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Teething syndrome

MedGen UID:
21474
Concept ID:
C0039437
Finding
Synonym: Teething
SNOMED CT: Teething syndrome (8004003)

Definition

An expected condition experienced by children during the emergence of deciduous teeth. Though a full set of 20 primary teeth takes more than two years to emerge, teething syndrome may be variably noted from the first paired eruption (usually at the sixth month) until the last. Characteristically, irritability, inflamed gingivae, drooling and chewing on solid objects may be seen several days prior to the eruption with rapid resolution. Typically, the lower central incisors appear first followed by the upper central incisors. Molars and canine teeth are the last to erupt. Anecdotal associations with fever and diarrhea are misattributed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTeething syndrome

Professional guidelines

PubMed

Goldstein G, Goodacre C, MacGregor K
J Prosthodont 2021 Apr;30(S1):12-19. doi: 10.1111/jopr.13315. PMID: 33783090
Testori T, Weinstein T, Scutellà F, Wang HL, Zucchelli G
Periodontol 2000 2018 Jun;77(1):176-196. Epub 2018 Feb 27 doi: 10.1111/prd.12211. PMID: 29484714
Suri L, Gagari E, Vastardis H
Am J Orthod Dentofacial Orthop 2004 Oct;126(4):432-45. doi: 10.1016/j.ajodo.2003.10.031. PMID: 15470346

Recent clinical studies

Etiology

Nahajowski M, Hnitecka S, Antoszewska-Smith J, Rumin K, Dubowik M, Sarul M
BMC Oral Health 2021 Apr 7;21(1):180. doi: 10.1186/s12903-021-01542-y. PMID: 33827533Free PMC Article
Chen X, Huo Y, Peng Y, Zhang Q, Zou J
Am J Orthod Dentofacial Orthop 2021 Feb;159(2):e169-e177. doi: 10.1016/j.ajodo.2020.09.020. PMID: 33546831
Hanisch M, Hanisch L, Kleinheinz J, Jung S
Head Face Med 2018 Mar 15;14(1):5. doi: 10.1186/s13005-018-0163-7. PMID: 29544499Free PMC Article
Mele M, Felice P, Sharma P, Mazzotti C, Bellone P, Zucchelli G
Periodontol 2000 2018 Jun;77(1):65-83. Epub 2018 Mar 4 doi: 10.1111/prd.12206. PMID: 29504162
Bardellini E, Amadori F, Pasini S, Majorana A
J Clin Pediatr Dent 2017;41(1):5-9. doi: 10.17796/1053-4628-41.1.5. PMID: 28052204

Diagnosis

Caeiro-Villasenín L, Serna-Muñoz C, Pérez-Silva A, Vicente-Hernández A, Poza-Pascual A, Ortiz-Ruiz AJ
Int J Environ Res Public Health 2022 Jan 10;19(2) doi: 10.3390/ijerph19020754. PMID: 35055575Free PMC Article
Becker A, Chaushu S
Am J Orthod Dentofacial Orthop 2015 Oct;148(4):557-67. doi: 10.1016/j.ajodo.2015.06.013. PMID: 26432311
Maspero C, Prevedello C, Giannini L, Galbiati G, Farronato G
Minerva Stomatol 2014 Jun;63(6):217-27. PMID: 25267151
Suri L, Gagari E, Vastardis H
Am J Orthod Dentofacial Orthop 2004 Oct;126(4):432-45. doi: 10.1016/j.ajodo.2003.10.031. PMID: 15470346
Russell KA, Folwarczna MA
J Can Dent Assoc 2003 Jun;69(6):362-6. PMID: 12787472

Therapy

Nahajowski M, Hnitecka S, Antoszewska-Smith J, Rumin K, Dubowik M, Sarul M
BMC Oral Health 2021 Apr 7;21(1):180. doi: 10.1186/s12903-021-01542-y. PMID: 33827533Free PMC Article
Lieblich SE, Dym H, Fenton D
J Oral Maxillofac Surg 2017 Aug;75(8S):e50-e73. doi: 10.1016/j.joms.2017.04.028. PMID: 28728738
Dean E
Nurs Stand 2016 Nov 23;31(13):15. doi: 10.7748/ns.31.13.15.s16. PMID: 27892232
Carvalho JC, Dige I, Machiulskiene V, Qvist V, Bakhshandeh A, Fatturi-Parolo C, Maltz M
Caries Res 2016;50(6):527-542. Epub 2016 Sep 23 doi: 10.1159/000448662. PMID: 27658123
McIntyre GT, McIntyre GM
Br Dent J 2002 Mar 9;192(5):251-5. doi: 10.1038/sj.bdj.4801349. PMID: 11924952

Prognosis

Chen X, Huo Y, Peng Y, Zhang Q, Zou J
Am J Orthod Dentofacial Orthop 2021 Feb;159(2):e169-e177. doi: 10.1016/j.ajodo.2020.09.020. PMID: 33546831
Maltagliati A, Ugolini A, Crippa R, Farronato M, Paglia M, Blasi S, Angiero F
Eur J Paediatr Dent 2020 Sep;21(3):199-202. doi: 10.23804/ejpd.2020.21.03.08. PMID: 32893652
Izadikhah I, Cao D, Zhao Z, Yan B
J Contemp Dent Pract 2020 Mar 1;21(3):326-336. PMID: 32434983
Hanisch M, Hanisch L, Kleinheinz J, Jung S
Head Face Med 2018 Mar 15;14(1):5. doi: 10.1186/s13005-018-0163-7. PMID: 29544499Free PMC Article
Carvalho JC, Dige I, Machiulskiene V, Qvist V, Bakhshandeh A, Fatturi-Parolo C, Maltz M
Caries Res 2016;50(6):527-542. Epub 2016 Sep 23 doi: 10.1159/000448662. PMID: 27658123

Clinical prediction guides

Chen X, Huo Y, Peng Y, Zhang Q, Zou J
Am J Orthod Dentofacial Orthop 2021 Feb;159(2):e169-e177. doi: 10.1016/j.ajodo.2020.09.020. PMID: 33546831
Hanisch M, Hanisch L, Kleinheinz J, Jung S
Head Face Med 2018 Mar 15;14(1):5. doi: 10.1186/s13005-018-0163-7. PMID: 29544499Free PMC Article
Bardellini E, Amadori F, Pasini S, Majorana A
J Clin Pediatr Dent 2017;41(1):5-9. doi: 10.17796/1053-4628-41.1.5. PMID: 28052204
Premalatha, Kannan VP; Madhu
J Indian Soc Pedod Prev Dent 2010 Oct-Dec;28(4):322-5. doi: 10.4103/0970-4388.76169. PMID: 21273726
Marks SC Jr, Schroeder HE
Anat Rec 1996 Jun;245(2):374-93. doi: 10.1002/(SICI)1097-0185(199606)245:2<374::AID-AR18>3.0.CO;2-M. PMID: 8769674

Recent systematic reviews

Gibbison R, Crozier R
Evid Based Dent 2022 Sep;23(3):112-113. Epub 2022 Sep 23 doi: 10.1038/s41432-022-0808-z. PMID: 36151286
Caeiro-Villasenín L, Serna-Muñoz C, Pérez-Silva A, Vicente-Hernández A, Poza-Pascual A, Ortiz-Ruiz AJ
Int J Environ Res Public Health 2022 Jan 10;19(2) doi: 10.3390/ijerph19020754. PMID: 35055575Free PMC Article
Turner S, Harrison JE, Sharif FN, Owens D, Millett DT
Cochrane Database Syst Rev 2021 Dec 31;12(12):CD003453. doi: 10.1002/14651858.CD003453.pub2. PMID: 34970995Free PMC Article
Nahajowski M, Hnitecka S, Antoszewska-Smith J, Rumin K, Dubowik M, Sarul M
BMC Oral Health 2021 Apr 7;21(1):180. doi: 10.1186/s12903-021-01542-y. PMID: 33827533Free PMC Article
Hanisch M, Hanisch L, Kleinheinz J, Jung S
Head Face Med 2018 Mar 15;14(1):5. doi: 10.1186/s13005-018-0163-7. PMID: 29544499Free PMC Article

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