U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Polymorphic Post-Transplant Lymphoproliferative Disorder

MedGen UID:
220971
•Concept ID:
C1301361
•
Neoplastic Process
Synonyms: Polymorphic B-Cell Lymphoma; Polymorphic B-Cell Post-Transplant Lymphoproliferative Disorder; Polymorphic lymphoproliferative disorder following transplant; Polymorphic post-transplant lymphoproliferative disorder; Polymorphic PTLD; Post-transplant lymphoproliferative disorder, polymorphic
SNOMED CT: Post-transplant lymphoproliferative disorder, polymorphic (397351004); Polymorphic post-transplant lymphoproliferative disorder (762316003); Polymorphic lymphoproliferative disorder following transplant (762316003)

Definition

A clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a polymorphic B-cell infiltrate composed of small and medium sized lymphocytes, immunoblasts, and plasma cells. In some cases, reduction of the immunosuppression therapy may lead to regression of the lesions. In other cases the lesions may progress to lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolymorphic Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Diagnostic and management roles of FDG PET/CT imaging in post-transplant lympho-proliferation in pediatric heart transplantation.
Brown AK, Carapellucci J, Oshrine B, Gomez A, Meoded A, Asante-Korang A
Clin Transplant 2023 Sep;37(9):e15015. Epub 2023 May 26 doi: 10.1111/ctr.15015. PMID: 37237443
Management of Non-Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder.
Major A, Kamdar M
Curr Treat Options Oncol 2018 May 24;19(7):33. doi: 10.1007/s11864-018-0549-6. PMID: 29797086
Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies.
Al-Mansour Z, Nelson BP, Evens AM
Curr Hematol Malig Rep 2013 Sep;8(3):173-83. doi: 10.1007/s11899-013-0162-5. PMID: 23737188Free PMC Article

Recent clinical studies

Etiology

The diagnostic and clinical significance of granulomas in gastrointestinal biopsies from haematopoietic transplant patients.
Wong NACS, Marks DI
Histopathology 2021 Apr;78(5):772-777. Epub 2021 Jan 28 doi: 10.1111/his.14303. PMID: 33217036
Iatrogenic immunodeficiency-associated lymphoproliferative disorder in a child with B-cell acute lymphoblastic leukemia.
Shahid S, Rossi C, Vyas P, Bollard C, Dave H
Pediatr Hematol Oncol 2019 Aug;36(5):309-316. Epub 2019 Jul 17 doi: 10.1080/08880018.2019.1637982. PMID: 31314679
Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients.
Cesarman E
Cancer Lett 2011 Jun 28;305(2):163-74. Epub 2011 Apr 13 doi: 10.1016/j.canlet.2011.03.003. PMID: 21493001Free PMC Article
Lymphoid neoplasms of the urinary tract and male genital organs: a clinicopathological study of 40 cases.
Schniederjan SD, Osunkoya AO
Mod Pathol 2009 Aug;22(8):1057-65. Epub 2009 Apr 17 doi: 10.1038/modpathol.2009.65. PMID: 19377442

Diagnosis

The diagnostic and clinical significance of granulomas in gastrointestinal biopsies from haematopoietic transplant patients.
Wong NACS, Marks DI
Histopathology 2021 Apr;78(5):772-777. Epub 2021 Jan 28 doi: 10.1111/his.14303. PMID: 33217036
Cutaneous involvement of polymorphic post-transplant lymphoproliferative disorder in a child after liver transplantation.
Chen KY, Lin CY, Kuo TT, Shih LY, Chang CH, Chen WT, Yang CY
Pediatr Dermatol 2019 Sep;36(5):681-685. Epub 2019 Jun 18 doi: 10.1111/pde.13903. PMID: 31215060
Primary cutaneous Hodgkin-like polymorphic post-transplant lymphoproliferative disorder.
Dunn C, Nguyen HP, Patel V, Barker HS, Diwan AH, Yared M, Elghetany T, Restrepo A, Dao H
J Cutan Pathol 2019 May;46(5):358-362. Epub 2019 Feb 27 doi: 10.1111/cup.13427. PMID: 30672006
High-dose Chemotherapy with Stem Cell Rescue Provided Durable Remission for Classical Hodgkin Lymphoma-type Post-transplant Lymphoproliferative Disorder after Unrelated Cord Blood Transplantation: A Case Report and Review of the Literature.
Itonaga H, Kato T, Fujioka M, Taguchi M, Taniguchi H, Imaizumi Y, Yoshida S, Miyoshi H, Moriuchi Y, Ohshima K, Miyazaki Y
Intern Med 2017;56(14):1873-1877. Epub 2017 Jul 15 doi: 10.2169/internalmedicine.56.7938. PMID: 28717085Free PMC Article
Lymphoid neoplasms of the urinary tract and male genital organs: a clinicopathological study of 40 cases.
Schniederjan SD, Osunkoya AO
Mod Pathol 2009 Aug;22(8):1057-65. Epub 2009 Apr 17 doi: 10.1038/modpathol.2009.65. PMID: 19377442

Therapy

The diagnostic and clinical significance of granulomas in gastrointestinal biopsies from haematopoietic transplant patients.
Wong NACS, Marks DI
Histopathology 2021 Apr;78(5):772-777. Epub 2021 Jan 28 doi: 10.1111/his.14303. PMID: 33217036
Trisomy 3, a sole recurrent cytogenetic abnormality in pediatric polymorphic post-transplant lymphoproliferative disorder (PTLD).
Shestakova A, Grove N, Said J, Song S, Quintero-Rivera F
Cancer Genet 2020 Oct;248-249:39-48. Epub 2020 Oct 2 doi: 10.1016/j.cancergen.2020.09.006. PMID: 33065430
Iatrogenic immunodeficiency-associated lymphoproliferative disorder in a child with B-cell acute lymphoblastic leukemia.
Shahid S, Rossi C, Vyas P, Bollard C, Dave H
Pediatr Hematol Oncol 2019 Aug;36(5):309-316. Epub 2019 Jul 17 doi: 10.1080/08880018.2019.1637982. PMID: 31314679
Cutaneous involvement of polymorphic post-transplant lymphoproliferative disorder in a child after liver transplantation.
Chen KY, Lin CY, Kuo TT, Shih LY, Chang CH, Chen WT, Yang CY
Pediatr Dermatol 2019 Sep;36(5):681-685. Epub 2019 Jun 18 doi: 10.1111/pde.13903. PMID: 31215060
Post-transplant plasma cell myeloma and polymorphic lymphoproliferative disorder with monoclonal serum protein occurring in solid organ transplant recipients.
Sun X, Peterson LC, Gong Y, Traynor AE, Nelson BP
Mod Pathol 2004 Apr;17(4):389-94. doi: 10.1038/modpathol.3800080. PMID: 14976525

Prognosis

Trisomy 3, a sole recurrent cytogenetic abnormality in pediatric polymorphic post-transplant lymphoproliferative disorder (PTLD).
Shestakova A, Grove N, Said J, Song S, Quintero-Rivera F
Cancer Genet 2020 Oct;248-249:39-48. Epub 2020 Oct 2 doi: 10.1016/j.cancergen.2020.09.006. PMID: 33065430
Post-transplant plasma cell myeloma and polymorphic lymphoproliferative disorder with monoclonal serum protein occurring in solid organ transplant recipients.
Sun X, Peterson LC, Gong Y, Traynor AE, Nelson BP
Mod Pathol 2004 Apr;17(4):389-94. doi: 10.1038/modpathol.3800080. PMID: 14976525

Clinical prediction guides

Lymphoid neoplasms of the urinary tract and male genital organs: a clinicopathological study of 40 cases.
Schniederjan SD, Osunkoya AO
Mod Pathol 2009 Aug;22(8):1057-65. Epub 2009 Apr 17 doi: 10.1038/modpathol.2009.65. PMID: 19377442

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...