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Gastric Parietal Cell Adenocarcinoma

MedGen UID:
226833
•Concept ID:
C1266026
•
Neoplastic Process
Synonyms: Parietal Cell Adenocarcinoma; Parietal cell adenocarcinoma; Parietal cell carcinoma
SNOMED CT: Parietal cell adenocarcinoma (128654005); Parietal cell carcinoma (128654005)

Definition

An adenocarcinoma of the stomach arising from the parietal cells. It is characterized by the presence of malignant cells with eosinophilic, finely granular cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Parietal Cell Adenocarcinoma

Professional guidelines

PubMed

EPO-R expression patterns in resected gastric adenocarcinoma followed by adjuvant chemoradiation treatment.
Sereno M, De Castro J, Belda-Iniesta C, Garcia-Cabezas MA, Cejas P, Casado E, Barriuso J, Feliu J, Larrauri J
Pathol Oncol Res 2009 Mar;15(1):1-10. Epub 2008 Nov 11 doi: 10.1007/s12253-008-9118-9. PMID: 19002606
Gastric endocrine tumors type I: treatment with long-acting somatostatin analogs.
Campana D, Nori F, Pezzilli R, Piscitelli L, Santini D, Brocchi E, Corinaldesi R, Tomassetti P
Endocr Relat Cancer 2008 Mar;15(1):337-42. doi: 10.1677/ERC-07-0251. PMID: 18310299

Recent clinical studies

Etiology

Exploring the spectrum of incidental gastric polyps in autoimmune gastritis.
Massironi S, Elvevi A, Gallo C, Laffusa A, Tortorella A, Invernizzi P
Dig Liver Dis 2023 Sep;55(9):1201-1207. Epub 2023 Feb 28 doi: 10.1016/j.dld.2023.02.008. PMID: 36858908
Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies.
Boutzios G, Koukoulioti E, Goules AV, Kalliakmanis I, Giovannopoulos I, Vlachoyiannopoulos P, Moutsopoulos HM, Tzioufas AG
Front Endocrinol (Lausanne) 2022;13:860880. Epub 2022 Apr 22 doi: 10.3389/fendo.2022.860880. PMID: 35528009Free PMC Article
Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus.
Evans JA, Carlotti E, Lin ML, Hackett RJ, Haughey MJ, Passman AM, Dunn L, Elia G, Porter RJ, McLean MH, Hughes F, ChinAleong J, Woodland P, Preston SL, Griffin SM, Lovat L, Rodriguez-Justo M, Huang W, Wright NA, Jansen M, McDonald SAC
Gastroenterology 2022 Apr;162(4):1197-1209.e13. Epub 2021 Dec 29 doi: 10.1053/j.gastro.2021.12.271. PMID: 34973296Free PMC Article
Autoimmune gastritis: Pathologist's viewpoint.
Coati I, Fassan M, Farinati F, Graham DY, Genta RM, Rugge M
World J Gastroenterol 2015 Nov 14;21(42):12179-89. doi: 10.3748/wjg.v21.i42.12179. PMID: 26576102Free PMC Article
Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint.
Waldum HL, Qvigstad G, Fossmark R, Kleveland PM, Sandvik AK
Scand J Gastroenterol 2010 Apr;45(4):389-94. doi: 10.3109/00365520903477348. PMID: 20001749

Diagnosis

MENIN-mediated regulation of gastrin gene expression and its role in gastrinoma development.
Elvis-Offiah UB, Duan S, Merchant JL
FASEB J 2023 May;37(5):e22913. doi: 10.1096/fj.202201809RR. PMID: 37078545
NNMT enriches for AQP5(+) cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma.
Wang Z, Wang Q, Chen C, Zhao X, Wang H, Xu L, Fu Y, Huang G, Li M, Xu J, Zhang Q, Wang B, Xu G, Wang L, Zou X, Wang S
Gut 2023 Dec 7;73(1):63-77. doi: 10.1136/gutjnl-2022-328408. PMID: 36977555
Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies.
Boutzios G, Koukoulioti E, Goules AV, Kalliakmanis I, Giovannopoulos I, Vlachoyiannopoulos P, Moutsopoulos HM, Tzioufas AG
Front Endocrinol (Lausanne) 2022;13:860880. Epub 2022 Apr 22 doi: 10.3389/fendo.2022.860880. PMID: 35528009Free PMC Article
Autoimmune gastritis.
Lenti MV, Rugge M, Lahner E, Miceli E, Toh BH, Genta RM, De Block C, Hershko C, Di Sabatino A
Nat Rev Dis Primers 2020 Jul 9;6(1):56. doi: 10.1038/s41572-020-0187-8. PMID: 32647173
Autoimmune gastritis: Pathologist's viewpoint.
Coati I, Fassan M, Farinati F, Graham DY, Genta RM, Rugge M
World J Gastroenterol 2015 Nov 14;21(42):12179-89. doi: 10.3748/wjg.v21.i42.12179. PMID: 26576102Free PMC Article

Therapy

Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer.
Duckworth CA, Burkitt MD, Williams JM, Parsons BN, Tang JMF, Pritchard DM
Curr Protoc Pharmacol 2015 Jun 1;69:14.34.1-14.34.35. doi: 10.1002/0471141755.ph1434s69. PMID: 26344212
Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint.
Waldum HL, Qvigstad G, Fossmark R, Kleveland PM, Sandvik AK
Scand J Gastroenterol 2010 Apr;45(4):389-94. doi: 10.3109/00365520903477348. PMID: 20001749
Proton pump inhibitors in GORD An overview of their pharmacology, efficacy and safety.
Savarino V, Di Mario F, Scarpignato C
Pharmacol Res 2009 Mar;59(3):135-53. Epub 2008 Oct 8 doi: 10.1016/j.phrs.2008.09.016. PMID: 18977444
The biopsy diagnosis of gastroesophageal reflux disease, "carditis," and Barrett's esophagus, and sequelae of therapy.
Riddell RH
Am J Surg Pathol 1996;20 Suppl 1:S31-50. doi: 10.1097/00000478-199600001-00005. PMID: 8694147
Enterochromaffin-like (ECL) cells and their growths: relationships to gastrin, reduced acid secretion and gastritis.
Solcia E, Rindi G, Silini E, Villani L
Baillieres Clin Gastroenterol 1993 Mar;7(1):149-65. doi: 10.1016/0950-3528(93)90035-q. PMID: 7682874

Prognosis

NNMT enriches for AQP5(+) cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma.
Wang Z, Wang Q, Chen C, Zhao X, Wang H, Xu L, Fu Y, Huang G, Li M, Xu J, Zhang Q, Wang B, Xu G, Wang L, Zou X, Wang S
Gut 2023 Dec 7;73(1):63-77. doi: 10.1136/gutjnl-2022-328408. PMID: 36977555
Exploring the spectrum of incidental gastric polyps in autoimmune gastritis.
Massironi S, Elvevi A, Gallo C, Laffusa A, Tortorella A, Invernizzi P
Dig Liver Dis 2023 Sep;55(9):1201-1207. Epub 2023 Feb 28 doi: 10.1016/j.dld.2023.02.008. PMID: 36858908
Factors associated with preoperative and postoperative seizures in patients undergoing resection of brain metastases.
Garcia JH, Morshed RA, Chung J, Millares Chavez MA, Sudhakar V, Saggi S, Avalos LN, Gallagher A, Young JS, Daras M, McDermott MW, Garcia PA, Chang EF, Aghi MK
J Neurosurg 2023 Jan 1;138(1):19-26. Epub 2022 Apr 29 doi: 10.3171/2022.3.JNS212285. PMID: 35535842
Gastric Adenocarcinoma of the Fundic Gland Type: Update and Literature Review.
Benedict MA, Lauwers GY, Jain D
Am J Clin Pathol 2018 Apr 25;149(6):461-473. doi: 10.1093/ajcp/aqy019. PMID: 29648578
Autoimmune gastritis: Pathologist's viewpoint.
Coati I, Fassan M, Farinati F, Graham DY, Genta RM, Rugge M
World J Gastroenterol 2015 Nov 14;21(42):12179-89. doi: 10.3748/wjg.v21.i42.12179. PMID: 26576102Free PMC Article

Clinical prediction guides

Exploring the spectrum of incidental gastric polyps in autoimmune gastritis.
Massironi S, Elvevi A, Gallo C, Laffusa A, Tortorella A, Invernizzi P
Dig Liver Dis 2023 Sep;55(9):1201-1207. Epub 2023 Feb 28 doi: 10.1016/j.dld.2023.02.008. PMID: 36858908
Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies.
Boutzios G, Koukoulioti E, Goules AV, Kalliakmanis I, Giovannopoulos I, Vlachoyiannopoulos P, Moutsopoulos HM, Tzioufas AG
Front Endocrinol (Lausanne) 2022;13:860880. Epub 2022 Apr 22 doi: 10.3389/fendo.2022.860880. PMID: 35528009Free PMC Article
Helicobacter pylori-Induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease.
Smolka AJ, Schubert ML
Curr Top Microbiol Immunol 2017;400:227-252. doi: 10.1007/978-3-319-50520-6_10. PMID: 28124156
Deletion of Men1 and somatostatin induces hypergastrinemia and gastric carcinoids.
Sundaresan S, Kang AJ, Hayes MM, Choi EK, Merchant JL
Gut 2017 Jun;66(6):1012-1021. Epub 2016 Feb 9 doi: 10.1136/gutjnl-2015-310928. PMID: 26860771Free PMC Article
Autoimmune gastritis: Pathologist's viewpoint.
Coati I, Fassan M, Farinati F, Graham DY, Genta RM, Rugge M
World J Gastroenterol 2015 Nov 14;21(42):12179-89. doi: 10.3748/wjg.v21.i42.12179. PMID: 26576102Free PMC Article

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