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Fundic Gland Polyp

MedGen UID:
214715
•Concept ID:
C0920184
•
Neoplastic Process
Synonym: Polyps, fundic gland
SNOMED CT: Fundic gland polyp (447420007)

Definition

The most common gastric polyp in the Western hemisphere. The lesion consists of a localized hyperplasia of the deep epithelial compartment of the oxyntic mucosa, with variable degrees of cystic dilatation. Malignant transformation is the exception. (WHO, 2000) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFundic Gland Polyp

Professional guidelines

PubMed

Evaluation and management of gastric epithelial polyps.
Castro R, Pimentel-Nunes P, Dinis-Ribeiro M
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):381-387. Epub 2017 Jun 13 doi: 10.1016/j.bpg.2017.06.001. PMID: 28842047
Management of Non-neoplastic Gastric Lesions.
Schmocker RK, Lidor AO
Surg Clin North Am 2017 Apr;97(2):387-403. doi: 10.1016/j.suc.2016.11.011. PMID: 28325193

Recent clinical studies

Etiology

Changes of Gastric Juice Microenvironment in Patients with Fundic Gland Polyp and Hyperplastic Polyp.
Gao H, Chang L, Wang L, Zhou X, Wang N
Pathobiology 2021;88(6):383-391. Epub 2021 Sep 9 doi: 10.1159/000516855. PMID: 34500447
Histomorphological analysis of gastric polyps.
Amarapurkar AD, Kale KM, Naik LP, Shukla AP
Indian J Pathol Microbiol 2021 Jun;64(Supplement):S69-S72. doi: 10.4103/IJPM.IJPM_118_20. PMID: 34135141
Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) - A Helicobacter-opposite point.
Tacheci I, Repak R, Podhola M, Benesova L, Cyrany J, Bures J, Kohoutova D
Best Pract Res Clin Gastroenterol 2021 Mar-Apr;50-51:101728. Epub 2021 Feb 15 doi: 10.1016/j.bpg.2021.101728. PMID: 33975682
Fundic gland polyp prevalence according to Helicobacter pylori infection status.
Notsu T, Adachi K, Mishiro T, Ishimura N, Ishihara S
J Gastroenterol Hepatol 2020 Jul;35(7):1158-1162. Epub 2019 Dec 31 doi: 10.1111/jgh.14934. PMID: 31734951
Systematic review with meta-analysis: fundic gland polyps and proton pump inhibitors.
Martin FC, Chenevix-Trench G, Yeomans ND
Aliment Pharmacol Ther 2016 Nov;44(9):915-925. Epub 2016 Sep 15 doi: 10.1111/apt.13800. PMID: 27634363

Diagnosis

Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) - A Helicobacter-opposite point.
Tacheci I, Repak R, Podhola M, Benesova L, Cyrany J, Bures J, Kohoutova D
Best Pract Res Clin Gastroenterol 2021 Mar-Apr;50-51:101728. Epub 2021 Feb 15 doi: 10.1016/j.bpg.2021.101728. PMID: 33975682
Case-control analysis of fundic gland polyps and proton-pump inhibitors. A pathologist's perspective.
Velazquez-Dohorn M, López-Durand CF, Candanedo-González F, Araujo-Villalvazo EA, Gamboa-Domínguez A
Rev Gastroenterol Mex (Engl Ed) 2020 Jan-Mar;85(1):42-47. Epub 2019 May 22 doi: 10.1016/j.rgmx.2019.02.007. PMID: 31126726
Changing Trends in Gastric Polyps.
Velázquez-Dohorn ME, López-Durand CF, Gamboa-Domínguez A
Rev Invest Clin 2018;70(1):40-45. doi: 10.24875/RIC.17002430. PMID: 29513301
Evaluation and management of gastric epithelial polyps.
Castro R, Pimentel-Nunes P, Dinis-Ribeiro M
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):381-387. Epub 2017 Jun 13 doi: 10.1016/j.bpg.2017.06.001. PMID: 28842047
Management of Non-neoplastic Gastric Lesions.
Schmocker RK, Lidor AO
Surg Clin North Am 2017 Apr;97(2):387-403. doi: 10.1016/j.suc.2016.11.011. PMID: 28325193

Therapy

Case-control analysis of fundic gland polyps and proton-pump inhibitors. A pathologist's perspective.
Velazquez-Dohorn M, López-Durand CF, Candanedo-González F, Araujo-Villalvazo EA, Gamboa-Domínguez A
Rev Gastroenterol Mex (Engl Ed) 2020 Jan-Mar;85(1):42-47. Epub 2019 May 22 doi: 10.1016/j.rgmx.2019.02.007. PMID: 31126726
Histological analysis of fundic gland polyps secondary to PPI therapy.
Fukuda M, Ishigaki H, Sugimoto M, Mukaisho KI, Matsubara A, Ishida H, Moritani S, Itoh Y, Sugihara H, Andoh A, Ogasawara K, Murakami K, Kushima R
Histopathology 2019 Oct;75(4):537-545. Epub 2019 Aug 2 doi: 10.1111/his.13902. PMID: 31087669
Systematic review with meta-analysis: fundic gland polyps and proton pump inhibitors.
Martin FC, Chenevix-Trench G, Yeomans ND
Aliment Pharmacol Ther 2016 Nov;44(9):915-925. Epub 2016 Sep 15 doi: 10.1111/apt.13800. PMID: 27634363
Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan.
Hongo M, Fujimoto K; Gastric Polyps Study Group
J Gastroenterol 2010 Jun;45(6):618-24. Epub 2010 Feb 23 doi: 10.1007/s00535-010-0207-7. PMID: 20177714
Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy.
Jalving M, Koornstra JJ, Wesseling J, Boezen HM, DE Jong S, Kleibeuker JH
Aliment Pharmacol Ther 2006 Nov 1;24(9):1341-8. doi: 10.1111/j.1365-2036.2006.03127.x. PMID: 17059515

Prognosis

Image-enhanced endoscopy for real-time differentiation between hyperplastic and fundic gland polyps in the stomach.
Dutta AK, Uedo N, David D, Chandramohan J, Jain A, Patnayak I, Gupta P, Ayapati BK, Chatterjee K, Jaleel R, Kurien RT, Chowdhury SD, Simon EG, Joseph AJ, Pulimood AB
Indian J Gastroenterol 2022 Dec;41(6):599-609. Epub 2022 Dec 23 doi: 10.1007/s12664-022-01278-9. PMID: 36562941
GASTRIC FUNDIC GLAND POLYPS: CAN HISTOLOGY BE USEFUL TO PREDICT PROTON PUMP INHIBITORS USE?
Brito HLF, Barros C, Freire MV, Silva Filho MND, Nascimento TV
Arq Gastroenterol 2018 Oct-Dec;55(4):380-384. doi: 10.1590/S0004-2803.201800000-82. PMID: 30785522
Upper gastrointestinal tumours in Japanese familial adenomatous polyposis patients.
Yamaguchi T, Ishida H, Ueno H, Kobayashi H, Hinoi T, Inoue Y, Ishida F, Kanemitsu Y, Konishi T, Tomita N, Matsubara N, Watanabe T, Sugihara K
Jpn J Clin Oncol 2016 Apr;46(4):310-5. Epub 2016 Jan 26 doi: 10.1093/jjco/hyv210. PMID: 26819281Free PMC Article
Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan.
Hongo M, Fujimoto K; Gastric Polyps Study Group
J Gastroenterol 2010 Jun;45(6):618-24. Epub 2010 Feb 23 doi: 10.1007/s00535-010-0207-7. PMID: 20177714
Gastric fundic gland polyps and colonic polyps - is there a link, really?
Teichmann J, Weickert U, Riemann JF
Eur J Med Res 2008 May 26;13(5):192-5. PMID: 18559299

Clinical prediction guides

Image-enhanced endoscopy for real-time differentiation between hyperplastic and fundic gland polyps in the stomach.
Dutta AK, Uedo N, David D, Chandramohan J, Jain A, Patnayak I, Gupta P, Ayapati BK, Chatterjee K, Jaleel R, Kurien RT, Chowdhury SD, Simon EG, Joseph AJ, Pulimood AB
Indian J Gastroenterol 2022 Dec;41(6):599-609. Epub 2022 Dec 23 doi: 10.1007/s12664-022-01278-9. PMID: 36562941
High interobserver variability and frequent overdiagnosis of dysplasia in fundic gland polyps can be improved by detecting atypia on the surface epithelium and an abrupt transition to non-neoplastic cells.
Orr CE, Beneck D, Jessurun J, Qin L, Tyryshkin K, Yantiss RK, Chen YT
Histopathology 2022 Jan;80(2):314-321. Epub 2021 Oct 13 doi: 10.1111/his.14549. PMID: 34424570
GASTRIC FUNDIC GLAND POLYPS: CAN HISTOLOGY BE USEFUL TO PREDICT PROTON PUMP INHIBITORS USE?
Brito HLF, Barros C, Freire MV, Silva Filho MND, Nascimento TV
Arq Gastroenterol 2018 Oct-Dec;55(4):380-384. doi: 10.1590/S0004-2803.201800000-82. PMID: 30785522
Changing Trends in Gastric Polyps.
Velázquez-Dohorn ME, López-Durand CF, Gamboa-Domínguez A
Rev Invest Clin 2018;70(1):40-45. doi: 10.24875/RIC.17002430. PMID: 29513301
Gastric fundic gland polyps and colonic polyps - is there a link, really?
Teichmann J, Weickert U, Riemann JF
Eur J Med Res 2008 May 26;13(5):192-5. PMID: 18559299

Recent systematic reviews

Systematic review with meta-analysis: fundic gland polyps and proton pump inhibitors.
Martin FC, Chenevix-Trench G, Yeomans ND
Aliment Pharmacol Ther 2016 Nov;44(9):915-925. Epub 2016 Sep 15 doi: 10.1111/apt.13800. PMID: 27634363

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