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Nongerminomatous germ cell tumor

MedGen UID:
220426
•Concept ID:
C1266158
•
Neoplastic Process
Synonyms: Germ cell tumor, nonseminomatous; Non-seminomatous germ-cell tumors; NONSEMINOMATOUS GERM CELL TUMORS, SOMATIC
SNOMED CT: Germ cell tumor, nonseminomatous (128766005)
 
Monarch Initiative: MONDO:0021656
OMIM®: 273300

Definition

A term that refers to teratoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, or mixed forms of these tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNongerminomatous germ cell tumor

Professional guidelines

PubMed

A multimodal approach including craniospinal irradiation improves the treatment outcome of high-risk intracranial nongerminomatous germ cell tumors.
Kim JW, Kim WC, Cho JH, Kim DS, Shim KW, Lyu CJ, Won SC, Suh CO
Int J Radiat Oncol Biol Phys 2012 Nov 1;84(3):625-31. Epub 2012 Mar 13 doi: 10.1016/j.ijrobp.2011.12.077. PMID: 22420971
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Testicular Cancer, 2024

Recent clinical studies

Etiology

Clinical outcomes of pediatric patients with autism spectrum disorder and other neurodevelopmental disorders and intracranial germ cell tumors.
Liu KX, Sethi RV, Pulsifer MB, D'Gama AM, LaVally B, Ebb DH, Tarbell NJ, Yock TI, MacDonald SM
Pediatr Blood Cancer 2021 Aug;68(8):e28935. Epub 2021 Mar 10 doi: 10.1002/pbc.28935. PMID: 33694260
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Optimal radiotherapy target volumes in intracranial nongerminomatous germ cell tumors: Long-term institutional experience with chemotherapy, surgery, and dose- and field-adapted radiotherapy.
Breen WG, Blanchard MJ, Rao AN, Daniels DJ, Buckner JC, Laack NNI
Pediatr Blood Cancer 2017 Nov;64(11) Epub 2017 Jul 11 doi: 10.1002/pbc.26637. PMID: 28695992
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765
Control of extraneural metastasis of a primary intracranial nongerminomatous germ-cell tumor. Case report.
Watterson J, Priest JR
J Neurosurg 1989 Oct;71(4):601-4. doi: 10.3171/jns.1989.71.4.0601. PMID: 2477515

Diagnosis

Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Central Nervous System Germ Cell Tumors: A Review of the Literature.
Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y
J Child Neurol 2018 Aug;33(9):610-620. Epub 2018 May 30 doi: 10.1177/0883073818772470. PMID: 29848146
Extraneural metastasis of a nongerminomatous germ cell tumor of the central nervous system in a pediatric patient with a ventriculoperitoneal shunt: a case report and review of the literature.
Belongia M, Jogal S
J Pediatr Hematol Oncol 2012 Jan;34(1):e12-6. doi: 10.1097/MPH.0b013e31823dd370. PMID: 22215101
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland: a case report and review.
O'Callaghan AM, Katapodis O, Ellison DW, Theaker JM, Mead GM
Cancer 1997 Sep 1;80(5):942-7. doi: 10.1002/(sici)1097-0142(19970901)80:5<942::aid-cncr16>3.0.co;2-w. PMID: 9307195

Therapy

Ophthalmological outcomes of patients treated for pineal region tumors.
Hankinson EV, Lyons CJ, Hukin J, Cochrane DD
J Neurosurg Pediatr 2016 May;17(5):558-63. Epub 2016 Jan 22 doi: 10.3171/2015.10.PEDS15415. PMID: 26799411
Treatment of intracranial nongerminomatous germ-cell tumor by high-dose chemotherapy and autologous stem-cell rescue.
Tada T, Takizawa T, Nakazato F, Kobayashi S, Koike K, Oguchi M, Ishii E, Amano Y
J Neurooncol 1999 Aug;44(1):71-6. doi: 10.1023/a:1006395719917. PMID: 10582672
The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland: a case report and review.
O'Callaghan AM, Katapodis O, Ellison DW, Theaker JM, Mead GM
Cancer 1997 Sep 1;80(5):942-7. doi: 10.1002/(sici)1097-0142(19970901)80:5<942::aid-cncr16>3.0.co;2-w. PMID: 9307195
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765
Control of extraneural metastasis of a primary intracranial nongerminomatous germ-cell tumor. Case report.
Watterson J, Priest JR
J Neurosurg 1989 Oct;71(4):601-4. doi: 10.3171/jns.1989.71.4.0601. PMID: 2477515

Prognosis

Extraneural recurrence of an intracranial nongerminomatous germ cell tumor to cervical lymph nodes in a pediatric patient: Case report.
Howell J, Dandoy C, Wright JM, Chow L, El-Sheikh A, Dole M, Vatner RE, Kamian K
Cancer Rep (Hoboken) 2022 Aug;5(8):e1586. Epub 2021 Nov 18 doi: 10.1002/cnr2.1586. PMID: 34796700Free PMC Article
Treatment of intracranial nongerminomatous germ-cell tumor by high-dose chemotherapy and autologous stem-cell rescue.
Tada T, Takizawa T, Nakazato F, Kobayashi S, Koike K, Oguchi M, Ishii E, Amano Y
J Neurooncol 1999 Aug;44(1):71-6. doi: 10.1023/a:1006395719917. PMID: 10582672
Germ cell tumors of the CNS in children: recent advances in therapy.
Diez B, Balmaceda C, Matsutani M, Weiner HL
Childs Nerv Syst 1999 Oct;15(10):578-85. doi: 10.1007/s003810050546. PMID: 10550589
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765
Control of extraneural metastasis of a primary intracranial nongerminomatous germ-cell tumor. Case report.
Watterson J, Priest JR
J Neurosurg 1989 Oct;71(4):601-4. doi: 10.3171/jns.1989.71.4.0601. PMID: 2477515

Clinical prediction guides

Primary intracranial pure endodermal sinus tumor: A retrospective series of 6 cases in a single center and a systematic review of overall survival.
Raynald, Yang H, Zhang X, Ma'ruf L, Li C, Jiang T
Neurochirurgie 2021 Nov;67(6):587-598. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.02.014. PMID: 33753128
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Clinical features, radiologic findings, and treatment of pediatric germ cell tumors involving the basal ganglia and thalamus: a retrospective series of 15 cases at a single center.
Wang M, Zhou P, Zhang S, Liu X, Lv L, Wang Z, Ye F, Ju Y, Jiang S
Childs Nerv Syst 2018 Mar;34(3):423-430. Epub 2017 Oct 24 doi: 10.1007/s00381-017-3632-6. PMID: 29067503
Apparent diffusion coefficient of intracranial germ cell tumors.
Ogiwara H, Tsutsumi Y, Matsuoka K, Kiyotani C, Terashima K, Morota N
J Neurooncol 2015 Feb;121(3):565-71. Epub 2014 Nov 21 doi: 10.1007/s11060-014-1668-y. PMID: 25413617
Treatment of intracranial nongerminomatous germ-cell tumor by high-dose chemotherapy and autologous stem-cell rescue.
Tada T, Takizawa T, Nakazato F, Kobayashi S, Koike K, Oguchi M, Ishii E, Amano Y
J Neurooncol 1999 Aug;44(1):71-6. doi: 10.1023/a:1006395719917. PMID: 10582672

Recent systematic reviews

Primary intracranial pure endodermal sinus tumor: A retrospective series of 6 cases in a single center and a systematic review of overall survival.
Raynald, Yang H, Zhang X, Ma'ruf L, Li C, Jiang T
Neurochirurgie 2021 Nov;67(6):587-598. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.02.014. PMID: 33753128

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Testicular Cancer, 2024

    Reviews

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