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Gastric Parietal Cell Adenocarcinoma

MedGen UID:
226833
•Concept ID:
C1266026
•
Neoplastic Process
Synonyms: Parietal Cell Adenocarcinoma; Parietal cell adenocarcinoma; Parietal cell carcinoma
SNOMED CT: Parietal cell adenocarcinoma (128654005); Parietal cell carcinoma (128654005)

Definition

An adenocarcinoma of the stomach arising from the parietal cells. It is characterized by the presence of malignant cells with eosinophilic, finely granular cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Parietal Cell Adenocarcinoma

Professional guidelines

PubMed

EPO-R expression patterns in resected gastric adenocarcinoma followed by adjuvant chemoradiation treatment.
Sereno M, De Castro J, Belda-Iniesta C, Garcia-Cabezas MA, Cejas P, Casado E, Barriuso J, Feliu J, Larrauri J
Pathol Oncol Res 2009 Mar;15(1):1-10. Epub 2008 Nov 11 doi: 10.1007/s12253-008-9118-9. PMID: 19002606
Gastric endocrine tumors type I: treatment with long-acting somatostatin analogs.
Campana D, Nori F, Pezzilli R, Piscitelli L, Santini D, Brocchi E, Corinaldesi R, Tomassetti P
Endocr Relat Cancer 2008 Mar;15(1):337-42. doi: 10.1677/ERC-07-0251. PMID: 18310299

Recent clinical studies

Etiology

Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies.
Boutzios G, Koukoulioti E, Goules AV, Kalliakmanis I, Giovannopoulos I, Vlachoyiannopoulos P, Moutsopoulos HM, Tzioufas AG
Front Endocrinol (Lausanne) 2022;13:860880. Epub 2022 Apr 22 doi: 10.3389/fendo.2022.860880. PMID: 35528009Free PMC Article
Fundic gland polyps related to diverse aetiologies show subtle morphological differences: a multicentre retrospective study.
Kővári B, El Naili R, Pereira DV, Kumarasinghe P, De Boer WB, Jiang K, Pimiento JM, Fukuda M, Misdraji J, Kushima R, Lauwers GY
Histopathology 2022 Apr;80(5):827-835. Epub 2022 Mar 7 doi: 10.1111/his.14623. PMID: 35092716
Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus.
Evans JA, Carlotti E, Lin ML, Hackett RJ, Haughey MJ, Passman AM, Dunn L, Elia G, Porter RJ, McLean MH, Hughes F, ChinAleong J, Woodland P, Preston SL, Griffin SM, Lovat L, Rodriguez-Justo M, Huang W, Wright NA, Jansen M, McDonald SAC
Gastroenterology 2022 Apr;162(4):1197-1209.e13. Epub 2021 Dec 29 doi: 10.1053/j.gastro.2021.12.271. PMID: 34973296Free PMC Article
Autoimmune gastritis: Pathologist's viewpoint.
Coati I, Fassan M, Farinati F, Graham DY, Genta RM, Rugge M
World J Gastroenterol 2015 Nov 14;21(42):12179-89. doi: 10.3748/wjg.v21.i42.12179. PMID: 26576102Free PMC Article
Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint.
Waldum HL, Qvigstad G, Fossmark R, Kleveland PM, Sandvik AK
Scand J Gastroenterol 2010 Apr;45(4):389-94. doi: 10.3109/00365520903477348. PMID: 20001749

Diagnosis

Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies.
Boutzios G, Koukoulioti E, Goules AV, Kalliakmanis I, Giovannopoulos I, Vlachoyiannopoulos P, Moutsopoulos HM, Tzioufas AG
Front Endocrinol (Lausanne) 2022;13:860880. Epub 2022 Apr 22 doi: 10.3389/fendo.2022.860880. PMID: 35528009Free PMC Article
Autoimmune gastritis.
Lenti MV, Rugge M, Lahner E, Miceli E, Toh BH, Genta RM, De Block C, Hershko C, Di Sabatino A
Nat Rev Dis Primers 2020 Jul 9;6(1):56. doi: 10.1038/s41572-020-0187-8. PMID: 32647173
Autoimmune Gastritis in Pediatrics: A Review of 3 Cases.
Mitsinikos T, Shillingford N, Cynamon H, Bhardwaj V
J Pediatr Gastroenterol Nutr 2020 Feb;70(2):252-257. doi: 10.1097/MPG.0000000000002547. PMID: 31978028
Autoimmune gastritis: Pathologist's viewpoint.
Coati I, Fassan M, Farinati F, Graham DY, Genta RM, Rugge M
World J Gastroenterol 2015 Nov 14;21(42):12179-89. doi: 10.3748/wjg.v21.i42.12179. PMID: 26576102Free PMC Article
Autoimmune gastritis in type 1 diabetes: a clinically oriented review.
De Block CE, De Leeuw IH, Van Gaal LF
J Clin Endocrinol Metab 2008 Feb;93(2):363-71. Epub 2007 Nov 20 doi: 10.1210/jc.2007-2134. PMID: 18029461

Therapy

Gastric adenocarcinoma of fundic gland type (chief cell predominant type): proposal for a new entity of gastric adenocarcinoma.
Ueyama H, Yao T, Nakashima Y, Hirakawa K, Oshiro Y, Hirahashi M, Iwashita A, Watanabe S
Am J Surg Pathol 2010 May;34(5):609-19. doi: 10.1097/PAS.0b013e3181d94d53. PMID: 20410811
Rebound acid hypersecretion from a physiological, pathophysiological and clinical viewpoint.
Waldum HL, Qvigstad G, Fossmark R, Kleveland PM, Sandvik AK
Scand J Gastroenterol 2010 Apr;45(4):389-94. doi: 10.3109/00365520903477348. PMID: 20001749
Proton pump inhibitors in GORD An overview of their pharmacology, efficacy and safety.
Savarino V, Di Mario F, Scarpignato C
Pharmacol Res 2009 Mar;59(3):135-53. Epub 2008 Oct 8 doi: 10.1016/j.phrs.2008.09.016. PMID: 18977444
The biopsy diagnosis of gastroesophageal reflux disease, "carditis," and Barrett's esophagus, and sequelae of therapy.
Riddell RH
Am J Surg Pathol 1996;20 Suppl 1:S31-50. doi: 10.1097/00000478-199600001-00005. PMID: 8694147
Enterochromaffin-like (ECL) cells and their growths: relationships to gastrin, reduced acid secretion and gastritis.
Solcia E, Rindi G, Silini E, Villani L
Baillieres Clin Gastroenterol 1993 Mar;7(1):149-65. doi: 10.1016/0950-3528(93)90035-q. PMID: 7682874

Prognosis

Serologic Profile of Antiparietal Cell Antibodies, Pepsinogens, and H. pylori and Risk of Upper Gastrointestinal Cancer: A Nested Case-Control Study in China.
Wang SM, Roth MJ, Murphy GA, Dawsey SM, Fan JH, Taylor PR, Qiao YL, Abnet CC
Cancer Epidemiol Biomarkers Prev 2019 Dec;28(12):2022-2029. Epub 2019 Sep 9 doi: 10.1158/1055-9965.EPI-19-0512. PMID: 31501152Free PMC Article
Gastric Adenocarcinoma of the Fundic Gland Type: Update and Literature Review.
Benedict MA, Lauwers GY, Jain D
Am J Clin Pathol 2018 Apr 25;149(6):461-473. doi: 10.1093/ajcp/aqy019. PMID: 29648578
Autoimmune gastritis: Pathologist's viewpoint.
Coati I, Fassan M, Farinati F, Graham DY, Genta RM, Rugge M
World J Gastroenterol 2015 Nov 14;21(42):12179-89. doi: 10.3748/wjg.v21.i42.12179. PMID: 26576102Free PMC Article
Proton pump inhibitors in GORD An overview of their pharmacology, efficacy and safety.
Savarino V, Di Mario F, Scarpignato C
Pharmacol Res 2009 Mar;59(3):135-53. Epub 2008 Oct 8 doi: 10.1016/j.phrs.2008.09.016. PMID: 18977444
Oncocytic adenocarcinoma of the stomach: parietal cell carcinoma.
Takubo K, Honma N, Sawabe M, Arai T, Izumiyama-Shimomura N, Kammori M, Sasajima K, Esaki Y
Am J Surg Pathol 2002 Apr;26(4):458-65. doi: 10.1097/00000478-200204000-00007. PMID: 11914623

Clinical prediction guides

Hashimoto Thyroiditis, Anti-Parietal Cell Antibodies: Associations With Autoimmune Diseases and Malignancies.
Boutzios G, Koukoulioti E, Goules AV, Kalliakmanis I, Giovannopoulos I, Vlachoyiannopoulos P, Moutsopoulos HM, Tzioufas AG
Front Endocrinol (Lausanne) 2022;13:860880. Epub 2022 Apr 22 doi: 10.3389/fendo.2022.860880. PMID: 35528009Free PMC Article
Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus.
Evans JA, Carlotti E, Lin ML, Hackett RJ, Haughey MJ, Passman AM, Dunn L, Elia G, Porter RJ, McLean MH, Hughes F, ChinAleong J, Woodland P, Preston SL, Griffin SM, Lovat L, Rodriguez-Justo M, Huang W, Wright NA, Jansen M, McDonald SAC
Gastroenterology 2022 Apr;162(4):1197-1209.e13. Epub 2021 Dec 29 doi: 10.1053/j.gastro.2021.12.271. PMID: 34973296Free PMC Article
Helicobacter pylori-Induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease.
Smolka AJ, Schubert ML
Curr Top Microbiol Immunol 2017;400:227-252. doi: 10.1007/978-3-319-50520-6_10. PMID: 28124156
Deletion of Men1 and somatostatin induces hypergastrinemia and gastric carcinoids.
Sundaresan S, Kang AJ, Hayes MM, Choi EK, Merchant JL
Gut 2017 Jun;66(6):1012-1021. Epub 2016 Feb 9 doi: 10.1136/gutjnl-2015-310928. PMID: 26860771Free PMC Article
Autoimmune gastritis: Pathologist's viewpoint.
Coati I, Fassan M, Farinati F, Graham DY, Genta RM, Rugge M
World J Gastroenterol 2015 Nov 14;21(42):12179-89. doi: 10.3748/wjg.v21.i42.12179. PMID: 26576102Free PMC Article

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