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Myeloproliferative neoplasm

MedGen UID:
220955
Concept ID:
C1292778
Neoplastic Process
Synonyms: chronic myeloproliferative disease; Chronic Myeloproliferative Disorder; chronic myeloproliferative disorder; Chronic myeloproliferative disorder (clinical); chronic myeloproliferative disorders; Chronic Myeloproliferative Neoplasm; chronic myeloproliferative neoplasm; CMPD; CMPD, U; MPD; MPN; Myeloproliferative Disease; Myeloproliferative Disorder; Myeloproliferative disorder; myeloproliferative disorder; Myeloproliferative Neoplasm; myeloproliferative neoplasm; myeloproliferative neoplasm, chronic; myeloproliferative neoplasms; Myeloproliferative Tumor; myeloproliferative tumor; myeloproliferative tumour
SNOMED CT: Chronic myeloproliferative disorder (clinical) (109993000)
 
Monarch Initiative: MONDO:0020076
Orphanet: ORPHA98274

Definition

A group of myeloid neoplasms that includes the following: chronic myeloid leukemia, BCR-ABL1 positive; polycythemia vera; essential thrombocythemia; primary myelofibrosis; chronic neutrophilic leukemia; chronic eosinophilic leukemia, not otherwise specified; and myeloproliferative neoplasm, unclassifiable. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Tefferi A, Barbui T
Am J Hematol 2023 Sep;98(9):1465-1487. Epub 2023 Jun 26 doi: 10.1002/ajh.27002. PMID: 37357958
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myeloproliferative Neoplasms, 2023

Recent clinical studies

Etiology

Tefferi A, Vannucchi AM, Barbui T
Am J Hematol 2024 Apr;99(4):697-718. Epub 2024 Jan 25 doi: 10.1002/ajh.27216. PMID: 38269572
Prakash S, Arber DA, Bueso-Ramos C, Hasserjian RP, Orazi A
Virchows Arch 2023 Jan;482(1):69-83. Epub 2022 Dec 5 doi: 10.1007/s00428-022-03465-7. PMID: 36469102
Shahin OA, Chifotides HT, Bose P, Masarova L, Verstovsek S
Acta Haematol 2021;144(5):484-499. Epub 2021 Apr 21 doi: 10.1159/000512929. PMID: 33882481Free PMC Article
Patnaik MM, Tefferi A
Am J Hematol 2021 Mar 1;96(3):379-394. Epub 2021 Jan 28 doi: 10.1002/ajh.26090. PMID: 33428785
Gangat N, Tefferi A
Br J Haematol 2020 Oct;191(2):152-170. Epub 2020 Mar 20 doi: 10.1111/bjh.16576. PMID: 32196650

Diagnosis

Tefferi A, Vannucchi AM, Barbui T
Am J Hematol 2024 Apr;99(4):697-718. Epub 2024 Jan 25 doi: 10.1002/ajh.27216. PMID: 38269572
Prakash S, Arber DA, Bueso-Ramos C, Hasserjian RP, Orazi A
Virchows Arch 2023 Jan;482(1):69-83. Epub 2022 Dec 5 doi: 10.1007/s00428-022-03465-7. PMID: 36469102
Patnaik MM, Tefferi A
Am J Hematol 2021 Mar 1;96(3):379-394. Epub 2021 Jan 28 doi: 10.1002/ajh.26090. PMID: 33428785
Sharma A, Keshava SN, Eapen A, Elias E, Eapen CE
Dig Dis Sci 2021 Jun;66(6):1780-1790. Epub 2020 Jul 20 doi: 10.1007/s10620-020-06485-y. PMID: 32691382
Patnaik MM, Lasho TL
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):450-459. doi: 10.1182/hematology.2020000130. PMID: 33275756Free PMC Article

Therapy

Tefferi A, Barbui T
Am J Hematol 2023 Sep;98(9):1465-1487. Epub 2023 Jun 26 doi: 10.1002/ajh.27002. PMID: 37357958
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850
Osman AEG, Deininger MW
Blood Rev 2021 Sep;49:100825. Epub 2021 Mar 16 doi: 10.1016/j.blre.2021.100825. PMID: 33773846Free PMC Article
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article

Prognosis

Tefferi A, Vannucchi AM, Barbui T
Am J Hematol 2024 Apr;99(4):697-718. Epub 2024 Jan 25 doi: 10.1002/ajh.27216. PMID: 38269572
Tefferi A, Barbui T
Am J Hematol 2023 Sep;98(9):1465-1487. Epub 2023 Jun 26 doi: 10.1002/ajh.27002. PMID: 37357958
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article

Clinical prediction guides

Tefferi A, Barbui T
Am J Hematol 2023 Sep;98(9):1465-1487. Epub 2023 Jun 26 doi: 10.1002/ajh.27002. PMID: 37357958
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Shahin OA, Chifotides HT, Bose P, Masarova L, Verstovsek S
Acta Haematol 2021;144(5):484-499. Epub 2021 Apr 21 doi: 10.1159/000512929. PMID: 33882481Free PMC Article
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Gangat N, Tefferi A
Br J Haematol 2020 Oct;191(2):152-170. Epub 2020 Mar 20 doi: 10.1111/bjh.16576. PMID: 32196650

Recent systematic reviews

Allahverdi N, Yassin M, Ibrahim M
Cancer Control 2021 Jan-Dec;28:10732748211046802. doi: 10.1177/10732748211046802. PMID: 34645293Free PMC Article
Sayar Z, Nallamilli S, Efthymiou M, Lambert J, Cohen H
Lupus 2021 Aug;30(9):1502-1508. Epub 2021 Jul 1 doi: 10.1177/09612033211021154. PMID: 34192956
Kvernberg J, Grove EL, Ommen HB, Hvas AM
Semin Thromb Hemost 2021 Feb;47(1):90-101. Epub 2021 Feb 1 doi: 10.1055/s-0040-1718873. PMID: 33525042
Bewersdorf JP, Giri S, Wang R, Podoltsev N, Williams RT, Rampal RK, Tallman MS, Zeidan AM, Stahl M
Clin Lymphoma Myeloma Leuk 2020 Oct;20(10):e712-e723. Epub 2020 May 28 doi: 10.1016/j.clml.2020.05.018. PMID: 32669244Free PMC Article
Cruz NM, Gergis U, Silver RT
Expert Rev Hematol 2020 Jan;13(1):71-84. Epub 2019 Nov 30 doi: 10.1080/17474086.2020.1691519. PMID: 31709843

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Myeloproliferative Neoplasms, 2023

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