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Chronic leukemia

MedGen UID:
220905
•Concept ID:
C1279296
•
Neoplastic Process
Synonyms: adult chronic leukemia; Chronic blood cancer; Chronic leukaemia; Chronic Leukemia; chronic leukemia; chronic leukemia (disease); Chronic leukemia, disease; CLL; CML; leukemia (disease), chronic
SNOMED CT: Chronic leukemia (92812005); Chronic leukemia, disease (92812005); Chronic leukemia (2557004)
 
HPO: HP:0005558
Monarch Initiative: MONDO:0001014

Definition

A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic leukemia

Professional guidelines

PubMed

Drug Repositioning for the Treatment of Hematologic Disease: Limits, Challenges and Future Perspectives.
Allegra A, Imbesi C, Bitto A, Ettari R
Curr Med Chem 2021;28(11):2195-2217. doi: 10.2174/0929867327999200817102154. PMID: 33138750
Advances in the diagnosis and treatment of acute and chronic leukemia in Mexico.
Ruiz-Argüelles GJ
Salud Publica Mex 2016 Apr;58(2):291-5. doi: 10.21149/spm.v58i2.7799. PMID: 27557388
Best Practices in Chronic Myeloid Leukemia Monitoring and Management.
Soverini S, De Benedittis C, Mancini M, Martinelli G
Oncologist 2016 May;21(5):626-33. Epub 2016 Mar 31 doi: 10.1634/theoncologist.2015-0337. PMID: 27032870Free PMC Article

Recent clinical studies

Etiology

Treating Leukemia in the Time of COVID-19.
Paul S, Rausch CR, Jain N, Kadia T, Ravandi F, DiNardo CD, Welch MA, Dabaja BS, Daver N, Garcia-Manero G, Wierda W, Pemmaraju N, Montalban Bravo G, Thompson P, Verstovsek S, Konopleva M, Kantarjian H, Jabbour E
Acta Haematol 2021;144(2):132-145. Epub 2020 May 11 doi: 10.1159/000508199. PMID: 32392559Free PMC Article
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia.
Martí-Carvajal AJ, Simancas D, Cardona AF
Cochrane Database Syst Rev 2011 Jun 15;(6):CD008562. doi: 10.1002/14651858.CD008562.pub2. PMID: 21678379
How I treat acute and chronic leukemia in pregnancy.
Shapira T, Pereg D, Lishner M
Blood Rev 2008 Sep;22(5):247-59. Epub 2008 May 9 doi: 10.1016/j.blre.2008.03.006. PMID: 18472198
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089
Preleukemias.
Nowell PC
Hum Pathol 1981 Jun;12(6):522-30. doi: 10.1016/s0046-8177(81)80066-4. PMID: 7275093

Diagnosis

Leukocytosis and Leukemia.
Widick P, Winer ES
Prim Care 2016 Dec;43(4):575-587. Epub 2016 Oct 14 doi: 10.1016/j.pop.2016.07.007. PMID: 27866578
Chronic leukemia.
Greenberg EM, Probst A
Crit Care Nurs Clin North Am 2013 Dec;25(4):459-70, vi. doi: 10.1016/j.ccell.2013.09.003. PMID: 24267282
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089
The leukemias.
Preisler HD
Dis Mon 1994 Oct;40(10):525-79. PMID: 7924833
Preleukemias.
Nowell PC
Hum Pathol 1981 Jun;12(6):522-30. doi: 10.1016/s0046-8177(81)80066-4. PMID: 7275093

Therapy

Pleural effusions in acute and chronic leukemia and myelodysplastic syndrome.
Faiz SA, Sahay S, Jimenez CA
Curr Opin Pulm Med 2014 Jul;20(4):340-6. doi: 10.1097/MCP.0000000000000060. PMID: 24811835
Chronic leukemia.
Greenberg EM, Probst A
Crit Care Nurs Clin North Am 2013 Dec;25(4):459-70, vi. doi: 10.1016/j.ccell.2013.09.003. PMID: 24267282
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089
The leukemias.
Preisler HD
Dis Mon 1994 Oct;40(10):525-79. PMID: 7924833
Leukemia in pregnancy.
McLain CR Jr
Clin Obstet Gynecol 1974 Dec;17(4):185-94. doi: 10.1097/00003081-197412000-00013. PMID: 4615858

Prognosis

Pleural effusions in acute and chronic leukemia and myelodysplastic syndrome.
Faiz SA, Sahay S, Jimenez CA
Curr Opin Pulm Med 2014 Jul;20(4):340-6. doi: 10.1097/MCP.0000000000000060. PMID: 24811835
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089
Adult T-cell leukemia.
Aoki J, Sato N, Oya N, Inoue T, Endo K
Semin Musculoskelet Radiol 2001 Jun;5(2):95-8. doi: 10.1055/s-2001-15659. PMID: 11500147
The leukemias.
Preisler HD
Dis Mon 1994 Oct;40(10):525-79. PMID: 7924833
Preleukemias.
Nowell PC
Hum Pathol 1981 Jun;12(6):522-30. doi: 10.1016/s0046-8177(81)80066-4. PMID: 7275093

Clinical prediction guides

Chronic leukemia.
Greenberg EM, Probst A
Crit Care Nurs Clin North Am 2013 Dec;25(4):459-70, vi. doi: 10.1016/j.ccell.2013.09.003. PMID: 24267282
How I treat acute and chronic leukemia in pregnancy.
Shapira T, Pereg D, Lishner M
Blood Rev 2008 Sep;22(5):247-59. Epub 2008 May 9 doi: 10.1016/j.blre.2008.03.006. PMID: 18472198
Acute lymphoblastic leukemia.
Chan KW
Curr Probl Pediatr Adolesc Health Care 2002 Feb;32(2):40-9. doi: 10.1067/mps.2002.121790. PMID: 11951089
Adult T-cell leukemia.
Aoki J, Sato N, Oya N, Inoue T, Endo K
Semin Musculoskelet Radiol 2001 Jun;5(2):95-8. doi: 10.1055/s-2001-15659. PMID: 11500147
Preleukemias.
Nowell PC
Hum Pathol 1981 Jun;12(6):522-30. doi: 10.1016/s0046-8177(81)80066-4. PMID: 7275093

Recent systematic reviews

A Systematic Review of Psychometric Properties of Health-Related Quality-of-Life and Symptom Instruments in Adult Acute Leukemia Survivors.
Bryant AL, Walton A, Shaw-Kokot J, Mayer DK, Reeve BB
Cancer Nurs 2016 Sep-Oct;39(5):375-82. doi: 10.1097/NCC.0000000000000327. PMID: 26645111Free PMC Article
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia.
Martí-Carvajal AJ, Anand V, Solà I
Cochrane Database Syst Rev 2015 Jun 24;2015(6):CD008562. doi: 10.1002/14651858.CD008562.pub3. PMID: 26107113Free PMC Article
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia.
Martí-Carvajal AJ, Simancas D, Cardona AF
Cochrane Database Syst Rev 2011 Jun 15;(6):CD008562. doi: 10.1002/14651858.CD008562.pub2. PMID: 21678379

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