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Teething syndrome

MedGen UID:
21474
Concept ID:
C0039437
Finding
Synonym: Teething
SNOMED CT: Teething syndrome (8004003)

Definition

An expected condition experienced by children during the emergence of deciduous teeth. Though a full set of 20 primary teeth takes more than two years to emerge, teething syndrome may be variably noted from the first paired eruption (usually at the sixth month) until the last. Characteristically, irritability, inflamed gingivae, drooling and chewing on solid objects may be seen several days prior to the eruption with rapid resolution. Typically, the lower central incisors appear first followed by the upper central incisors. Molars and canine teeth are the last to erupt. Anecdotal associations with fever and diarrhea are misattributed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTeething syndrome

Professional guidelines

PubMed

Goldstein G, Goodacre C, MacGregor K
J Prosthodont 2021 Apr;30(S1):12-19. doi: 10.1111/jopr.13315. PMID: 33783090
Suri L, Gagari E, Vastardis H
Am J Orthod Dentofacial Orthop 2004 Oct;126(4):432-45. doi: 10.1016/j.ajodo.2003.10.031. PMID: 15470346
Russell KA, Folwarczna MA
J Can Dent Assoc 2003 Jun;69(6):362-6. PMID: 12787472

Recent clinical studies

Etiology

Abdulsatar F, Miller MR, Taheri S
J Can Dent Assoc 2022 Aug;88:m7. PMID: 36322634
Nahajowski M, Hnitecka S, Antoszewska-Smith J, Rumin K, Dubowik M, Sarul M
BMC Oral Health 2021 Apr 7;21(1):180. doi: 10.1186/s12903-021-01542-y. PMID: 33827533Free PMC Article
Hanisch M, Hanisch L, Kleinheinz J, Jung S
Head Face Med 2018 Mar 15;14(1):5. doi: 10.1186/s13005-018-0163-7. PMID: 29544499Free PMC Article
Mele M, Felice P, Sharma P, Mazzotti C, Bellone P, Zucchelli G
Periodontol 2000 2018 Jun;77(1):65-83. Epub 2018 Mar 4 doi: 10.1111/prd.12206. PMID: 29504162
Alpiste-Illueca F
Med Oral Patol Oral Cir Bucal 2011 Jan 1;16(1):e100-4. doi: 10.4317/medoral.16.e100. PMID: 20711147

Diagnosis

Caeiro-Villasenín L, Serna-Muñoz C, Pérez-Silva A, Vicente-Hernández A, Poza-Pascual A, Ortiz-Ruiz AJ
Int J Environ Res Public Health 2022 Jan 10;19(2) doi: 10.3390/ijerph19020754. PMID: 35055575Free PMC Article
Becker A, Chaushu S
Am J Orthod Dentofacial Orthop 2015 Oct;148(4):557-67. doi: 10.1016/j.ajodo.2015.06.013. PMID: 26432311
Maspero C, Prevedello C, Giannini L, Galbiati G, Farronato G
Minerva Stomatol 2014 Jun;63(6):217-27. PMID: 25267151
Suri L, Gagari E, Vastardis H
Am J Orthod Dentofacial Orthop 2004 Oct;126(4):432-45. doi: 10.1016/j.ajodo.2003.10.031. PMID: 15470346
Russell KA, Folwarczna MA
J Can Dent Assoc 2003 Jun;69(6):362-6. PMID: 12787472

Therapy

Seehra J, Mortaja K, Wazwaz F, Papageorgiou SN, Newton JT, Cobourne MT
Am J Orthod Dentofacial Orthop 2023 May;163(5):594-608. Epub 2023 Mar 11 doi: 10.1016/j.ajodo.2023.01.004. PMID: 36907703
Nahajowski M, Hnitecka S, Antoszewska-Smith J, Rumin K, Dubowik M, Sarul M
BMC Oral Health 2021 Apr 7;21(1):180. doi: 10.1186/s12903-021-01542-y. PMID: 33827533Free PMC Article
Dean E
Nurs Stand 2016 Nov 23;31(13):15. doi: 10.7748/ns.31.13.15.s16. PMID: 27892232
McIntyre GT, McIntyre GM
Br Dent J 2002 Mar 9;192(5):251-5. doi: 10.1038/sj.bdj.4801349. PMID: 11924952
Proffit WR
Angle Orthod 1978 Jul;48(3):175-86. doi: 10.1043/0003-3219(1978)048<0175:ETRFIP>2.0.CO;2. PMID: 280125

Prognosis

Mutneja P, Mutneja AR, Vg M, Patil K
Minerva Dent Oral Sci 2021 Oct;70(5):180-183. Epub 2021 Apr 28 doi: 10.23736/S2724-6329.21.04392-2. PMID: 33908748
Maltagliati A, Ugolini A, Crippa R, Farronato M, Paglia M, Blasi S, Angiero F
Eur J Paediatr Dent 2020 Sep;21(3):199-202. doi: 10.23804/ejpd.2020.21.03.08. PMID: 32893652
Hanisch M, Hanisch L, Kleinheinz J, Jung S
Head Face Med 2018 Mar 15;14(1):5. doi: 10.1186/s13005-018-0163-7. PMID: 29544499Free PMC Article
Phillips C, White RP Jr
J Oral Maxillofac Surg 2012 Sep;70(9 Suppl 1):S11-4. Epub 2012 Jun 16 doi: 10.1016/j.joms.2012.04.024. PMID: 22705213
Silberberg N, Goldstein M, Smidt A
Quintessence Int 2009 Nov-Dec;40(10):809-18. PMID: 19898712

Clinical prediction guides

Alpayçetin E, Karaduran B, Baysan C, Koruyucu M, Nce EBT
J Dent Child (Chic) 2023 Nov 15;90(3):164-167. PMID: 38123926
Alkhozaim DA, Al-Haj Ali SN, Farah RI
PeerJ 2022;10:e13948. Epub 2022 Aug 18 doi: 10.7717/peerj.13948. PMID: 35999852Free PMC Article
Hanisch M, Hanisch L, Kleinheinz J, Jung S
Head Face Med 2018 Mar 15;14(1):5. doi: 10.1186/s13005-018-0163-7. PMID: 29544499Free PMC Article
Silberberg N, Goldstein M, Smidt A
Quintessence Int 2009 Nov-Dec;40(10):809-18. PMID: 19898712
Marks SC Jr, Schroeder HE
Anat Rec 1996 Jun;245(2):374-93. doi: 10.1002/(SICI)1097-0185(199606)245:2<374::AID-AR18>3.0.CO;2-M. PMID: 8769674

Recent systematic reviews

Seehra J, Mortaja K, Wazwaz F, Papageorgiou SN, Newton JT, Cobourne MT
Am J Orthod Dentofacial Orthop 2023 May;163(5):594-608. Epub 2023 Mar 11 doi: 10.1016/j.ajodo.2023.01.004. PMID: 36907703
Caeiro-Villasenín L, Serna-Muñoz C, Pérez-Silva A, Vicente-Hernández A, Poza-Pascual A, Ortiz-Ruiz AJ
Int J Environ Res Public Health 2022 Jan 10;19(2) doi: 10.3390/ijerph19020754. PMID: 35055575Free PMC Article
Turner S, Harrison JE, Sharif FN, Owens D, Millett DT
Cochrane Database Syst Rev 2021 Dec 31;12(12):CD003453. doi: 10.1002/14651858.CD003453.pub2. PMID: 34970995Free PMC Article
Nahajowski M, Hnitecka S, Antoszewska-Smith J, Rumin K, Dubowik M, Sarul M
BMC Oral Health 2021 Apr 7;21(1):180. doi: 10.1186/s12903-021-01542-y. PMID: 33827533Free PMC Article
Hanisch M, Hanisch L, Kleinheinz J, Jung S
Head Face Med 2018 Mar 15;14(1):5. doi: 10.1186/s13005-018-0163-7. PMID: 29544499Free PMC Article

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