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Malignant glomus tumor

MedGen UID:
226840
•Concept ID:
C1266111
•
Neoplastic Process
Synonyms: Glomangiosarcoma; glomangiosarcoma; Glomoid sarcoma; Glomus tumor, malignant; glomus tumor, malignant; Malignant Glomus Neoplasm; malignant glomus neoplasm; Malignant Glomus Tumor; malignant glomus tumor
SNOMED CT: Glomus tumor, malignant (128908003); Glomangiosarcoma (13875003); Glomoid sarcoma (13875003)
 
Monarch Initiative: MONDO:0003340

Definition

A very rare morphologic variant of glomus tumor with a size greater than 2 cm. The tumor arises in subfascial or visceral tissues. It is characterized by the presence of atypical mitotic figures, or marked nuclear atypia, or the combination of both. It has an aggressive clinical course. [from NCI]

Professional guidelines

PubMed

Glomangioma in the hand: diagnosis, treatment, and challenges.
Szmyd B, Malicki M, Blaszczyk M, Karuga FF, Braun M, Sołek J, Jabbar R, Jankowski J, Wysiadecki G, Radek M
Neurol Neurochir Pol 2023;57(4):387-391. Epub 2023 Jun 21 doi: 10.5603/PJNNS.a2023.0039. PMID: 37341191
Diagnosis and surgical treatment of benign nail unit tumors.
Starace M, Rubin AI, Di Chiacchio NG, Pampaloni F, Alessandrini A, Piraccini BM, Iorizzo M
J Dtsch Dermatol Ges 2023 Feb;21(2):116-129. doi: 10.1111/ddg.14942. PMID: 36808456
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797

Recent clinical studies

Etiology

Malignant glomus tumors of the head and neck in children and adults: Evaluation and management.
Wolter NE, Adil E, Irace AL, Werger A, Perez-Atayde AR, Weldon C, Orbach DB, Rodriguez-Galindo C, Rahbar R
Laryngoscope 2017 Dec;127(12):2873-2882. Epub 2017 Mar 14 doi: 10.1002/lary.26550. PMID: 28294349
Malignant Glomus Tumor Arising in a Long Standing Precursor Lesion.
Damavandy AA, Anatelli F, Skelsey MK
Am J Dermatopathol 2016 May;38(5):384-7. doi: 10.1097/DAD.0000000000000481. PMID: 26760685
Pericyte Antigens in Perivascular Soft Tissue Tumors.
Shen J, Shrestha S, Yen YH, Asatrian G, Mravic M, Soo C, Ting K, Dry SM, Peault B, James AW
Int J Surg Pathol 2015 Dec;23(8):638-48. Epub 2015 Jun 17 doi: 10.1177/1066896915591272. PMID: 26085647Free PMC Article
Malignant glomus tumor of the palm: a case report.
Terada T, Fujimoto J, Shirakashi Y, Kamo M, Sugiura M
J Cutan Pathol 2011 Apr;38(4):381-4. doi: 10.1111/j.1600-0560.2009.01490.x. PMID: 19958439
Atypical and malignant glomus tumors: analysis of 52 cases, with a proposal for the reclassification of glomus tumors.
Folpe AL, Fanburg-Smith JC, Miettinen M, Weiss SW
Am J Surg Pathol 2001 Jan;25(1):1-12. doi: 10.1097/00000478-200101000-00001. PMID: 11145243

Diagnosis

A malignant glomus tumor in the nasal cavity responding to radiation therapy.
Nam J, Park D, Kim W, Kim D
J Cancer Res Ther 2023 Jul-Sep;19(5):1436-1438. doi: 10.4103/jcrt.jcrt_1394_21. PMID: 37787324
Malignant Glomus Tumor of the Ureter.
Demir M, Tuncekin A, Yagmur I, Aydogdu A
J Coll Physicians Surg Pak 2022 Dec;32(12):SS206-SS208. doi: 10.29271/jcpsp.2022.Supp0.SS206. PMID: 36597340
Malignant glomus tumor of the intestinal ileum with multiorgan metastases: A case report and review of literature.
Chen JH, Lin L, Liu KL, Su H, Wang LL, Ding PP, Zhou Q, Liu H, Wu J
World J Gastroenterol 2020 Feb 21;26(7):770-776. doi: 10.3748/wjg.v26.i7.770. PMID: 32116424Free PMC Article
Malignant glomus tumors of the head and neck in children and adults: Evaluation and management.
Wolter NE, Adil E, Irace AL, Werger A, Perez-Atayde AR, Weldon C, Orbach DB, Rodriguez-Galindo C, Rahbar R
Laryngoscope 2017 Dec;127(12):2873-2882. Epub 2017 Mar 14 doi: 10.1002/lary.26550. PMID: 28294349
Symplastic Glomus Tumor.
Kabukçuoğlu F, Özkayalar H, Sakiz D, Kabukçuoğlu Y
Turk Patoloji Derg 2015;31(3):211-4. doi: 10.5146/tjpath.2014.01247. PMID: 26456968

Prognosis

A case of cutaneous malignant glomus tumor.
Senff S, Orschulok TP, Lambie DL, Lehane F
J Cutan Pathol 2024 Jan;51(1):50-52. Epub 2023 Sep 3 doi: 10.1111/cup.14531. PMID: 37661598
Malignant glomus tumor of the thyroid gland: a case report.
Liu Y, Wu R, Yu T, Cao Y, Lu L
J Int Med Res 2019 Jun;47(6):2723-2727. Epub 2019 Apr 30 doi: 10.1177/0300060519844872. PMID: 31039649Free PMC Article
Symplastic Glomus Tumor.
Kabukçuoğlu F, Özkayalar H, Sakiz D, Kabukçuoğlu Y
Turk Patoloji Derg 2015;31(3):211-4. doi: 10.5146/tjpath.2014.01247. PMID: 26456968
Malignant glomus tumor of the thyroid gland where is heretofore an unreported organ: a case report and literature review.
Chung DH, Kim NR, Kim T, Ahn J, Lee S, Lee YD, Cho HY
Endocr Pathol 2015 Mar;26(1):37-44. doi: 10.1007/s12022-014-9352-5. PMID: 25544269
Malignant glomus tumor of kidney: the first reported case and review of literature.
Lamba G, Rafiyath SM, Kaur H, Khan S, Singh P, Hamilton AM, Ang DC
Hum Pathol 2011 Aug;42(8):1200-3. Epub 2011 Feb 18 doi: 10.1016/j.humpath.2010.11.009. PMID: 21333326

Clinical prediction guides

Malignant Glomus Tumor of the Ureter.
Demir M, Tuncekin A, Yagmur I, Aydogdu A
J Coll Physicians Surg Pak 2022 Dec;32(12):SS206-SS208. doi: 10.29271/jcpsp.2022.Supp0.SS206. PMID: 36597340
Symplastic Glomus Tumor.
Kabukçuoğlu F, Özkayalar H, Sakiz D, Kabukçuoğlu Y
Turk Patoloji Derg 2015;31(3):211-4. doi: 10.5146/tjpath.2014.01247. PMID: 26456968
Atypical and malignant glomus tumors: analysis of 52 cases, with a proposal for the reclassification of glomus tumors.
Folpe AL, Fanburg-Smith JC, Miettinen M, Weiss SW
Am J Surg Pathol 2001 Jan;25(1):1-12. doi: 10.1097/00000478-200101000-00001. PMID: 11145243
Malignant glomus tumor: a case report and review of the literature.
Hiruta N, Kameda N, Tokudome T, Tsuchiya K, Nonaka H, Hatori T, Akima M, Miura M
Am J Surg Pathol 1997 Sep;21(9):1096-103. doi: 10.1097/00000478-199709000-00015. PMID: 9298887

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