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Metaplastic Carcinoma

MedGen UID:
224759
Concept ID:
C1266089
Neoplastic Process
Synonym: Metaplastic carcinoma
SNOMED CT: Metaplastic carcinoma (128705006)

Definition

A general term used to describe carcinomas arising from epithelial cells that have been transformed into another cells type (metaplastic epithelial cells). A representative example is the adenocarcinoma arising in Barrett esophagus. This term is also used to describe carcinomas in which the malignant epithelial cells show differentiation towards another cell type. A representative example of the latter is the metaplastic breast carcinoma in which the malignant glandular cells show squamous, spindle cell, or chondroid/osseous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetaplastic Carcinoma

Professional guidelines

PubMed

Benoist P, Mureau A, Joueidi Y, Arbion F, Vilde A, Body G, Michenet P, Leveque J, Ouldamer L
J Gynecol Obstet Hum Reprod 2018 Sep;47(7):275-280. Epub 2018 Jun 27 doi: 10.1016/j.jogoh.2018.06.007. PMID: 29959086
Artioli G, Wabersich J, Ludwig K, Gardiman MP, Borgato L, Garbin F
Crit Rev Oncol Hematol 2015 Apr;94(1):98-104. Epub 2014 Nov 7 doi: 10.1016/j.critrevonc.2014.10.013. PMID: 25468677
Sanguinetti A, Lucchini R, Santoprete S, Farabi R, Fioriti L, Bistoni G, Triola R, Avenia N
Ann Ital Chir 2014 Mar-Apr;85(2):109-13. PMID: 24195912

Recent clinical studies

Etiology

Khoury T
Surg Pathol Clin 2022 Mar;15(1):159-174. Epub 2022 Jan 31 doi: 10.1016/j.path.2021.11.011. PMID: 35236632
Rakha EA, Brogi E, Castellano I, Quinn C
Virchows Arch 2022 Jan;480(1):127-145. Epub 2021 Jul 29 doi: 10.1007/s00428-021-03162-x. PMID: 34322734Free PMC Article
Hasdemir OA, Tokgöz S, Köybaşıoğlu F, Karabacak H, Yücesoy C, İmamoğlu Gİ
Adv Clin Exp Med 2018 Apr;27(4):509-513. doi: 10.17219/acem/68293. PMID: 29558027
El Zein D, Hughes M, Kumar S, Peng X, Oyasiji T, Jabbour H, Khoury T
Clin Breast Cancer 2017 Aug;17(5):382-391. Epub 2017 Apr 26 doi: 10.1016/j.clbc.2017.04.009. PMID: 28529029Free PMC Article
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Diagnosis

Yoon EC, Wang G, Parkinson B, Huo L, Peng Y, Wang J, Salisbury T, Wu Y, Chen H, Albarracin CT, Resetkova E, Middleton LP, Krishnamurthy S, Gan Q, Sun H, Huang X, Shen T, Chen W, Parwani AV, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Jul;125:97-107. Epub 2022 Apr 9 doi: 10.1016/j.humpath.2022.04.006. PMID: 35413381
Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
Rakha EA, Brogi E, Castellano I, Quinn C
Virchows Arch 2022 Jan;480(1):127-145. Epub 2021 Jul 29 doi: 10.1007/s00428-021-03162-x. PMID: 34322734Free PMC Article
Surenkok S, Tahberer E, Cinkaya A, Kodaz H, Deger A
J Pak Med Assoc 2018 Mar;68(3):466-468. PMID: 29540888
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Therapy

Early AP, Moon W
Clin Breast Cancer 2021 Feb;21(1):e96-e101. Epub 2020 Aug 3 doi: 10.1016/j.clbc.2020.07.015. PMID: 32855081
Bartlett H, Elghobashy M, Deshmukh N, Rao R, Shaaban AM
Pathobiology 2020;87(5):322-326. Epub 2020 Sep 11 doi: 10.1159/000509580. PMID: 32920553
Takala S, Heikkilä P, Nevanlinna H, Blomqvist C, Mattson J
Breast J 2019 May;25(3):418-424. Epub 2019 Mar 29 doi: 10.1111/tbj.13234. PMID: 30925636
Salemis NS
Breast Dis 2018;37(3):169-175. doi: 10.3233/BD-170313. PMID: 29504519
McKinnon E, Xiao P
Arch Pathol Lab Med 2015 Jun;139(6):819-22. doi: 10.5858/arpa.2013-0358-RS. PMID: 26030252

Prognosis

Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
McMullen ER, Zoumberos NA, Kleer CG
Arch Pathol Lab Med 2019 Dec;143(12):1492-1496. doi: 10.5858/arpa.2019-0396-RA. PMID: 31765246
Surenkok S, Tahberer E, Cinkaya A, Kodaz H, Deger A
J Pak Med Assoc 2018 Mar;68(3):466-468. PMID: 29540888
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
McKinnon E, Xiao P
Arch Pathol Lab Med 2015 Jun;139(6):819-22. doi: 10.5858/arpa.2013-0358-RS. PMID: 26030252

Clinical prediction guides

Li Z, Dabbs DJ
Pathobiology 2022;89(5):309-323. Epub 2022 Mar 4 doi: 10.1159/000521682. PMID: 35249034
Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694

Recent systematic reviews

Born LJ, Khachemoune A
Arch Dermatol Res 2023 Oct;315(8):2195-2205. Epub 2023 Feb 15 doi: 10.1007/s00403-023-02551-3. PMID: 36790451
Schizas D, Mastoraki A, Bagias G, Ioannidi M, Kanavidis P, Moris D, Tsilimigras DI, Spartalis E, Arkadopoulos N, Liakakos T
J BUON 2018 Sep-Oct;23(5):1432-1438. PMID: 30570870

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