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Melanotic medulloblastoma

MedGen UID:
224818
Concept ID:
C1275668
Neoplastic Process
Synonyms: Medulloblastoma, Melanocytic; Medulloblastomas, Melanocytic; Melanocytic Medulloblastoma; Melanocytic Medulloblastomas
SNOMED CT: Medulloblastoma, melanotic (397380008); Melanotic medulloblastoma (397380008)
 
Monarch Initiative: MONDO:0002796

Definition

A rare malignant embryonal neoplasm characterized by the presence of small cells which resemble the cells of classic medulloblastoma and a minor population of melanin-forming neuroepithelial cells. It usually has an unfavorable clinical course. [from NCI]

Professional guidelines

PubMed

Menyhárt O, Győrffy B
Cancer Metastasis Rev 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. PMID: 31970590Free PMC Article
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article

Recent clinical studies

Diagnosis

Li WY, Ma L, Liu J, Yang H, Mao Q
Childs Nerv Syst 2011 Apr;27(4):517-21. Epub 2011 Jan 26 doi: 10.1007/s00381-011-1389-x. PMID: 21267583
Zanini C, Mandili G, Pulerà F, Morra I, Peretta P, Turrini F, Forni M
Pediatr Blood Cancer 2009 Jul;52(7):875-7. doi: 10.1002/pbc.21887. PMID: 19061219

Prognosis

Li WY, Ma L, Liu J, Yang H, Mao Q
Childs Nerv Syst 2011 Apr;27(4):517-21. Epub 2011 Jan 26 doi: 10.1007/s00381-011-1389-x. PMID: 21267583
MacDonald TJ
J Child Neurol 2008 Oct;23(10):1195-204. doi: 10.1177/0883073808321769. PMID: 18952586Free PMC Article

Clinical prediction guides

Li WY, Ma L, Liu J, Yang H, Mao Q
Childs Nerv Syst 2011 Apr;27(4):517-21. Epub 2011 Jan 26 doi: 10.1007/s00381-011-1389-x. PMID: 21267583
Kubota KC, Itoh T, Yamada Y, Yamaguchi S, Ishida Y, Nakasu Y, Watanabe R, Ito I, Sawamura Y, Matsuno Y, Nagashima K
Neuropathology 2009 Feb;29(1):72-7. Epub 2008 Apr 16 doi: 10.1111/j.1440-1789.2008.00913.x. PMID: 18422908

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