U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atypical metaplasia

MedGen UID:
220401
•Concept ID:
C1265956
•
Pathologic Function
Synonym: Atypical Metaplasia
SNOMED CT: Atypical metaplasia (125544002)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical metaplasia

Professional guidelines

PubMed

Clinical implications of morular metaplasia in fertility-preserving treatment for atypical endometrial hyperplasia and early endometrial carcinoma patients.
Wu P, Lv Q, Guan J, Shan W, Chen X, Zhu Q, Luo X
Arch Gynecol Obstet 2022 Oct;306(4):1135-1146. Epub 2022 Mar 4 doi: 10.1007/s00404-021-06382-3. PMID: 35246715Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Atypical myeloproliferative disorders: diagnosis and management.
Tefferi A, Elliott MA, Pardanani A
Mayo Clin Proc 2006 Apr;81(4):553-63. doi: 10.4065/81.4.553. PMID: 16610578

Recent clinical studies

Etiology

Reappraisal of cytology-histology correlation in cervical cytology based on the recent American Society of Cytopathology guidelines (2017) at a cancer research centre.
Gupta R, Hariprasad R, Dhanasekaran K, Sodhani P, Mehrotra R, Kumar N, Gupta S
Cytopathology 2020 Jan;31(1):53-58. Epub 2019 Oct 23 doi: 10.1111/cyt.12774. PMID: 31535740
Cervical high-grade squamous intraepithelial lesion on conventional cytology: Cytological patterns, pitfalls, and diagnostic clues.
Gupta R, Sodhani P, Mehrotra R, Gupta S
Diagn Cytopathol 2019 Dec;47(12):1267-1276. Epub 2019 Aug 5 doi: 10.1002/dc.24293. PMID: 31381273
Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia.
Keating JT, Cviko A, Riethdorf S, Riethdorf L, Quade BJ, Sun D, Duensing S, Sheets EE, Munger K, Crum CP
Am J Surg Pathol 2001 Jul;25(7):884-91. doi: 10.1097/00000478-200107000-00006. PMID: 11420459
Clinical detection of lung cancer progression markers.
Tockman MS
J Cell Biochem Suppl 1996;25:177-84. PMID: 9027616
Atypical metaplasia and incidence of bronchogenic carcinoma.
Vine MF, Schoenbach VJ, Hulka BS, Koch GG, Samsa G
Am J Epidemiol 1990 May;131(5):781-93. doi: 10.1093/oxfordjournals.aje.a115569. PMID: 2321623

Diagnosis

Cervical high-grade squamous intraepithelial lesion on conventional cytology: Cytological patterns, pitfalls, and diagnostic clues.
Gupta R, Sodhani P, Mehrotra R, Gupta S
Diagn Cytopathol 2019 Dec;47(12):1267-1276. Epub 2019 Aug 5 doi: 10.1002/dc.24293. PMID: 31381273
Cytopathic effects of human papillomavirus infection and the severity of cervical intraepithelial neoplasia : A frequency study.
Alves de Sousa NL, Alves RR, Martins MR, Barros NK, Ribeiro AA, Zeferino LC, Dufloth RM, Rabelo-Santos SH
Diagn Cytopathol 2012 Oct;40(10):871-5. Epub 2011 May 17 doi: 10.1002/dc.21656. PMID: 21591275
Atypical squamous and glandular cells of undetermined significance (ASCUS and AGUS) of the uterine cervix.
Cenci M, Vecchione A
Anticancer Res 2000 Sep-Oct;20(5C):3701-7. PMID: 11268442
Clinical detection of lung cancer progression markers.
Tockman MS
J Cell Biochem Suppl 1996;25:177-84. PMID: 9027616
Hematoporphyrin-derivative-fluorescence test colposcopy and colpophotography in the diagnosis of atypical metaplasia, dysplasia, and carcinoma in situ of the cervix uteri.
Kyriazis GA, Balin H, Lipson RL
Am J Obstet Gynecol 1973 Oct 1;117(3):375-80. doi: 10.1016/0002-9378(73)90041-0. PMID: 4729730

Therapy

Malignancy associated changes in bronchial epithelial cells and clinical application as a biomarker.
Ikeda N, MacAulay C, Lam S, LeRiche J, Payne P, Garner D, Konaka C, Kato H, Palcic B
Lung Cancer 1998 Mar;19(3):161-6. doi: 10.1016/s0169-5002(97)00095-0. PMID: 9631363
Effects of 13-CIS retinoids on premalignant and malignant cells of lung origin.
Saccomanno G, Moran PG, Schmidt R, Hartshorn DF, Brian DA, Dreher WH, Sowada BJ
Acta Cytol 1982 Jan-Feb;26(1):78-85. PMID: 7039202
A correlative nuclear DNA and histologic study of genital squamous lesions in DES exposed progeny.
Reagan JW, Herbst AL
Obstet Gynecol Surv 1979 Nov;34(11):849-50. doi: 10.1097/00006254-197911000-00028. PMID: 523035
Colposcopic evaluation of DES-exposed progeny at two large medical centers: the squamous neoplasia problem.
Lurain JR, Gallup DG
South Med J 1978 Jul;71(7):809-12. doi: 10.1097/00007611-197807000-00022. PMID: 663728

Prognosis

Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia.
Keating JT, Cviko A, Riethdorf S, Riethdorf L, Quade BJ, Sun D, Duensing S, Sheets EE, Munger K, Crum CP
Am J Surg Pathol 2001 Jul;25(7):884-91. doi: 10.1097/00000478-200107000-00006. PMID: 11420459
Clinical detection of lung cancer progression markers.
Tockman MS
J Cell Biochem Suppl 1996;25:177-84. PMID: 9027616
Atypical metaplasia and incidence of bronchogenic carcinoma.
Vine MF, Schoenbach VJ, Hulka BS, Koch GG, Samsa G
Am J Epidemiol 1990 May;131(5):781-93. doi: 10.1093/oxfordjournals.aje.a115569. PMID: 2321623
Discriminant analysis of lower respiratory tract components associated with cigarette smoking, based on quantitative sputum cytology.
Roby TJ, Swan GE, Sorensen KW, Hubbard GA, Schumann GB
Acta Cytol 1990 Mar-Apr;34(2):147-54. PMID: 2321446
Effects of 13-CIS retinoids on premalignant and malignant cells of lung origin.
Saccomanno G, Moran PG, Schmidt R, Hartshorn DF, Brian DA, Dreher WH, Sowada BJ
Acta Cytol 1982 Jan-Feb;26(1):78-85. PMID: 7039202

Clinical prediction guides

Reappraisal of cytology-histology correlation in cervical cytology based on the recent American Society of Cytopathology guidelines (2017) at a cancer research centre.
Gupta R, Hariprasad R, Dhanasekaran K, Sodhani P, Mehrotra R, Kumar N, Gupta S
Cytopathology 2020 Jan;31(1):53-58. Epub 2019 Oct 23 doi: 10.1111/cyt.12774. PMID: 31535740
Cytopathic effects of human papillomavirus infection and the severity of cervical intraepithelial neoplasia : A frequency study.
Alves de Sousa NL, Alves RR, Martins MR, Barros NK, Ribeiro AA, Zeferino LC, Dufloth RM, Rabelo-Santos SH
Diagn Cytopathol 2012 Oct;40(10):871-5. Epub 2011 May 17 doi: 10.1002/dc.21656. PMID: 21591275
Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia.
Keating JT, Cviko A, Riethdorf S, Riethdorf L, Quade BJ, Sun D, Duensing S, Sheets EE, Munger K, Crum CP
Am J Surg Pathol 2001 Jul;25(7):884-91. doi: 10.1097/00000478-200107000-00006. PMID: 11420459
Clinical detection of lung cancer progression markers.
Tockman MS
J Cell Biochem Suppl 1996;25:177-84. PMID: 9027616
Localized deficiencies of folic acid in aerodigestive tissues.
Heimburger DC
Ann N Y Acad Sci 1992 Sep 30;669:87-95; discussion 95-6. doi: 10.1111/j.1749-6632.1992.tb17091.x. PMID: 1444061

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...