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Endometrial Adenocarcinoma

MedGen UID:
218862
Concept ID:
C1153706
Neoplastic Process
Synonyms: Endometrial adenocarcinoma; Uterine adenocarcinoma
SNOMED CT: Adenocarcinoma of endometrium (123845008); Endometrial adenocarcinoma (123845008); Adenocarcinoma of uterus (309245001)

Definition

An adenocarcinoma arising from the uterine body cavity. This is the most frequent malignant tumor affecting the uterine body, and is linked to estrogen therapy. Most patients present with uterine bleeding and are over age 40 at the time of diagnosis. The prognosis depends on the stage of the tumor, the depth of the uterine wall invasion, and the histologic subtype. Endometrioid adenocarcinoma is the most frequently seen morphologic variant of endometrial adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Adenocarcinoma

Professional guidelines

PubMed

Fernandez-Montoli ME, Sabadell J, Contreras-Perez NA
Adv Ther 2021 May;38(5):2717-2731. Epub 2021 Apr 8 doi: 10.1007/s12325-021-01693-y. PMID: 33830463
Janda M, McGrath S, Obermair A
Best Pract Res Clin Obstet Gynaecol 2019 Feb;55:93-108. Epub 2018 Aug 31 doi: 10.1016/j.bpobgyn.2018.08.004. PMID: 30243603
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231

Recent clinical studies

Etiology

Socolov D, Socolov R, Lupascu IA, Rugina V, Gabia O, Garauleanu DM, Carauleanu A
Rev Med Chir Soc Med Nat Iasi 2016 Apr-Jun;120(2):355-62. PMID: 27483717
Jarboe EA, Mutter GL
Semin Diagn Pathol 2010 Nov;27(4):215-25. doi: 10.1053/j.semdp.2010.09.007. PMID: 21309257
Noumoff JS, Faruqi S
Microsc Res Tech 1993 Jun 15;25(3):246-54. doi: 10.1002/jemt.1070250306. PMID: 8400424
Gambrell RD Jr
Invest Radiol 1986 Apr;21(4):369-78. doi: 10.1097/00004424-198604000-00017. PMID: 3516923
Gambrell RD Jr, Bagnell CA, Greenblatt RB
Am J Obstet Gynecol 1983 Jul 15;146(6):696-707. doi: 10.1016/0002-9378(83)91014-1. PMID: 6307050

Diagnosis

Joehlin-Price AS, Garg K
Adv Anat Pathol 2018 Mar;25(2):96-105. doi: 10.1097/PAP.0000000000000175. PMID: 28945610
Jarboe EA, Mutter GL
Semin Diagn Pathol 2010 Nov;27(4):215-25. doi: 10.1053/j.semdp.2010.09.007. PMID: 21309257
Zaino RJ
Int J Gynecol Pathol 2009 Jan;28(1):1-9. doi: 10.1097/PGP.0b013e3181846c6d. PMID: 19047915
Marchetti M, Vasile C, Chiarelli S
Eur J Gynaecol Oncol 2005;26(5):479-84. PMID: 16285561
Ferenczy A
Hum Reprod Update 1998 Jul-Aug;4(4):312-22. doi: 10.1093/humupd/4.4.312. PMID: 9825847

Therapy

Fernandez-Montoli ME, Sabadell J, Contreras-Perez NA
Adv Ther 2021 May;38(5):2717-2731. Epub 2021 Apr 8 doi: 10.1007/s12325-021-01693-y. PMID: 33830463
Socolov D, Socolov R, Lupascu IA, Rugina V, Gabia O, Garauleanu DM, Carauleanu A
Rev Med Chir Soc Med Nat Iasi 2016 Apr-Jun;120(2):355-62. PMID: 27483717
Campagnoli C, Abbà C, Ambroggio S, Brucato T, Pasanisi P
Gynecol Endocrinol 2013 Feb;29(2):119-24. Epub 2012 Sep 5 doi: 10.3109/09513590.2012.706671. PMID: 22946682
Keys HM, Roberts JA, Brunetto VL, Zaino RJ, Spirtos NM, Bloss JD, Pearlman A, Maiman MA, Bell JG; Gynecologic Oncology Group
Gynecol Oncol 2004 Mar;92(3):744-51. doi: 10.1016/j.ygyno.2003.11.048. PMID: 14984936
Gambrell RD Jr
Invest Radiol 1986 Apr;21(4):369-78. doi: 10.1097/00004424-198604000-00017. PMID: 3516923

Prognosis

Jones AC, Brown KH, Guan T, Smith LA, Formslag CR, Farjado ED, Bai Q, Luechtefeld HD, Wakefield MR, Dong L, Fang Y
Med Oncol 2023 May 23;40(7):186. doi: 10.1007/s12032-023-02040-7. PMID: 37219649
Dong H, Sun M, Li H, Yue Y
BMC Med Genomics 2023 Feb 7;16(1):20. doi: 10.1186/s12920-023-01451-9. PMID: 36750966Free PMC Article
Hao J, Gao X, Wang YP, Liu Q, Zhu H, Zhao SJ, Qin QH, Meng J, Li LL, Lin SC, Song Z, Li H
Anticancer Drugs 2022 Jun 1;33(5):467-477. doi: 10.1097/CAD.0000000000001280. PMID: 35276691
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
Jarboe EA, Mutter GL
Semin Diagn Pathol 2010 Nov;27(4):215-25. doi: 10.1053/j.semdp.2010.09.007. PMID: 21309257

Clinical prediction guides

Hao J, Gao X, Wang YP, Liu Q, Zhu H, Zhao SJ, Qin QH, Meng J, Li LL, Lin SC, Song Z, Li H
Anticancer Drugs 2022 Jun 1;33(5):467-477. doi: 10.1097/CAD.0000000000001280. PMID: 35276691
Laban M, El-Swaify ST, Ali SH, Refaat MA, Sabbour M, Farrag N, Hassanin AS
Reprod Sci 2022 Apr;29(4):1068-1085. Epub 2021 Apr 15 doi: 10.1007/s43032-021-00565-8. PMID: 33856667
Jarboe EA, Mutter GL
Semin Diagn Pathol 2010 Nov;27(4):215-25. doi: 10.1053/j.semdp.2010.09.007. PMID: 21309257
Barwick TD, Rockall AG, Barton DP, Sohaib SA
Clin Radiol 2006 Jul;61(7):545-55. doi: 10.1016/j.crad.2006.03.011. PMID: 16784939
Gambrell RD Jr
Invest Radiol 1986 Apr;21(4):369-78. doi: 10.1097/00004424-198604000-00017. PMID: 3516923

Recent systematic reviews

De Milliano I, Van Hattum D, Ket JCF, Huirne JAF, Hehenkamp WJK
Eur J Obstet Gynecol Reprod Biol 2017 Jul;214:56-64. Epub 2017 Apr 28 doi: 10.1016/j.ejogrb.2017.04.042. PMID: 28482329
Bogliolo S, Gardella B, Dominoni M, Musacchi V, Cassani C, Zanellini F, De Silvestri A, Gaggero CR, Babilonti L, Spinillo A
Arch Gynecol Obstet 2016 Apr;293(4):701-8. Epub 2015 Dec 15 doi: 10.1007/s00404-015-3974-9. PMID: 26671487
Baker J, Obermair A, Gebski V, Janda M
Gynecol Oncol 2012 Apr;125(1):263-70. Epub 2011 Dec 3 doi: 10.1016/j.ygyno.2011.11.043. PMID: 22196499
AlHilli MM, Hopkins MR, Famuyide AO
J Minim Invasive Gynecol 2011 May-Jun;18(3):393-400. doi: 10.1016/j.jmig.2011.02.004. PMID: 21545966
Chiva de Agustín L, Lapuente Sastre F, Corraliza Galán V, Granados Galainena L, González Martín A, González Cortijo L, Carballo González N
Clin Transl Oncol 2008 Mar;10(3):155-62. doi: 10.1007/s12094-008-0173-1. PMID: 18321818

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