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Spindle cell hemangioma

MedGen UID:
224916
•Concept ID:
C1304508
•
Neoplastic Process
Synonyms: SCh; Spindle -Cell Hemangioma; spindle -cell hemangioma; Spindle cell angioendothelioma; Spindle cell hemangioendothelioma; Spindle Cell Hemangioendothelioma; spindle cell hemangioendothelioma; Spindle Cell Hemangioma; spindle cell hemangioma
SNOMED CT: Spindle cell hemangioma (403967000); Spindle cell angioendothelioma (128769003); Spindle cell hemangioendothelioma (128769003); Spindle cell hemangioma (128769003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016222
Orphanet: ORPHA210584

Definition

Spindle cell hemangioma (SCH), also known as spindle cell hemangioendothelioma, is a rare benign vascular tumor either solitary or multiple, characterized by cavernous blood vessels separated by spindle cells reminiscent of those in Kaposi?s sarcoma and located in the dermis and subcutis. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpindle cell hemangioma
Follow this link to review classifications for Spindle cell hemangioma in Orphanet.

Professional guidelines

PubMed

Kaposiform haemangioendothelioma: a review with emphasis on histological differential diagnosis.
Putra J, Gupta A
Pathology 2017 Jun;49(4):356-362. Epub 2017 Apr 21 doi: 10.1016/j.pathol.2017.03.001. PMID: 28438388
Epithelioid hemangioendothelioma of the head and neck: role of podoplanin in the differential diagnosis.
Naqvi J, Ordonez NG, Luna MA, Williams MD, Weber RS, El-Naggar AK
Head Neck Pathol 2008 Mar;2(1):25-30. Epub 2007 Oct 26 doi: 10.1007/s12105-007-0035-0. PMID: 20614338Free PMC Article
Primary sarcomas of the lung.
Suster S
Semin Diagn Pathol 1995 May;12(2):140-57. PMID: 7638447

Recent clinical studies

Etiology

The First Case of Composite Hemangioendothelioma in The Heart.
Zhang X, Wang S, Jin M
Heart Surg Forum 2022 Apr 22;25(2):E284-E287. doi: 10.1532/hsf.4587. PMID: 35486043
Somatic IDH1 variant (p.R132C) in an adult male with Maffucci syndrome.
Brown NJ, Ye Z, Stutterd C, Jayasinghe SI, Schneider A, Mullen S, Mandelstam SA, Hildebrand MS
Cold Spring Harb Mol Case Stud 2021 Dec;7(6) Epub 2021 Dec 9 doi: 10.1101/mcs.a006127. PMID: 34588213Free PMC Article
Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report.
Papez J, Starha J, Zerhau P, Pavlovska D, Jezova M, Jurencak T, Slaba K, Sterba M, Kerekes A, Merta T, Haluskova T, Palova H, Slaby O, Sterba J, Jabandziev P
Genes (Basel) 2021 Feb 3;12(2) doi: 10.3390/genes12020220. PMID: 33546375Free PMC Article
Intramedullary spindle cell hemangioma: case report.
Nasser R, Ashayeri K, Legatt AD, Houten JK
J Neurosurg Spine 2016 Sep;25(3):379-82. Epub 2016 Apr 8 doi: 10.3171/2015.11.SPINE15641. PMID: 27058496
Spindle cell hemangioma.
Tomasini C, Aloi F, Soro E, Elia V
Dermatology 1999;199(3):274-6. doi: 10.1159/000018265. PMID: 10592415

Diagnosis

Spindle cell hemangioma of nasal passage and ethmoidal sinus in a 4-month old infant.
Tastemel Ozturk T, Suslu AE, Kavuncuoglu A, Gumeler E, Kosemehmetoglu K, Yalcin B
Arch Argent Pediatr 2021 Feb;119(1):e36-e40. doi: 10.5546/aap.2021.eng.e36. PMID: 33458988
Vascular tumors.
Mansfield SA, Williams RF, Iacobas I
Semin Pediatr Surg 2020 Oct;29(5):150975. Epub 2020 Sep 16 doi: 10.1016/j.sempedsurg.2020.150975. PMID: 33069294
Multiple spindle cell hemangiomas in both lungs: a rare case report and review of the literature.
Duqing X, Zhaohong W, Gefei W
J Cardiothorac Surg 2019 May 2;14(1):86. doi: 10.1186/s13019-019-0906-y. PMID: 31046794Free PMC Article
The Molecular Diagnostics of Vascular Neoplasms.
Habeeb O, Rubin BP
Surg Pathol Clin 2019 Mar;12(1):35-49. Epub 2018 Dec 4 doi: 10.1016/j.path.2018.10.002. PMID: 30709447
Histopathology of Spindle Cell Vascular Tumors.
Marušić Z, Billings SD
Surg Pathol Clin 2017 Jun;10(2):345-366. Epub 2017 Mar 31 doi: 10.1016/j.path.2017.01.006. PMID: 28477885

Prognosis

Intramedullary spindle cell hemangioma: case report.
Nasser R, Ashayeri K, Legatt AD, Houten JK
J Neurosurg Spine 2016 Sep;25(3):379-82. Epub 2016 Apr 8 doi: 10.3171/2015.11.SPINE15641. PMID: 27058496
Periosteal spindle cell hemangioma of the fibula: a case report.
Tsukamoto S, Honoki K, Shimada K, Fujii H, Kido A, Takano M, Enomoto Y, Kasai T, Konishi N, Tanaka Y
Skeletal Radiol 2013 Aug;42(8):1165-8. Epub 2013 Mar 24 doi: 10.1007/s00256-013-1603-x. PMID: 23525489
Prox1 transcription factor as a marker for vascular tumors-evaluation of 314 vascular endothelial and 1086 nonvascular tumors.
Miettinen M, Wang ZF
Am J Surg Pathol 2012 Mar;36(3):351-9. doi: 10.1097/PAS.0b013e318236c312. PMID: 22067331Free PMC Article
Spindle cell hemangioendothelioma. An analysis of 78 cases with reassessment of its pathogenesis and biologic behavior.
Perkins P, Weiss SW
Am J Surg Pathol 1996 Oct;20(10):1196-204. doi: 10.1097/00000478-199610000-00004. PMID: 8827025

Clinical prediction guides

Spindle cell hemangioma of the spleen: A case report.
Gao BQ, Zhou DK, Qian XH, Zhang W, Ying LX, Wang WL
Medicine (Baltimore) 2019 Mar;98(9):e14555. doi: 10.1097/MD.0000000000014555. PMID: 30817572Free PMC Article
Prox1 transcription factor as a marker for vascular tumors-evaluation of 314 vascular endothelial and 1086 nonvascular tumors.
Miettinen M, Wang ZF
Am J Surg Pathol 2012 Mar;36(3):351-9. doi: 10.1097/PAS.0b013e318236c312. PMID: 22067331Free PMC Article
Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndrome.
Fukunaga M, Suzuki K, Saegusa N, Folpe AL
Am J Surg Pathol 2007 Oct;31(10):1567-72. doi: 10.1097/PAS.0b013e318038f6b5. PMID: 17895759
Congenital composite hemangioendothelioma: case report and reappraisal of the hemangioendothelioma spectrum.
Reis-Filho JS, Paiva ME, Lopes JM
J Cutan Pathol 2002 Apr;29(4):226-31. doi: 10.1034/j.1600-0560.2002.290405.x. PMID: 12028155

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