U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tic

MedGen UID:
21556
Concept ID:
C0040188
Mental or Behavioral Dysfunction
Synonyms: Tic Disorder; Tic Disorders
SNOMED CT: Tic (386783003); Tics (386783003); Tic disorder (568005)

Definition

Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994) [from MeSH]

Professional guidelines

PubMed

Roessner V, Eichele H, Stern JS, Skov L, Rizzo R, Debes NM, Nagy P, Cavanna AE, Termine C, Ganos C, Münchau A, Szejko N, Cath D, Müller-Vahl KR, Verdellen C, Hartmann A, Rothenberger A, Hoekstra PJ, Plessen KJ
Eur Child Adolesc Psychiatry 2022 Mar;31(3):425-441. Epub 2021 Nov 10 doi: 10.1007/s00787-021-01899-z. PMID: 34757514Free PMC Article
Szejko N, Robinson S, Hartmann A, Ganos C, Debes NM, Skov L, Haas M, Rizzo R, Stern J, Münchau A, Czernecki V, Dietrich A, Murphy TL, Martino D, Tarnok Z, Hedderly T, Müller-Vahl KR, Cath DC
Eur Child Adolesc Psychiatry 2022 Mar;31(3):383-402. Epub 2021 Oct 18 doi: 10.1007/s00787-021-01842-2. PMID: 34661764Free PMC Article
Pringsheim T, Okun MS, Müller-Vahl K, Martino D, Jankovic J, Cavanna AE, Woods DW, Robinson M, Jarvie E, Roessner V, Oskoui M, Holler-Managan Y, Piacentini J
Neurology 2019 May 7;92(19):896-906. doi: 10.1212/WNL.0000000000007466. PMID: 31061208Free PMC Article

Recent clinical studies

Etiology

Huang J, Li R, Li L, Song Y, Jin L
Neurosci Biobehav Rev 2022 Jan;132:362-377. Epub 2021 Dec 6 doi: 10.1016/j.neubiorev.2021.12.004. PMID: 34883165
Dempsey N, Rosenthal A, Dabas N, Kropotova Y, Lippman M, Bishopric NH
Breast Cancer Res Treat 2021 Jul;188(1):21-36. Epub 2021 Jun 11 doi: 10.1007/s10549-021-06280-x. PMID: 34115243
Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schöchl H, Hunt BJ, Sauaia A
Nat Rev Dis Primers 2021 Apr 29;7(1):30. doi: 10.1038/s41572-021-00264-3. PMID: 33927200Free PMC Article
Qi Y, Zheng Y, Li Z, Liu Z, Xiong L
Methods Mol Biol 2019;2011:547-571. doi: 10.1007/978-1-4939-9554-7_32. PMID: 31273721
Osland ST, Steeves TD, Pringsheim T
Cochrane Database Syst Rev 2018 Jun 26;6(6):CD007990. doi: 10.1002/14651858.CD007990.pub3. PMID: 29944175Free PMC Article

Diagnosis

Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schöchl H, Hunt BJ, Sauaia A
Nat Rev Dis Primers 2021 Apr 29;7(1):30. doi: 10.1038/s41572-021-00264-3. PMID: 33927200Free PMC Article
Deeb W, Malaty IA, Mathews CA
Handb Clin Neurol 2019;165:123-153. doi: 10.1016/B978-0-444-64012-3.00008-3. PMID: 31727209
Singer HS
Continuum (Minneap Minn) 2019 Aug;25(4):936-958. doi: 10.1212/CON.0000000000000752. PMID: 31356288
Petros S
Hamostaseologie 2019 Feb;39(1):20-27. Epub 2019 Jan 31 doi: 10.1055/s-0039-1677853. PMID: 30703820
Bruce MM, Kassam-Adams N, Rogers M, Anderson KM, Sluys KP, Richmond TS
J Trauma Nurs 2018 Mar/Apr;25(2):131-138. doi: 10.1097/JTN.0000000000000356. PMID: 29521782Free PMC Article

Therapy

Rizzo R, Prato A, Scerbo M, Saia F, Barone R, Curatolo P
Nutrients 2022 Feb 18;14(4) doi: 10.3390/nu14040852. PMID: 35215501Free PMC Article
Pringsheim T, Holler-Managan Y, Okun MS, Jankovic J, Piacentini J, Cavanna AE, Martino D, Müller-Vahl K, Woods DW, Robinson M, Jarvie E, Roessner V, Oskoui M
Neurology 2019 May 7;92(19):907-915. doi: 10.1212/WNL.0000000000007467. PMID: 31061209Free PMC Article
Osland ST, Steeves TD, Pringsheim T
Cochrane Database Syst Rev 2018 Jun 26;6(6):CD007990. doi: 10.1002/14651858.CD007990.pub3. PMID: 29944175Free PMC Article
Lipner SR, Scher RK
J Dermatolog Treat 2018 Jun;29(4):411-414. Epub 2017 Nov 9 doi: 10.1080/09546634.2017.1395799. PMID: 29057689
Yang C, Hao Z, Zhang LL, Guo Q
Pediatr Res 2015 Aug;78(2):112-9. Epub 2015 May 7 doi: 10.1038/pr.2015.91. PMID: 25950453

Prognosis

Huang J, Li R, Li L, Song Y, Jin L
Neurosci Biobehav Rev 2022 Jan;132:362-377. Epub 2021 Dec 6 doi: 10.1016/j.neubiorev.2021.12.004. PMID: 34883165
Wu CC, Wong LC, Hsu CJ, Yang CW, Tsai YC, Cheng FS, Hu HY, Lee WT
Nutrients 2021 Oct 21;13(11) doi: 10.3390/nu13113698. PMID: 34835954Free PMC Article
Dempsey N, Rosenthal A, Dabas N, Kropotova Y, Lippman M, Bishopric NH
Breast Cancer Res Treat 2021 Jul;188(1):21-36. Epub 2021 Jun 11 doi: 10.1007/s10549-021-06280-x. PMID: 34115243
Bruce MM, Kassam-Adams N, Rogers M, Anderson KM, Sluys KP, Richmond TS
J Trauma Nurs 2018 Mar/Apr;25(2):131-138. doi: 10.1097/JTN.0000000000000356. PMID: 29521782Free PMC Article
Leckman JF, Peterson BS, Pauls DL, Cohen DJ
Psychiatr Clin North Am 1997 Dec;20(4):839-61. doi: 10.1016/s0193-953x(05)70348-8. PMID: 9443353

Clinical prediction guides

Gilbert DL, Dubow JS, Cunniff TM, Wanaski SP, Atkinson SD, Mahableshwarkar AR
Pediatrics 2023 Feb 1;151(2) doi: 10.1542/peds.2022-059574. PMID: 36628546
Huang J, Li R, Li L, Song Y, Jin L
Neurosci Biobehav Rev 2022 Jan;132:362-377. Epub 2021 Dec 6 doi: 10.1016/j.neubiorev.2021.12.004. PMID: 34883165
Goldman KJ, DeLeon IG
Behav Modif 2020 Mar;44(2):296-315. Epub 2018 Oct 29 doi: 10.1177/0145445518809046. PMID: 30373380
Yu D, Sul JH, Tsetsos F, Nawaz MS, Huang AY, Zelaya I, Illmann C, Osiecki L, Darrow SM, Hirschtritt ME, Greenberg E, Muller-Vahl KR, Stuhrmann M, Dion Y, Rouleau G, Aschauer H, Stamenkovic M, Schlögelhofer M, Sandor P, Barr CL, Grados M, Singer HS, Nöthen MM, Hebebrand J, Hinney A, King RA, Fernandez TV, Barta C, Tarnok Z, Nagy P, Depienne C, Worbe Y, Hartmann A, Budman CL, Rizzo R, Lyon GJ, McMahon WM, Batterson JR, Cath DC, Malaty IA, Okun MS, Berlin C, Woods DW, Lee PC, Jankovic J, Robertson MM, Gilbert DL, Brown LW, Coffey BJ, Dietrich A, Hoekstra PJ, Kuperman S, Zinner SH, Luðvigsson P, Sæmundsen E, Thorarensen Ó, Atzmon G, Barzilai N, Wagner M, Moessner R, Ophoff R, Pato CN, Pato MT, Knowles JA, Roffman JL, Smoller JW, Buckner RL, Willsey AJ, Tischfield JA, Heiman GA, Stefansson H, Stefansson K, Posthuma D, Cox NJ, Pauls DL, Freimer NB, Neale BM, Davis LK, Paschou P, Coppola G, Mathews CA, Scharf JM; Tourette Association of America International Consortium for Genetics, the Gilles de la Tourette GWAS Replication Initiative, the Tourette International Collaborative Genetics Study, and the Psychiatric Genomics Consortium Tourette Syndrome Working Group
Am J Psychiatry 2019 Mar 1;176(3):217-227. doi: 10.1176/appi.ajp.2018.18070857. PMID: 30818990Free PMC Article
Bruce MM, Kassam-Adams N, Rogers M, Anderson KM, Sluys KP, Richmond TS
J Trauma Nurs 2018 Mar/Apr;25(2):131-138. doi: 10.1097/JTN.0000000000000356. PMID: 29521782Free PMC Article

Recent systematic reviews

Farhat LC, Behling E, Landeros-Weisenberger A, Levine JLS, Macul Ferreira de Barros P, Wang Z, Bloch MH
Lancet Child Adolesc Health 2023 Feb;7(2):112-126. Epub 2022 Dec 14 doi: 10.1016/S2352-4642(22)00316-9. PMID: 36528030
Huang J, Li R, Li L, Song Y, Jin L
Neurosci Biobehav Rev 2022 Jan;132:362-377. Epub 2021 Dec 6 doi: 10.1016/j.neubiorev.2021.12.004. PMID: 34883165
Dubey P, Thakur B, Rodriguez S, Cox J, Sanchez S, Fonseca A, Reddy S, Clegg D, Dwivedi AK
Transl Psychiatry 2021 Nov 8;11(1):569. doi: 10.1038/s41398-021-01699-8. PMID: 34750348Free PMC Article
Pringsheim T, Holler-Managan Y, Okun MS, Jankovic J, Piacentini J, Cavanna AE, Martino D, Müller-Vahl K, Woods DW, Robinson M, Jarvie E, Roessner V, Oskoui M
Neurology 2019 May 7;92(19):907-915. doi: 10.1212/WNL.0000000000007467. PMID: 31061209Free PMC Article
Osland ST, Steeves TD, Pringsheim T
Cochrane Database Syst Rev 2018 Jun 26;6(6):CD007990. doi: 10.1002/14651858.CD007990.pub3. PMID: 29944175Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    • Tic
      Tic
      MedGen

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...