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Takayasu arteritis

MedGen UID:
21458
•Concept ID:
C0039263
•
Disease or Syndrome
Synonyms: Aortic arch syndrome; Pulseless disease; Takayasu disease; Young female arteritis
SNOMED CT: Takayasu disease (359789008); Takayasu's disease (359789008); Acquired aortoarteritis (359789008); Aortic arch arteritis (359789008); Occlusive thromboarteriopathy (359789008); Primary arteritis (359789008); Pulseless disease (359789008); Idiopathic medial aortopathy AND arteriopathy (359789008); Reverse coarctation (359789008); Atypical coarctation (359789008); Takayasu's arteriopathy (359789008); Takayasu's arteritis (359789008); Martorell syndrome (359789008); Nonspecific arteritis (359789008); Sclerosing aortitis AND arteritis (359789008); Nonspecific aortoarteritis (359789008); Raeder-Harbitz syndrome (359789008); Young female arteritis (359789008)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0017991
OMIM®: 207600
Orphanet: ORPHA3287

Definition

A rare, congenital anomaly of the great arteries characterized by cranially situated aortic arch ascending into the neck above the clavicles. Most patients remain asymptomatic, some present with a murmur and a pulsatile neck mass, stridor, dyspnea, recurrent bronchitis, dysphagia or signs and symptoms of a stenosis/aneurism of the aortic arch. Other congenital heart anomalies are frequently associated, including abnormalities of arch laterality and branching, aortic coarctation or aneurysm. [from ORDO]

Clinical features

From HPO
Arteritis
MedGen UID:
13916
•Concept ID:
C0003860
•
Pathologic Function
Arterial inflammation.
See: Feature record | Search on this feature
  • Abnormality of the cardiovascular system

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTakayasu arteritis
Follow this link to review classifications for Takayasu arteritis in Orphanet.

Professional guidelines

PubMed

Treatment Guidelines in Vasculitis.
Kermani TA, Warrington KJ, Dua AB
Rheum Dis Clin North Am 2022 Aug;48(3):705-724. Epub 2022 Jul 5 doi: 10.1016/j.rdc.2022.03.006. PMID: 35953232
2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis.
Maz M, Chung SA, Abril A, Langford CA, Gorelik M, Guyatt G, Archer AM, Conn DL, Full KA, Grayson PC, Ibarra MF, Imundo LF, Kim S, Merkel PA, Rhee RL, Seo P, Stone JH, Sule S, Sundel RP, Vitobaldi OI, Warner A, Byram K, Dua AB, Husainat N, James KE, Kalot MA, Lin YC, Springer JM, Turgunbaev M, Villa-Forte A, Turner AS, Mustafa RA
Arthritis Rheumatol 2021 Aug;73(8):1349-1365. Epub 2021 Jul 8 doi: 10.1002/art.41774. PMID: 34235884
2018 Update of the EULAR recommendations for the management of large vessel vasculitis.
Hellmich B, Agueda A, Monti S, Buttgereit F, de Boysson H, Brouwer E, Cassie R, Cid MC, Dasgupta B, Dejaco C, Hatemi G, Hollinger N, Mahr A, Mollan SP, Mukhtyar C, Ponte C, Salvarani C, Sivakumar R, Tian X, Tomasson G, Turesson C, Schmidt W, Villiger PM, Watts R, Young C, Luqmani RA
Ann Rheum Dis 2020 Jan;79(1):19-30. Epub 2019 Jul 3 doi: 10.1136/annrheumdis-2019-215672. PMID: 31270110

Recent clinical studies

Etiology

Treatment Guidelines in Vasculitis.
Kermani TA, Warrington KJ, Dua AB
Rheum Dis Clin North Am 2022 Aug;48(3):705-724. Epub 2022 Jul 5 doi: 10.1016/j.rdc.2022.03.006. PMID: 35953232
Takayasu arteritis.
Esatoglu SN, Hatemi G
Curr Opin Rheumatol 2022 Jan 1;34(1):18-24. doi: 10.1097/BOR.0000000000000852. PMID: 34698679
Vasculitis therapy refines vasculitis mechanistic classification.
Torp CK, Brüner M, Keller KK, Brouwer E, Hauge EM, McGonagle D, Kragstrup TW
Autoimmun Rev 2021 Jun;20(6):102829. Epub 2021 Apr 16 doi: 10.1016/j.autrev.2021.102829. PMID: 33872767
Aortitis: an update.
Erdogan M
Curr Opin Rheumatol 2021 Jan;33(1):34-40. doi: 10.1097/BOR.0000000000000762. PMID: 33186247
Takayasu arteritis in paediatrics.
Di Santo M, Stelmaszewski EV, Villa A
Cardiol Young 2018 Mar;28(3):354-361. Epub 2017 Dec 13 doi: 10.1017/S1047951117001998. PMID: 29233197

Diagnosis

Takayasu arteritis: advanced understanding is leading to new horizons.
Tombetti E, Mason JC
Rheumatology (Oxford) 2019 Feb 1;58(2):206-219. doi: 10.1093/rheumatology/key040. PMID: 29635396
Takayasu arteritis: an update.
Keser G, Aksu K, Direskeneli H
Turk J Med Sci 2018 Aug 16;48(4):681-697. doi: 10.3906/sag-1804-136. PMID: 30114347
Takayasu arteritis in paediatrics.
Di Santo M, Stelmaszewski EV, Villa A
Cardiol Young 2018 Mar;28(3):354-361. Epub 2017 Dec 13 doi: 10.1017/S1047951117001998. PMID: 29233197
Takayasu arteritis: challenges in diagnosis and management.
Kim ESH, Beckman J
Heart 2018 Apr;104(7):558-565. Epub 2017 Nov 25 doi: 10.1136/heartjnl-2016-310848. PMID: 29175979
Diagnostic and classification criteria of Takayasu arteritis.
de Souza AW, de Carvalho JF
J Autoimmun 2014 Feb-Mar;48-49:79-83. Epub 2014 Jan 21 doi: 10.1016/j.jaut.2014.01.012. PMID: 24461381

Therapy

Updates in the diagnosis and management of Takayasu's arteritis.
Somashekar A, Leung YT
Postgrad Med 2023 Jan;135(sup1):14-21. Epub 2023 Jan 2 doi: 10.1080/00325481.2022.2159723. PMID: 36588528
Vasculitis therapy refines vasculitis mechanistic classification.
Torp CK, Brüner M, Keller KK, Brouwer E, Hauge EM, McGonagle D, Kragstrup TW
Autoimmun Rev 2021 Jun;20(6):102829. Epub 2021 Apr 16 doi: 10.1016/j.autrev.2021.102829. PMID: 33872767
2018 Update of the EULAR recommendations for the management of large vessel vasculitis.
Hellmich B, Agueda A, Monti S, Buttgereit F, de Boysson H, Brouwer E, Cassie R, Cid MC, Dasgupta B, Dejaco C, Hatemi G, Hollinger N, Mahr A, Mollan SP, Mukhtyar C, Ponte C, Salvarani C, Sivakumar R, Tian X, Tomasson G, Turesson C, Schmidt W, Villiger PM, Watts R, Young C, Luqmani RA
Ann Rheum Dis 2020 Jan;79(1):19-30. Epub 2019 Jul 3 doi: 10.1136/annrheumdis-2019-215672. PMID: 31270110
Takayasu arteritis: advanced understanding is leading to new horizons.
Tombetti E, Mason JC
Rheumatology (Oxford) 2019 Feb 1;58(2):206-219. doi: 10.1093/rheumatology/key040. PMID: 29635396
Takayasu arteritis: an update.
Keser G, Aksu K, Direskeneli H
Turk J Med Sci 2018 Aug 16;48(4):681-697. doi: 10.3906/sag-1804-136. PMID: 30114347

Prognosis

Childhood-onset Takayasu arteritis.
Millan P, Gavcovich TB, Abitbol C
Curr Opin Pediatr 2022 Apr 1;34(2):223-228. doi: 10.1097/MOP.0000000000001113. PMID: 35142753
Aortitis: an update.
Erdogan M
Curr Opin Rheumatol 2021 Jan;33(1):34-40. doi: 10.1097/BOR.0000000000000762. PMID: 33186247
Takayasu Arteritis: Recent Developments.
Zaldivar Villon MLF, de la Rocha JAL, Espinoza LR
Curr Rheumatol Rep 2019 Jul 18;21(9):45. doi: 10.1007/s11926-019-0848-3. PMID: 31321560
Takayasu arteritis: an update.
Keser G, Aksu K, Direskeneli H
Turk J Med Sci 2018 Aug 16;48(4):681-697. doi: 10.3906/sag-1804-136. PMID: 30114347
Takayasu arteritis in paediatrics.
Di Santo M, Stelmaszewski EV, Villa A
Cardiol Young 2018 Mar;28(3):354-361. Epub 2017 Dec 13 doi: 10.1017/S1047951117001998. PMID: 29233197

Clinical prediction guides

Biomarkers in Takayasu arteritis.
Wen D, Feng L, Du X, Dong JZ, Ma CS
Int J Cardiol 2023 Jan 15;371:413-417. Epub 2022 Sep 5 doi: 10.1016/j.ijcard.2022.08.058. PMID: 36067923
Aortitis: an update.
Erdogan M
Curr Opin Rheumatol 2021 Jan;33(1):34-40. doi: 10.1097/BOR.0000000000000762. PMID: 33186247
Imaging for Diagnosis, Monitoring, and Outcome Prediction of Large Vessel Vasculitides.
Schäfer VS, Jin L, Schmidt WA
Curr Rheumatol Rep 2020 Sep 21;22(11):76. doi: 10.1007/s11926-020-00955-y. PMID: 32959107Free PMC Article
Giant coronary aneurysms, from diagnosis to treatment: A literature review.
Pham V, Hemptinne Q, Grinda JM, Duboc D, Varenne O, Picard F
Arch Cardiovasc Dis 2020 Jan;113(1):59-69. Epub 2019 Dec 19 doi: 10.1016/j.acvd.2019.10.008. PMID: 31866173
Takayasu arteritis: an update.
Keser G, Aksu K, Direskeneli H
Turk J Med Sci 2018 Aug 16;48(4):681-697. doi: 10.3906/sag-1804-136. PMID: 30114347

Recent systematic reviews

Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of 31 Randomized Controlled Trials.
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H
Front Immunol 2022;13:896476. Epub 2022 Aug 1 doi: 10.3389/fimmu.2022.896476. PMID: 35979355Free PMC Article
2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis.
Maz M, Chung SA, Abril A, Langford CA, Gorelik M, Guyatt G, Archer AM, Conn DL, Full KA, Grayson PC, Ibarra MF, Imundo LF, Kim S, Merkel PA, Rhee RL, Seo P, Stone JH, Sule S, Sundel RP, Vitobaldi OI, Warner A, Byram K, Dua AB, Husainat N, James KE, Kalot MA, Lin YC, Springer JM, Turgunbaev M, Villa-Forte A, Turner AS, Mustafa RA
Arthritis Rheumatol 2021 Aug;73(8):1349-1365. Epub 2021 Jul 8 doi: 10.1002/art.41774. PMID: 34235884
Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis.
van der Geest KSM, Treglia G, Glaudemans AWJM, Brouwer E, Sandovici M, Jamar F, Gheysens O, Slart RHJA
Eur J Nucl Med Mol Imaging 2021 Nov;48(12):3886-3902. Epub 2021 May 3 doi: 10.1007/s00259-021-05362-8. PMID: 33942141Free PMC Article
Vasculitis therapy refines vasculitis mechanistic classification.
Torp CK, Brüner M, Keller KK, Brouwer E, Hauge EM, McGonagle D, Kragstrup TW
Autoimmun Rev 2021 Jun;20(6):102829. Epub 2021 Apr 16 doi: 10.1016/j.autrev.2021.102829. PMID: 33872767
EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice.
Dejaco C, Ramiro S, Duftner C, Besson FL, Bley TA, Blockmans D, Brouwer E, Cimmino MA, Clark E, Dasgupta B, Diamantopoulos AP, Direskeneli H, Iagnocco A, Klink T, Neill L, Ponte C, Salvarani C, Slart RHJA, Whitlock M, Schmidt WA
Ann Rheum Dis 2018 May;77(5):636-643. Epub 2018 Jan 22 doi: 10.1136/annrheumdis-2017-212649. PMID: 29358285

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