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Precursor T-lymphoblastic lymphoma/leukemia

MedGen UID:
224897
•Concept ID:
C1301359
•
Neoplastic Process
Synonym: T Lymphoblastic Leukemia/Lymphoma
SNOMED CT: Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma (397348006); T-lymphoblastic lymphoma/leukemia (397348006); Precursor T cell lymphoblastic leukemia/lymphoblastic lymphoma (420890002); T lymphoblastic leukemia/lymphoma (703821009)
 
Monarch Initiative: MONDO:0003537

Definition

A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called T acute lymphoblastic leukemia. When it involves nodal or extranodal sites it is called T lymphoblastic lymphoma. (WHO, 2001) [from NCI]

Recent clinical studies

Etiology

Prognostic factors of Chinese patients with T/NK-cell lymphoma: a single institution study of 170 patients.
Xu PP, Wang Y, Shen Y, Wang L, Shen ZX, Zhao WL
Med Oncol 2012 Sep;29(3):2176-82. Epub 2011 Jun 28 doi: 10.1007/s12032-011-0011-0. PMID: 21710236
Primary and secondary T-cell lymphomas of the breast: clinico-pathologic features of 11 cases.
Gualco G, Chioato L, Harrington WJ Jr, Weiss LM, Bacchi CE
Appl Immunohistochem Mol Morphol 2009 Jul;17(4):301-6. doi: 10.1097/PAI.0b013e318195286d. PMID: 19318917Free PMC Article
Dexamethazone-induced acute tumor lysis syndrome in a T-cell malignant lymphoma.
Lerza R, Botta M, Barsotti B, Schenone E, Mencoboni M, Bogliolo G, Pannacciulli I, Arboscello E
Leuk Lymphoma 2002 May;43(5):1129-32. doi: 10.1080/10428190290021452. PMID: 12148896

Diagnosis

Prognostic factors of Chinese patients with T/NK-cell lymphoma: a single institution study of 170 patients.
Xu PP, Wang Y, Shen Y, Wang L, Shen ZX, Zhao WL
Med Oncol 2012 Sep;29(3):2176-82. Epub 2011 Jun 28 doi: 10.1007/s12032-011-0011-0. PMID: 21710236
Flow cytometry in the diagnosis of mediastinal tumors with emphasis on differentiating thymocytes from precursor T-lymphoblastic lymphoma/leukemia.
Gorczyca W, Tugulea S, Liu Z, Li X, Wong JY, Weisberger J
Leuk Lymphoma 2004 Mar;45(3):529-38. doi: 10.1080/10428190310001598008. PMID: 15160915
Dexamethazone-induced acute tumor lysis syndrome in a T-cell malignant lymphoma.
Lerza R, Botta M, Barsotti B, Schenone E, Mencoboni M, Bogliolo G, Pannacciulli I, Arboscello E
Leuk Lymphoma 2002 May;43(5):1129-32. doi: 10.1080/10428190290021452. PMID: 12148896

Therapy

Prognostic factors of Chinese patients with T/NK-cell lymphoma: a single institution study of 170 patients.
Xu PP, Wang Y, Shen Y, Wang L, Shen ZX, Zhao WL
Med Oncol 2012 Sep;29(3):2176-82. Epub 2011 Jun 28 doi: 10.1007/s12032-011-0011-0. PMID: 21710236
Dexamethazone-induced acute tumor lysis syndrome in a T-cell malignant lymphoma.
Lerza R, Botta M, Barsotti B, Schenone E, Mencoboni M, Bogliolo G, Pannacciulli I, Arboscello E
Leuk Lymphoma 2002 May;43(5):1129-32. doi: 10.1080/10428190290021452. PMID: 12148896

Prognosis

Prognostic factors of Chinese patients with T/NK-cell lymphoma: a single institution study of 170 patients.
Xu PP, Wang Y, Shen Y, Wang L, Shen ZX, Zhao WL
Med Oncol 2012 Sep;29(3):2176-82. Epub 2011 Jun 28 doi: 10.1007/s12032-011-0011-0. PMID: 21710236

Clinical prediction guides

Prognostic factors of Chinese patients with T/NK-cell lymphoma: a single institution study of 170 patients.
Xu PP, Wang Y, Shen Y, Wang L, Shen ZX, Zhao WL
Med Oncol 2012 Sep;29(3):2176-82. Epub 2011 Jun 28 doi: 10.1007/s12032-011-0011-0. PMID: 21710236

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