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Mixed epithelial stromal tumor of the kidney

MedGen UID:
220870
•Concept ID:
C1272677
•
Neoplastic Process
Synonyms: adult mesoblastic nephroma; Benign Kidney Mixed Epithelial and Stromal Tumor; Benign MEST; benign MEST; Benign mixed epithelial and stromal tumor of kidney; Benign Mixed Epithelial Stromal Tumor of the Kidney; Kidney Mixed Epithelial and Stromal Tumor; MEST; Mixed epithelial and stromal tumor of kidney; mixed epithelial and stromal tumor of kidney; mixed epithelial and stromal tumour of kidney; Mixed Epithelial Stromal Tumor of the Kidney; mixed epithelial stromal tumor of the kidney; Renal Epithelial Stromal Tumor
SNOMED CT: Benign mixed epithelial and stromal tumor of kidney (388985009); Mixed epithelial and stromal tumor of kidney (388985009)
 
Monarch Initiative: MONDO:0002386

Definition

A rare, usually benign tumor that arises from the kidney. It belongs to the spectrum of mixed epithelial and stromal tumor family. It usually affects females. It is characterized by the presence of a biphasic pattern with tubular and cystic structures in a spindle cell stroma. Patients usually present with flank pain and hematuria. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed epithelial stromal tumor of the kidney

Professional guidelines

PubMed

Immunohistochemical characteristics of renomedullary interstitial cell tumor: a study of 41 tumors with emphasis on differential diagnosis of mesenchymal neoplasms.
Lu Z, Al-Obaidy K, Cheng L, Perry KD, Grignon DJ, Williamson SR
Hum Pathol 2018 Dec;82:46-50. Epub 2018 Jul 18 doi: 10.1016/j.humpath.2018.07.010. PMID: 30031100
Characterization and management of various renal cystic lesions by sonographic features.
Tay SY, Tiu CM, Hu B, Wang HK, Chiou HJ, Lin YH, Lai YC, Chan WP, Chou YH
J Chin Med Assoc 2018 Dec;81(12):1017-1026. Epub 2018 Jul 13 doi: 10.1016/j.jcma.2018.04.008. PMID: 30017809
Tubulocystic renal cell carcinoma: a review of literature focused on radiological findings for differential diagnosis.
Honda Y, Nakamura Y, Goto K, Terada H, Sentani K, Yasui W, Sekino Y, Hayashi T, Teishima J, Matsubara A, Akagi M, Fuji T, Baba Y, Iida M, Awai K
Abdom Radiol (NY) 2018 Jul;43(7):1540-1545. doi: 10.1007/s00261-018-1643-8. PMID: 29796844

Recent clinical studies

Etiology

Histopathological spectrum of adult renal tumours: A single center experience and review of literature.
Sheenu VS, Paul RS, Pushpa M, Ami EM, Rashmi R, Iona ML, Elizabeth M
Indian J Pathol Microbiol 2023 Apr-Jun;66(2):307-313. doi: 10.4103/ijpm.ijpm_53_21. PMID: 37077073
Mixed epithelial and stromal tumor of the kidney: A retrospective clinicopathological evaluation.
Feng R, Zhang T, Ke C, Tao Y, Wang Y
Ann Diagn Pathol 2023 Apr;63:152088. Epub 2022 Dec 23 doi: 10.1016/j.anndiagpath.2022.152088. PMID: 36577187
Key Renal Neoplasms With a Female Predominance.
Baniak N, Barletta JA, Hirsch MS
Adv Anat Pathol 2021 Jul 1;28(4):228-250. doi: 10.1097/PAP.0000000000000301. PMID: 34009777
The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.
Srigley JR, Delahunt B, Eble JN, Egevad L, Epstein JI, Grignon D, Hes O, Moch H, Montironi R, Tickoo SK, Zhou M, Argani P; ISUP Renal Tumor Panel
Am J Surg Pathol 2013 Oct;37(10):1469-89. doi: 10.1097/PAS.0b013e318299f2d1. PMID: 24025519
Mixed epithelial and stromal tumor of the kidney.
Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ
Am J Surg Pathol 2000 Jul;24(7):958-70. doi: 10.1097/00000478-200007000-00007. PMID: 10895818

Diagnosis

Mixed epithelial and stromal tumor of the kidney: A retrospective clinicopathological evaluation.
Feng R, Zhang T, Ke C, Tao Y, Wang Y
Ann Diagn Pathol 2023 Apr;63:152088. Epub 2022 Dec 23 doi: 10.1016/j.anndiagpath.2022.152088. PMID: 36577187
Malignant Mixed Epithelial and Stromal Tumor of the Kidney: Report of a Carcinosarcoma Case and an Updated Literature Review.
Yu J, Yu S, Jia M, Gao H, Sun PL
Int J Surg Pathol 2023 Apr;31(2):195-202. Epub 2022 Apr 28 doi: 10.1177/10668969221097389. PMID: 35477307
Imaging of Unusual Renal Tumors.
Castillo RP, Santoscoy JF, Pisani L, Madrazo BL, Casillas VJ
Curr Urol Rep 2019 Jan 21;20(1):5. doi: 10.1007/s11934-019-0867-7. PMID: 30663008
Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update.
Moslemi MK
Urol J 2010 Summer;7(3):141-7. PMID: 20845287
Mixed epithelial and stromal tumors of the kidney: an overview.
Mohanty SK, Parwani AV
Arch Pathol Lab Med 2009 Sep;133(9):1483-6. doi: 10.5858/133.9.1483. PMID: 19722760

Therapy

The effect of preoperative chemotherapy on histological subtyping and staging of Wilms tumors: The United Kingdom Children's Cancer Study Group (UKCCSG) Wilms tumor trial 3 (UKW3) experience.
Vujanić GM, D'Hooghe E, Popov SD, Sebire NJ, Kelsey A
Pediatr Blood Cancer 2019 Mar;66(3):e27549. Epub 2018 Nov 8 doi: 10.1002/pbc.27549. PMID: 30408319
Increased risk of solid renal tumors in lithium-treated patients.
Zaidan M, Stucker F, Stengel B, Vasiliu V, Hummel A, Landais P, Boffa JJ, Ronco P, Grünfeld JP, Servais A
Kidney Int 2014 Jul;86(1):184-90. Epub 2014 Jan 22 doi: 10.1038/ki.2014.2. PMID: 24451323
Mixed epithelial and stromal tumors of the kidney: evidence for a single cell of origin with capacity for epithelial and stromal differentiation.
Kum JB, Grignon DJ, Wang M, Zhou M, Montironi R, Shen SS, Zhang S, Lopez-Beltran A, Eble JN, Cheng L
Am J Surg Pathol 2011 Aug;35(8):1114-22. doi: 10.1097/PAS.0b013e3182233fb6. PMID: 21753695
Nested stromal epithelial tumor of the liver: six cases of a distinctive pediatric neoplasm with frequent calcifications and association with cushing syndrome.
Heerema-McKenney A, Leuschner I, Smith N, Sennesh J, Finegold MJ
Am J Surg Pathol 2005 Jan;29(1):10-20. doi: 10.1097/01.pas.0000147398.03015.9e. PMID: 15613852
Mixed epithelial and stromal tumor of the kidney.
Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ
Am J Surg Pathol 2000 Jul;24(7):958-70. doi: 10.1097/00000478-200007000-00007. PMID: 10895818

Prognosis

Mixed epithelial and stromal tumor of the kidney: report of eight cases and literature review.
Wang CJ, Lin YW, Xiang H, Fang DB, Jiang P, Shen BH
World J Surg Oncol 2013 Aug 20;11(1):207. doi: 10.1186/1477-7819-11-207. PMID: 23958048Free PMC Article
Mixed epithelial and stromal tumor of the kidney.
Zheng S, Yuan HC, Liu LR, Wei Q, Han P
Kaohsiung J Med Sci 2013 May;29(5):280-3. Epub 2012 Dec 21 doi: 10.1016/j.kjms.2012.09.008. PMID: 23639516
Mixed epithelial and stromal tumor of the kidney--a case report.
Hou CP, Chiang YJ, Chu SH, Ng KF, Wang HH
Chang Gung Med J 2010 Nov-Dec;33(6):693-8. PMID: 21199615
Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update.
Moslemi MK
Urol J 2010 Summer;7(3):141-7. PMID: 20845287
2009 update on the classification of renal epithelial tumors in adults.
Lopez-Beltran A, Carrasco JC, Cheng L, Scarpelli M, Kirkali Z, Montironi R
Int J Urol 2009 May;16(5):432-43. Epub 2009 Apr 20 doi: 10.1111/j.1442-2042.2009.02302.x. PMID: 19453547

Clinical prediction guides

Mixed epithelial and stromal tumor of the kidney: A retrospective clinicopathological evaluation.
Feng R, Zhang T, Ke C, Tao Y, Wang Y
Ann Diagn Pathol 2023 Apr;63:152088. Epub 2022 Dec 23 doi: 10.1016/j.anndiagpath.2022.152088. PMID: 36577187
Mixed Epithelial and Stromal Tumor Family of Kidney (Adult Cystic Nephroma, Mixed Epithelial and Stromal Tumor): Retrospective Clinicopathological Evaluation.
Demir H, Sahin Z, Ozman O, Demirbilek M, Ozden SB, Gurses I, Durak H, Uygun N, Onal B
Turk Patoloji Derg 2022;38(3):251-260. doi: 10.5146/tjpath.2022.01575. PMID: 35642344Free PMC Article
Clinical-radiologic correlation of mixed epithelial and stromal tumor of the kidneys: Cases analysis.
Tsai SH, Wang JH, Lai YC, Chang YH, Chung HJ, Chang LS
J Chin Med Assoc 2016 Oct;79(10):554-8. Epub 2016 Jun 24 doi: 10.1016/j.jcma.2016.02.012. PMID: 27349941
Mixed epithelial and stromal tumor of the kidney or adult mesoblastic nephroma: an update.
Moslemi MK
Urol J 2010 Summer;7(3):141-7. PMID: 20845287
Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity?
Montironi R, Mazzucchelli R, Lopez-Beltran A, Martignoni G, Cheng L, Montorsi F, Scarpelli M
Eur Urol 2008 Dec;54(6):1237-46. Epub 2007 Nov 1 doi: 10.1016/j.eururo.2007.10.040. PMID: 18006141

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