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Non-Small Cell Carcinoma

MedGen UID:
220404
Concept ID:
C1266002
Neoplastic Process
Synonym: Non-small cell carcinoma
SNOMED CT: Non-small cell carcinoma (128632008)

Definition

A malignant epithelial neoplasm characterized by the absence of neoplastic small epithelial cells. A representative example is the lung non-small cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Small Cell Carcinoma

Professional guidelines

PubMed

Vinod SK, Hau E
Respirology 2020 Nov;25 Suppl 2:61-71. Epub 2020 Jun 9 doi: 10.1111/resp.13870. PMID: 32516852
Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, Bubendorf L, Mino-Kenudson M, Yoshida A, Geisinger KR, Noguchi M, Chirieac LR, Bolting J, Chung JH, Chou TY, Chen G, Poleri C, Lopez-Rios F, Papotti M, Sholl LM, Roden AC, Travis WD, Hirsch FR, Kerr KM, Tsao MS, Nicholson AG, Wistuba I, Moreira AL
J Thorac Oncol 2019 Mar;14(3):377-407. Epub 2018 Dec 18 doi: 10.1016/j.jtho.2018.12.005. PMID: 30572031Free PMC Article
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

Berezowska S, Maillard M, Keyter M, Bisig B
Histopathology 2024 Jan;84(1):32-49. Epub 2023 Nov 7 doi: 10.1111/his.15076. PMID: 37936498
Perez Holguin RA, Olecki EJ, Wong WG, Stahl KA, Go PH, Taylor MD, Reed MF, Shen C
J Thorac Cardiovasc Surg 2023 Mar;165(3):853-861.e3. Epub 2022 Jun 1 doi: 10.1016/j.jtcvs.2022.05.032. PMID: 35760619
Mlika M, Saidi A, Mejri N, Abdennadher M, Haddouchi C, Labidi S, Khiari H, Boussen H, Hsairi M, Mezni F
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):177-184. Epub 2021 Sep 24 doi: 10.1177/02184923211042129. PMID: 34558296
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705
Farol LT, Hymes KB
Expert Rev Anticancer Ther 2004 Apr;4(2):180-8. doi: 10.1586/14737140.4.2.180. PMID: 15056048

Diagnosis

Ng J, Cai L, Girard L, Prall OWJ, Rajan N, Khoo C, Batrouney A, Byrne DJ, Boyd DK, Kersbergen AJ, Christie M, Minna JD, Burr ML, Sutherland KD
Clin Cancer Res 2024 May 1;30(9):1846-1858. doi: 10.1158/1078-0432.CCR-23-2360. PMID: 38180245Free PMC Article
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, Bubendorf L, Mino-Kenudson M, Yoshida A, Geisinger KR, Noguchi M, Chirieac LR, Bolting J, Chung JH, Chou TY, Chen G, Poleri C, Lopez-Rios F, Papotti M, Sholl LM, Roden AC, Travis WD, Hirsch FR, Kerr KM, Tsao MS, Nicholson AG, Wistuba I, Moreira AL
J Thorac Oncol 2019 Mar;14(3):377-407. Epub 2018 Dec 18 doi: 10.1016/j.jtho.2018.12.005. PMID: 30572031Free PMC Article
Carcano C, Savage E, Diacovo MJ, Kirsch J
J Radiol Case Rep 2012 Oct;6(10):26-31. Epub 2012 Oct 1 doi: 10.3941/jrcr.v6i10.1049. PMID: 23378874Free PMC Article
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Therapy

Parra ER, Zhang J, Duose DY, Gonzalez-Kozlova E, Redman MW, Chen H, Manyam GC, Kumar G, Zhang J, Song X, Lazcano R, Marques-Piubelli ML, Laberiano-Fernandez C, Rojas F, Zhang B, Taing L, Jhaveri A, Geisberg J, Altreuter J, Michor F, Provencher J, Yu J, Cerami E, Moravec R, Kannan K, Luthra R, Alatrash G, Huang HH, Xie H, Patel M, Nie K, Harris J, Argueta K, Lindsay J, Biswas R, Van Nostrand S, Kim-Schulze S, Gray JE, Herbst RS, Wistuba II, Gettinger S, Kelly K, Bazhenova L, Gnjatic S, Lee JJ, Zhang J, Haymaker C
Clin Cancer Res 2024 Apr 15;30(8):1655-1668. doi: 10.1158/1078-0432.CCR-23-0251. PMID: 38277235Free PMC Article
Vinod SK, Hau E
Respirology 2020 Nov;25 Suppl 2:61-71. Epub 2020 Jun 9 doi: 10.1111/resp.13870. PMID: 32516852
Sacco PC, Gridelli C
Expert Opin Emerg Drugs 2017 Sep;22(3):213-222. doi: 10.1080/14728214.2017.1369952. PMID: 28836854
Casaluce F, Sgambato A, Maione P, Ciardiello F, Gridelli C
Expert Opin Emerg Drugs 2013 Mar;18(1):97-107. doi: 10.1517/14728214.2013.777426. PMID: 23448156
Farol LT, Hymes KB
Expert Rev Anticancer Ther 2004 Apr;4(2):180-8. doi: 10.1586/14737140.4.2.180. PMID: 15056048

Prognosis

Alsoudi AF, Parvus MN, Pulido J, Chevez-Barrios P, Teh BS, Bernicker E, Miles S, Schefler A
Retin Cases Brief Rep 2024 Sep 1;18(5):642-646. doi: 10.1097/ICB.0000000000001443. PMID: 37307600
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Yatabe Y, Dacic S, Borczuk AC, Warth A, Russell PA, Lantuejoul S, Beasley MB, Thunnissen E, Pelosi G, Rekhtman N, Bubendorf L, Mino-Kenudson M, Yoshida A, Geisinger KR, Noguchi M, Chirieac LR, Bolting J, Chung JH, Chou TY, Chen G, Poleri C, Lopez-Rios F, Papotti M, Sholl LM, Roden AC, Travis WD, Hirsch FR, Kerr KM, Tsao MS, Nicholson AG, Wistuba I, Moreira AL
J Thorac Oncol 2019 Mar;14(3):377-407. Epub 2018 Dec 18 doi: 10.1016/j.jtho.2018.12.005. PMID: 30572031Free PMC Article
Carcano C, Savage E, Diacovo MJ, Kirsch J
J Radiol Case Rep 2012 Oct;6(10):26-31. Epub 2012 Oct 1 doi: 10.3941/jrcr.v6i10.1049. PMID: 23378874Free PMC Article
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Clinical prediction guides

Parra ER, Zhang J, Duose DY, Gonzalez-Kozlova E, Redman MW, Chen H, Manyam GC, Kumar G, Zhang J, Song X, Lazcano R, Marques-Piubelli ML, Laberiano-Fernandez C, Rojas F, Zhang B, Taing L, Jhaveri A, Geisberg J, Altreuter J, Michor F, Provencher J, Yu J, Cerami E, Moravec R, Kannan K, Luthra R, Alatrash G, Huang HH, Xie H, Patel M, Nie K, Harris J, Argueta K, Lindsay J, Biswas R, Van Nostrand S, Kim-Schulze S, Gray JE, Herbst RS, Wistuba II, Gettinger S, Kelly K, Bazhenova L, Gnjatic S, Lee JJ, Zhang J, Haymaker C
Clin Cancer Res 2024 Apr 15;30(8):1655-1668. doi: 10.1158/1078-0432.CCR-23-0251. PMID: 38277235Free PMC Article
Patel AJ, Khan N, Richter A, Naidu B, Drayson MT, Middleton GW
Front Immunol 2023;14:1198665. Epub 2023 Jun 15 doi: 10.3389/fimmu.2023.1198665. PMID: 37398676Free PMC Article
Pan D, Bao X, Hu M, Jiao M, Li F, Li CY
Cancer Res 2022 Aug 3;82(15):2748-2760. doi: 10.1158/0008-5472.CAN-21-3523. PMID: 35648422Free PMC Article
Mlika M, Saidi A, Mejri N, Abdennadher M, Haddouchi C, Labidi S, Khiari H, Boussen H, Hsairi M, Mezni F
Asian Cardiovasc Thorac Ann 2022 Feb;30(2):177-184. Epub 2021 Sep 24 doi: 10.1177/02184923211042129. PMID: 34558296
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article

Recent systematic reviews

Mollberg NM, Bennette C, Howell E, Backhus L, Devine B, Ferguson MK
Ann Thorac Surg 2014 Mar;97(3):965-71. Epub 2014 Jan 11 doi: 10.1016/j.athoracsur.2013.11.002. PMID: 24424014
Mohamed W, Ahuja N, Shah A
J Neurol Sci 2012 Jun 15;317(1-2):6-12. Epub 2012 Mar 11 doi: 10.1016/j.jns.2012.02.016. PMID: 22414800

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