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Nongerminomatous germ cell tumor

MedGen UID:
220426
Concept ID:
C1266158
Neoplastic Process
Synonyms: Germ cell tumor, nonseminomatous; Non-seminomatous germ-cell tumors; NONSEMINOMATOUS GERM CELL TUMORS, SOMATIC
SNOMED CT: Germ cell tumor, nonseminomatous (128766005)
 
Monarch Initiative: MONDO:0021656
OMIM®: 273300

Definition

A term that refers to teratoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, or mixed forms of these tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNongerminomatous germ cell tumor

Professional guidelines

PubMed

Jinguji S, Yoshimura J, Nishiyama K, Yoneoka Y, Sano M, Fukuda M, Fujii Y
Acta Neurochir (Wien) 2015 Dec;157(12):2175-83. Epub 2015 Oct 20 doi: 10.1007/s00701-015-2614-2. PMID: 26482943
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Testicular Cancer, 2024

Recent clinical studies

Etiology

Zhang KX, Varma H, Cao Y, Shah VS
J Neuroophthalmol 2023 Jun 1;43(2):254-260. Epub 2022 Nov 7 doi: 10.1097/WNO.0000000000001731. PMID: 36342135Free PMC Article
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Wang M, Zhou P, Zhang S, Liu X, Lv L, Wang Z, Ye F, Ju Y, Jiang S
Childs Nerv Syst 2018 Mar;34(3):423-430. Epub 2017 Oct 24 doi: 10.1007/s00381-017-3632-6. PMID: 29067503
Qi S, Fan J, Zhang XA, Zhang H, Qiu B, Fang L
Acta Neurochir (Wien) 2014 Dec;156(12):2253-62. Epub 2014 Sep 23 doi: 10.1007/s00701-014-2224-4. PMID: 25246142

Diagnosis

Howell J, Dandoy C, Wright JM, Chow L, El-Sheikh A, Dole M, Vatner RE, Kamian K
Cancer Rep (Hoboken) 2022 Aug;5(8):e1586. Epub 2021 Nov 18 doi: 10.1002/cnr2.1586. PMID: 34796700Free PMC Article
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y
J Child Neurol 2018 Aug;33(9):610-620. Epub 2018 May 30 doi: 10.1177/0883073818772470. PMID: 29848146
Qi S, Fan J, Zhang XA, Zhang H, Qiu B, Fang L
Acta Neurochir (Wien) 2014 Dec;156(12):2253-62. Epub 2014 Sep 23 doi: 10.1007/s00701-014-2224-4. PMID: 25246142

Therapy

Breen WG, Blanchard MJ, Rao AN, Daniels DJ, Buckner JC, Laack NNI
Pediatr Blood Cancer 2017 Nov;64(11) Epub 2017 Jul 11 doi: 10.1002/pbc.26637. PMID: 28695992
Hankinson EV, Lyons CJ, Hukin J, Cochrane DD
J Neurosurg Pediatr 2016 May;17(5):558-63. Epub 2016 Jan 22 doi: 10.3171/2015.10.PEDS15415. PMID: 26799411
Jinguji S, Yoshimura J, Nishiyama K, Yoneoka Y, Sano M, Fukuda M, Fujii Y
Acta Neurochir (Wien) 2015 Dec;157(12):2175-83. Epub 2015 Oct 20 doi: 10.1007/s00701-015-2614-2. PMID: 26482943
O'Callaghan AM, Katapodis O, Ellison DW, Theaker JM, Mead GM
Cancer 1997 Sep 1;80(5):942-7. doi: 10.1002/(sici)1097-0142(19970901)80:5<942::aid-cncr16>3.0.co;2-w. PMID: 9307195
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Prognosis

Howell J, Dandoy C, Wright JM, Chow L, El-Sheikh A, Dole M, Vatner RE, Kamian K
Cancer Rep (Hoboken) 2022 Aug;5(8):e1586. Epub 2021 Nov 18 doi: 10.1002/cnr2.1586. PMID: 34796700Free PMC Article
Wang M, Zhou P, Zhang S, Liu X, Lv L, Wang Z, Ye F, Ju Y, Jiang S
Childs Nerv Syst 2018 Mar;34(3):423-430. Epub 2017 Oct 24 doi: 10.1007/s00381-017-3632-6. PMID: 29067503
Breen WG, Blanchard MJ, Rao AN, Daniels DJ, Buckner JC, Laack NNI
Pediatr Blood Cancer 2017 Nov;64(11) Epub 2017 Jul 11 doi: 10.1002/pbc.26637. PMID: 28695992
Diez B, Balmaceda C, Matsutani M, Weiner HL
Childs Nerv Syst 1999 Oct;15(10):578-85. doi: 10.1007/s003810050546. PMID: 10550589
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Clinical prediction guides

Zhang KX, Varma H, Cao Y, Shah VS
J Neuroophthalmol 2023 Jun 1;43(2):254-260. Epub 2022 Nov 7 doi: 10.1097/WNO.0000000000001731. PMID: 36342135Free PMC Article
Kajiwara S, Nakamura H, Sakata K, Komaki S, Negoto T, Morioka M
BMC Pediatr 2022 Nov 28;22(1):683. doi: 10.1186/s12887-022-03743-y. PMID: 36443673Free PMC Article
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Qi S, Fan J, Zhang XA, Zhang H, Qiu B, Fang L
Acta Neurochir (Wien) 2014 Dec;156(12):2253-62. Epub 2014 Sep 23 doi: 10.1007/s00701-014-2224-4. PMID: 25246142

Recent systematic reviews

Raynald, Yang H, Zhang X, Ma'ruf L, Li C, Jiang T
Neurochirurgie 2021 Nov;67(6):587-598. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.02.014. PMID: 33753128

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Testicular Cancer, 2024

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