TJ
Sci Rep 2023 May 19;13(1):8137. doi: 10.1038/s41598-023-35177-6. PMID: 37208385Free PMC Article
Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus).
Güere ME, Våge J, Tharaldsen H, Benestad SL, Vikøren T, Madslien K, Hopp P, Rolandsen CM, Røed KH, Tranulis MA
Prion 2020 Dec;14(1):1-10. doi: 10.1080/19336896.2019.1702446. PMID: 31852336Free PMC Article
Chronic Wasting Disease in Cervids: Implications for Prion Transmission to Humans and Other Animal Species.
Osterholm MT, Anderson CJ, Zabel MD, Scheftel JM, Moore KA, Appleby BS
mBio 2019 Jul 23;10(4) doi: 10.1128/mBio.01091-19. PMID: 31337719Free PMC Article
Caribou consumption in northern Canadian communities.
Chiu A, Goddard E, Parlee B
J Toxicol Environ Health A 2016;79(16-17):762-97. doi: 10.1080/15287394.2016.1174011. PMID: 27556568
Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models.
Kong Q, Huang S, Zou W, Vanegas D, Wang M, Wu D, Yuan J, Zheng M, Bai H, Deng H, Chen K, Jenny AL, O'Rourke K, Belay ED, Schonberger LB, Petersen RB, Sy MS, Chen SG, Gambetti P
J Neurosci 2005 Aug 31;25(35):7944-9. doi: 10.1523/JNEUROSCI.2467-05.2005. PMID: 16135751Free PMC Article

Clinical prediction guides

Bayesian forecasting of disease spread with little or no local data.
Cook JD, Williams DM, Walsh DP, Hefley TJ
Sci Rep 2023 May 19;13(1):8137. doi: 10.1038/s41598-023-35177-6. PMID: 37208385Free PMC Article
Maintaining Weight and Nutritional Status with Ninjin'yoeito in Elderly Patients with Chronic Wasting Diseases.
Nakagawa Y, Kagohashi K, Shioya A, Kinoshita K, Tsuji H, Satoh H
Sultan Qaboos Univ Med J 2022 May;22(2):280-282. Epub 2022 May 26 doi: 10.18295/squmj.4.2021.071. PMID: 35673286Free PMC Article
Chronic Wasting Disease: Current Assessment of Transmissibility.
Sakudo A
Curr Issues Mol Biol 2020;36:13-22. Epub 2019 Sep 9 doi: 10.21775/cimb.036.013. PMID: 31496519
Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay.
Race B, Williams K, Chesebro B
Vet Res 2019 Jan 22;50(1):6. doi: 10.1186/s13567-019-0626-2. PMID: 30670087Free PMC Article
Chronic wasting disease of cervids.
Miller MW, Williams ES
Curr Top Microbiol Immunol 2004;284:193-214. doi: 10.1007/978-3-662-08441-0_8. PMID: 15148993

Recent systematic reviews

Current evidence on the transmissibility of chronic wasting disease prions to humans-A systematic review.
Waddell L, Greig J, Mascarenhas M, Otten A, Corrin T, Hierlihy K
Transbound Emerg Dis 2018 Feb;65(1):37-49. Epub 2017 Jan 30 doi: 10.1111/tbed.12612. PMID: 28139079

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