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Vogt-Koyanagi-Harada disease

MedGen UID:
22599
•Concept ID:
C0042170
•
Disease or Syndrome
Synonyms: Disease, Vogt-Koyanagi-Harada; Syndrome, Uveomeningoencephalitic; Syndrome, VKH; Syndrome, VKH (Vogt Koyanagi Harada); Syndrome, Vogt Koyanagi Harada; Syndrome, Vogt-Koyanagi-Harada; Uveomeningoencephalitic Syndrome; Uveomeningoencephalitides; Uveomeningoencephalitis; VKH (Vogt Koyanagi Harada) Syndrome; VKH Syndrome; VKH Syndrome (Vogt Koyanagi Harada); Vogt Koyanagi Harada Disease; Vogt Koyanagi Harada Syndrome; Vogt-Koyanagi-Harada Disease; Vogt-Koyanagi-Harada Syndrome
SNOMED CT: Vogt-Koyanagi syndrome (193497004); Vogt-Koyanagi-Harada disease (193497004); VKH - Vogt-Koyanagi-Harada syndrome (193497004); Harada disease (193497004); Vogt's disease (193497004); Vogt-Koyanagi-Harada syndrome (193497004); Harada's disease (193497004)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0018092
Orphanet: ORPHA3437

Definition

Vogt-Koyanagi-Harada disease is a bilateral, chronic, diffuse granulomatous panuveitis typically characterized by serous retinal detachment and frequently associated with neurological (meningitis), auditory, and dermatological alterations. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVogt-Koyanagi-Harada disease

Professional guidelines

PubMed

Classification Criteria for Vogt-Koyanagi-Harada Disease.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:205-211. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.036. PMID: 33845018Free PMC Article
Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease.
Yang P, Zhong Y, Du L, Chi W, Chen L, Zhang R, Zhang M, Wang H, Lu H, Yang L, Zhuang W, Yang Y, Xing L, Feng L, Jiang Z, Zhang X, Wang Y, Zhong H, Jiang L, Zhao C, Li F, Cao S, Liu X, Chen X, Shi Y, Zhao W, Kijlstra A
JAMA Ophthalmol 2018 Sep 1;136(9):1025-1031. doi: 10.1001/jamaophthalmol.2018.2664. PMID: 29978190Free PMC Article
Vogt-Koyanagi-Harada disease: Novel insights into pathophysiology, diagnosis and treatment.
Du L, Kijlstra A, Yang P
Prog Retin Eye Res 2016 May;52:84-111. Epub 2016 Feb 11 doi: 10.1016/j.preteyeres.2016.02.002. PMID: 26875727

Recent clinical studies

Etiology

Pathogenesis of Non-Infectious Uveitis Elucidated by Recent Genetic Findings.
Takeuchi M, Mizuki N, Ohno S
Front Immunol 2021;12:640473. Epub 2021 Apr 12 doi: 10.3389/fimmu.2021.640473. PMID: 33912164Free PMC Article
Classification Criteria for Vogt-Koyanagi-Harada Disease.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:205-211. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.036. PMID: 33845018Free PMC Article
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis.
Zhong Z, Su G, Kijlstra A, Yang P
Prog Retin Eye Res 2021 Jan;80:100866. Epub 2020 May 16 doi: 10.1016/j.preteyeres.2020.100866. PMID: 32422390
Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease.
Yang P, Zhong Y, Du L, Chi W, Chen L, Zhang R, Zhang M, Wang H, Lu H, Yang L, Zhuang W, Yang Y, Xing L, Feng L, Jiang Z, Zhang X, Wang Y, Zhong H, Jiang L, Zhao C, Li F, Cao S, Liu X, Chen X, Shi Y, Zhao W, Kijlstra A
JAMA Ophthalmol 2018 Sep 1;136(9):1025-1031. doi: 10.1001/jamaophthalmol.2018.2664. PMID: 29978190Free PMC Article
Vogt-Koyanagi-Harada disease: Novel insights into pathophysiology, diagnosis and treatment.
Du L, Kijlstra A, Yang P
Prog Retin Eye Res 2016 May;52:84-111. Epub 2016 Feb 11 doi: 10.1016/j.preteyeres.2016.02.002. PMID: 26875727

Diagnosis

Vogt-Koyanagi-Harada disease.
Joye A, Suhler E
Curr Opin Ophthalmol 2021 Nov 1;32(6):574-582. doi: 10.1097/ICU.0000000000000809. PMID: 34545845
Classification Criteria for Vogt-Koyanagi-Harada Disease.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:205-211. Epub 2021 Apr 9 doi: 10.1016/j.ajo.2021.03.036. PMID: 33845018Free PMC Article
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis.
Zhong Z, Su G, Kijlstra A, Yang P
Prog Retin Eye Res 2021 Jan;80:100866. Epub 2020 May 16 doi: 10.1016/j.preteyeres.2020.100866. PMID: 32422390
Vogt-Koyanagi-Harada disease.
O'Keefe GA, Rao NA
Surv Ophthalmol 2017 Jan-Feb;62(1):1-25. Epub 2016 May 27 doi: 10.1016/j.survophthal.2016.05.002. PMID: 27241814
Vogt-Koyanagi-Harada disease: Novel insights into pathophysiology, diagnosis and treatment.
Du L, Kijlstra A, Yang P
Prog Retin Eye Res 2016 May;52:84-111. Epub 2016 Feb 11 doi: 10.1016/j.preteyeres.2016.02.002. PMID: 26875727

Therapy

Ocular Adverse Events After COVID-19 Vaccination.
Ng XL, Betzler BK, Testi I, Ho SL, Tien M, Ngo WK, Zierhut M, Chee SP, Gupta V, Pavesio CE, de Smet MD, Agrawal R
Ocul Immunol Inflamm 2021 Aug 18;29(6):1216-1224. Epub 2021 Sep 24 doi: 10.1080/09273948.2021.1976221. PMID: 34559576Free PMC Article
Vogt-Koyanagi-Harada disease.
Street D, Sivaguru A, Sreekantam S, Mollan SP
Pract Neurol 2019 Aug;19(4):364-367. Epub 2019 Mar 19 doi: 10.1136/practneurol-2018-002152. PMID: 30890584
Vogt-Koyanagi-Harada disease.
O'Keefe GA, Rao NA
Surv Ophthalmol 2017 Jan-Feb;62(1):1-25. Epub 2016 May 27 doi: 10.1016/j.survophthal.2016.05.002. PMID: 27241814
Vogt-Koyanagi-Harada disease.
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153
Vogt-Koyanagi-Harada disease.
Read RW, Rao NA, Cunningham ET
Curr Opin Ophthalmol 2000 Dec;11(6):437-42. doi: 10.1097/00055735-200012000-00009. PMID: 11141638

Prognosis

Vogt-Koyanagi-Harada disease in Spain.
Arriola-Villalobos P, Moll-Udina A, Carrasco-López-Brea M, Sacristan C, Capella MJ, Peiteado D, Garrote-Llordén A, Albert Fort M, Jódar Márquez M, Jacobo Gonzalez Guijarro J, Demetrio-Pablo R, Luis Sánchez Sevilla J, Carreño E, González-López J, Miguel-Escuder L, Cuadros C, Díaz-Valle D, Adan A; Contributors: VKH Spanish Study Group, Benítez Del Castillo JM, Fonollosa A, Cordero M, Martínez Costa L, Blanco-Alonso R
Eur J Ophthalmol 2022 May;32(3):1547-1554. Epub 2021 Jul 16 doi: 10.1177/11206721211033477. PMID: 34269103
Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease.
Yang P, Zhong Y, Du L, Chi W, Chen L, Zhang R, Zhang M, Wang H, Lu H, Yang L, Zhuang W, Yang Y, Xing L, Feng L, Jiang Z, Zhang X, Wang Y, Zhong H, Jiang L, Zhao C, Li F, Cao S, Liu X, Chen X, Shi Y, Zhao W, Kijlstra A
JAMA Ophthalmol 2018 Sep 1;136(9):1025-1031. doi: 10.1001/jamaophthalmol.2018.2664. PMID: 29978190Free PMC Article
Vogt-Koyanagi-Harada disease.
Burkholder BM
Curr Opin Ophthalmol 2015 Nov;26(6):506-11. doi: 10.1097/ICU.0000000000000206. PMID: 26448042
Vogt-Koyanagi-Harada disease.
Damico FM, Kiss S, Young LH
Semin Ophthalmol 2005 Jul-Sep;20(3):183-90. doi: 10.1080/08820530500232126. PMID: 16282153
Vogt-Koyanagi-Harada disease.
Read RW, Rao NA, Cunningham ET
Curr Opin Ophthalmol 2000 Dec;11(6):437-42. doi: 10.1097/00055735-200012000-00009. PMID: 11141638

Clinical prediction guides

Clinical features, diagnosis, and management of COVID-19 vaccine-associated Vogt-Koyanagi-Harada disease.
Xu K, Gao B, Li J, Xiang Y, Cao L, Zhao M
Hum Vaccin Immunother 2023 Aug 1;19(2):2220630. Epub 2023 Jun 6 doi: 10.1080/21645515.2023.2220630. PMID: 37282614Free PMC Article
Vogt-Koyanagi-Harada disease in pediatric, adult and elderly: clinical characteristics and visual outcomes.
Yang P, Liao W, Pu Y, Zhong Z, Wang H, Yu Q, Cai J, Wang W, Su G
Graefes Arch Clin Exp Ophthalmol 2023 Sep;261(9):2641-2650. Epub 2023 Apr 14 doi: 10.1007/s00417-023-06058-5. PMID: 37058172
Bacillary Layer Detachment in Acute Vogt-Koyanagi-Harada Disease.
Ataş F, Kaya M, Saatci AO
Turk J Ophthalmol 2022 Dec 28;52(6):400-404. doi: 10.4274/tjo.galenos.2021.86821. PMID: 36578215Free PMC Article
Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease.
Yang P, Zhong Y, Du L, Chi W, Chen L, Zhang R, Zhang M, Wang H, Lu H, Yang L, Zhuang W, Yang Y, Xing L, Feng L, Jiang Z, Zhang X, Wang Y, Zhong H, Jiang L, Zhao C, Li F, Cao S, Liu X, Chen X, Shi Y, Zhao W, Kijlstra A
JAMA Ophthalmol 2018 Sep 1;136(9):1025-1031. doi: 10.1001/jamaophthalmol.2018.2664. PMID: 29978190Free PMC Article
Multispectral image analysis in Vogt-Koyanagi-Harada disease.
Huang G, Peng J, Ye Z, Kijlstra A, Zhang D, Yang P
Acta Ophthalmol 2018 Jun;96(4):411-419. Epub 2017 Dec 8 doi: 10.1111/aos.13606. PMID: 29220112

Recent systematic reviews

Non-biologic, steroid-sparing therapies for non-infectious intermediate, posterior, and panuveitis in adults.
Edwards Mayhew RG, Li T, McCann P, Leslie L, Strong Caldwell A, Palestine AG
Cochrane Database Syst Rev 2022 Oct 31;10(10):CD014831. doi: 10.1002/14651858.CD014831.pub2. PMID: 36315029Free PMC Article
Unusual neurologic manifestations of Vogt-Koyanagi-Harada disease: a systematic literature review.
Toudou-Daouda M, Ibrahim-Mamadou AK
BMC Neurol 2022 Feb 4;22(1):44. doi: 10.1186/s12883-022-02569-6. PMID: 35120474Free PMC Article
Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis.
Liu B, Deng T, Zhu L, Zhong J
Medicine (Baltimore) 2018 Feb;97(7):e9914. doi: 10.1097/MD.0000000000009914. PMID: 29443768Free PMC Article
Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: a systematic review and meta-analysis.
Shi T, Lv W, Zhang L, Chen J, Chen H
Sci Rep 2014 Nov 10;4:6887. doi: 10.1038/srep06887. PMID: 25382027Free PMC Article
Outcomes of cataract surgery in patients with uveitis: a systematic review and meta-analysis.
Mehta S, Linton MM, Kempen JH
Am J Ophthalmol 2014 Oct;158(4):676-692.e7. Epub 2014 Jun 28 doi: 10.1016/j.ajo.2014.06.018. PMID: 24983790

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