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Uterine prolapse

MedGen UID:
22591
Concept ID:
C0042140
Anatomical Abnormality; Finding
Synonyms: Prolapse, Uterine; Prolapses, Uterine; Uterine Prolapse; Uterine Prolapses
SNOMED CT: Uterine prolapse (24976005); Descensus uteri (24976005); Uterine hernia (24976005); Prolapse of uterus (24976005); Prolapsed uterus (24976005); Descens uteri (24976005)
 
HPO: HP:0000139

Definition

The presence of prolapse of the uterus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUterine prolapse

Conditions with this feature

Coffin-Lowry syndrome
MedGen UID:
75556
Concept ID:
C0265252
Disease or Syndrome
Coffin-Lowry syndrome (CLS) is usually characterized by severe-to-profound intellectual disability in males; less severely impaired individuals have been reported. Neuropsychiatric concerns can include behavioral problems, loss of strength, progressive spasticity or paraplegia, sleep apnea, or stroke. Stimulus-induced drop attacks (SIDAs) in which unexpected tactile or auditory stimuli or excitement triggers a brief collapse but no loss of consciousness are present in approximately 20% of affected individuals. Typically SIDAs begin between mid-childhood and the teens. Characteristic facial features may be more apparent with age. Upper-extremity differences may be subtle and include short, soft, fleshy hands with tapered fingers as well as fleshy forearms. Progressive kyphoscoliosis is one of the most difficult aspects of long-term care. Affected females tend to have intellectual disability in the mild-to-moderate range and may also have the typical facial, hand, and skeletal findings noted in males.
Ehlers-Danlos syndrome, type 4
MedGen UID:
82790
Concept ID:
C0268338
Disease or Syndrome
Vascular Ehlers-Danlos syndrome (vEDS) is characterized by arterial, intestinal, and/or uterine fragility; thin, translucent skin; easy bruising; characteristic facial appearance (thin vermilion of the lips, micrognathia, narrow nose, prominent eyes); and an aged appearance to the extremities, particularly the hands. Vascular dissection or rupture, gastrointestinal perforation, or organ rupture are the presenting signs in most adults with vEDS. Arterial rupture may be preceded by aneurysm, arteriovenous fistulae, or dissection but also may occur spontaneously. The majority (60%) of individuals with vEDS who are diagnosed before age 18 years are identified because of a positive family history. Neonates may present with clubfoot, hip dislocation, limb deficiency, and/or amniotic bands. Approximately half of children tested for vEDS in the absence of a positive family history present with a major complication at an average age of 11 years. Four minor diagnostic features – distal joint hypermobility, easy bruising, thin skin, and clubfeet – are most often present in those children ascertained without a major complication.
Aneurysm-osteoarthritis syndrome
MedGen UID:
462437
Concept ID:
C3151087
Disease or Syndrome
Loeys-Dietz syndrome (LDS) is characterized by vascular findings (cerebral, thoracic, and abdominal arterial aneurysms and/or dissections), skeletal manifestations (pectus excavatum or pectus carinatum, scoliosis, joint laxity, arachnodactyly, talipes equinovarus, cervical spine malformation and/or instability), craniofacial features (widely spaced eyes, strabismus, bifid uvula / cleft palate, and craniosynostosis that can involve any sutures), and cutaneous findings (velvety and translucent skin, easy bruising, and dystrophic scars). Individuals with LDS are predisposed to widespread and aggressive arterial aneurysms and pregnancy-related complications including uterine rupture and death. Individuals with LDS can show a strong predisposition for allergic/inflammatory disease including asthma, eczema, and reactions to food or environmental allergens. There is also an increased incidence of gastrointestinal inflammation including eosinophilic esophagitis and gastritis or inflammatory bowel disease. Wide variation in the distribution and severity of clinical features can be seen in individuals with LDS, even among affected individuals within a family who have the same pathogenic variant.
Cutis laxa, autosomal dominant 1
MedGen UID:
478169
Concept ID:
C3276539
Disease or Syndrome
FBLN5-related cutis laxa is characterized by cutis laxa, early childhood-onset pulmonary emphysema, peripheral pulmonary artery stenosis, and other evidence of a generalized connective disorder such as inguinal hernias and hollow viscus diverticula (e.g., intestine, bladder). Occasionally, supravalvar aortic stenosis is observed. Intrafamilial variability in age of onset is observed. Cardiorespiratory failure from complications of pulmonary emphysema (respiratory or cardiac insufficiency) is the most common cause of death.

Professional guidelines

PubMed

Geoffrion R, Larouche M
J Obstet Gynaecol Can 2021 Apr;43(4):511-523.e1. Epub 2021 Feb 3 doi: 10.1016/j.jogc.2021.02.001. PMID: 33548503
Tso C, Lee W, Austin-Ketch T, Winkler H, Zitkus B
Nurs Womens Health 2018 Jun;22(3):228-239. doi: 10.1016/j.nwh.2018.03.007. PMID: 29885711
Tsikouras P, Dafopoulos A, Vrachnis N, Iliodromiti Z, Bouchlariotou S, Pinidis P, Tsagias N, Liberis V, Galazios G, Von Tempelhoff GF
J Matern Fetal Neonatal Med 2014 Feb;27(3):297-302. Epub 2013 Jul 9 doi: 10.3109/14767058.2013.807235. PMID: 23692627

Recent clinical studies

Etiology

Norby N, Murchison AB, McLeish S, Ghahremani T, Whitham M, Magann EF
Obstet Gynecol Surv 2023 Sep;78(9):537-543. doi: 10.1097/OGX.0000000000001192. PMID: 37976302
Schulten SFM, Detollenaere RJ, Stekelenburg J, IntHout J, Kluivers KB, van Eijndhoven HWF
BMJ 2019 Sep 10;366:l5149. doi: 10.1136/bmj.l5149. PMID: 31506252Free PMC Article
Jan H, Ghai V, Thakar R
J Minim Invasive Gynecol 2018 Nov-Dec;25(7):1134. Epub 2018 Jan 31 doi: 10.1016/j.jmig.2018.01.014. PMID: 29371171
Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN
Int Urogynecol J 2010 Jan;21(1):5-26. Epub 2009 Nov 25 doi: 10.1007/s00192-009-0976-9. PMID: 19937315
Varner M
Crit Care Clin 1991 Oct;7(4):883-97. PMID: 1747807

Diagnosis

Norby N, Murchison AB, McLeish S, Ghahremani T, Whitham M, Magann EF
Obstet Gynecol Surv 2023 Sep;78(9):537-543. doi: 10.1097/OGX.0000000000001192. PMID: 37976302
Brown OE, Mou TP, Ackenbom MF
JAMA 2023 Oct 17;330(15):1486-1487. doi: 10.1001/jama.2023.16277. PMID: 37747737
Schulten SFM, Detollenaere RJ, Stekelenburg J, IntHout J, Kluivers KB, van Eijndhoven HWF
BMJ 2019 Sep 10;366:l5149. doi: 10.1136/bmj.l5149. PMID: 31506252Free PMC Article
Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN
Int Urogynecol J 2010 Jan;21(1):5-26. Epub 2009 Nov 25 doi: 10.1007/s00192-009-0976-9. PMID: 19937315
Bump RC, Mattiasson A, Bø K, Brubaker LP, DeLancey JO, Klarskov P, Shull BL, Smith AR
Am J Obstet Gynecol 1996 Jul;175(1):10-7. doi: 10.1016/s0002-9378(96)70243-0. PMID: 8694033

Therapy

Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Schulten SFM, Detollenaere RJ, Stekelenburg J, IntHout J, Kluivers KB, van Eijndhoven HWF
BMJ 2019 Sep 10;366:l5149. doi: 10.1136/bmj.l5149. PMID: 31506252Free PMC Article
Jelovsek JE, Barber MD, Brubaker L, Norton P, Gantz M, Richter HE, Weidner A, Menefee S, Schaffer J, Pugh N, Meikle S; NICHD Pelvic Floor Disorders Network
JAMA 2018 Apr 17;319(15):1554-1565. doi: 10.1001/jama.2018.2827. PMID: 29677302Free PMC Article
Jan H, Ghai V, Thakar R
J Minim Invasive Gynecol 2018 Nov-Dec;25(7):1134. Epub 2018 Jan 31 doi: 10.1016/j.jmig.2018.01.014. PMID: 29371171
Maher C, Feiner B, Baessler K, Schmid C
Cochrane Database Syst Rev 2013 Apr 30;(4):CD004014. doi: 10.1002/14651858.CD004014.pub5. PMID: 23633316

Prognosis

Deshpande RR, Matsuzaki S, Cox KR, Foy OB, Mandelbaum RS, Ouzounian JG, Dancz CE, Matsuo K
Am J Obstet Gynecol MFM 2023 Aug;5(8):101020. Epub 2023 May 27 doi: 10.1016/j.ajogmf.2023.101020. PMID: 37245607
Schulten SFM, Detollenaere RJ, Stekelenburg J, IntHout J, Kluivers KB, van Eijndhoven HWF
BMJ 2019 Sep 10;366:l5149. doi: 10.1136/bmj.l5149. PMID: 31506252Free PMC Article
Ridgeway B, Frick AC, Walter MD
Minerva Ginecol 2008 Dec;60(6):509-28. PMID: 18981978
Dasgupta S
J Indian Med Assoc 1995 Feb;93(2):55-7. PMID: 7658038
Varner M
Crit Care Clin 1991 Oct;7(4):883-97. PMID: 1747807

Clinical prediction guides

Norby N, Murchison AB, McLeish S, Ghahremani T, Whitham M, Magann EF
Obstet Gynecol Surv 2023 Sep;78(9):537-543. doi: 10.1097/OGX.0000000000001192. PMID: 37976302
Badacho AS, Lelu MA, Gelan Z, Woltamo DD
PLoS One 2022;17(1):e0262077. Epub 2022 Jan 21 doi: 10.1371/journal.pone.0262077. PMID: 35061761Free PMC Article
Hemming C, Constable L, Goulao B, Kilonzo M, Boyers D, Elders A, Cooper K, Smith A, Freeman R, Breeman S, McDonald A, Hagen S, Montgomery I, Norrie J, Glazener C
Health Technol Assess 2020 Mar;24(13):1-220. doi: 10.3310/hta24130. PMID: 32138809Free PMC Article
Schulten SFM, Detollenaere RJ, Stekelenburg J, IntHout J, Kluivers KB, van Eijndhoven HWF
BMJ 2019 Sep 10;366:l5149. doi: 10.1136/bmj.l5149. PMID: 31506252Free PMC Article
Barber MD, Walters MD, Bump RC
Am J Obstet Gynecol 2005 Jul;193(1):103-13. doi: 10.1016/j.ajog.2004.12.025. PMID: 16021067

Recent systematic reviews

Page AS, Page G, Deprest J
Eur J Obstet Gynecol Reprod Biol 2022 Dec;279:60-71. Epub 2022 Oct 6 doi: 10.1016/j.ejogrb.2022.10.004. PMID: 36260964
He L, Feng D, Zha X, Liao XY, Gong ZL, Gu DQ, Lin YH, Huang L
Int Urogynecol J 2022 Jul;33(7):1917-1925. Epub 2021 Jul 2 doi: 10.1007/s00192-021-04913-9. PMID: 34213602
Geoffrion R, Larouche M
J Obstet Gynaecol Can 2021 Apr;43(4):511-523.e1. Epub 2021 Feb 3 doi: 10.1016/j.jogc.2021.02.001. PMID: 33548503
Bugge C, Adams EJ, Gopinath D, Stewart F, Dembinsky M, Sobiesuo P, Kearney R
Cochrane Database Syst Rev 2020 Nov 18;11(11):CD004010. doi: 10.1002/14651858.CD004010.pub4. PMID: 33207004Free PMC Article
Maher C, Feiner B, Baessler K, Schmid C
Cochrane Database Syst Rev 2013 Apr 30;(4):CD004014. doi: 10.1002/14651858.CD004014.pub5. PMID: 23633316

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