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Post-traumatic stress disorder(PTSD)

MedGen UID:
21345
Concept ID:
C0038436
Mental or Behavioral Dysfunction
Synonym: PTSD
SNOMED CT: Traumatic neurosis (47505003); PTSD - Post-traumatic stress disorder (47505003); Post-traumatic stress syndrome (47505003); Post-traumatic stress disorder (47505003); Posttraumatic stress disorder (47505003)
 
Monarch Initiative: MONDO:0005146

Definition

An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by intrusive recurring thoughts or images of the traumatic event; avoidance of anything associated with the event; a state of hyperarousal and diminished emotional responsiveness. These symptoms are present for at least one month and the disorder is usually long-term. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPost-traumatic stress disorder

Professional guidelines

PubMed

Schrader C, Ross A
Mo Med 2021 Nov-Dec;118(6):546-551. PMID: 34924624Free PMC Article
Crook H, Raza S, Nowell J, Young M, Edison P
BMJ 2021 Jul 26;374:n1648. doi: 10.1136/bmj.n1648. PMID: 34312178
Smith PJ, Merwin RM
Annu Rev Med 2021 Jan 27;72:45-62. Epub 2020 Nov 30 doi: 10.1146/annurev-med-060619-022943. PMID: 33256493Free PMC Article

Recent clinical studies

Etiology

Zuo C, Zhuang Z, Yang P, Zhang H, Li X, Huang T, Ahluwalia TS
J Affect Disord 2023 Jul 15;333:436-445. Epub 2023 Apr 20 doi: 10.1016/j.jad.2023.04.080. PMID: 37086801
Thakur A, Choudhary D, Kumar B, Chaudhary A
Curr Mol Pharmacol 2022;15(3):502-516. doi: 10.2174/1874467214666210525160944. PMID: 34036925
Ertan D, Hingray C, Burlacu E, Sterlé A, El-Hage W
BMC Psychiatry 2021 Mar 16;21(1):155. doi: 10.1186/s12888-021-03158-6. PMID: 33726703Free PMC Article
Dean E
Nurs Stand 2016 Jul 13;30(46):15. doi: 10.7748/ns.30.46.15.s17. PMID: 27406490
Qi W, Gevonden M, Shalev A
Curr Psychiatry Rep 2016 Feb;18(2):20. doi: 10.1007/s11920-015-0655-0. PMID: 26800995Free PMC Article

Diagnosis

Merians AN, Spiller T, Harpaz-Rotem I, Krystal JH, Pietrzak RH
Med Clin North Am 2023 Jan;107(1):85-99. Epub 2022 Oct 28 doi: 10.1016/j.mcna.2022.04.003. PMID: 36402502
Maercker A, Cloitre M, Bachem R, Schlumpf YR, Khoury B, Hitchcock C, Bohus M
Lancet 2022 Jul 2;400(10345):60-72. doi: 10.1016/S0140-6736(22)00821-2. PMID: 35780794
Thakur A, Choudhary D, Kumar B, Chaudhary A
Curr Mol Pharmacol 2022;15(3):502-516. doi: 10.2174/1874467214666210525160944. PMID: 34036925
Ertan D, Hingray C, Burlacu E, Sterlé A, El-Hage W
BMC Psychiatry 2021 Mar 16;21(1):155. doi: 10.1186/s12888-021-03158-6. PMID: 33726703Free PMC Article
Kirkpatrick HA, Heller GM
Int J Psychiatry Med 2014;47(4):337-46. doi: 10.2190/PM.47.4.h. PMID: 25084856

Therapy

Afzali Rubin M, Svensson TL, Herling SF, Jabre P, Møller AM
Cochrane Database Syst Rev 2023 May 9;5(5):CD013619. doi: 10.1002/14651858.CD013619.pub2. PMID: 37159193Free PMC Article
Crook H, Raza S, Nowell J, Young M, Edison P
BMJ 2021 Jul 26;374:n1648. doi: 10.1136/bmj.n1648. PMID: 34312178
Nutt D
Dialogues Clin Neurosci 2019;21(2):139-147. doi: 10.31887/DCNS.2019.21.2/dnutt. PMID: 31636488Free PMC Article
Novo Navarro P, Landin-Romero R, Guardiola-Wanden-Berghe R, Moreno-Alcázar A, Valiente-Gómez A, Lupo W, García F, Fernández I, Pérez V, Amann BL
Rev Psiquiatr Salud Ment (Engl Ed) 2018 Apr-Jun;11(2):101-114. Epub 2016 Feb 11 doi: 10.1016/j.rpsm.2015.12.002. PMID: 26877093
Bisson JI, Roberts NP, Andrew M, Cooper R, Lewis C
Cochrane Database Syst Rev 2013 Dec 13;2013(12):CD003388. doi: 10.1002/14651858.CD003388.pub4. PMID: 24338345Free PMC Article

Prognosis

Crook H, Raza S, Nowell J, Young M, Edison P
BMJ 2021 Jul 26;374:n1648. doi: 10.1136/bmj.n1648. PMID: 34312178
Small MJ, Gondwe KW, Brown HL
Obstet Gynecol Clin North Am 2020 Sep;47(3):453-461. Epub 2020 May 31 doi: 10.1016/j.ogc.2020.04.004. PMID: 32762930
Karadag M, Gokcen C, Sarp AS
Int J Psychiatry Clin Pract 2020 Mar;24(1):77-82. Epub 2019 Oct 30 doi: 10.1080/13651501.2019.1682171. PMID: 31663396
Edmondson D, von Känel R
Lancet Psychiatry 2017 Apr;4(4):320-329. Epub 2017 Jan 19 doi: 10.1016/S2215-0366(16)30377-7. PMID: 28109646Free PMC Article
Alisic E, Zalta AK, van Wesel F, Larsen SE, Hafstad GS, Hassanpour K, Smid GE
Br J Psychiatry 2014;204:335-40. doi: 10.1192/bjp.bp.113.131227. PMID: 24785767

Clinical prediction guides

Zuo C, Zhuang Z, Yang P, Zhang H, Li X, Huang T, Ahluwalia TS
J Affect Disord 2023 Jul 15;333:436-445. Epub 2023 Apr 20 doi: 10.1016/j.jad.2023.04.080. PMID: 37086801
Mclay R, Fesperman S, Webb-Murphy J, Delaney E, Ram V, Nebeker B, Burce CM
Mil Med 2023 May 16;188(5-6):e1117-e1124. doi: 10.1093/milmed/usab454. PMID: 34791409
Ertan D, Hingray C, Burlacu E, Sterlé A, El-Hage W
BMC Psychiatry 2021 Mar 16;21(1):155. doi: 10.1186/s12888-021-03158-6. PMID: 33726703Free PMC Article
Raskind MA, Peskind ER, Chow B, Harris C, Davis-Karim A, Holmes HA, Hart KL, McFall M, Mellman TA, Reist C, Romesser J, Rosenheck R, Shih MC, Stein MB, Swift R, Gleason T, Lu Y, Huang GD
N Engl J Med 2018 Feb 8;378(6):507-517. doi: 10.1056/NEJMoa1507598. PMID: 29414272
Koenen KC, Sumner JA, Gilsanz P, Glymour MM, Ratanatharathorn A, Rimm EB, Roberts AL, Winning A, Kubzansky LD
Psychol Med 2017 Jan;47(2):209-225. Epub 2016 Oct 4 doi: 10.1017/S0033291716002294. PMID: 27697083Free PMC Article

Recent systematic reviews

Hudays A, Gallagher R, Hazazi A, Arishi A, Bahari G
Int J Environ Res Public Health 2022 Dec 15;19(24) doi: 10.3390/ijerph192416836. PMID: 36554717Free PMC Article
Hailes HP, Yu R, Danese A, Fazel S
Lancet Psychiatry 2019 Oct;6(10):830-839. Epub 2019 Sep 10 doi: 10.1016/S2215-0366(19)30286-X. PMID: 31519507Free PMC Article
Denis D, French CC, Gregory AM
Sleep Med Rev 2018 Apr;38:141-157. Epub 2017 Jun 8 doi: 10.1016/j.smrv.2017.05.005. PMID: 28735779
Yildiz PD, Ayers S, Phillips L
J Affect Disord 2017 Jan 15;208:634-645. Epub 2016 Oct 27 doi: 10.1016/j.jad.2016.10.009. PMID: 27865585
Bisson JI, Roberts NP, Andrew M, Cooper R, Lewis C
Cochrane Database Syst Rev 2013 Dec 13;2013(12):CD003388. doi: 10.1002/14651858.CD003388.pub4. PMID: 24338345Free PMC Article

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