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Follicular dendritic cell sarcoma

MedGen UID:
220355
Concept ID:
C1260325
Neoplastic Process
Synonyms: Dendritic Cell Sarcoma, Follicular; Follicular Dendritic Cell Sarcoma
SNOMED CT: Follicular dendritic cell tumor (128816008); Follicular dendritic cell sarcoma (128816008)
 
Monarch Initiative: MONDO:0005764
Orphanet: ORPHA86902

Definition

A rare dendritic cell neoplasm characterized by a proliferation of spindled to ovoid cells with morphological and immunophenotypic features of follicular dendritic cells. Conventional follicular dendritic cell sarcomas are negative for EBV. The tumor arises as a painless, slow-growing mass in lymph nodes (most often cervical), extranodal sites (such as tonsils, gastrointestinal tract, soft tissue, mediastinum, or lung, among others), or both. Paraneoplastic pemphigus may occur in rare cases. Predictive factors are tumor size, presence of coagulative necrosis, mitotic count, and presence of significant cytological atypia. [from ORDO]

Professional guidelines

PubMed

Jain P, Milgrom SA, Patel KP, Nastoupil L, Fayad L, Wang M, Pinnix CC, Dabaja BS, Smith GL, Yu J, Hu S, Bueso Ramos CE, Kanagal-Shamanna R, Medeiros LJ, Oki Y, Fowler N
Br J Haematol 2017 Aug;178(3):403-412. Epub 2017 Apr 6 doi: 10.1111/bjh.14672. PMID: 28382648Free PMC Article
Dalia S, Shao H, Sagatys E, Cualing H, Sokol L
Cancer Control 2014 Oct;21(4):290-300. doi: 10.1177/107327481402100405. PMID: 25310210
Ohtake H, Yamakawa M
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Recent clinical studies

Etiology

Chen S, Sun Y, Sun W, Dan M, Jiang Y
Hematology 2023 Dec;28(1):2260975. Epub 2023 Sep 21 doi: 10.1080/16078454.2023.2260975. PMID: 37732620
Xue N, Xue X, Sheng C, Lu M, Wang Y, Zhang S, Xu Y
Ann Palliat Med 2021 Dec;10(12):12140-12148. doi: 10.21037/apm-21-2776. PMID: 35016402
Patra S, Trivedi P, Kaur K
Indian J Pathol Microbiol 2021 Apr-Jun;64(2):316-322. doi: 10.4103/IJPM.IJPM_461_20. PMID: 33851626
Mao S, Dong J, Wang Y, Zhang C, Dong A, Shen J
AJR Am J Roentgenol 2021 Mar;216(3):835-843. Epub 2021 Jan 6 doi: 10.2214/AJR.19.22759. PMID: 33405946
Pan Z, Xu ML
Surg Pathol Clin 2019 Sep;12(3):805-829. Epub 2019 Jun 8 doi: 10.1016/j.path.2019.03.013. PMID: 31352989

Diagnosis

Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892
Facchetti F, Simbeni M, Lorenzi L
Pathologica 2021 Oct;113(5):316-329. doi: 10.32074/1591-951X-331. PMID: 34837090Free PMC Article
Kim-Orden N, Chambers T, Sinha U
JAMA Otolaryngol Head Neck Surg 2018 Dec 1;144(12):1178-1179. doi: 10.1001/jamaoto.2018.2371. PMID: 30267038
Zeppa P, Cozzolino I
Monogr Clin Cytol 2018;23:102-112. Epub 2017 Nov 13 doi: 10.1159/000478886. PMID: 29131006
Chen T, Gopal P
Arch Pathol Lab Med 2017 Apr;141(4):596-599. doi: 10.5858/arpa.2016-0126-RS. PMID: 28353378

Therapy

Patra S, Trivedi P, Kaur K
Indian J Pathol Microbiol 2021 Apr-Jun;64(2):316-322. doi: 10.4103/IJPM.IJPM_461_20. PMID: 33851626
Jain P, Milgrom SA, Patel KP, Nastoupil L, Fayad L, Wang M, Pinnix CC, Dabaja BS, Smith GL, Yu J, Hu S, Bueso Ramos CE, Kanagal-Shamanna R, Medeiros LJ, Oki Y, Fowler N
Br J Haematol 2017 Aug;178(3):403-412. Epub 2017 Apr 6 doi: 10.1111/bjh.14672. PMID: 28382648Free PMC Article
Rice BL, Bedocs LA, Sahi H
Chest 2010 May;137(5):1236-9. doi: 10.1378/chest.09-2143. PMID: 20442126
Zhu X, Zhang B
J Dermatol 2007 Aug;34(8):503-11. doi: 10.1111/j.1346-8138.2007.00322.x. PMID: 17683379
Azim HA, Elsedewy E, Azim HA Jr
Onkologie 2007 Jul;30(7):381-4. Epub 2007 Jun 27 doi: 10.1159/000103586. PMID: 17596748

Prognosis

Chen S, Sun Y, Sun W, Dan M, Jiang Y
Hematology 2023 Dec;28(1):2260975. Epub 2023 Sep 21 doi: 10.1080/16078454.2023.2260975. PMID: 37732620
Pan Z, Xu ML
Surg Pathol Clin 2019 Sep;12(3):805-829. Epub 2019 Jun 8 doi: 10.1016/j.path.2019.03.013. PMID: 31352989
Rosa G, Piliang M
Cutis 2018 May;101(5):327;341;342;345. PMID: 29894533
Chen T, Gopal P
Arch Pathol Lab Med 2017 Apr;141(4):596-599. doi: 10.5858/arpa.2016-0126-RS. PMID: 28353378
Wu A, Pullarkat S
Arch Pathol Lab Med 2016 Feb;140(2):186-90. doi: 10.5858/arpa.2014-0374-RS. PMID: 26910224

Clinical prediction guides

Cho YJ, Han SI, Lim SC
Medicine (Baltimore) 2021 Sep 10;100(36):e27209. doi: 10.1097/MD.0000000000027209. PMID: 34516525Free PMC Article
Xu L, Ge R, Gao S
BMC Med Imaging 2021 Mar 17;21(1):52. doi: 10.1186/s12880-021-00584-6. PMID: 33731032Free PMC Article
Ge R, Liu C, Yin X, Chen J, Zhou X, Huang C, Yu W, Shen X
Int J Clin Exp Pathol 2014;7(5):2421-9. Epub 2014 Apr 15 PMID: 24966952Free PMC Article
Wang H, Su Z, Hu Z, Wen J, Liu B
Diagn Pathol 2010 Oct 11;5:67. doi: 10.1186/1746-1596-5-67. PMID: 20937101Free PMC Article
Fonseca R, Yamakawa M, Nakamura S, van Heerde P, Miettinen M, Shek TW, Myhre Jensen O, Rousselet MC, Tefferi A
Am J Hematol 1998 Oct;59(2):161-7. doi: 10.1002/(sici)1096-8652(199810)59:2<161::aid-ajh10>3.0.co;2-c. PMID: 9766802

Recent systematic reviews

Li X, Gu J, He Q, Han S, Wu H
World J Surg Oncol 2023 Jul 21;21(1):212. doi: 10.1186/s12957-023-03115-5. PMID: 37480085Free PMC Article
Gui H, Chaudhari J, Mannan R
Diagn Pathol 2022 Aug 8;17(1):64. doi: 10.1186/s13000-022-01246-z. PMID: 35941667Free PMC Article
Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N
Crit Rev Oncol Hematol 2013 Nov;88(2):253-71. Epub 2013 Jun 5 doi: 10.1016/j.critrevonc.2013.05.006. PMID: 23755890

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