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Recurrent respiratory papillomatosis(RRP)

MedGen UID:
216998
Concept ID:
C1168198
Neoplastic Process
Synonyms: Adult-onset recurrent respiratory papillomatosis (type); AORRP (type); JORRP (type); Juvenile laryngeal papilloma; Juvenile-onset recurrent respiratory papillomatosis (type); Laryngeal papilloma, recurrent; RRP
SNOMED CT: Recurrent respiratory papillomatosis (472827002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018955
Orphanet: ORPHA60032

Definition

Recurrent respiratory papillomatosis is a rare respiratory disease characterized by the development of exophytic papillomas, affecting the mucosa of the upper aero-digestive tract (with a strong predilection for the larynx), caused by an infection with human papilloma virus. Symptoms at presentation may include hoarseness, chronic cough, dyspnea, recurrent upper respiratory tract infections, pneumonia, dysphagia, stridor, and/or failure to thrive. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent respiratory papillomatosis
Follow this link to review classifications for Recurrent respiratory papillomatosis in Orphanet.

Professional guidelines

PubMed

Zhao X, Wang J, Chen Q, Wu X, Mao W, Ma J, Fang R, He P, Wei C
Eur Arch Otorhinolaryngol 2024 Apr;281(4):1865-1875. Epub 2024 Jan 5 doi: 10.1007/s00405-023-08430-x. PMID: 38180605
Allen CT
Otolaryngol Clin North Am 2021 Aug;54(4):769-777. Epub 2021 Jun 5 doi: 10.1016/j.otc.2021.05.002. PMID: 34099306Free PMC Article
Wilcox LJ, Hull BP, Baldassari CM, Derkay CS
Pediatr Infect Dis J 2014 Dec;33(12):1283-4. doi: 10.1097/INF.0000000000000551. PMID: 25229272

Recent clinical studies

Etiology

Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A
J Endocrinol Invest 2024 Feb;47(2):261-274. Epub 2023 Sep 28 doi: 10.1007/s40618-023-02192-3. PMID: 37770654Free PMC Article
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Vives A, Cosentino M, Palou J
Actas Urol Esp (Engl Ed) 2020 Mar;44(2):86-93. Epub 2019 Dec 23 doi: 10.1016/j.acuro.2019.08.010. PMID: 31874781
Ribeiro AL, Caodaglio AS, Sichero L
Clinics (Sao Paulo) 2018 Oct 11;73(suppl 1):e486s. doi: 10.6061/clinics/2018/e486s. PMID: 30328948Free PMC Article
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457

Diagnosis

Vives A, Cosentino M, Palou J
Actas Urol Esp (Engl Ed) 2020 Mar;44(2):86-93. Epub 2019 Dec 23 doi: 10.1016/j.acuro.2019.08.010. PMID: 31874781
Frazier AA
Radiographics 2018 Nov-Dec;38(7):2150. doi: 10.1148/rg.2018184010. PMID: 30422770
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Lancet 1988 Dec 17;2(8625):1406. PMID: 2904531

Therapy

Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A
J Endocrinol Invest 2024 Feb;47(2):261-274. Epub 2023 Sep 28 doi: 10.1007/s40618-023-02192-3. PMID: 37770654Free PMC Article
Derkay CS, Bluher AE
Otolaryngol Clin North Am 2019 Aug;52(4):669-679. Epub 2019 May 8 doi: 10.1016/j.otc.2019.03.011. PMID: 31078306
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Lancet 1988 Dec 17;2(8625):1406. PMID: 2904531

Prognosis

Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Maturo SC, Hartnick CJ
Adv Otorhinolaryngol 2012;73:105-8. Epub 2012 Mar 29 doi: 10.1159/000334457. PMID: 22472239

Clinical prediction guides

Zhao X, Wang J, Chen Q, Wu X, Mao W, Ma J, Fang R, He P, Wei C
Eur Arch Otorhinolaryngol 2024 Apr;281(4):1865-1875. Epub 2024 Jan 5 doi: 10.1007/s00405-023-08430-x. PMID: 38180605
Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A
J Endocrinol Invest 2024 Feb;47(2):261-274. Epub 2023 Sep 28 doi: 10.1007/s40618-023-02192-3. PMID: 37770654Free PMC Article
Norberg SM, Bai K, Sievers C, Robbins Y, Friedman J, Yang X, Kenyon M, Ward E, Schlom J, Gulley J, Lankford A, Semnani R, Sabzevari H, Brough DE, Allen CT
Sci Transl Med 2023 Oct 25;15(719):eadj0740. doi: 10.1126/scitranslmed.adj0740. PMID: 37878675Free PMC Article
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562

Recent systematic reviews

Liu S, Wang J, Shao J
Clin Otolaryngol 2023 May;48(3):403-413. Epub 2023 Jan 15 doi: 10.1111/coa.14023. PMID: 36536541
Chen S, Connors J, Zhang Y, Wang B, Vieira D, Shapira-Galitz Y, Garber D, Amin MR
Ann Otol Rhinol Laryngol 2021 Mar;130(3):234-244. Epub 2020 Aug 12 doi: 10.1177/0003489420949586. PMID: 32781827
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562
San Giorgi MR, Helder HM, Lindeman RJ, de Bock GH, Dikkers FG
Laryngoscope 2016 Oct;126(10):2330-9. Epub 2016 Apr 26 doi: 10.1002/lary.25898. PMID: 27113025
Lieder A, Khan MK, Lippert BM
Cochrane Database Syst Rev 2014 Jun 5;2014(6):CD009810. doi: 10.1002/14651858.CD009810.pub2. PMID: 24898010Free PMC Article

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