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Vogt-Koyanagi-Harada disease

MedGen UID:
22599
Concept ID:
C0042170
Disease or Syndrome
Synonyms: Disease, Vogt-Koyanagi-Harada; Syndrome, Uveomeningoencephalitic; Syndrome, VKH; Syndrome, VKH (Vogt Koyanagi Harada); Syndrome, Vogt Koyanagi Harada; Syndrome, Vogt-Koyanagi-Harada; Uveomeningoencephalitic Syndrome; Uveomeningoencephalitides; Uveomeningoencephalitis; VKH (Vogt Koyanagi Harada) Syndrome; VKH Syndrome; VKH Syndrome (Vogt Koyanagi Harada); Vogt Koyanagi Harada Disease; Vogt Koyanagi Harada Syndrome; Vogt-Koyanagi-Harada Disease; Vogt-Koyanagi-Harada Syndrome
SNOMED CT: Vogt-Koyanagi syndrome (193497004); Vogt-Koyanagi-Harada disease (193497004); VKH - Vogt-Koyanagi-Harada syndrome (193497004); Harada disease (193497004); Vogt's disease (193497004); Vogt-Koyanagi-Harada syndrome (193497004); Harada's disease (193497004)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
 
Monarch Initiative: MONDO:0018092
Orphanet: ORPHA3437

Definition

Vogt-Koyanagi-Harada disease is a bilateral, chronic, diffuse granulomatous panuveitis typically characterized by serous retinal detachment and frequently associated with neurological (meningitis), auditory, and dermatological alterations. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVogt-Koyanagi-Harada disease

Professional guidelines

PubMed

Souto FMS, Lavezzo MM, Oyamada MK, Yamamoto JH
Clin Exp Ophthalmol 2022 Jul;50(5):569-572. Epub 2022 Apr 29 doi: 10.1111/ceo.14081. PMID: 35384212
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:205-211. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.036. PMID: 33845018Free PMC Article
Du L, Kijlstra A, Yang P
Prog Retin Eye Res 2016 May;52:84-111. Epub 2016 Feb 11 doi: 10.1016/j.preteyeres.2016.02.002. PMID: 26875727

Recent clinical studies

Etiology

Gentile P, Ragusa E, Bolletta E, De Simone L, Gozzi F, Cappella M, Fastiggi M, De Fanti A, Cimino L
Ocul Immunol Inflamm 2023 Dec;31(10):2050-2059. Epub 2023 Dec 14 doi: 10.1080/09273948.2023.2271988. PMID: 37922466
Arriola-Villalobos P, Moll-Udina A, Carrasco-López-Brea M, Sacristan C, Capella MJ, Peiteado D, Garrote-Llordén A, Albert Fort M, Jódar Márquez M, Jacobo Gonzalez Guijarro J, Demetrio-Pablo R, Luis Sánchez Sevilla J, Carreño E, González-López J, Miguel-Escuder L, Cuadros C, Díaz-Valle D, Adan A; Contributors: VKH Spanish Study Group, Benítez Del Castillo JM, Fonollosa A, Cordero M, Martínez Costa L, Blanco-Alonso R
Eur J Ophthalmol 2022 May;32(3):1547-1554. Epub 2021 Jul 16 doi: 10.1177/11206721211033477. PMID: 34269103
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:205-211. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.036. PMID: 33845018Free PMC Article
Zhong Z, Su G, Kijlstra A, Yang P
Prog Retin Eye Res 2021 Jan;80:100866. Epub 2020 May 16 doi: 10.1016/j.preteyeres.2020.100866. PMID: 32422390
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153

Diagnosis

Tugal-Tutkun I, Smit DP, Abu El-Asrar AM, Herbort CP Jr, Thorne JE
Ocul Immunol Inflamm 2024 May;32(4):363-366. Epub 2024 Apr 24 doi: 10.1080/09273948.2024.2331401. PMID: 38657222
Joye A, Suhler E
Curr Opin Ophthalmol 2021 Nov 1;32(6):574-582. doi: 10.1097/ICU.0000000000000809. PMID: 34545845
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:205-211. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.036. PMID: 33845018Free PMC Article
O'Keefe GA, Rao NA
Surv Ophthalmol 2017 Jan-Feb;62(1):1-25. Epub 2016 May 27 doi: 10.1016/j.survophthal.2016.05.002. PMID: 27241814
Cunningham ET Jr, Rathinam SR, Tugal-Tutkun I, Muccioli C, Zierhut M
Ocul Immunol Inflamm 2014 Aug;22(4):249-52. doi: 10.3109/09273948.2014.939530. PMID: 25014114

Therapy

Tugal-Tutkun I, Smit DP, Abu El-Asrar AM, Herbort CP Jr, Thorne JE
Ocul Immunol Inflamm 2024 May;32(4):363-366. Epub 2024 Apr 24 doi: 10.1080/09273948.2024.2331401. PMID: 38657222
Habot-Wilner Z, Neri P, Okada AA, Agrawal R, Xin Le N, Cohen S, Fischer N, Kilmartin F, Coman A, Kilmartin D
Ocul Immunol Inflamm 2023 Aug;31(6):1198-1205. Epub 2023 May 5 doi: 10.1080/09273948.2023.2200858. PMID: 37145198
Street D, Sivaguru A, Sreekantam S, Mollan SP
Pract Neurol 2019 Aug;19(4):364-367. Epub 2019 Mar 19 doi: 10.1136/practneurol-2018-002152. PMID: 30890584
O'Keefe GA, Rao NA
Surv Ophthalmol 2017 Jan-Feb;62(1):1-25. Epub 2016 May 27 doi: 10.1016/j.survophthal.2016.05.002. PMID: 27241814
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153

Prognosis

Habot-Wilner Z, Neri P, Okada AA, Agrawal R, Xin Le N, Cohen S, Fischer N, Kilmartin F, Coman A, Kilmartin D
Ocul Immunol Inflamm 2023 Aug;31(6):1198-1205. Epub 2023 May 5 doi: 10.1080/09273948.2023.2200858. PMID: 37145198
Arriola-Villalobos P, Moll-Udina A, Carrasco-López-Brea M, Sacristan C, Capella MJ, Peiteado D, Garrote-Llordén A, Albert Fort M, Jódar Márquez M, Jacobo Gonzalez Guijarro J, Demetrio-Pablo R, Luis Sánchez Sevilla J, Carreño E, González-López J, Miguel-Escuder L, Cuadros C, Díaz-Valle D, Adan A; Contributors: VKH Spanish Study Group, Benítez Del Castillo JM, Fonollosa A, Cordero M, Martínez Costa L, Blanco-Alonso R
Eur J Ophthalmol 2022 May;32(3):1547-1554. Epub 2021 Jul 16 doi: 10.1177/11206721211033477. PMID: 34269103
Burkholder BM
Curr Opin Ophthalmol 2015 Nov;26(6):506-11. doi: 10.1097/ICU.0000000000000206. PMID: 26448042
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153
Read RW, Rao NA, Cunningham ET
Curr Opin Ophthalmol 2000 Dec;11(6):437-42. doi: 10.1097/00055735-200012000-00009. PMID: 11141638

Clinical prediction guides

Wang Q, Wu S, Ye X, Tan S, Huang F, Su G, Kijlstra A, Yang P
J Autoimmun 2023 May;137:103055. Epub 2023 May 18 doi: 10.1016/j.jaut.2023.103055. PMID: 37208257
Yang P, Liao W, Pu Y, Zhong Z, Wang H, Yu Q, Cai J, Wang W, Su G
Graefes Arch Clin Exp Ophthalmol 2023 Sep;261(9):2641-2650. Epub 2023 Apr 14 doi: 10.1007/s00417-023-06058-5. PMID: 37058172
Ataş F, Kaya M, Saatci AO
Turk J Ophthalmol 2022 Dec 28;52(6):400-404. doi: 10.4274/tjo.galenos.2021.86821. PMID: 36578215Free PMC Article
Alvarez-Guzman C, Valdez-Garcia JE, Ruiz-Lozano RE, Rodriguez-Garcia A, Navas-Villar CF, Hartleben-Matkin C, Pedroza-Seres M
Int Ophthalmol 2022 Dec;42(12):3913-3921. Epub 2022 Jul 5 doi: 10.1007/s10792-022-02412-4. PMID: 35789316
Huang G, Peng J, Ye Z, Kijlstra A, Zhang D, Yang P
Acta Ophthalmol 2018 Jun;96(4):411-419. Epub 2017 Dec 8 doi: 10.1111/aos.13606. PMID: 29220112

Recent systematic reviews

Edwards Mayhew RG, Li T, McCann P, Leslie L, Strong Caldwell A, Palestine AG
Cochrane Database Syst Rev 2022 Oct 31;10(10):CD014831. doi: 10.1002/14651858.CD014831.pub2. PMID: 36315029Free PMC Article
Toudou-Daouda M, Ibrahim-Mamadou AK
BMC Neurol 2022 Feb 4;22(1):44. doi: 10.1186/s12883-022-02569-6. PMID: 35120474Free PMC Article
Liu B, Deng T, Zhu L, Zhong J
Medicine (Baltimore) 2018 Feb;97(7):e9914. doi: 10.1097/MD.0000000000009914. PMID: 29443768Free PMC Article
Shi T, Lv W, Zhang L, Chen J, Chen H
Sci Rep 2014 Nov 10;4:6887. doi: 10.1038/srep06887. PMID: 25382027Free PMC Article
Mehta S, Linton MM, Kempen JH
Am J Ophthalmol 2014 Oct;158(4):676-692.e7. Epub 2014 Jun 28 doi: 10.1016/j.ajo.2014.06.018. PMID: 24983790

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