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Salivary duct carcinoma

MedGen UID:
220969
•Concept ID:
C1301194
•
Neoplastic Process
Synonyms: carcinoma of duct of salivary gland; Carcinoma of Salivary Duct; carcinoma of salivary duct; Carcinoma of the Salivary Duct; carcinoma of the salivary duct; duct of salivary gland carcinoma; High Grade Salivary Duct Carcinoma; high grade salivary duct carcinoma; Salivary Duct Carcinoma; salivary duct carcinoma
SNOMED CT: Salivary duct carcinoma (397082006)
 
Monarch Initiative: MONDO:0044915

Definition

An aggressive, high grade adenocarcinoma that arises from the salivary glands. It usually affects elderly males and presents as a rapidly enlarging mass. It metastasizes to regional lymph nodes and distant anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary duct carcinoma

Professional guidelines

PubMed

Postoperative Management of Salivary Gland Tumors.
Joshi NP, Broughman JR
Curr Treat Options Oncol 2021 Feb 9;22(3):23. doi: 10.1007/s11864-021-00820-9. PMID: 33560478
Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.
Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944Free PMC Article
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877

Recent clinical studies

Etiology

Salivary duct carcinoma: A report of 70 FNA cases and review of the literature.
Wakely PE
Cancer Cytopathol 2022 Aug;130(8):595-608. Epub 2022 Mar 7 doi: 10.1002/cncy.22568. PMID: 35255198
Salivary Gland Cancers.
Tchekmedyian V
Hematol Oncol Clin North Am 2021 Oct;35(5):973-990. doi: 10.1016/j.hoc.2021.05.011. PMID: 34503735
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Salivary duct carcinoma.
Kumar RV, Kini L, Bhargava AK, Mukherjee G, Hazarika D, Shenoy AM, Anantha N
J Surg Oncol 1993 Nov;54(3):193-8. doi: 10.1002/jso.2930540315. PMID: 8412179

Diagnosis

Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.
Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Salivary duct carcinoma: what is already known, and can we improve survival?
Wee DT, Thomas AA, Bradley PJ
J Laryngol Otol 2012 Jul;126 Suppl 2:S2-7. Epub 2012 Apr 12 doi: 10.1017/S0022215112000412. PMID: 22495125
Salivary duct carcinoma.
Murrah VA, Batsakis JG
Ann Otol Rhinol Laryngol 1994 Mar;103(3):244-7. doi: 10.1177/000348949410300315. PMID: 8122843

Therapy

Systemic therapy for salivary gland malignancy: current status and future perspectives.
Imamura Y, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Yokota T, Okano S, Tanaka K, Onoe T, Ariizumi Y, Homma A
Jpn J Clin Oncol 2022 Apr 6;52(4):293-302. doi: 10.1093/jjco/hyac008. PMID: 35134985
Postoperative Management of Salivary Gland Tumors.
Joshi NP, Broughman JR
Curr Treat Options Oncol 2021 Feb 9;22(3):23. doi: 10.1007/s11864-021-00820-9. PMID: 33560478
Parotid salivary duct carcinoma: a single institution's 20-year experience.
Stodulski D, Mikaszewski B, Majewska H, Kuczkowski J
Eur Arch Otorhinolaryngol 2019 Jul;276(7):2031-2038. Epub 2019 May 6 doi: 10.1007/s00405-019-05454-0. PMID: 31062093Free PMC Article
Phase II Trial of Trastuzumab and Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2-Positive Salivary Duct Carcinoma.
Takahashi H, Tada Y, Saotome T, Akazawa K, Ojiri H, Fushimi C, Masubuchi T, Matsuki T, Tani K, Osamura RY, Hirai H, Yamada S, Kawakita D, Miura K, Kamata SE, Nagao T
J Clin Oncol 2019 Jan 10;37(2):125-134. Epub 2018 Nov 19 doi: 10.1200/JCO.18.00545. PMID: 30452336
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article

Prognosis

Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.
Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Salivary duct carcinoma: what is already known, and can we improve survival?
Wee DT, Thomas AA, Bradley PJ
J Laryngol Otol 2012 Jul;126 Suppl 2:S2-7. Epub 2012 Apr 12 doi: 10.1017/S0022215112000412. PMID: 22495125
Salivary duct carcinoma.
Murrah VA, Batsakis JG
Ann Otol Rhinol Laryngol 1994 Mar;103(3):244-7. doi: 10.1177/000348949410300315. PMID: 8122843
Salivary duct carcinoma.
Delgado R, Vuitch F, Albores-Saavedra J
Cancer 1993 Sep 1;72(5):1503-12. doi: 10.1002/1097-0142(19930901)72:5<1503::aid-cncr2820720503>3.0.co;2-k. PMID: 7688652

Clinical prediction guides

Phase II Trial of Trastuzumab and Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2-Positive Salivary Duct Carcinoma.
Takahashi H, Tada Y, Saotome T, Akazawa K, Ojiri H, Fushimi C, Masubuchi T, Matsuki T, Tani K, Osamura RY, Hirai H, Yamada S, Kawakita D, Miura K, Kamata SE, Nagao T
J Clin Oncol 2019 Jan 10;37(2):125-134. Epub 2018 Nov 19 doi: 10.1200/JCO.18.00545. PMID: 30452336
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Perineural Invasion in Parotid Gland Malignancies.
Huyett P, Duvvuri U, Ferris RL, Johnson JT, Schaitkin BM, Kim S
Otolaryngol Head Neck Surg 2018 Jun;158(6):1035-1041. Epub 2018 Jan 16 doi: 10.1177/0194599817751888. PMID: 29337642Free PMC Article
Salivary Duct Carcinoma: An Update on Morphologic Mimics and Diagnostic Use of Androgen Receptor Immunohistochemistry.
Udager AM, Chiosea SI
Head Neck Pathol 2017 Sep;11(3):288-294. Epub 2017 Mar 20 doi: 10.1007/s12105-017-0798-x. PMID: 28321773Free PMC Article
Salivary duct carcinoma. Clinicopathologic and immunohistochemical review of 26 cases.
Lewis JE, McKinney BC, Weiland LH, Ferreiro JA, Olsen KD
Cancer 1996 Jan 15;77(2):223-30. doi: 10.1002/(SICI)1097-0142(19960115)77:2<223::AID-CNCR1>3.0.CO;2-N. PMID: 8625227

Recent systematic reviews

Role of HER2 in Prognosis of Salivary Duct Carcinoma: A Systematic Review and Meta-Analysis.
Williams CYK, Townson AT, Terry N, Schmitt NC, Sharma A
Laryngoscope 2023 Mar;133(3):476-484. Epub 2022 May 14 doi: 10.1002/lary.30214. PMID: 35567387
Evaluation of HER2/neu expression in different types of salivary gland tumors: a systematic review and meta-analysis.
Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077Free PMC Article
Systemic therapy in the management of recurrent or metastatic salivary duct carcinoma: A systematic review.
Uijen MJM, Lassche G, van Engen-van Grunsven ACH, Tada Y, Verhaegh GW, Schalken JA, Driessen CML, van Herpen CML
Cancer Treat Rev 2020 Sep;89:102069. Epub 2020 Jul 15 doi: 10.1016/j.ctrv.2020.102069. PMID: 32717621
Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases.
Palicelli A
APMIS 2020 Mar;128(3):191-200. Epub 2020 Jan 3 doi: 10.1111/apm.13009. PMID: 31697865
Impact of tumour profiling on clinical trials in salivary gland cancer.
Rack S, Rahman R, Carter L, McKay C, Metcalf R
Clin Otolaryngol 2019 Jan;44(1):1-6. Epub 2018 Sep 3 doi: 10.1111/coa.13206. PMID: 30102009

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