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Recurrent respiratory papillomatosis(RRP)

MedGen UID:
216998
•Concept ID:
C1168198
•
Neoplastic Process
Synonyms: Adult-onset recurrent respiratory papillomatosis (type); AORRP (type); JORRP (type); Juvenile laryngeal papilloma; Juvenile-onset recurrent respiratory papillomatosis (type); Laryngeal papilloma, recurrent; RRP
SNOMED CT: Recurrent respiratory papillomatosis (472827002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018955
Orphanet: ORPHA60032

Definition

Recurrent respiratory papillomatosis is a rare respiratory disease characterized by the development of exophytic papillomas, affecting the mucosa of the upper aero-digestive tract (with a strong predilection for the larynx), caused by an infection with human papilloma virus. Symptoms at presentation may include hoarseness, chronic cough, dyspnea, recurrent upper respiratory tract infections, pneumonia, dysphagia, stridor, and/or failure to thrive. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent respiratory papillomatosis
Follow this link to review classifications for Recurrent respiratory papillomatosis in Orphanet.

Professional guidelines

PubMed

Biologics for the Treatment of Recurrent Respiratory Papillomatosis.
Allen CT
Otolaryngol Clin North Am 2021 Aug;54(4):769-777. Epub 2021 Jun 5 doi: 10.1016/j.otc.2021.05.002. PMID: 34099306Free PMC Article
Multidisciplinary, evidence-based consensus guidelines for human papillomavirus (HPV) vaccination in high-risk populations, Spain, 2016.
Martínez-Gómez X, Curran A, Campins M, Alemany L, Rodrigo-Pendás JÁ, Borruel N, Castellsagué X, Díaz-de-Heredia C, Moraga-Llop FA, Del Pino M, Torné A
Euro Surveill 2019 Feb;24(7) doi: 10.2807/1560-7917.ES.2019.24.7.1700857. PMID: 30782268Free PMC Article
Surgical treatment and adjuvant therapies of recurrent respiratory papillomatosis.
Avelino MA, Zaiden TC, Gomes RO
Braz J Otorhinolaryngol 2013 Sep-Oct;79(5):636-42. doi: 10.5935/1808-8694.20130114. PMID: 24141682Free PMC Article

Recent clinical studies

Etiology

Infantile recurrent respiratory papillomatosis: review of adjuvant therapies.
Patel A, Orban N
J Laryngol Otol 2021 Nov;135(11):958-963. Epub 2021 Sep 2 doi: 10.1017/S0022215121002322. PMID: 34470689
The role of human papilloma virus test in men: First exhaustive review of literature.
Vives A, Cosentino M, Palou J
Actas Urol Esp (Engl Ed) 2020 Mar;44(2):86-93. Epub 2019 Dec 23 doi: 10.1016/j.acuro.2019.08.010. PMID: 31874781
Recurrent respiratory papillomatosis: update 2018.
Derkay CS, Bluher AE
Curr Opin Otolaryngol Head Neck Surg 2018 Dec;26(6):421-425. doi: 10.1097/MOO.0000000000000490. PMID: 30300210
Epidemiology and burden of HPV-related disease.
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457
Recurrent respiratory papillomatosis.
Kashima HK, Mounts P, Shah K
Obstet Gynecol Clin North Am 1996 Sep;23(3):699-706. PMID: 8869953

Diagnosis

The role of human papilloma virus test in men: First exhaustive review of literature.
Vives A, Cosentino M, Palou J
Actas Urol Esp (Engl Ed) 2020 Mar;44(2):86-93. Epub 2019 Dec 23 doi: 10.1016/j.acuro.2019.08.010. PMID: 31874781
Recurrent Respiratory Papillomatosis.
Frazier AA
Radiographics 2018 Nov-Dec;38(7):2150. doi: 10.1148/rg.2018184010. PMID: 30422770
Recurrent respiratory papillomatosis: update 2018.
Derkay CS, Bluher AE
Curr Opin Otolaryngol Head Neck Surg 2018 Dec;26(6):421-425. doi: 10.1097/MOO.0000000000000490. PMID: 30300210
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article

Therapy

Update on Recurrent Respiratory Papillomatosis.
Derkay CS, Bluher AE
Otolaryngol Clin North Am 2019 Aug;52(4):669-679. Epub 2019 May 8 doi: 10.1016/j.otc.2019.03.011. PMID: 31078306
Recurrent respiratory papillomatosis: update 2018.
Derkay CS, Bluher AE
Curr Opin Otolaryngol Head Neck Surg 2018 Dec;26(6):421-425. doi: 10.1097/MOO.0000000000000490. PMID: 30300210
A Systematic Review.
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Recurrent respiratory papillomatosis.
Derkay CS, Darrow DH
Ann Otol Rhinol Laryngol 2006 Jan;115(1):1-11. doi: 10.1177/000348940611500101. PMID: 16466093

Prognosis

Role of chemokines in HPV-induced cancers.
Israr M, DeVoti JA, Papayannakos CJ, Bonagura VR
Semin Cancer Biol 2022 Dec;87:170-183. Epub 2022 Nov 17 doi: 10.1016/j.semcancer.2022.11.010. PMID: 36402301
Epidemiology and burden of HPV-related disease.
Serrano B, Brotons M, Bosch FX, Bruni L
Best Pract Res Clin Obstet Gynaecol 2018 Feb;47:14-26. Epub 2017 Sep 2 doi: 10.1016/j.bpobgyn.2017.08.006. PMID: 29037457
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Recurrent respiratory papillomatosis.
Derkay CS, Darrow DH
Ann Otol Rhinol Laryngol 2006 Jan;115(1):1-11. doi: 10.1177/000348940611500101. PMID: 16466093

Clinical prediction guides

Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population.
Carvalho AMAS, Brito DS, Cunha APA, Monteiro PM, Ferreira MB, Assis DSFR, Bentivi JO, Andrade MS, Vidal FCB, Salgado Filho N
Rev Inst Med Trop Sao Paulo 2021;63:e63. Epub 2021 Aug 16 doi: 10.1590/S1678-9946202163063. PMID: 34406288Free PMC Article
A Systematic Review.
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562
The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review.
San Giorgi MR, Helder HM, Lindeman RJ, de Bock GH, Dikkers FG
Laryngoscope 2016 Oct;126(10):2330-9. Epub 2016 Apr 26 doi: 10.1002/lary.25898. PMID: 27113025
Adjuvant antiviral therapy for recurrent respiratory papillomatosis.
Chadha NK, James A
Cochrane Database Syst Rev 2012 Dec 12;12(12):CD005053. doi: 10.1002/14651858.CD005053.pub4. PMID: 23235619Free PMC Article

Recent systematic reviews

Recurrent Respiratory Papillomatosis Office versus Operating Room: Systematic Review and Meta-Analysis.
Chen S, Connors J, Zhang Y, Wang B, Vieira D, Shapira-Galitz Y, Garber D, Amin MR
Ann Otol Rhinol Laryngol 2021 Mar;130(3):234-244. Epub 2020 Aug 12 doi: 10.1177/0003489420949586. PMID: 32781827
A Systematic Review.
Drejet S, Halum S, Brigger M, Skopelja E, Parker NP
Otolaryngol Head Neck Surg 2017 Mar;156(3):435-441. Epub 2017 Jan 10 doi: 10.1177/0194599816683384. PMID: 28072562
The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review.
San Giorgi MR, Helder HM, Lindeman RJ, de Bock GH, Dikkers FG
Laryngoscope 2016 Oct;126(10):2330-9. Epub 2016 Apr 26 doi: 10.1002/lary.25898. PMID: 27113025
Photodynamic therapy for recurrent respiratory papillomatosis.
Lieder A, Khan MK, Lippert BM
Cochrane Database Syst Rev 2014 Jun 5;(6):CD009810. doi: 10.1002/14651858.CD009810.pub2. PMID: 24898010
Risk factors for the development and severity of juvenile-onset recurrent respiratory papillomatosis: a systematic review.
Niyibizi J, Rodier C, Wassef M, Trottier H
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):186-97. Epub 2013 Dec 6 doi: 10.1016/j.ijporl.2013.11.036. PMID: 24367938

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