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Sarcoma(Liposarcoma)

MedGen UID:
224714
Concept ID:
C1261473
Neoplastic Process
Synonym: Liposarcoma
SNOMED CT: Sarcoma (424413001); Malignant mesenchymal tumor (1187396000); Sarcoma (1187396000); Soft tissue sarcoma (1187396000); Malignant soft tissue tumor (1187396000)
 
HPO: HP:0100242
Monarch Initiative: MONDO:0005089

Definition

A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSarcoma

Conditions with this feature

Reticulum cell sarcoma
MedGen UID:
44224
Concept ID:
C0024302
Neoplastic Process
A rare dendritic cell tumor characterized by a neoplasm composed of spindle to ovoid cells with phenotypic features similar to those of interdigitating dendritic cells. Solitary lymph node involvement is common, although extranodal localization (in particular skin and soft tissue) has also been reported. Patients usually present with an asymptomatic mass, sometimes with systemic symptoms such as fatigue, fever, and night sweats. Generalized lymphadenopathy, splenomegaly, or hepatomegaly may be seen in rare cases. The clinical course is generally aggressive.
Li-Fraumeni syndrome 2
MedGen UID:
322930
Concept ID:
C1836482
Disease or Syndrome
Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults.\n\nA very similar condition called Li-Fraumeni-like syndrome shares many of the features of classic Li-Fraumeni syndrome. Both conditions significantly increase the chances of developing multiple cancers beginning in childhood; however, the pattern of specific cancers seen in affected family members is different.\n\nThe cancers most often associated with Li-Fraumeni syndrome include breast cancer, a form of bone cancer called osteosarcoma, and cancers of soft tissues (such as muscle) called soft tissue sarcomas. Other cancers commonly seen in this syndrome include brain tumors, cancers of blood-forming tissues (leukemias), and a cancer called adrenocortical carcinoma that affects the outer layer of the adrenal glands (small hormone-producing glands on top of each kidney). Several other types of cancer also occur more frequently in people with Li-Fraumeni syndrome.
Melanoma-pancreatic cancer syndrome
MedGen UID:
325450
Concept ID:
C1838547
Disease or Syndrome
Melanoma-pancreatic cancer syndrome is an inherited cancer predisposition syndrome in which mutation carriers have an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer (summary by Harinck et al., 2012). For background and phenotypic information on malignant melanoma and pancreatic cancer, see 155600 and 260350, respectively.

Professional guidelines

PubMed

Desmoid Tumor Working Group
Eur J Cancer 2020 Mar;127:96-107. Epub 2020 Jan 28 doi: 10.1016/j.ejca.2019.11.013. PMID: 32004793
Ferguson JL, Turner SP
Am Fam Physician 2018 Aug 15;98(4):205-213. PMID: 30215968
Rizvi S, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Curated

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Recent clinical studies

Etiology

Kunisada T, Nakata E, Fujiwara T, Hosono A, Takihira S, Kondo H, Ozaki T
Int J Clin Oncol 2023 Jan;28(1):1-11. Epub 2022 Jan 27 doi: 10.1007/s10147-022-02119-7. PMID: 35084598
Eaton BR, Claude L, Indelicato DJ, Vatner R, Yeh B, Schwarz R, Laack N
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28355. doi: 10.1002/pbc.28355. PMID: 33818887
Shahin OA, Ravandi F
Curr Opin Hematol 2020 Mar;27(2):88-94. doi: 10.1097/MOH.0000000000000571. PMID: 31904666
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811
Balamuth NJ, Womer RB
Lancet Oncol 2010 Feb;11(2):184-92. doi: 10.1016/S1470-2045(09)70286-4. PMID: 20152770

Diagnosis

Martin RF
Surg Clin North Am 2022 Aug;102(4):xiii-xv. doi: 10.1016/j.suc.2022.05.006. PMID: 35952697
Tillman BN, Liu JC
Otolaryngol Clin North Am 2021 Apr;54(2):369-378. Epub 2021 Feb 16 doi: 10.1016/j.otc.2020.11.010. PMID: 33602520
Shahin OA, Ravandi F
Curr Opin Hematol 2020 Mar;27(2):88-94. doi: 10.1097/MOH.0000000000000571. PMID: 31904666
Brownstein JM, DeLaney TF
Hematol Oncol Clin North Am 2020 Feb;34(1):161-175. Epub 2019 Oct 28 doi: 10.1016/j.hoc.2019.08.022. PMID: 31739942
Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A
Clin Lymphoma Myeloma Leuk 2017 May;17(5):263-267. Epub 2017 Mar 7 doi: 10.1016/j.clml.2017.02.027. PMID: 28342811

Therapy

Kasper B, Baumgarten C, Garcia J, Bonvalot S, Haas R, Haller F, Hohenberger P, Penel N, Messiou C, van der Graaf WT, Gronchi A; Desmoid Working Group
Ann Oncol 2017 Oct 1;28(10):2399-2408. doi: 10.1093/annonc/mdx323. PMID: 28961825Free PMC Article
Dancsok AR, Asleh-Aburaya K, Nielsen TO
Oncotarget 2017 Jan 24;8(4):7068-7093. doi: 10.18632/oncotarget.12548. PMID: 27732970Free PMC Article
Goldberg JM
Curr Opin Oncol 2013 Jul;25(4):390-7. doi: 10.1097/CCO.0b013e3283622c8a. PMID: 23736878
Higgins JP, Thompson SG
Stat Med 2002 Jun 15;21(11):1539-58. doi: 10.1002/sim.1186. PMID: 12111919
Maki R
Oncologist 2001;6(4):333-7. doi: 10.1634/theoncologist.6-4-333. PMID: 11524551

Prognosis

Yeung CM, Kaiser CL, Peleteiro-Pensado M, Barrientos-Ruiz I, Ortiz-Cruz EJ, Anderson ME, Raskin KA, Lozano-Calderón SA
Surg Oncol 2021 Sep;38:101619. Epub 2021 Jun 16 doi: 10.1016/j.suronc.2021.101619. PMID: 34157657
Liu B, Youlden DR, Wabinga H, Nambooze S, Amulen PM, Aitken JF, Parkin DM
Pediatr Blood Cancer 2021 Mar;68(3):e28876. Epub 2020 Dec 31 doi: 10.1002/pbc.28876. PMID: 33381877
Zichová A, Eckschlager T, Ganevová M, Malinová B, Lukš A, Kruseová J
Cancer Epidemiol 2020 Oct;68:101779. Epub 2020 Jul 15 doi: 10.1016/j.canep.2020.101779. PMID: 32682319
Tonorezos ES, Friedman DN, Barnea D, Bosscha MI, Chantada G, Dommering CJ, de Graaf P, Dunkel IJ, Fabius AWM, Francis JH, Greer MC, Kleinerman RA, Kors WA, Laughlin S, Moll AC, Morton LM, Temming P, Tucker MA, van Leeuwen FE, Walsh MF, Oeffinger KC, Abramson DH
Ophthalmology 2020 Nov;127(11):1549-1557. Epub 2020 May 15 doi: 10.1016/j.ophtha.2020.05.024. PMID: 32422154Free PMC Article
Sampo MM, Klintrup K, Tukiainen EJ, Böhling TO, Blomqvist CP
Acta Orthop 2017 Feb;88(1):116-120. Epub 2016 Jun 20 doi: 10.1080/17453674.2016.1196429. PMID: 27321676Free PMC Article

Clinical prediction guides

Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Vacirca A, Faggioli G, Pini R, Freyrie A, Indelicato G, Fenelli C, Bacchi Reggiani ML, Vasuri F, Pasquinelli G, Stella A, Gargiulo M
J Vasc Surg 2020 May;71(5):1771-1780. Epub 2019 Dec 17 doi: 10.1016/j.jvs.2019.09.030. PMID: 31862201
Mariño-Enríquez A, Bovée JV
Surg Pathol Clin 2016 Sep;9(3):457-73. doi: 10.1016/j.path.2016.04.009. PMID: 27523972Free PMC Article
Catana D, Koziarz A, Cenic A, Nath S, Singh S, Almenawer SA, Kachur E
World Neurosurg 2016 Sep;93:73-80. Epub 2016 Jun 4 doi: 10.1016/j.wneu.2016.05.084. PMID: 27268313
Antonescu C
Mod Pathol 2014 Jan;27 Suppl 1:S30-8. doi: 10.1038/modpathol.2013.176. PMID: 24384851

Recent systematic reviews

Papakonstantinou A, Gonzalez NS, Pimentel I, Suñol A, Zamora E, Ortiz C, Espinosa-Bravo M, Peg V, Vivancos A, Saura C, Villacampa G, Oliveira M
Cancer Treat Rev 2022 Mar;104:102362. Epub 2022 Feb 18 doi: 10.1016/j.ctrv.2022.102362. PMID: 35219090
Nardone V, Reginelli A, Grassi R, Boldrini L, Vacca G, D'Ippolito E, Annunziata S, Farchione A, Belfiore MP, Desideri I, Cappabianca S
Radiol Med 2021 Dec;126(12):1571-1583. Epub 2021 Dec 4 doi: 10.1007/s11547-021-01436-7. PMID: 34865190
Akazawa M, Hashimoto K
Artif Intell Med 2021 Oct;120:102164. Epub 2021 Sep 3 doi: 10.1016/j.artmed.2021.102164. PMID: 34629152
Cupp MA, Cariolou M, Tzoulaki I, Aune D, Evangelou E, Berlanga-Taylor AJ
BMC Med 2020 Nov 20;18(1):360. doi: 10.1186/s12916-020-01817-1. PMID: 33213430Free PMC Article
Conforti F, Pala L, Bagnardi V, De Pas T, Martinetti M, Viale G, Gelber RD, Goldhirsch A
Lancet Oncol 2018 Jun;19(6):737-746. Epub 2018 May 16 doi: 10.1016/S1470-2045(18)30261-4. PMID: 29778737

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

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