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Angiomyofibroblastoma

MedGen UID:
220421
•Concept ID:
C1266123
•
Neoplastic Process
SNOMED CT: Angiomyofibroblastoma (128739005)

Definition

A benign myofibroblastic neoplasm, usually arising in the pelviperineal region. It is characterized by the presence of neoplastic spindle to round cells, dilated thin walled vessels, and stromal edema. Most patients present with painless circumscribed masses. [from NCI]

Recent clinical studies

Etiology

Mesenchymal lesions of the vulva.
Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293
Genital soft tissue tumors.
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211
A review and update of morphologically bland vulvovaginal mesenchymal lesions.
McCluggage WG
Int J Gynecol Pathol 2005 Jan;24(1):26-38. PMID: 15626915
Mesenchymal tumors and tumor-like lesions of the female genital tract: a selective review with emphasis on recently described entities.
Nielsen GP, Young RH
Int J Gynecol Pathol 2001 Apr;20(2):105-27. doi: 10.1097/00004347-200104000-00002. PMID: 11293156
Myofibroblastic tumours: an update.
Fletcher CD
Verh Dtsch Ges Pathol 1998;82:75-82. PMID: 10095420

Diagnosis

Mesenchymal lesions of the vulva.
Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293
Mesenchymal Extratesticular Tumors and Tumorlike Conditions: From the Radiologic Pathology Archives.
Wolfman DJ, Marko J, Gould CF, Sesterhenn IA, Lattin GE Jr
Radiographics 2015 Nov-Dec;35(7):1943-54. Epub 2015 Oct 30 doi: 10.1148/rg.2015150179. PMID: 26517315
Cellular angiofibroma in women: a review of the literature.
Mandato VD, Santagni S, Cavazza A, Aguzzoli L, Abrate M, La Sala GB
Diagn Pathol 2015 Jul 19;10:114. doi: 10.1186/s13000-015-0361-6. PMID: 26187500Free PMC Article
Genital soft tissue tumors.
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211
Angiomyofibroblastoma of the vulva.
Nasu K, Fujisawa K, Takai N, Miyakawa I
Int J Gynecol Cancer 2002 Mar-Apr;12(2):228-31. doi: 10.1046/j.1525-1438.2002.01101.x. PMID: 11975687

Therapy

Angiomyofibroblastoma-like tumor (cellular angiofibroma) in the male inguinal region.
Miyajima K, Hasegawa S, Oda Y, Toyoshima S, Tsuneyoshi M, Motooka M, Matsuura Y, Ishioka H, Ono M
Radiat Med 2007 May;25(4):173-7. Epub 2007 May 28 doi: 10.1007/s11604-006-0114-2. PMID: 17514368
Angiomyofibroblastoma of the vagina in a postmenopausal breast cancer patient treated with tamoxifen: clinicopathologic analysis of a case and review of the literature.
Varras M, Akrivis C, Demou A, Kitsiou E, Antoniou N
Int J Gynecol Cancer 2006 Mar-Apr;16(2):581-5. doi: 10.1111/j.1525-1438.2006.00365.x. PMID: 16681729
Prolapse of the fallopian tube after hysterectomy associated with exuberant angiomyofibroblastic stroma response: a diagnostic pitfall.
Michal M, Rokyta Z, Mejchar B, Pelikan K, Kummel M, Mukensnabl P
Virchows Arch 2000 Oct;437(4):436-9. doi: 10.1007/s004280000257. PMID: 11097370

Prognosis

A Rare Case of Intravesical Angiomyofibroblastoma.
Deka PM, Bagawade JA, Deka P, Baruah R, Shah N
Urology 2017 Aug;106:e15-e18. Epub 2017 May 11 doi: 10.1016/j.urology.2017.05.008. PMID: 28502834
Giant pelvic angiomyofibroblastoma: case report and literature review.
Qiu P, Wang Z, Li Y, Cui G
Diagn Pathol 2014 Jun 3;9:106. doi: 10.1186/1746-1596-9-106. PMID: 24894537Free PMC Article
Angiomyofibroblastoma of the vulva.
Ibnerasa SN, Yasmeen F, Shami N
J Coll Physicians Surg Pak 2012 Feb;22(2):108-10. PMID: 22313649
Mesenchymal tumors and tumor-like lesions of the female genital tract: a selective review with emphasis on recently described entities.
Nielsen GP, Young RH
Int J Gynecol Pathol 2001 Apr;20(2):105-27. doi: 10.1097/00004347-200104000-00002. PMID: 11293156
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

Clinical prediction guides

Cellular angiofibroma in the retroperitoneal space during pregnancy: A case report.
Abe H, Nakao S, Itagaki H, Hosokawa Y, Shikama A, Tasaka N, Akiyama A, Minaguchi T, Satoh T
BMC Womens Health 2023 Feb 10;23(1):57. doi: 10.1186/s12905-023-02182-w. PMID: 36765343Free PMC Article
Potential pathogenetic link between angiomyofibroblastoma and superficial myofibroblastoma in the female lower genital tract based on a novel MTG1-CYP2E1 fusion.
Tajiri R, Shiba E, Iwamura R, Kubo C, Nawata A, Harada H, Yoshino K, Hisaoka M
Mod Pathol 2021 Dec;34(12):2222-2228. Epub 2021 Aug 12 doi: 10.1038/s41379-021-00886-8. PMID: 34385605
A 10-Year Case Series of Surgically Managed Periurethral Masses at a Single Tertiary Care Institution.
Wyman AM, McDowell M, Prieto I, Jackson E, Bassaly R, Ordorica R, Greene KA
Female Pelvic Med Reconstr Surg 2020 Nov;26(11):668-670. doi: 10.1097/SPV.0000000000000651. PMID: 31742566
Giant pelvic angiomyofibroblastoma: case report and literature review.
Qiu P, Wang Z, Li Y, Cui G
Diagn Pathol 2014 Jun 3;9:106. doi: 10.1186/1746-1596-9-106. PMID: 24894537Free PMC Article
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

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