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Tolosa-Hunt syndrome

MedGen UID:
21197
•Concept ID:
C0040381
•
Disease or Syndrome
Synonyms: Nonspecific inflammation of the cavernous sinus or superior orbital fissure; Ophthalmoplegia, painful
SNOMED CT: Tolosa-Hunt syndrome (95794005)
 
Monarch Initiative: MONDO:0018983
Orphanet: ORPHA64686

Definition

An ophthalmoplegic syndrome, affecting all age groups, with characteristics of acute attacks (lasting a few days to a few weeks) of periorbital pain, ipsilateral ocular motor nerve palsies, ptosis, disordered eye movements and blurred vision usually caused by a non-specific inflammatory process in the cavernous sinus and superior orbital fissure. It has an unpredictable course with spontaneous remission occurring in some and recurrence of attacks in others. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTolosa-Hunt syndrome

Professional guidelines

PubMed

Tolosa-Hunt Syndrome: Appraising the ICHD-3 beta diagnostic criteria.
Mullen E, Green M, Hersh E, Iloreta AM, Bederson J, Shrivastava R
Cephalalgia 2018 Sep;38(10):1696-1700. Epub 2017 Nov 23 doi: 10.1177/0333102417745271. PMID: 29169256
A prospective multicentre study to evaluate the consistency of the IHS diagnostic criteria, the usefulness of brain MRI for the diagnosis, follow-up and treatment management, and the outcome after high dosage 6-methylprednisolone therapy, in subjects with Tolosa-Hunt syndrome.
Colnaghi S, Versino M, Marchioni E, Tassorelli C, Bastianello S, Sandrini G, Nappi G
J Headache Pain 2010 Jun;11(3):285. Epub 2010 Mar 25 doi: 10.1007/s10194-010-0206-3. PMID: 20336343Free PMC Article
Tolosa-Hunt syndrome: critical literature review based on IHS 2004 criteria.
Dach F, Speciali J
Cephalalgia 2007 Aug;27(8):960; author reply 960-1. doi: 10.1111/j.1468-2982.2007.01383_1.x. PMID: 17661871

Recent clinical studies

Etiology

Recurrence and long-term outcomes of Tolosa-Hunt syndrome.
Kim HJ, Lee SU, Lee ES, Choi JY, Kim JS
J Neurol 2024 Feb;271(2):935-943. Epub 2023 Oct 19 doi: 10.1007/s00415-023-12044-y. PMID: 37853245
The clinical features and outcomes of Tolosa-Hunt syndrome.
Kim H, Oh SY
BMC Ophthalmol 2021 May 27;21(1):237. doi: 10.1186/s12886-021-02007-0. PMID: 34044807Free PMC Article
Orbital inflammatory disease.
Lutt JR, Lim LL, Phal PM, Rosenbaum JT
Semin Arthritis Rheum 2008 Feb;37(4):207-22. Epub 2007 Sep 4 doi: 10.1016/j.semarthrit.2007.06.003. PMID: 17765951
Tolosa-Hunt syndrome.
Palacios E, Valvassori G, Bresler M
Ear Nose Throat J 1999 Mar;78(3):150. PMID: 10188349
Painful ophthalmoplegia: the Tolosa-Hunt syndrome.
Roca PD
Ann Ophthalmol 1975 Jun;7(6):828-34. PMID: 1147510

Diagnosis

Review of Tolosa-Hunt Syndrome, Recent Updates.
Kmeid M, Medrea I
Curr Pain Headache Rep 2023 Dec;27(12):843-849. Epub 2023 Nov 30 doi: 10.1007/s11916-023-01193-4. PMID: 38032539
Escaping from the hunt.
Park B, Raviskanthan S, Mortensen P, Lee AG, Bilyk JR
Surv Ophthalmol 2021 Nov-Dec;66(6):1065-1069. Epub 2020 Oct 28 doi: 10.1016/j.survophthal.2020.10.005. PMID: 33129799
Cavernous sinus lesions.
Munawar K, Nayak G, Fatterpekar GM, Sen C, Zagzag D, Zan E, Hagiwara M
Clin Imaging 2020 Dec;68:71-89. Epub 2020 Jun 18 doi: 10.1016/j.clinimag.2020.06.029. PMID: 32574933
Imaging of the Sella and Parasellar Region.
Go JL, Rajamohan AG
Radiol Clin North Am 2017 Jan;55(1):83-101. doi: 10.1016/j.rcl.2016.09.002. PMID: 27890190
The Tolosa-Hunt syndrome.
Kline LB, Hoyt WF
J Neurol Neurosurg Psychiatry 2001 Nov;71(5):577-82. doi: 10.1136/jnnp.71.5.577. PMID: 11606665Free PMC Article

Therapy

Recurrent Tolosa-Hunt Syndrome in a Child Accompanied by Idiopathic Aseptic Meningitis.
Ishikura T, Kiyosaki K, Koga H
Pediatr Neurol 2021 Dec;125:16-17. Epub 2021 Sep 9 doi: 10.1016/j.pediatrneurol.2021.09.003. PMID: 34583233
Tolosa-Hunt syndrome--a rare cause of headache and ophthalmoplegia.
Zurawski J, Akhondi H
Lancet 2013 Sep 7;382(9895):912. doi: 10.1016/S0140-6736(13)61442-7. PMID: 24012271
The Tolosa-Hunt syndrome.
Kline LB, Hoyt WF
J Neurol Neurosurg Psychiatry 2001 Nov;71(5):577-82. doi: 10.1136/jnnp.71.5.577. PMID: 11606665Free PMC Article
Tolosa-Hunt syndrome.
Palacios E, Valvassori G, Bresler M
Ear Nose Throat J 1999 Mar;78(3):150. PMID: 10188349
Tolosa-Hunt syndrome and antinuclear factor.
Lesser R, Jampol LM
Am J Ophthalmol 1974 May;77(5):732-4. doi: 10.1016/0002-9394(74)90540-6. PMID: 4596034

Prognosis

Clinical profile and outcomes in Tolosa-Hunt Syndrome; a systematic review.
Ahmed HS, Shivananda DB, Pulkurthi SR, Dias AF, Sahoo PP
J Clin Neurosci 2024 Nov;129:110858. Epub 2024 Oct 3 doi: 10.1016/j.jocn.2024.110858. PMID: 39366127
Recurrence and long-term outcomes of Tolosa-Hunt syndrome.
Kim HJ, Lee SU, Lee ES, Choi JY, Kim JS
J Neurol 2024 Feb;271(2):935-943. Epub 2023 Oct 19 doi: 10.1007/s00415-023-12044-y. PMID: 37853245
Is Hypertrophic Pachymeningitis Really Idiopathic?
Jagiasi K, Barvalia PP
Neurol India 2022 Nov-Dec;70(6):2422-2426. doi: 10.4103/0028-3886.364052. PMID: 36537427
Tolosa-Hunt syndrome.
Palacios E, Valvassori G, Bresler M
Ear Nose Throat J 1999 Mar;78(3):150. PMID: 10188349
Painful ophthalmoplegia: the Tolosa-Hunt syndrome.
Roca PD
Ann Ophthalmol 1975 Jun;7(6):828-34. PMID: 1147510

Clinical prediction guides

Clinical profile and outcomes in Tolosa-Hunt Syndrome; a systematic review.
Ahmed HS, Shivananda DB, Pulkurthi SR, Dias AF, Sahoo PP
J Clin Neurosci 2024 Nov;129:110858. Epub 2024 Oct 3 doi: 10.1016/j.jocn.2024.110858. PMID: 39366127
Clinical and diagnostic profile of Tolosa-Hunt syndrome; a 7-year retrospective observational study.
Ahmed HS, Thrishulamurthy CJ, Bhaskar T, Lokanath H, Srikanteshwara PK
Eur J Ophthalmol 2024 Jul;34(4):1255-1265. Epub 2023 Dec 13 doi: 10.1177/11206721231221590. PMID: 38092690
Recurrence and long-term outcomes of Tolosa-Hunt syndrome.
Kim HJ, Lee SU, Lee ES, Choi JY, Kim JS
J Neurol 2024 Feb;271(2):935-943. Epub 2023 Oct 19 doi: 10.1007/s00415-023-12044-y. PMID: 37853245
Is Hypertrophic Pachymeningitis Really Idiopathic?
Jagiasi K, Barvalia PP
Neurol India 2022 Nov-Dec;70(6):2422-2426. doi: 10.4103/0028-3886.364052. PMID: 36537427
Evaluation and Management of Tolosa-Hunt Syndrome in Children: A Clinical Update.
Pérez CA, Evangelista M
Pediatr Neurol 2016 Sep;62:18-26. Epub 2016 Jun 25 doi: 10.1016/j.pediatrneurol.2016.06.017. PMID: 27473647

Recent systematic reviews

Clinical profile and outcomes in Tolosa-Hunt Syndrome; a systematic review.
Ahmed HS, Shivananda DB, Pulkurthi SR, Dias AF, Sahoo PP
J Clin Neurosci 2024 Nov;129:110858. Epub 2024 Oct 3 doi: 10.1016/j.jocn.2024.110858. PMID: 39366127
Neuromuscular diseases associated with COVID-19 vaccines: a systematic review and pooled analysis of 258 patients.
Tayebi A, Samimisedeh P, Jafari Afshar E, Mahmoudnia S, Milan N, Ayati A, Madady A, Rastad H
BMC Neurol 2023 Dec 11;23(1):437. doi: 10.1186/s12883-023-03486-y. PMID: 38082244Free PMC Article
Diagnostic controversies in recurrent painful ophthalmoplegic neuropathy: single case report with a systematic review.
Falsaperla R, Presti S, Lo Bianco M, Catanzaro S, Marino S, Ruggieri M
Ital J Pediatr 2022 Jun 3;48(1):82. doi: 10.1186/s13052-022-01274-x. PMID: 35659705Free PMC Article
Tolosa-Hunt Syndrome in Childhood and Adolescence: A Literature Review in the Last 10 Years.
Gama BP, Silva-Néto RP
Neuropediatrics 2021 Feb;52(1):1-5. Epub 2020 Sep 6 doi: 10.1055/s-0040-1715632. PMID: 32892335
Actinomyces cavernous sinus infection: a case and systematic literature review.
Lubomski M, Dalgliesh J, Lee K, Damodaran O, McKew G, Reddel S
Pract Neurol 2018 Oct;18(5):373-377. Epub 2018 Apr 12 doi: 10.1136/practneurol-2017-001844. PMID: 29650638

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