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Vitamin A deficiency

MedGen UID:
22668
Concept ID:
C0042842
Disease or Syndrome
Synonyms: Deficiencies, Vitamin A; Deficiency, Vitamin A; Vitamin A Deficiencies; Vitamin A Deficiency
SNOMED CT: Vitamin A deficiency (72000004); Hypovitaminosis A (72000004); Deficiency of vitamin A (72000004)
 
Monarch Initiative: MONDO:0007016

Definition

Deficiency of vitamin A due to malnutrition, malabsorption, or dietary lack. It is manifested with reduced night vision, night blindness, and xerophthalmia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVitamin A deficiency

Professional guidelines

PubMed

Miranda WD, Guimarães EAA, Campos DS, Luz ZMPD
Cien Saude Colet 2023 Aug;28(8):2323-2333. Epub 2023 Apr 28 doi: 10.1590/1413-81232023288.05922023. PMID: 37531540
Mathur ML
Natl Med J India 2007 Jan-Feb;20(1):16-21. PMID: 17557517
D'Souza RM, D'Souza R
J Trop Pediatr 2002 Dec;48(6):323-7. doi: 10.1093/tropej/48.6.323. PMID: 12521271

Recent clinical studies

Etiology

Podell BK, Aibana O, Huang CC, DiLisio JE, Harris MC, Ackart DF, Armann K, Grover A, Severe P, Juste MAJ, Dupnik K, Basaraba RJ, Murray MB
Clin Infect Dis 2022 Dec 19;75(12):2178-2185. doi: 10.1093/cid/ciac326. PMID: 35486953Free PMC Article
Song A, Mousa HM, Soifer M, Perez VL
Curr Opin Pediatr 2022 Apr 1;34(2):241-247. doi: 10.1097/MOP.0000000000001110. PMID: 35125379Free PMC Article
Zinder R, Cooley R, Vlad LG, Molnar JA
Nutr Clin Pract 2019 Dec;34(6):839-849. doi: 10.1002/ncp.10420. PMID: 31697447
Timoneda J, Rodríguez-Fernández L, Zaragozá R, Marín MP, Cabezuelo MT, Torres L, Viña JR, Barber T
Nutrients 2018 Aug 21;10(9) doi: 10.3390/nu10091132. PMID: 30134568Free PMC Article
Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, Mathers C, Rivera J; Maternal and Child Undernutrition Study Group
Lancet 2008 Jan 19;371(9608):243-60. doi: 10.1016/S0140-6736(07)61690-0. PMID: 18207566

Diagnosis

Ali MJ
Ophthalmic Plast Reconstr Surg 2023 Nov-Dec 01;39(6):648-649. Epub 2023 Nov 3 doi: 10.1097/IOP.0000000000002438. PMID: 37922047
Podell BK, Aibana O, Huang CC, DiLisio JE, Harris MC, Ackart DF, Armann K, Grover A, Severe P, Juste MAJ, Dupnik K, Basaraba RJ, Murray MB
Clin Infect Dis 2022 Dec 19;75(12):2178-2185. doi: 10.1093/cid/ciac326. PMID: 35486953Free PMC Article
Song A, Mousa HM, Soifer M, Perez VL
Curr Opin Pediatr 2022 Apr 1;34(2):241-247. doi: 10.1097/MOP.0000000000001110. PMID: 35125379Free PMC Article
Ram J, Jinagal J
N Engl J Med 2018 Aug 30;379(9):869. doi: 10.1056/NEJMicm1715354. PMID: 30157394
McLaren DS, Kraemer K
World Rev Nutr Diet 2012;103:65-75. Epub 2012 Aug 27 doi: 10.1159/000185254. PMID: 23008038

Therapy

Podell BK, Aibana O, Huang CC, DiLisio JE, Harris MC, Ackart DF, Armann K, Grover A, Severe P, Juste MAJ, Dupnik K, Basaraba RJ, Murray MB
Clin Infect Dis 2022 Dec 19;75(12):2178-2185. doi: 10.1093/cid/ciac326. PMID: 35486953Free PMC Article
The Lancet
Lancet 2018 May 12;391(10133):1866. Epub 2018 May 10 doi: 10.1016/S0140-6736(18)31035-3. PMID: 29781430
Wirth JP, Petry N, Tanumihardjo SA, Rogers LM, McLean E, Greig A, Garrett GS, Klemm RD, Rohner F
Nutrients 2017 Feb 24;9(3) doi: 10.3390/nu9030190. PMID: 28245571Free PMC Article
Smith J, Steinemann TL
Int Ophthalmol Clin 2000 Fall;40(4):83-91. doi: 10.1097/00004397-200010000-00007. PMID: 11064859
Bhaskaram P
Natl Med J India 1992 Mar-Apr;5(2):47-9. PMID: 1304261

Prognosis

Everts HB, Akuailou EN
Nutrients 2021 Jan 5;13(1) doi: 10.3390/nu13010153. PMID: 33466372Free PMC Article
Dowling JE
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2020 May;206(3):389-399. Epub 2020 Feb 7 doi: 10.1007/s00359-020-01403-z. PMID: 32034476
McCauley ME, van den Broek N, Dou L, Othman M
Cochrane Database Syst Rev 2015 Oct 27;2015(10):CD008666. doi: 10.1002/14651858.CD008666.pub3. PMID: 26503498Free PMC Article
Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, Mathers C, Rivera J; Maternal and Child Undernutrition Study Group
Lancet 2008 Jan 19;371(9608):243-60. doi: 10.1016/S0140-6736(07)61690-0. PMID: 18207566
Smith J, Steinemann TL
Int Ophthalmol Clin 2000 Fall;40(4):83-91. doi: 10.1097/00004397-200010000-00007. PMID: 11064859

Clinical prediction guides

Imdad A, Mayo-Wilson E, Haykal MR, Regan A, Sidhu J, Smith A, Bhutta ZA
Cochrane Database Syst Rev 2022 Mar 16;3(3):CD008524. doi: 10.1002/14651858.CD008524.pub4. PMID: 35294044Free PMC Article
Dowling JE
Annu Rev Vis Sci 2018 Sep 15;4:1-23. doi: 10.1146/annurev-vision-091517-034222. PMID: 30222531
Thurnham DI
Food Nutr Bull 2015 Sep;36(3):290-8. Epub 2015 Aug 27 doi: 10.1177/0379572115597514. PMID: 26314733
Beijer MR, Kraal G, den Haan JM
Immunology 2014 May;142(1):39-45. doi: 10.1111/imm.12228. PMID: 24843870Free PMC Article
Verma AS, Fitzpatrick DR
Orphanet J Rare Dis 2007 Nov 26;2:47. doi: 10.1186/1750-1172-2-47. PMID: 18039390Free PMC Article

Recent systematic reviews

Imdad A, Mayo-Wilson E, Haykal MR, Regan A, Sidhu J, Smith A, Bhutta ZA
Cochrane Database Syst Rev 2022 Mar 16;3(3):CD008524. doi: 10.1002/14651858.CD008524.pub4. PMID: 35294044Free PMC Article
Venkatesh U, Sharma A, Ananthan VA, Subbiah P, Durga R; CSIR Summer Research training team
J Nutr Sci 2021;10:e110. Epub 2021 Dec 21 doi: 10.1017/jns.2021.102. PMID: 35059191Free PMC Article
Soares MM, Silva MA, Garcia PPC, Silva LSD, Costa GDD, Araújo RMA, Cotta RMM
Cien Saude Colet 2019 Mar;24(3):827-838. doi: 10.1590/1413-81232018243.07112017. PMID: 30892504
Neves PA, Saunders C, Barros DC, Ramalho A
Rev Bras Epidemiol 2015 Oct-Dec;18(4):824-36. doi: 10.1590/1980-5497201500040012. PMID: 26982298
McCauley ME, van den Broek N, Dou L, Othman M
Cochrane Database Syst Rev 2015 Oct 27;2015(10):CD008666. doi: 10.1002/14651858.CD008666.pub3. PMID: 26503498Free PMC Article

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