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Giant Cell Sarcoma

MedGen UID:
226790
•Concept ID:
C1261358
•
Neoplastic Process
Synonyms: Giant cell sarcoma; Pleomorphic cell sarcoma; Undifferentiated pleomorphic cell sarcoma
SNOMED CT: Pleomorphic cell sarcoma (302840001); Giant cell sarcoma (302840001); Undifferentiated pleomorphic cell sarcoma (302840001)

Definition

A sarcoma characterized by the presence of large, anaplastic malignant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant Cell Sarcoma

Professional guidelines

PubMed

Antiblastic hyperthermic regional perfusion in the treatment of malignant neoplasms of the limbs.
Monticelli G, Santori FS, Folliero A, Ghera S, Cavaliere R, Di Fillippo F, Cavallaro A
Ital J Orthop Traumatol 1983 Jun;9(2):167-80. PMID: 6581150

Recent clinical studies

Etiology

Understanding giant cell sarcoma of the head and neck: A population-based study.
Sawhney R, Ahsanuddin S, Sheorey L, Wassef DW, Baredes S, Park RCW
Head Neck 2021 Sep;43(9):2786-2794. Epub 2021 Jun 14 doi: 10.1002/hed.26765. PMID: 34121252
Primary liver sarcomas in the modern era: Resection or transplantation?
Konstantinidis IT, Nota C, Jutric Z, Ituarte P, Chow W, Chu P, Singh G, Warner SG, Melstrom LG, Fong Y
J Surg Oncol 2018 Apr;117(5):886-891. Epub 2018 Jan 22 doi: 10.1002/jso.24979. PMID: 29355969Free PMC Article
Orbital Involvement In Sinonasal Diseases.
Qazi ZU, Latif S, Awan SM
J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):687-693. PMID: 28586604
Parental cancer as a risk factor for bone cancer: a nation-wide study from Sweden.
Li X, Hemminki K
J Clin Epidemiol 2002 Feb;55(2):111-4. doi: 10.1016/s0895-4356(01)00435-8. PMID: 11809347
Favourable results of acrylic cementation for giant cell tumors.
Persson BM, Ekelund L, Lövdahl R, Gunterberg B
Acta Orthop Scand 1984 Apr;55(2):209-14. doi: 10.3109/17453678408992339. PMID: 6369866

Diagnosis

Understanding giant cell sarcoma of the head and neck: A population-based study.
Sawhney R, Ahsanuddin S, Sheorey L, Wassef DW, Baredes S, Park RCW
Head Neck 2021 Sep;43(9):2786-2794. Epub 2021 Jun 14 doi: 10.1002/hed.26765. PMID: 34121252
Orbital Involvement In Sinonasal Diseases.
Qazi ZU, Latif S, Awan SM
J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):687-693. PMID: 28586604
Parental cancer as a risk factor for bone cancer: a nation-wide study from Sweden.
Li X, Hemminki K
J Clin Epidemiol 2002 Feb;55(2):111-4. doi: 10.1016/s0895-4356(01)00435-8. PMID: 11809347
Antiblastic hyperthermic regional perfusion in the treatment of malignant neoplasms of the limbs.
Monticelli G, Santori FS, Folliero A, Ghera S, Cavaliere R, Di Fillippo F, Cavallaro A
Ital J Orthop Traumatol 1983 Jun;9(2):167-80. PMID: 6581150
Treatment of bone and soft tissue malignant tumours of the extremities by radical resection. A preliminary report of 12 cases.
Guo F, Ding BF
Arch Orthop Trauma Surg (1978) 1981;98(3):201-8. doi: 10.1007/BF00632978. PMID: 6942794

Therapy

Favourable results of acrylic cementation for giant cell tumors.
Persson BM, Ekelund L, Lövdahl R, Gunterberg B
Acta Orthop Scand 1984 Apr;55(2):209-14. doi: 10.3109/17453678408992339. PMID: 6369866
Antiblastic hyperthermic regional perfusion in the treatment of malignant neoplasms of the limbs.
Monticelli G, Santori FS, Folliero A, Ghera S, Cavaliere R, Di Fillippo F, Cavallaro A
Ital J Orthop Traumatol 1983 Jun;9(2):167-80. PMID: 6581150
Short- and long-term effects of a massive dose of 6-OH-DA upon marsh mice.
Bryson G, Bischoff F
Res Commun Chem Pathol Pharmacol 1977 Jul;17(3):411-20. PMID: 561426

Prognosis

Understanding giant cell sarcoma of the head and neck: A population-based study.
Sawhney R, Ahsanuddin S, Sheorey L, Wassef DW, Baredes S, Park RCW
Head Neck 2021 Sep;43(9):2786-2794. Epub 2021 Jun 14 doi: 10.1002/hed.26765. PMID: 34121252
Primary liver sarcomas in the modern era: Resection or transplantation?
Konstantinidis IT, Nota C, Jutric Z, Ituarte P, Chow W, Chu P, Singh G, Warner SG, Melstrom LG, Fong Y
J Surg Oncol 2018 Apr;117(5):886-891. Epub 2018 Jan 22 doi: 10.1002/jso.24979. PMID: 29355969Free PMC Article
Familial risk for histology-specific bone cancers: an updated study in Sweden.
Ji J, Hemminki K
Eur J Cancer 2006 Sep;42(14):2343-9. Epub 2006 Jul 21 doi: 10.1016/j.ejca.2005.11.043. PMID: 16859907
A case of pulmonary metastases of synovial sarcoma surviving for a long period after active surgery.
Inoue K, Yamamoto R, Nishiyama N, Hori T, Miyamoto Y, Takehara S, Kaji M, Kin T, Katoh T, Iwata T, Nishida T, Kinoshita H
Osaka City Med J 1998 Jun;44(1):125-31. PMID: 9834625
Treatment of bone and soft tissue malignant tumours of the extremities by radical resection. A preliminary report of 12 cases.
Guo F, Ding BF
Arch Orthop Trauma Surg (1978) 1981;98(3):201-8. doi: 10.1007/BF00632978. PMID: 6942794

Clinical prediction guides

Understanding giant cell sarcoma of the head and neck: A population-based study.
Sawhney R, Ahsanuddin S, Sheorey L, Wassef DW, Baredes S, Park RCW
Head Neck 2021 Sep;43(9):2786-2794. Epub 2021 Jun 14 doi: 10.1002/hed.26765. PMID: 34121252
Feline giant-cell pleomorphic sarcoma: cytologic, histologic and immunohistochemical characterization.
de Cecco BS, Argenta FF, Bianchi RM, De Lorenzo C, Wronski JG, Bandinelli MB, da Costa FV, Driemeier D, Pavarini SP, Sonne L
J Feline Med Surg 2021 Aug;23(8):738-744. Epub 2020 Nov 18 doi: 10.1177/1098612X20972667. PMID: 33206030
Familial risk for histology-specific bone cancers: an updated study in Sweden.
Ji J, Hemminki K
Eur J Cancer 2006 Sep;42(14):2343-9. Epub 2006 Jul 21 doi: 10.1016/j.ejca.2005.11.043. PMID: 16859907
A case of pulmonary metastases of synovial sarcoma surviving for a long period after active surgery.
Inoue K, Yamamoto R, Nishiyama N, Hori T, Miyamoto Y, Takehara S, Kaji M, Kin T, Katoh T, Iwata T, Nishida T, Kinoshita H
Osaka City Med J 1998 Jun;44(1):125-31. PMID: 9834625

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