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Uterine leiomyoma(UL)

MedGen UID:
21801
Concept ID:
C0042133
Neoplastic Process
Synonyms: UL; Uterine corpus leiomyoma
SNOMED CT: Uterine leiomyoma (95315005); Leiomyoma of uterus (95315005); Leiomyoma (146801000119103); Uterine fibroid (95315005); Uterine fibroids (95315005); Uterine leiomyoma - fibroids (95315005); Fibroids (95315005); Leiomyoma of body of uterus (95315005); Fibroid uterus (95315005)
 
HPO: HP:0000131
Monarch Initiative: MONDO:0007886
OMIM®: 150699

Definition

Uterine leiomyoma (UL), commonly known as fibroids, are benign tumors of the uterine myometrium. They represent the most prevalent pelvic tumors in women and are found in more than 75% of women of reproductive age. Approximately 20 to 25% of women with UL exhibit symptoms including menorrhagia, infertility, pelvic pain, and a range of complications during pregnancy. UL are the leading cause for hysterectomy in the United States, accounting for 30% of all hysterectomies (summary by Eggert et al., 2012). [from OMIM]

Clinical features

From HPO
Uterine leiomyoma
MedGen UID:
21801
Concept ID:
C0042133
Neoplastic Process
Uterine leiomyoma (UL), commonly known as fibroids, are benign tumors of the uterine myometrium. They represent the most prevalent pelvic tumors in women and are found in more than 75% of women of reproductive age. Approximately 20 to 25% of women with UL exhibit symptoms including menorrhagia, infertility, pelvic pain, and a range of complications during pregnancy. UL are the leading cause for hysterectomy in the United States, accounting for 30% of all hysterectomies (summary by Eggert et al., 2012).

Conditions with this feature

Uterine leiomyoma
MedGen UID:
21801
Concept ID:
C0042133
Neoplastic Process
Uterine leiomyoma (UL), commonly known as fibroids, are benign tumors of the uterine myometrium. They represent the most prevalent pelvic tumors in women and are found in more than 75% of women of reproductive age. Approximately 20 to 25% of women with UL exhibit symptoms including menorrhagia, infertility, pelvic pain, and a range of complications during pregnancy. UL are the leading cause for hysterectomy in the United States, accounting for 30% of all hysterectomies (summary by Eggert et al., 2012).
Multiple cutaneous leiomyomas
MedGen UID:
353771
Concept ID:
C1708350
Neoplastic Process
FH tumor predisposition syndrome is characterized by cutaneous leiomyomata, uterine leiomyomata (fibroids), and/or renal tumors. Pheochromocytoma and paraganglioma have also been described in a small number of families. Cutaneous leiomyomata appear as skin-colored to light brown papules or nodules distributed over the trunk and extremities, and occasionally on the face, and appear at a mean age of 30 years, increasing in size and number with age. Uterine leiomyomata tend to be numerous and large; age at diagnosis ranges from 18 to 53 years, with most women experiencing irregular or heavy menstruation and pelvic pain. Renal tumors are usually unilateral, solitary, and aggressive. They are associated with poor survival due to clinical aggressiveness and propensity to metastasize despite small primary tumor size. The median age of detection is approximately age 40 years.
Severe achondroplasia-developmental delay-acanthosis nigricans syndrome
MedGen UID:
393098
Concept ID:
C2674173
Congenital Abnormality
SADDAN dysplasia (severe achondroplasia with developmental delay and acanthosis nigricans) is a very rare skeletal dysplasia characterized by the constellation of these features. Radiology reveals 'ram's horn' shaped clavicles and reverse bowing of lower limbs. Approximately half of patients die before the fourth week of life secondary to respiratory failure (summary by Zankl et al., 2008).
Familial adenomatous polyposis 4
MedGen UID:
934686
Concept ID:
C4310719
Disease or Syndrome
Familial adenomatous polyposis-4 is an autosomal recessive tumor predisposition syndrome characterized by the development of multiple colonic adenomas in adulthood, often with progression to colorectal cancer. Proliferative lesions in other tissues may also occur (summary by Adam et al., 2016). For a discussion of genetic heterogeneity of familial adenomatous polyposis, see FAP1 (175100).

Professional guidelines

PubMed

Lin Y, Wu RC, Huang YL, Chen K, Tseng SC, Wang CJ, Chao A, Lai CH, Lin G
Abdom Radiol (NY) 2022 Jun;47(6):2197-2208. Epub 2022 Mar 26 doi: 10.1007/s00261-022-03431-6. PMID: 35347386
Lewis TD, Malik M, Britten J, San Pablo AM, Catherino WH
Biomed Res Int 2018;2018:2414609. Epub 2018 Jan 28 doi: 10.1155/2018/2414609. PMID: 29780819Free PMC Article
Owen C, Armstrong AY
Obstet Gynecol Clin North Am 2015 Mar;42(1):67-85. Epub 2014 Dec 5 doi: 10.1016/j.ogc.2014.09.009. PMID: 25681841

Recent clinical studies

Etiology

Qu Y, Chen L, Guo S, Liu Y, Wu H
Front Endocrinol (Lausanne) 2023;14:1133260. Epub 2023 Jul 27 doi: 10.3389/fendo.2023.1133260. PMID: 37576957Free PMC Article
Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Wu X, Xiao C, Han Z, Zhang L, Zhao X, Hao Y, Xiao J, Gallagher CS, Kraft P, Morton CC, Li J, Jiang X
Am J Hum Genet 2022 Jul 7;109(7):1272-1285. doi: 10.1016/j.ajhg.2022.05.015. PMID: 35803233Free PMC Article
Coutinho LM, Assis WA, Spagnuolo-Souza A, Reis FM
Reprod Sci 2022 Aug;29(8):2145-2151. Epub 2021 Jun 17 doi: 10.1007/s43032-021-00656-6. PMID: 34142343
McWilliams MM, Chennathukuzhi VM
Semin Reprod Med 2017 Mar;35(2):181-189. Epub 2017 Mar 9 doi: 10.1055/s-0037-1599090. PMID: 28278535Free PMC Article

Diagnosis

Ung CY, Warwick A, Onoufriadis A, Barker JN, Parsons M, McGrath JA, Shaw TJ, Dand N
JAMA Dermatol 2023 Feb 1;159(2):172-181. doi: 10.1001/jamadermatol.2022.5607. PMID: 36598763Free PMC Article
Iizuka T, Yin P, Zuberi A, Kujawa S, Coon JS 5th, Björvang RD, Damdimopoulou P, Pacyga DC, Strakovsky RS, Flaws JA, Bulun SE
Proc Natl Acad Sci U S A 2022 Nov 22;119(47):e2208886119. Epub 2022 Nov 14 doi: 10.1073/pnas.2208886119. PMID: 36375056Free PMC Article
Coutinho LM, Assis WA, Spagnuolo-Souza A, Reis FM
Reprod Sci 2022 Aug;29(8):2145-2151. Epub 2021 Jun 17 doi: 10.1007/s43032-021-00656-6. PMID: 34142343
Stoica RA, Bistriceanu I, Sima R, Iordache N
J Med Life 2014 Oct-Dec;7(4):522-4. PMID: 25713613Free PMC Article
Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM
Am J Obstet Gynecol 2003 Jan;188(1):100-7. doi: 10.1067/mob.2003.99. PMID: 12548202

Therapy

Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Wu X, Xiao C, Han Z, Zhang L, Zhao X, Hao Y, Xiao J, Gallagher CS, Kraft P, Morton CC, Li J, Jiang X
Am J Hum Genet 2022 Jul 7;109(7):1272-1285. doi: 10.1016/j.ajhg.2022.05.015. PMID: 35803233Free PMC Article
Coutinho LM, Assis WA, Spagnuolo-Souza A, Reis FM
Reprod Sci 2022 Aug;29(8):2145-2151. Epub 2021 Jun 17 doi: 10.1007/s43032-021-00656-6. PMID: 34142343
Afrin S, AlAshqar A, El Sabeh M, Miyashita-Ishiwata M, Reschke L, Brennan JT, Fader A, Borahay MA
Nutrients 2021 May 21;13(6) doi: 10.3390/nu13061747. PMID: 34063835Free PMC Article
Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM
Am J Obstet Gynecol 2003 Jan;188(1):100-7. doi: 10.1067/mob.2003.99. PMID: 12548202

Prognosis

Lin LC, Chang HY, Kuo TT, Chen HY, Liu WS, Lo YJ, Hsia SM, Huang TC
Redox Biol 2023 Oct;66:102861. Epub 2023 Aug 25 doi: 10.1016/j.redox.2023.102861. PMID: 37666118Free PMC Article
Qu Y, Chen L, Guo S, Liu Y, Wu H
Front Endocrinol (Lausanne) 2023;14:1133260. Epub 2023 Jul 27 doi: 10.3389/fendo.2023.1133260. PMID: 37576957Free PMC Article
Bahmyari S, Jamali Z, Khatami SH, Vakili O, Roozitalab M, Savardashtaki A, Solati A, Mousavi P, Shabaninejad Z, Vakili S, Behrouj H, Ghasemi H, Movahedpour A
Cell Biochem Funct 2021 Dec;39(8):955-969. Epub 2021 Oct 27 doi: 10.1002/cbf.3671. PMID: 34708430
Deng Y, Dong S, Song B
Heart Lung Circ 2021 Feb;30(2):240-246. Epub 2020 Aug 21 doi: 10.1016/j.hlc.2020.07.006. PMID: 32830033
Owen C, Armstrong AY
Obstet Gynecol Clin North Am 2015 Mar;42(1):67-85. Epub 2014 Dec 5 doi: 10.1016/j.ogc.2014.09.009. PMID: 25681841

Clinical prediction guides

Qu Y, Chen L, Guo S, Liu Y, Wu H
Front Endocrinol (Lausanne) 2023;14:1133260. Epub 2023 Jul 27 doi: 10.3389/fendo.2023.1133260. PMID: 37576957Free PMC Article
Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Wu X, Xiao C, Han Z, Zhang L, Zhao X, Hao Y, Xiao J, Gallagher CS, Kraft P, Morton CC, Li J, Jiang X
Am J Hum Genet 2022 Jul 7;109(7):1272-1285. doi: 10.1016/j.ajhg.2022.05.015. PMID: 35803233Free PMC Article
Afrin S, AlAshqar A, El Sabeh M, Miyashita-Ishiwata M, Reschke L, Brennan JT, Fader A, Borahay MA
Nutrients 2021 May 21;13(6) doi: 10.3390/nu13061747. PMID: 34063835Free PMC Article
Jenabi E, Ebrahimzadeh Zagami S
J Matern Fetal Neonatal Med 2017 Nov;30(22):2742-2746. Epub 2016 Nov 29 doi: 10.1080/14767058.2016.1261401. PMID: 27844480

Recent systematic reviews

Morris JM, Liang A, Fleckenstein K, Singh B, Segars J
Reprod Sci 2023 May;30(5):1495-1505. Epub 2022 Nov 18 doi: 10.1007/s43032-022-01120-9. PMID: 36401073
Niaz R, Saeed M, Khan H, Ali MA, Irshad A, Faiz M, Irshad A, Fatima F, Tunio SA, Aiman W
J Obstet Gynaecol Can 2022 Dec;44(12):1279-1288. Epub 2022 Nov 9 doi: 10.1016/j.jogc.2022.10.012. PMID: 36368594
Formoso G, Perrone E, Maltoni S, Balduzzi S, Wilkinson J, Basevi V, Marata AM, Magrini N, D'Amico R, Bassi C, Maestri E
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD008536. doi: 10.1002/14651858.CD008536.pub3. PMID: 27733017Free PMC Article
Liu QW, Han T, Yang M, Tong XW, Wang JJ
J Huazhong Univ Sci Technolog Med Sci 2016 Feb;36(1):142-149. Epub 2016 Feb 3 doi: 10.1007/s11596-016-1557-z. PMID: 26838756
Moroni RM, Vieira CS, Ferriani RA, Reis RM, Nogueira AA, Brito LG
BMC Womens Health 2015 Jan 22;15:4. doi: 10.1186/s12905-015-0162-9. PMID: 25609056Free PMC Article

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