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Testicular Mixed Sex Cord-Stromal Tumor

MedGen UID:
226839
•Concept ID:
C1266103
•
Neoplastic Process
Synonyms: Mixed Testicular Sex Cord-Gonadal Stromal Tumor; Mixed Testicular Sex Cord-Stromal Tumor; Sex Cord-Gonadal Stromal Tumor, Mixed Forms; Sex cord-gonadal stromal tumor, mixed forms; Testicular Sex Cord-Gonadal Stromal Tumor, Mixed Forms
SNOMED CT: Sex cord-gonadal stromal tumor, mixed forms (128722008)

Definition

A sex cord-stromal tumor of the testis which may contain any combination of cell types, for example Sertoli cells, Leydig cells, and granulosa cells. Symptoms include testicular swelling and gynecomastia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Sex Cord-Stromal Tumor

Professional guidelines

PubMed

Mixed germ cell-sex cord stromal tumor of the testis with an intratubular component: a problem in differential diagnosis.
Roth LM, Cheng L
Hum Pathol 2016 May;51:51-6. Epub 2016 Jan 7 doi: 10.1016/j.humpath.2015.12.016. PMID: 27067782

Recent clinical studies

Etiology

Malignant testicular tumors in children: A single institution's 12-year experience.
Chiu CC, Jaing TH, Lai JY, Chen SH, Chang TY, Hsueh C, Wen YC, Tsay PK
Medicine (Baltimore) 2022 Jul 22;101(29):e29735. doi: 10.1097/MD.0000000000029735. PMID: 35866814Free PMC Article
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Perspectives in Pediatric Pathology, Chapter 25. Testicular and Paratesticular Tumors in the Pediatric Age Group.
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
Sex-Cord Stromal Tumors in Children and Teenagers: Results of the TGM-95 Study.
Fresneau B, Orbach D, Faure-Conter C, Verité C, Castex MP, Kalfa N, Martelli H, Patte C
Pediatr Blood Cancer 2015 Dec;62(12):2114-9. Epub 2015 Jul 23 doi: 10.1002/pbc.25614. PMID: 26206391
Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
Young RH
Mod Pathol 2005 Feb;18 Suppl 2:S81-98. doi: 10.1038/modpathol.3800311. PMID: 15502809

Diagnosis

Clinicopathologic and molecular spectrum of testicular sex cord-stromal tumors not amenable to specific histopathologic subclassification.
Siegmund SE, Sholl LM, Tsai HK, Yang Y, Vasudevaraja V, Tran I, Snuderl M, Fletcher CDM, Cornejo KM, Idrees MT, Al-Obaidy KI, Collins K, Gordetsky JB, Wobker SE, Hirsch MS, Trpkov K, Yilmaz A, Anderson WJ, Quiroga-Garza G, Magi-Galluzzi C, Canete-Portillo S, Acosta AM
Mod Pathol 2022 Dec;35(12):1944-1954. Epub 2022 Sep 30 doi: 10.1038/s41379-022-01155-y. PMID: 36180576
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms.
Roth LM, Lyu B, Cheng L
Hum Pathol 2017 Jul;65:1-14. Epub 2017 Apr 23 doi: 10.1016/j.humpath.2017.04.009. PMID: 28445692
Sex-Cord Stromal Tumors in Children and Teenagers: Results of the TGM-95 Study.
Fresneau B, Orbach D, Faure-Conter C, Verité C, Castex MP, Kalfa N, Martelli H, Patte C
Pediatr Blood Cancer 2015 Dec;62(12):2114-9. Epub 2015 Jul 23 doi: 10.1002/pbc.25614. PMID: 26206391
Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
Young RH
Mod Pathol 2005 Feb;18 Suppl 2:S81-98. doi: 10.1038/modpathol.3800311. PMID: 15502809

Therapy

Sex-Cord Stromal Tumors in Children and Teenagers: Results of the TGM-95 Study.
Fresneau B, Orbach D, Faure-Conter C, Verité C, Castex MP, Kalfa N, Martelli H, Patte C
Pediatr Blood Cancer 2015 Dec;62(12):2114-9. Epub 2015 Jul 23 doi: 10.1002/pbc.25614. PMID: 26206391
Prepubertal testicular and paratesticular tumors in China: a single-center experience over a 10-year period.
Wang X, Xu S, Tang D, Li M, Wu D, Huang Y
J Pediatr Surg 2012 Aug;47(8):1576-80. doi: 10.1016/j.jpedsurg.2011.11.005. PMID: 22901920
Therapeutic drug monitoring for dose individualization of Cisplatin in testicular cancer patients based upon total platinum measurement in plasma.
Salas S, Mercier C, Ciccolini J, Pourroy B, Fanciullino R, Tranchand B, Monjanel-Mouterde S, Baciuchka-Palmaro M, Dupuis C, Yang C, Balti M, Lacarelle B, Duffaud F, Durand A, Favre R
Ther Drug Monit 2006 Aug;28(4):532-9. doi: 10.1097/00007691-200608000-00008. PMID: 16885721

Prognosis

Oncological and endocrinological outcomes for children and adolescents with testicular and ovarian sex cord-stromal tumors. Results of the TGM13 National Registry.
Fuentes C, Ouldbey Y, Orbach D, Sudour-Bonnange H, Verité C, Rome A, Dumesnil C, Thebaud E, Hameury F, Dijoud F, Chabaud S, Cote MD, Fresneau B, Faure-Conter C
Pediatr Blood Cancer 2024 Apr;71(4):e30864. Epub 2024 Jan 23 doi: 10.1002/pbc.30864. PMID: 38259036
Clinicopathologic and molecular spectrum of testicular sex cord-stromal tumors not amenable to specific histopathologic subclassification.
Siegmund SE, Sholl LM, Tsai HK, Yang Y, Vasudevaraja V, Tran I, Snuderl M, Fletcher CDM, Cornejo KM, Idrees MT, Al-Obaidy KI, Collins K, Gordetsky JB, Wobker SE, Hirsch MS, Trpkov K, Yilmaz A, Anderson WJ, Quiroga-Garza G, Magi-Galluzzi C, Canete-Portillo S, Acosta AM
Mod Pathol 2022 Dec;35(12):1944-1954. Epub 2022 Sep 30 doi: 10.1038/s41379-022-01155-y. PMID: 36180576
Perspectives in Pediatric Pathology, Chapter 25. Testicular and Paratesticular Tumors in the Pediatric Age Group.
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
Sex-Cord Stromal Tumors in Children and Teenagers: Results of the TGM-95 Study.
Fresneau B, Orbach D, Faure-Conter C, Verité C, Castex MP, Kalfa N, Martelli H, Patte C
Pediatr Blood Cancer 2015 Dec;62(12):2114-9. Epub 2015 Jul 23 doi: 10.1002/pbc.25614. PMID: 26206391
Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
Young RH
Mod Pathol 2005 Feb;18 Suppl 2:S81-98. doi: 10.1038/modpathol.3800311. PMID: 15502809

Clinical prediction guides

Testis-sparing surgery in children with testicular tumors: A systematic review and meta-analysis.
Miao X, Li Y, Zhou T, Lv M
Asian J Surg 2021 Dec;44(12):1503-1509. Epub 2021 Apr 21 doi: 10.1016/j.asjsur.2021.03.016. PMID: 33893031
Perspectives in Pediatric Pathology, Chapter 25. Testicular and Paratesticular Tumors in the Pediatric Age Group.
Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M
Pediatr Dev Pathol 2016 Nov/Dec;19(6):471-492. Epub 2016 Sep 14 doi: 10.2350/16-09-1829-PER.1. PMID: 27626837
Mixed germ cell-sex cord stromal tumor of the testis with an intratubular component: a problem in differential diagnosis.
Roth LM, Cheng L
Hum Pathol 2016 May;51:51-6. Epub 2016 Jan 7 doi: 10.1016/j.humpath.2015.12.016. PMID: 27067782
Predictors of spermatogenesis in orchiectomy specimens.
Choy JT, Wiser HJ, Bell SW, Cashy J, Brannigan RE, Köhler TS
Urology 2013 Feb;81(2):288-92. doi: 10.1016/j.urology.2012.10.038. PMID: 23374785
Sex cord-stromal tumors of the testis in children. A clinicopathologic report from the Italian TREP project.
Cecchetto G, Alaggio R, Bisogno G, Virgone C, Dall'Igna P, Terenziani M, Boldrini R, D'Onofrio V, Ferrari A, Bernini G
J Pediatr Surg 2010 Sep;45(9):1868-73. doi: 10.1016/j.jpedsurg.2010.02.120. PMID: 20850634

Recent systematic reviews

Testis-sparing surgery in children with testicular tumors: A systematic review and meta-analysis.
Miao X, Li Y, Zhou T, Lv M
Asian J Surg 2021 Dec;44(12):1503-1509. Epub 2021 Apr 21 doi: 10.1016/j.asjsur.2021.03.016. PMID: 33893031

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