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Classic Hodgkin lymphoma, lymphocyte-rich type

MedGen UID:
224769
•Concept ID:
C1266194
•
Neoplastic Process
Synonym: Hodgkin's lymphoma, lymphocytic-histiocytic predominance
SNOMED CT: Hodgkin lymphoma, lymphocyte-rich (clinical) (118607005); Classical Hodgkin lymphoma, lymphocyte-rich (128799007); Hodgkin lymphoma, lymphocyte-rich (128799007); Hodgkin lymphoma, lymphocyte-rich (118607005); Lymphocyte-rich classical Hodgkin lymphoma (118607005)
 
Monarch Initiative: MONDO:0004604
Orphanet: ORPHA98845

Definition

A subtype of classic Hodgkin lymphoma with scattered Hodgkin and Reed-Sternberg cells and a nodular or less often diffuse cellular background consisting of small lymphocytes and with an absence of neutrophils and eosinophils. (WHO, 2008) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassic Hodgkin lymphoma, lymphocyte-rich type
Follow this link to review classifications for Classic Hodgkin lymphoma, lymphocyte-rich type in Orphanet.

Professional guidelines

PubMed

Management of elderly patients with malignant lymphoma.
Miyazaki K
Jpn J Clin Oncol 2022 Jul 8;52(7):690-699. doi: 10.1093/jjco/hyac056. PMID: 35435235
Lymphoproliferative disorders after solid organ transplantation-classification, incidence, risk factors, early detection and treatment options.
Végso G, Hajdu M, Sebestyén A
Pathol Oncol Res 2011 Sep;17(3):443-54. Epub 2010 Dec 31 doi: 10.1007/s12253-010-9329-8. PMID: 21193979
Hodgkin's disease: classification and differential diagnosis.
Harris NL
Mod Pathol 1999 Feb;12(2):159-75. PMID: 10071341

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Hodgkin Lymphoma, 2022

Recent clinical studies

Etiology

ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma.
Nowakowski GS, Chiappella A, Gascoyne RD, Scott DW, Zhang Q, Jurczak W, Özcan M, Hong X, Zhu J, Jin J, Belada D, Bergua JM, Piazza F, Mócikova H, Molinari AL, Yoon DH, Cavallo F, Tani M, Yamamoto K, Izutsu K, Kato K, Czuczman M, Hersey S, Kilcoyne A, Russo J, Hudak K, Zhang J, Wade S, Witzig TE, Vitolo U
J Clin Oncol 2021 Apr 20;39(12):1317-1328. Epub 2021 Feb 23 doi: 10.1200/JCO.20.01366. PMID: 33621109Free PMC Article
Relationship of Tumor-Associated Macrophage Population Detected by CD68 PG-M1, CD68 KP1, and CD163 with Latent EBV Infection and Prognosis in Classical Hodgkin Lymphoma.
Mavili HS, Isisag A, Tan A, Miskioglu M, Baraz LS, Nese N
Turk Patoloji Derg 2021;37(2):130-138. doi: 10.5146/tjpath.2020.01514. PMID: 33085074Free PMC Article
Coincidental Expression of Classic Hodgkin Lymphoma and Neurofibromatosis Type I and Literature Review.
Cabrera TB, Wang W, Yedururi S, Slopis JM, Steiner RE, Rytting ME, Cuglievan B
J Pediatr Hematol Oncol 2021 May 1;43(4):e535-e538. doi: 10.1097/MPH.0000000000001811. PMID: 32366782
Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1.
Reinke S, Bröckelmann PJ, Iaccarino I, Garcia-Marquez M, Borchmann S, Jochims F, Kotrova M, Pal K, Brüggemann M, Hartmann E, Sasse S, Kobe C, Mathas S, Soekler M, Keller U, Bormann M, Zimmermann A, Richter J, Fuchs M, von Tresckow B, Borchmann P, Schlößer H, von Bergwelt-Baildon M, Rosenwald A, Engert A, Klapper W
Blood 2020 Dec 17;136(25):2851-2863. doi: 10.1182/blood.2020008553. PMID: 33113552
Cutaneous lymphoma: Kids are not just little people.
Ferenczi K, Makkar HS
Clin Dermatol 2016 Nov-Dec;34(6):749-759. Epub 2016 Jul 10 doi: 10.1016/j.clindermatol.2016.07.010. PMID: 27968935

Diagnosis

Composite Classic Hodgkin Lymphoma and Follicular Lymphoma: A Clinicopathologic Study of 22 Cases With Review of 27 Additional Cases in the Literature.
Huang Y, Hu S, Larson DP, Shi M, He R, Dave BJ, Greiner TC, Fu K, McPhail ED, Ketterling RP, Medeiros LJ, Yuan J
Am J Surg Pathol 2022 Jun 1;46(6):793-800. Epub 2022 Jan 24 doi: 10.1097/PAS.0000000000001828. PMID: 35067515
Syncytial variant of nodular sclerosis Hodgkin lymphoma: an under-emphasized variant.
Wang W, Zhang Q, Medeiros LJ
Hum Pathol 2021 Nov;117:115-125. Epub 2021 May 28 doi: 10.1016/j.humpath.2021.05.008. PMID: 34058246
Coincidental Expression of Classic Hodgkin Lymphoma and Neurofibromatosis Type I and Literature Review.
Cabrera TB, Wang W, Yedururi S, Slopis JM, Steiner RE, Rytting ME, Cuglievan B
J Pediatr Hematol Oncol 2021 May 1;43(4):e535-e538. doi: 10.1097/MPH.0000000000001811. PMID: 32366782
Pediatric lymphoma diagnosis: role of FNAC, biopsy, immunohistochemistry and molecular diagnostics.
Iyer VK
Indian J Pediatr 2013 Sep;80(9):756-63. Epub 2013 Aug 8 doi: 10.1007/s12098-013-1128-2. PMID: 23925793
T-cell-rich B-cell lymphoma.
Rodriguez J, Pugh WC, Cabanillas F
Blood 1993 Sep 1;82(5):1586-9. PMID: 8364208

Therapy

ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma.
Nowakowski GS, Chiappella A, Gascoyne RD, Scott DW, Zhang Q, Jurczak W, Özcan M, Hong X, Zhu J, Jin J, Belada D, Bergua JM, Piazza F, Mócikova H, Molinari AL, Yoon DH, Cavallo F, Tani M, Yamamoto K, Izutsu K, Kato K, Czuczman M, Hersey S, Kilcoyne A, Russo J, Hudak K, Zhang J, Wade S, Witzig TE, Vitolo U
J Clin Oncol 2021 Apr 20;39(12):1317-1328. Epub 2021 Feb 23 doi: 10.1200/JCO.20.01366. PMID: 33621109Free PMC Article
Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1.
Reinke S, Bröckelmann PJ, Iaccarino I, Garcia-Marquez M, Borchmann S, Jochims F, Kotrova M, Pal K, Brüggemann M, Hartmann E, Sasse S, Kobe C, Mathas S, Soekler M, Keller U, Bormann M, Zimmermann A, Richter J, Fuchs M, von Tresckow B, Borchmann P, Schlößer H, von Bergwelt-Baildon M, Rosenwald A, Engert A, Klapper W
Blood 2020 Dec 17;136(25):2851-2863. doi: 10.1182/blood.2020008553. PMID: 33113552
PD-1/PD-L1 Pathway and Its Blockade in Patients with Classic Hodgkin Lymphoma and Non-Hodgkin Large-Cell Lymphomas.
Xie W, Medeiros LJ, Li S, Yin CC, Khoury JD, Xu J
Curr Hematol Malig Rep 2020 Aug;15(4):372-381. doi: 10.1007/s11899-020-00589-y. PMID: 32394185
Gray zone lymphoma: better treated like hodgkin lymphoma or mediastinal large B-cell lymphoma?
Dunleavy K, Grant C, Eberle FC, Pittaluga S, Jaffe ES, Wilson WH
Curr Hematol Malig Rep 2012 Sep;7(3):241-7. doi: 10.1007/s11899-012-0130-5. PMID: 22833351Free PMC Article
T-cell-rich B-cell lymphoma.
Rodriguez J, Pugh WC, Cabanillas F
Blood 1993 Sep 1;82(5):1586-9. PMID: 8364208

Prognosis

ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma.
Nowakowski GS, Chiappella A, Gascoyne RD, Scott DW, Zhang Q, Jurczak W, Özcan M, Hong X, Zhu J, Jin J, Belada D, Bergua JM, Piazza F, Mócikova H, Molinari AL, Yoon DH, Cavallo F, Tani M, Yamamoto K, Izutsu K, Kato K, Czuczman M, Hersey S, Kilcoyne A, Russo J, Hudak K, Zhang J, Wade S, Witzig TE, Vitolo U
J Clin Oncol 2021 Apr 20;39(12):1317-1328. Epub 2021 Feb 23 doi: 10.1200/JCO.20.01366. PMID: 33621109Free PMC Article
Relationship of Tumor-Associated Macrophage Population Detected by CD68 PG-M1, CD68 KP1, and CD163 with Latent EBV Infection and Prognosis in Classical Hodgkin Lymphoma.
Mavili HS, Isisag A, Tan A, Miskioglu M, Baraz LS, Nese N
Turk Patoloji Derg 2021;37(2):130-138. doi: 10.5146/tjpath.2020.01514. PMID: 33085074Free PMC Article
Cutaneous lymphoma: Kids are not just little people.
Ferenczi K, Makkar HS
Clin Dermatol 2016 Nov-Dec;34(6):749-759. Epub 2016 Jul 10 doi: 10.1016/j.clindermatol.2016.07.010. PMID: 27968935
Pathology and "molecular histology' of Hodgkin's disease and the border to non-Hodgkin's lymphomas.
Hansmann ML, Küppers R
Baillieres Clin Haematol 1996 Sep;9(3):459-77. doi: 10.1016/s0950-3536(96)80021-7. PMID: 8922240
T-cell-rich B-cell lymphoma.
Rodriguez J, Pugh WC, Cabanillas F
Blood 1993 Sep 1;82(5):1586-9. PMID: 8364208

Clinical prediction guides

Cytologic manifestations of Hodgkin lymphoma in serous effusions.
AbdullGaffar B, Raman L
Diagn Cytopathol 2022 Sep;50(9):E255-E263. Epub 2022 May 17 doi: 10.1002/dc.24976. PMID: 35581946
ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma.
Nowakowski GS, Chiappella A, Gascoyne RD, Scott DW, Zhang Q, Jurczak W, Özcan M, Hong X, Zhu J, Jin J, Belada D, Bergua JM, Piazza F, Mócikova H, Molinari AL, Yoon DH, Cavallo F, Tani M, Yamamoto K, Izutsu K, Kato K, Czuczman M, Hersey S, Kilcoyne A, Russo J, Hudak K, Zhang J, Wade S, Witzig TE, Vitolo U
J Clin Oncol 2021 Apr 20;39(12):1317-1328. Epub 2021 Feb 23 doi: 10.1200/JCO.20.01366. PMID: 33621109Free PMC Article
Relationship of Tumor-Associated Macrophage Population Detected by CD68 PG-M1, CD68 KP1, and CD163 with Latent EBV Infection and Prognosis in Classical Hodgkin Lymphoma.
Mavili HS, Isisag A, Tan A, Miskioglu M, Baraz LS, Nese N
Turk Patoloji Derg 2021;37(2):130-138. doi: 10.5146/tjpath.2020.01514. PMID: 33085074Free PMC Article
Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1.
Reinke S, Bröckelmann PJ, Iaccarino I, Garcia-Marquez M, Borchmann S, Jochims F, Kotrova M, Pal K, Brüggemann M, Hartmann E, Sasse S, Kobe C, Mathas S, Soekler M, Keller U, Bormann M, Zimmermann A, Richter J, Fuchs M, von Tresckow B, Borchmann P, Schlößer H, von Bergwelt-Baildon M, Rosenwald A, Engert A, Klapper W
Blood 2020 Dec 17;136(25):2851-2863. doi: 10.1182/blood.2020008553. PMID: 33113552
Classical Hodgkin's lymphoma arising in different host's conditions: pathobiology parameters, therapeutic options, and outcome.
Carbone A, Spina M, Gloghini A, Tirelli U
Am J Hematol 2011 Feb;86(2):170-9. doi: 10.1002/ajh.21910. PMID: 21264899

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    Curated

    • NCCN, 2022
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Hodgkin Lymphoma, 2022

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