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Degenerative disorder

MedGen UID:
224837
•Concept ID:
C1285162
•
Disease or Syndrome
Synonyms: Degenerative Disease; Degenerative Disorder
SNOMED CT: Degenerative disorder (362975008)

Definition

A disorder characterized by the progressive loss of function and/or structure of the affected tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDegenerative disorder

Professional guidelines

PubMed

Omaveloxolone: an activator of Nrf2 for the treatment of Friedreich ataxia.
Profeta V, McIntyre K, Wells M, Park C, Lynch DR
Expert Opin Investig Drugs 2023 Jan;32(1):5-16. Epub 2023 Feb 8 doi: 10.1080/13543784.2023.2173063. PMID: 36708320
Patellar Tendinopathy: Diagnosis and Treatment.
Figueroa D, Figueroa F, Calvo R
J Am Acad Orthop Surg 2016 Dec;24(12):e184-e192. doi: 10.5435/JAAOS-D-15-00703. PMID: 27855131
Osteoarthritis: diagnosis and treatment.
Sinusas K
Am Fam Physician 2012 Jan 1;85(1):49-56. PMID: 22230308

Recent clinical studies

Etiology

A causal relationship between leukocyte telomere length and multiple sclerosis: A Mendelian randomization study.
Liao Q, He J, Tian FF, Bi FF, Huang K
Front Immunol 2022;13:922922. Epub 2022 Jul 15 doi: 10.3389/fimmu.2022.922922. PMID: 35911771Free PMC Article
Plasma lipids and risk of aortic valve stenosis: a Mendelian randomization study.
Nazarzadeh M, Pinho-Gomes AC, Bidel Z, Dehghan A, Canoy D, Hassaine A, Ayala Solares JR, Salimi-Khorshidi G, Smith GD, Otto CM, Rahimi K
Eur Heart J 2020 Oct 21;41(40):3913-3920. doi: 10.1093/eurheartj/ehaa070. PMID: 32076698Free PMC Article
GBA, Gaucher Disease, and Parkinson's Disease: From Genetic to Clinic to New Therapeutic Approaches.
Riboldi GM, Di Fonzo AB
Cells 2019 Apr 19;8(4) doi: 10.3390/cells8040364. PMID: 31010158Free PMC Article
Patellar Tendinopathy: Diagnosis and Treatment.
Figueroa D, Figueroa F, Calvo R
J Am Acad Orthop Surg 2016 Dec;24(12):e184-e192. doi: 10.5435/JAAOS-D-15-00703. PMID: 27855131
Osteoarthritis: diagnosis and treatment.
Sinusas K
Am Fam Physician 2012 Jan 1;85(1):49-56. PMID: 22230308

Diagnosis

The Chiari I malformation.
McClugage SG, Oakes WJ
J Neurosurg Pediatr 2019 Sep 1;24(3):217-226. doi: 10.3171/2019.5.PEDS18382. PMID: 31473667
Primary Progressive Aphasias and Apraxia of Speech.
Botha H, Josephs KA
Continuum (Minneap Minn) 2019 Feb;25(1):101-127. doi: 10.1212/CON.0000000000000699. PMID: 30707189Free PMC Article
Patellar Tendinopathy: Diagnosis and Treatment.
Figueroa D, Figueroa F, Calvo R
J Am Acad Orthop Surg 2016 Dec;24(12):e184-e192. doi: 10.5435/JAAOS-D-15-00703. PMID: 27855131
Lateral epicondylitis of the elbow.
Tosti R, Jennings J, Sewards JM
Am J Med 2013 Apr;126(4):357.e1-6. Epub 2013 Feb 8 doi: 10.1016/j.amjmed.2012.09.018. PMID: 23398951
Osteoarthritis: diagnosis and treatment.
Sinusas K
Am Fam Physician 2012 Jan 1;85(1):49-56. PMID: 22230308

Therapy

Omaveloxolone: an activator of Nrf2 for the treatment of Friedreich ataxia.
Profeta V, McIntyre K, Wells M, Park C, Lynch DR
Expert Opin Investig Drugs 2023 Jan;32(1):5-16. Epub 2023 Feb 8 doi: 10.1080/13543784.2023.2173063. PMID: 36708320
A causal relationship between leukocyte telomere length and multiple sclerosis: A Mendelian randomization study.
Liao Q, He J, Tian FF, Bi FF, Huang K
Front Immunol 2022;13:922922. Epub 2022 Jul 15 doi: 10.3389/fimmu.2022.922922. PMID: 35911771Free PMC Article
Plasma lipids and risk of aortic valve stenosis: a Mendelian randomization study.
Nazarzadeh M, Pinho-Gomes AC, Bidel Z, Dehghan A, Canoy D, Hassaine A, Ayala Solares JR, Salimi-Khorshidi G, Smith GD, Otto CM, Rahimi K
Eur Heart J 2020 Oct 21;41(40):3913-3920. doi: 10.1093/eurheartj/ehaa070. PMID: 32076698Free PMC Article
Osteoarthritis: diagnosis and treatment.
Sinusas K
Am Fam Physician 2012 Jan 1;85(1):49-56. PMID: 22230308
Osteoarthritis.
Haq I, Murphy E, Dacre J
Postgrad Med J 2003 Jul;79(933):377-83. doi: 10.1136/pmj.79.933.377. PMID: 12897215Free PMC Article

Prognosis

Biomarkers Assessing Endothelial Dysfunction in Alzheimer's Disease.
Custodia A, Aramburu-Núñez M, Rodríguez-Arrizabalaga M, Pías-Peleteiro JM, Vázquez-Vázquez L, Camino-Castiñeiras J, Aldrey JM, Castillo J, Ouro A, Sobrino T, Romaus-Sanjurjo D
Cells 2023 Mar 22;12(6) doi: 10.3390/cells12060962. PMID: 36980302Free PMC Article
A causal relationship between leukocyte telomere length and multiple sclerosis: A Mendelian randomization study.
Liao Q, He J, Tian FF, Bi FF, Huang K
Front Immunol 2022;13:922922. Epub 2022 Jul 15 doi: 10.3389/fimmu.2022.922922. PMID: 35911771Free PMC Article
The Chiari I malformation.
McClugage SG, Oakes WJ
J Neurosurg Pediatr 2019 Sep 1;24(3):217-226. doi: 10.3171/2019.5.PEDS18382. PMID: 31473667
Primary Progressive Aphasias and Apraxia of Speech.
Botha H, Josephs KA
Continuum (Minneap Minn) 2019 Feb;25(1):101-127. doi: 10.1212/CON.0000000000000699. PMID: 30707189Free PMC Article
Inclusion body myositis.
Dimachkie MM, Barohn RJ
Semin Neurol 2012 Jul;32(3):237-45. Epub 2012 Nov 1 doi: 10.1055/s-0032-1329197. PMID: 23117948Free PMC Article

Clinical prediction guides

A causal relationship between leukocyte telomere length and multiple sclerosis: A Mendelian randomization study.
Liao Q, He J, Tian FF, Bi FF, Huang K
Front Immunol 2022;13:922922. Epub 2022 Jul 15 doi: 10.3389/fimmu.2022.922922. PMID: 35911771Free PMC Article
Emerging role of integrated PET-MRI in osteoarthritis.
Jena A, Taneja S, Rana P, Goyal N, Vaish A, Botchu R, Vaishya R
Skeletal Radiol 2021 Dec;50(12):2349-2363. Epub 2021 Jun 29 doi: 10.1007/s00256-021-03847-z. PMID: 34185124
Planning Future Clinical Trials for Machado-Joseph Disease.
Saute JAM, Jardim LB
Adv Exp Med Biol 2018;1049:321-348. doi: 10.1007/978-3-319-71779-1_17. PMID: 29427112
LINE-1 activity and regulation in cancer.
Rodic N
Front Biosci (Landmark Ed) 2018 Mar 1;23(9):1680-1686. doi: 10.2741/4666. PMID: 29293456
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.
Kimmatkar N, Thawani V, Hingorani L, Khiyani R
Phytomedicine 2003 Jan;10(1):3-7. doi: 10.1078/094471103321648593. PMID: 12622457

Recent systematic reviews

Proximal fibular osteotomy versus high tibial osteotomy for treating knee osteoarthritis: a systematic review and meta-analysis.
Wu ZX, Ren WX, Wang ZQ
J Orthop Surg Res 2022 Oct 28;17(1):470. doi: 10.1186/s13018-022-03299-8. PMID: 36307827Free PMC Article
Retinal biomarkers of Cerebral Small Vessel Disease: A systematic review.
Biffi E, Turple Z, Chung J, Biffi A
PLoS One 2022;17(4):e0266974. Epub 2022 Apr 14 doi: 10.1371/journal.pone.0266974. PMID: 35421194Free PMC Article
Diabetes Mellitus and Amyotrophic Lateral Sclerosis: A Systematic Review.
Ferri L, Ajdinaj P, Rispoli MG, Carrarini C, Barbone F, D'Ardes D, Capasso M, Muzio AD, Cipollone F, Onofrj M, Bonanni L
Biomolecules 2021 Jun 10;11(6) doi: 10.3390/biom11060867. PMID: 34200812Free PMC Article
Genetic factors of cervical spondylotic myelopathy-a systemic review.
Wang G, Cao Y, Wu T, Duan C, Wu J, Hu J, Lu H
J Clin Neurosci 2017 Oct;44:89-94. Epub 2017 Jul 19 doi: 10.1016/j.jocn.2017.06.043. PMID: 28734792
Epidemiological evidence for work load as a risk factor for osteoarthritis of the hip: a systematic review.
Sulsky SI, Carlton L, Bochmann F, Ellegast R, Glitsch U, Hartmann B, Pallapies D, Seidel D, Sun Y
PLoS One 2012;7(2):e31521. Epub 2012 Feb 14 doi: 10.1371/journal.pone.0031521. PMID: 22348095Free PMC Article

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