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Pigment dispersion syndrome(OPDG)

MedGen UID:
220866
Concept ID:
C1271398
Disease or Syndrome
Synonyms: GLAUCOMA, PIGMENT-DISPERSION TYPE; OCULAR PIGMENT DISPERSION WITH OR WITHOUT GLAUCOMA; OPDG
SNOMED CT: Pigment dispersion syndrome (392133001)
 
Monarch Initiative: MONDO:0010896
OMIM®: 600510
Orphanet: ORPHA26823

Definition

Ocular pigment dispersion syndrome is characterized by abnormal release of iris pigment, which then accumulates within the eye, including in the trabecular meshwork, through which fluid from the eye drains. Pigment deposition is believed to increase intraocular pressure by damaging trabecular meshwork cells and decreasing aqueous humor outflow (summary by van der Heide et al., 2021). [from OMIM]

Clinical features

From HPO
Open-angle glaucoma
MedGen UID:
6611
Concept ID:
C0017612
Disease or Syndrome
A type of glaucoma defined by an open, normal appearing anterior chamber angle and raised intraocular pressure,
Myopia
MedGen UID:
44558
Concept ID:
C0027092
Disease or Syndrome
Nearsightedness, also known as myopia, is an eye condition that causes blurry distance vision. People who are nearsighted have more trouble seeing things that are far away (such as when driving) than things that are close up (such as when reading or using a computer). If it is not treated with corrective lenses or surgery, nearsightedness can lead to squinting, eyestrain, headaches, and significant visual impairment.\n\nNearsightedness usually begins in childhood or adolescence. It tends to worsen with age until adulthood, when it may stop getting worse (stabilize). In some people, nearsightedness improves in later adulthood.\n\nFor normal vision, light passes through the clear cornea at the front of the eye and is focused by the lens onto the surface of the retina, which is the lining of the back of the eye that contains light-sensing cells. People who are nearsighted typically have eyeballs that are too long from front to back. As a result, light entering the eye is focused too far forward, in front of the retina instead of on its surface. It is this change that causes distant objects to appear blurry. The longer the eyeball is, the farther forward light rays will be focused and the more severely nearsighted a person will be.\n\nNearsightedness is measured by how powerful a lens must be to correct it. The standard unit of lens power is called a diopter. Negative (minus) powered lenses are used to correct nearsightedness. The more severe a person's nearsightedness, the larger the number of diopters required for correction. In an individual with nearsightedness, one eye may be more nearsighted than the other.\n\nEye doctors often refer to nearsightedness less than -5 or -6 diopters as "common myopia." Nearsightedness of -6 diopters or more is commonly called "high myopia." This distinction is important because high myopia increases a person's risk of developing other eye problems that can lead to permanent vision loss or blindness. These problems include tearing and detachment of the retina, clouding of the lens (cataract), and an eye disease called glaucoma that is usually related to increased pressure within the eye. The risk of these other eye problems increases with the severity of the nearsightedness. The term "pathological myopia" is used to describe cases in which high myopia leads to tissue damage within the eye.
Optic atrophy
MedGen UID:
18180
Concept ID:
C0029124
Disease or Syndrome
Atrophy of the optic nerve. Optic atrophy results from the death of the retinal ganglion cell axons that comprise the optic nerve and manifesting as a pale optic nerve on fundoscopy.

Professional guidelines

PubMed

Brusini P, Papa V
Surv Ophthalmol 2022 Nov-Dec;67(6):1723. Epub 2022 Jul 17 doi: 10.1016/j.survophthal.2022.07.003. PMID: 35858664
Marquis RE, Whitson JT
Drugs Aging 2005;22(1):1-21. doi: 10.2165/00002512-200522010-00001. PMID: 15663346
Lehto I, Vesti E
Curr Opin Ophthalmol 1998 Apr;9(2):61-4. doi: 10.1097/00055735-199804000-00012. PMID: 10180516

Recent clinical studies

Etiology

Simcoe MJ, Shah A, Fan B, Choquet H, Weisschuh N, Waseem NH, Jiang C, Melles RB, Ritch R, Mahroo OA, Wissinger B, Jorgenson E, Wiggs JL, Garway-Heath DF, Hysi PG, Hammond CJ
Ophthalmology 2022 Jun;129(6):626-636. Epub 2022 Jan 11 doi: 10.1016/j.ophtha.2022.01.005. PMID: 35031440
Tandon A, Zhang Z, Fingert JH, Kwon YH, Wang K, Alward WLM
Am J Ophthalmol 2019 Jun;202:55-61. Epub 2019 Feb 21 doi: 10.1016/j.ajo.2019.02.017. PMID: 30796891Free PMC Article
Lascaratos G, Shah A, Garway-Heath DF
Surv Ophthalmol 2013 Mar-Apr;58(2):164-75. Epub 2012 Dec 6 doi: 10.1016/j.survophthal.2012.08.002. PMID: 23218808
Niyadurupola N, Broadway DC
Clin Exp Ophthalmol 2008 Dec;36(9):868-82. doi: 10.1111/j.1442-9071.2009.01920.x. PMID: 19278484
Becker B, Shin DH, Cooper DG, Kass MA
Am J Ophthalmol 1977 Feb;83(2):161-6. doi: 10.1016/0002-9394(77)90610-9. PMID: 836656

Diagnosis

Pang R, Labisi SA, Wang N
Graefes Arch Clin Exp Ophthalmol 2023 Mar;261(3):601-614. Epub 2022 Sep 10 doi: 10.1007/s00417-022-05817-0. PMID: 36085315
Bustamante-Arias A, Ruiz-Lozano RE, Carlos Alvarez-Guzman J, Gonzalez-Godinez S, Rodriguez-Garcia A
Surv Ophthalmol 2021 Sep-Oct;66(5):743-760. Epub 2021 Jan 12 doi: 10.1016/j.survophthal.2021.01.002. PMID: 33444629
Gautam Seth N, Akella M, Singh Pandav S
Ophthalmol Glaucoma 2019 Mar-Apr;2(2):94. doi: 10.1016/j.ogla.2018.11.006. PMID: 32672610
Scuderi G, Contestabile MT, Scuderi L, Librando A, Fenicia V, Rahimi S
Int Ophthalmol 2019 Jul;39(7):1651-1662. Epub 2018 May 2 doi: 10.1007/s10792-018-0938-7. PMID: 29721842
Okafor K, Vinod K, Gedde SJ
Curr Opin Ophthalmol 2017 Mar;28(2):154-160. doi: 10.1097/ICU.0000000000000352. PMID: 27898469

Therapy

Mueller A, Lam I, Kishor K, Lee RK, Bhattacharya S
WIREs Mech Dis 2024 Jan-Feb;16(1):e1628. Epub 2023 Sep 5 doi: 10.1002/wsbm.1628. PMID: 37669762
Simcoe MJ, Shah A, Fan B, Choquet H, Weisschuh N, Waseem NH, Jiang C, Melles RB, Ritch R, Mahroo OA, Wissinger B, Jorgenson E, Wiggs JL, Garway-Heath DF, Hysi PG, Hammond CJ
Ophthalmology 2022 Jun;129(6):626-636. Epub 2022 Jan 11 doi: 10.1016/j.ophtha.2022.01.005. PMID: 35031440
Buffault J, Leray B, Bouillot A, Baudouin C, Labbé A
J Fr Ophtalmol 2017 Nov;40(9):e315-e321. Epub 2017 Oct 4 doi: 10.1016/j.jfo.2017.09.002. PMID: 28987446
Niyadurupola N, Broadway DC
Clin Exp Ophthalmol 2008 Dec;36(9):868-82. doi: 10.1111/j.1442-9071.2009.01920.x. PMID: 19278484
Kubicka-Trzaska A, Romanowska-Dixon B
Klin Oczna 2008;110(4-6):203-6. PMID: 18655463

Prognosis

Tandon A, Zhang Z, Fingert JH, Kwon YH, Wang K, Alward WLM
Am J Ophthalmol 2019 Jun;202:55-61. Epub 2019 Feb 21 doi: 10.1016/j.ajo.2019.02.017. PMID: 30796891Free PMC Article
Scuderi G, Contestabile MT, Scuderi L, Librando A, Fenicia V, Rahimi S
Int Ophthalmol 2019 Jul;39(7):1651-1662. Epub 2018 May 2 doi: 10.1007/s10792-018-0938-7. PMID: 29721842
Bower KS, Sia RK, Ryan DS, Mines MJ, Stutzman RD, Kuzmowych CP, Eaddy JB, Coe CD, Wroblewski KJ
J Refract Surg 2011 Sep;27(9):686-90. doi: 10.3928/1081597X-20110324-01. PMID: 21972450
Ritch R, Mudumbai R, Liebmann JM
Ophthalmology 2000 May;107(5):1004-8. doi: 10.1016/s0161-6420(00)00058-0. PMID: 10811097
Mudumbai R, Liebmann JM, Ritch R
Trans Am Ophthalmol Soc 1999;97:297-314; discussion 314-21. PMID: 10703130Free PMC Article

Clinical prediction guides

Li Y, Liu J, Tian Q, Ma X, Zhao Y, Bi H
Medicine (Baltimore) 2023 Feb 17;102(7):e32869. doi: 10.1097/MD.0000000000032869. PMID: 36800590Free PMC Article
Santos-Bueso E
Arch Soc Esp Oftalmol (Engl Ed) 2019 Oct;94(10):471-477. Epub 2019 Aug 1 doi: 10.1016/j.oftal.2019.06.006. PMID: 31378388
Doane JF, Rickstrew JJ, Tuckfield JQ, Cauble JE
J Glaucoma 2019 May;28(5):423-426. doi: 10.1097/IJG.0000000000001193. PMID: 30652983
Michelessi M, Lindsley K
Cochrane Database Syst Rev 2016 Feb 12;2(2):CD005655. doi: 10.1002/14651858.CD005655.pub2. PMID: 26871761Free PMC Article
Campbell DG, Schertzer RM
Curr Opin Ophthalmol 1995 Apr;6(2):96-101. doi: 10.1097/00055735-199504000-00015. PMID: 10150864

Recent systematic reviews

Pang R, Labisi SA, Wang N
Graefes Arch Clin Exp Ophthalmol 2023 Mar;261(3):601-614. Epub 2022 Sep 10 doi: 10.1007/s00417-022-05817-0. PMID: 36085315
Michelessi M, Lindsley K
Cochrane Database Syst Rev 2016 Feb 12;2(2):CD005655. doi: 10.1002/14651858.CD005655.pub2. PMID: 26871761Free PMC Article

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