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Traumatic hemorrhage

MedGen UID:
21247
•Concept ID:
C0040797
•
Pathologic Function
Synonym: Traumatic Hemorrhage
SNOMED CT: Traumatic hemorrhage (110149000)

Definition

Vascular rupture, and the resulting loss of blood, due to physical injury. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTraumatic hemorrhage

Professional guidelines

PubMed

Guidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients.
Cook AM, Morgan Jones G, Hawryluk GWJ, Mailloux P, McLaughlin D, Papangelou A, Samuel S, Tokumaru S, Venkatasubramanian C, Zacko C, Zimmermann LL, Hirsch K, Shutter L
Neurocrit Care 2020 Jun;32(3):647-666. doi: 10.1007/s12028-020-00959-7. PMID: 32227294Free PMC Article
Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma.
Cannon JW, Khan MA, Raja AS, Cohen MJ, Como JJ, Cotton BA, Dubose JJ, Fox EE, Inaba K, Rodriguez CJ, Holcomb JB, Duchesne JC
J Trauma Acute Care Surg 2017 Mar;82(3):605-617. doi: 10.1097/TA.0000000000001333. PMID: 28225743
Platelet transfusion: a clinical practice guideline from the AABB.
Kaufman RM, Djulbegovic B, Gernsheimer T, Kleinman S, Tinmouth AT, Capocelli KE, Cipolle MD, Cohn CS, Fung MK, Grossman BJ, Mintz PD, O'Malley BA, Sesok-Pizzini DA, Shander A, Stack GE, Webert KE, Weinstein R, Welch BG, Whitman GJ, Wong EC, Tobian AA; AABB
Ann Intern Med 2015 Feb 3;162(3):205-13. doi: 10.7326/M14-1589. PMID: 25383671

Recent clinical studies

Etiology

A comparative analysis of tranexamic acid dosing strategies in traumatic major hemorrhage.
Gunn F, Stevenson R, Almuwallad A, Rossetto A, Vulliamy P, Brohi K, Davenport R
J Trauma Acute Care Surg 2024 Feb 1;96(2):216-224. Epub 2023 Oct 24 doi: 10.1097/TA.0000000000004177. PMID: 37872678
Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.
Bouzat P, Charbit J, Abback PS, Huet-Garrigue D, Delhaye N, Leone M, Marcotte G, David JS, Levrat A, Asehnoune K, Pottecher J, Duranteau J, Courvalin E, Adolle A, Sourd D, Bosson JL, Riou B, Gauss T, Payen JF; PROCOAG Study Group
JAMA 2023 Apr 25;329(16):1367-1375. doi: 10.1001/jama.2023.4080. PMID: 36942533Free PMC Article
Whole Blood Transfusion.
Cap AP, Beckett A, Benov A, Borgman M, Chen J, Corley JB, Doughty H, Fisher A, Glassberg E, Gonzales R, Kane SF, Malloy WW, Nessen S, Perkins JG, Prat N, Quesada J, Reade M, Sailliol A, Spinella PC, Stockinger Z, Strandenes G, Taylor A, Yazer M, Bryant B, Gurney J
Mil Med 2018 Sep 1;183(suppl_2):44-51. doi: 10.1093/milmed/usy120. PMID: 30189061
Tourniquets in Trauma Care: A Review of Application.
Cornelius B, Campbell R, McGauly P
J Trauma Nurs 2017 May/Jun;24(3):203-207. doi: 10.1097/JTN.0000000000000290. PMID: 28486327
Blood product transfusions and reactions.
Osterman JL, Arora S
Emerg Med Clin North Am 2014 Aug;32(3):727-38. Epub 2014 Jun 12 doi: 10.1016/j.emc.2014.04.012. PMID: 25060259

Diagnosis

Massive transfusion in trauma.
Lier H, Hossfeld B
Curr Opin Anaesthesiol 2024 Apr 1;37(2):117-124. Epub 2024 Jan 19 doi: 10.1097/ACO.0000000000001347. PMID: 38390985
Traumatic hemorrhage and chain of survival.
Latif RK, Clifford SP, Baker JA, Lenhardt R, Haq MZ, Huang J, Farah I, Businger JR
Scand J Trauma Resusc Emerg Med 2023 May 24;31(1):25. doi: 10.1186/s13049-023-01088-8. PMID: 37226264Free PMC Article
Massive Hemorrhage Protocol: A Practical Approach to the Bleeding Trauma Patient.
Petrosoniak A, Pavenski K, da Luz LT, Callum J
Emerg Med Clin North Am 2023 Feb;41(1):51-69. doi: 10.1016/j.emc.2022.09.010. PMID: 36424044
Blood Product Transfusions and Reactions.
Osterman JL, Arora S
Hematol Oncol Clin North Am 2017 Dec;31(6):1159-1170. doi: 10.1016/j.hoc.2017.08.014. PMID: 29078929
Blood product transfusions and reactions.
Osterman JL, Arora S
Emerg Med Clin North Am 2014 Aug;32(3):727-38. Epub 2014 Jun 12 doi: 10.1016/j.emc.2014.04.012. PMID: 25060259

Therapy

Massive transfusion in trauma.
Lier H, Hossfeld B
Curr Opin Anaesthesiol 2024 Apr 1;37(2):117-124. Epub 2024 Jan 19 doi: 10.1097/ACO.0000000000001347. PMID: 38390985
A comparative analysis of tranexamic acid dosing strategies in traumatic major hemorrhage.
Gunn F, Stevenson R, Almuwallad A, Rossetto A, Vulliamy P, Brohi K, Davenport R
J Trauma Acute Care Surg 2024 Feb 1;96(2):216-224. Epub 2023 Oct 24 doi: 10.1097/TA.0000000000004177. PMID: 37872678
Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.
Bouzat P, Charbit J, Abback PS, Huet-Garrigue D, Delhaye N, Leone M, Marcotte G, David JS, Levrat A, Asehnoune K, Pottecher J, Duranteau J, Courvalin E, Adolle A, Sourd D, Bosson JL, Riou B, Gauss T, Payen JF; PROCOAG Study Group
JAMA 2023 Apr 25;329(16):1367-1375. doi: 10.1001/jama.2023.4080. PMID: 36942533Free PMC Article
Blood Product Transfusions and Reactions.
Osterman JL, Arora S
Hematol Oncol Clin North Am 2017 Dec;31(6):1159-1170. doi: 10.1016/j.hoc.2017.08.014. PMID: 29078929
Blood product transfusions and reactions.
Osterman JL, Arora S
Emerg Med Clin North Am 2014 Aug;32(3):727-38. Epub 2014 Jun 12 doi: 10.1016/j.emc.2014.04.012. PMID: 25060259

Prognosis

Preadmission Antiplatelet Use and Associated Outcomes and Costs Among ICU Patients With Intracranial Hemorrhage.
Fernando SM, Mok G, Rochwerg B, English SW, Thavorn K, McCredie VA, Dowlatshahi D, Perry JJ, Wijdicks EFM, Reardon PM, Tanuseputro P, Kyeremanteng K
J Intensive Care Med 2021 Jan;36(1):70-79. Epub 2019 Nov 19 doi: 10.1177/0885066619885347. PMID: 31741418
The extended autonomic system, dyshomeostasis, and COVID-19.
Goldstein DS
Clin Auton Res 2020 Aug;30(4):299-315. Epub 2020 Jul 22 doi: 10.1007/s10286-020-00714-0. PMID: 32700055Free PMC Article
Thromboelastography and rotational thromboelastometry for the surgical intensivist: A narrative review.
Drumheller BC, Stein DM, Moore LJ, Rizoli SB, Cohen MJ
J Trauma Acute Care Surg 2019 Apr;86(4):710-721. doi: 10.1097/TA.0000000000002206. PMID: 30633093Free PMC Article
Pediatric Massive Transfusion: A Systematic Review.
Maw G, Furyk C
Pediatr Emerg Care 2018 Aug;34(8):594-598. doi: 10.1097/PEC.0000000000001570. PMID: 30080793
Tourniquets in Trauma Care: A Review of Application.
Cornelius B, Campbell R, McGauly P
J Trauma Nurs 2017 May/Jun;24(3):203-207. doi: 10.1097/JTN.0000000000000290. PMID: 28486327

Clinical prediction guides

A comparative analysis of tranexamic acid dosing strategies in traumatic major hemorrhage.
Gunn F, Stevenson R, Almuwallad A, Rossetto A, Vulliamy P, Brohi K, Davenport R
J Trauma Acute Care Surg 2024 Feb 1;96(2):216-224. Epub 2023 Oct 24 doi: 10.1097/TA.0000000000004177. PMID: 37872678
Doing more with less: low-titer group O whole blood resulted in less total transfusions and an independent association with survival in adults with severe traumatic hemorrhage.
Shea SM, Mihalko EP, Lu L, Thomas KA, Schuerer D, Brown JB, Bochicchio GV, Spinella PC
J Thromb Haemost 2024 Jan;22(1):140-151. Epub 2023 Oct 4 doi: 10.1016/j.jtha.2023.09.025. PMID: 37797692Free PMC Article
Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.
Bouzat P, Charbit J, Abback PS, Huet-Garrigue D, Delhaye N, Leone M, Marcotte G, David JS, Levrat A, Asehnoune K, Pottecher J, Duranteau J, Courvalin E, Adolle A, Sourd D, Bosson JL, Riou B, Gauss T, Payen JF; PROCOAG Study Group
JAMA 2023 Apr 25;329(16):1367-1375. doi: 10.1001/jama.2023.4080. PMID: 36942533Free PMC Article
Effect of Desmopressin on Platelet Dysfunction During Antiplatelet Therapy: A Systematic Review.
Andersen LK, Hvas AM, Hvas CL
Neurocrit Care 2021 Jun;34(3):1026-1046. Epub 2020 Aug 4 doi: 10.1007/s12028-020-01055-6. PMID: 32748210
The extended autonomic system, dyshomeostasis, and COVID-19.
Goldstein DS
Clin Auton Res 2020 Aug;30(4):299-315. Epub 2020 Jul 22 doi: 10.1007/s10286-020-00714-0. PMID: 32700055Free PMC Article

Recent systematic reviews

Whole blood transfusion in the treatment of acute hemorrhage, a systematic review and meta-analysis.
van der Horst RA, Rijnhout TWH, Noorman F, Borger van der Burg BLS, van Waes OJF, Verhofstad MHJ, Hoencamp R
J Trauma Acute Care Surg 2023 Aug 1;95(2):256-266. Epub 2023 May 1 doi: 10.1097/TA.0000000000004000. PMID: 37125904
A systematic review and meta-analysis of sample size methodology for traumatic hemorrhage trials.
Ghossein J, Fernando SM, Rochwerg B, Inaba K, Lampron J, Tran A
J Trauma Acute Care Surg 2023 Jun 1;94(6):870-876. Epub 2023 Mar 7 doi: 10.1097/TA.0000000000003944. PMID: 36879398
Effect of Desmopressin on Platelet Dysfunction During Antiplatelet Therapy: A Systematic Review.
Andersen LK, Hvas AM, Hvas CL
Neurocrit Care 2021 Jun;34(3):1026-1046. Epub 2020 Aug 4 doi: 10.1007/s12028-020-01055-6. PMID: 32748210
Pediatric Massive Transfusion: A Systematic Review.
Maw G, Furyk C
Pediatr Emerg Care 2018 Aug;34(8):594-598. doi: 10.1097/PEC.0000000000001570. PMID: 30080793
Non-traumatic and spontaneous hemothorax in the setting of forensic medical examination: a systematic literature survey.
Janik M, Straka L, Krajcovic J, Hejna P, Hamzik J, Novomesky F
Forensic Sci Int 2014 Mar;236:22-9. Epub 2013 Dec 25 doi: 10.1016/j.forsciint.2013.12.013. PMID: 24529771

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