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Flat Adenoma

MedGen UID:: 226831
•Concept ID:: C1266024
•: Neoplastic Process

Synonyms:	Flat adenoma; Gastrointestinal Tract Flat Adenoma; GI Tract Flat Adenoma
SNOMED CT:	Flat adenoma (128652009)

Definition

An adenoma of the gastrointestinal tract mucosa which grossly and morphologically does not appear as an elevated or polypoid lesion. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVFlat Adenoma

Pathological process
- Disease
  - Neoplasm
    - Epithelial neoplasm
      - Adenoma
        Digestive system adenoma
        Flat Adenoma

Professional guidelines

PubMed

Enhanced flat adenoma detection rate with high definition colonoscopy plus i-scan for average-risk colorectal cancer screening.

Rodríguez-D Jesus A, Saperas E
Rev Esp Enferm Dig 2016 May;108(5):257-62. doi: 10.17235/reed.2016.4008/2015. PMID: 27023867

Gastric epithelial dysplasia and adenoma: historical review and histological criteria for grading.

Goldstein NS, Lewin KJ
Hum Pathol 1997 Feb;28(2):127-33. doi: 10.1016/s0046-8177(97)90095-2. PMID: 9023391

Endoscopic diagnosis and resection treatment for flat adenoma with severe dysplasia.

Karita M, Cantero D, Okita K
Am J Gastroenterol 1993 Sep;88(9):1421-3. PMID: 8362841

See all (3)

Recent clinical studies

Etiology

Shape-specific characterization of colorectal adenoma growth and transition to cancer with stochastic cell-based models.

Simonetto C, Mansmann U, Kaiser JC
PLoS Comput Biol 2023 Jan;19(1):e1010831. Epub 2023 Jan 23 doi: 10.1371/journal.pcbi.1010831. PMID: 36689547 Free PMC Article

Risk factors associated with the detection and missed diagnosis of colorectal flat adenoma: a Chinese multicenter observational study.

Xiang L, Zhan Q, Wang XF, Zhao XH, Zhou YB, An SL, Han ZL, Wang YD, Xu YZ, Li AM, Zhang YL, Liu SD
Scand J Gastroenterol 2018 Dec;53(12):1519-1525. Epub 2019 Jan 8 doi: 10.1080/00365521.2018.1533581. PMID: 30621477

Impact of cap-assisted colonoscopy on detection of proximal colon adenomas: systematic review and meta-analysis.

Desai M, Sanchez-Yague A, Choudhary A, Pervez A, Gupta N, Vennalaganti P, Vennelaganti S, Fugazza A, Repici A, Hassan C, Sharma P
Gastrointest Endosc 2017 Aug;86(2):274-281.e3. Epub 2017 Mar 29 doi: 10.1016/j.gie.2017.03.1524. PMID: 28365356

Meta-analysis for evaluating the accuracy of endoscopy with narrow band imaging in detecting colorectal adenomas.

Jin XF, Chai TH, Shi JW, Yang XC, Sun QY
J Gastroenterol Hepatol 2012 May;27(5):882-7. doi: 10.1111/j.1440-1746.2011.06987.x. PMID: 22098192

Hereditary intestinal polyposis syndromes.

Dean PA
Rev Gastroenterol Mex 1996 Apr-Jun;61(2):100-11. PMID: 8927912

See all (38)

Diagnosis

Shape-specific characterization of colorectal adenoma growth and transition to cancer with stochastic cell-based models.

Simonetto C, Mansmann U, Kaiser JC
PLoS Comput Biol 2023 Jan;19(1):e1010831. Epub 2023 Jan 23 doi: 10.1371/journal.pcbi.1010831. PMID: 36689547 Free PMC Article

Risk factors associated with the detection and missed diagnosis of colorectal flat adenoma: a Chinese multicenter observational study.

Meta-analysis for evaluating the accuracy of endoscopy with narrow band imaging in detecting colorectal adenomas.

Jin XF, Chai TH, Shi JW, Yang XC, Sun QY
J Gastroenterol Hepatol 2012 May;27(5):882-7. doi: 10.1111/j.1440-1746.2011.06987.x. PMID: 22098192

Magnification chromo-colonoscopy.

Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach.

Kushima R, Vieth M, Borchard F, Stolte M, Mukaisho K, Hattori T
Gastric Cancer 2006;9(3):177-84. doi: 10.1007/s10120-006-0381-8. PMID: 16952035

See all (37)

Therapy

Management of Pouch Neoplasia.

Sugita A, Koganei K, Tatsumi K
Dis Colon Rectum 2022 Dec 1;65(S1):S129-S135. Epub 2022 Jul 21 doi: 10.1097/DCR.0000000000002552. PMID: 35895865

Impact of cap-assisted colonoscopy on detection of proximal colon adenomas: systematic review and meta-analysis.

Prevalence of advanced histological features and synchronous neoplasia in patients with flat adenomas.

Naravadi V, Gupta N, Early D, Jonnalagadda S, Wani SB, Gaddam S, Sharma P, Edmundowicz SA, Bansal A, Rastogi A
Gastrointest Endosc 2016 Apr;83(4):795-9. Epub 2015 Sep 1 doi: 10.1016/j.gie.2015.08.040. PMID: 26341856

Association of smoking and flat adenomas: results from an asymptomatic population screened with a high-definition colonoscope.

Anderson JC, Stein B, Kahi CJ, Rajapakse R, Walker G, Alpern Z
Gastrointest Endosc 2010 Jun;71(7):1234-40. Epub 2010 Apr 24 doi: 10.1016/j.gie.2009.12.012. PMID: 20417931 Free PMC Article

High-definition chromocolonoscopy vs. high-definition white light colonoscopy for average-risk colorectal cancer screening.

Kahi CJ, Anderson JC, Waxman I, Kessler WR, Imperiale TF, Li X, Rex DK
Am J Gastroenterol 2010 Jun;105(6):1301-7. Epub 2010 Feb 23 doi: 10.1038/ajg.2010.51. PMID: 20179689

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Prognosis

Shape-specific characterization of colorectal adenoma growth and transition to cancer with stochastic cell-based models.

Simonetto C, Mansmann U, Kaiser JC
PLoS Comput Biol 2023 Jan;19(1):e1010831. Epub 2023 Jan 23 doi: 10.1371/journal.pcbi.1010831. PMID: 36689547 Free PMC Article

Endoscopic full-thickness resection in the colorectum with a novel over-the-scope device: first experience.

Schmidt A, Bauerfeind P, Gubler C, Damm M, Bauder M, Caca K
Endoscopy 2015 Aug;47(8):719-25. Epub 2015 Mar 12 doi: 10.1055/s-0034-1391781. PMID: 25763833

Risk factors associated with colorectal flat adenoma detection.

Nicolás-Pérez D, Parra-Blanco A, Gimeno-García AZ, Ortega-Sánchez JA, Carrillo-Palau M, Jiménez-Sosa A, Quintero-Carrion E
Eur J Gastroenterol Hepatol 2013 Mar;25(3):302-8. doi: 10.1097/MEG.0b013e32835b2d45. PMID: 23169312

Magnification chromo-colonoscopy.

Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

How do colorectal cancers develop?

Kuramoto S, Oohara T
Cancer 1995 Mar 15;75(6 Suppl):1534-8. doi: 10.1002/1097-0142(19950315)75:6+<1534::aid-cncr2820751525>3.0.co;2-2. PMID: 7889487

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Clinical prediction guides

Risk factors associated with the detection and missed diagnosis of colorectal flat adenoma: a Chinese multicenter observational study.

Endoscopic full-thickness resection in the colorectum with a novel over-the-scope device: first experience.

Schmidt A, Bauerfeind P, Gubler C, Damm M, Bauder M, Caca K
Endoscopy 2015 Aug;47(8):719-25. Epub 2015 Mar 12 doi: 10.1055/s-0034-1391781. PMID: 25763833

Risk factors associated with colorectal flat adenoma detection.

Chromosome 5q loss in colorectal flat adenomas.

Voorham QJ, Carvalho B, Spiertz AJ, van Grieken NC, Mongera S, Rondagh EJ, van de Wiel MA, Jordanova ES, Ylstra B, Kliment M, Grabsch H, Rembacken BJ, Arai T, de Bruïne AP, Sanduleanu S, Quirke P, Mulder CJ, van Engeland M, Meijer GA
Clin Cancer Res 2012 Sep 1;18(17):4560-9. Epub 2012 Jul 3 doi: 10.1158/1078-0432.CCR-11-2385. PMID: 22761468

Magnification chromo-colonoscopy.

Togashi K, Konishi F
ANZ J Surg 2006 Dec;76(12):1101-5. doi: 10.1111/j.1445-2197.2006.03933.x. PMID: 17199698

See all (21)