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Large cell medulloblastoma

MedGen UID:
226852
Concept ID:
C1266180
Neoplastic Process
Synonyms: Large Cell Medulloblastoma; large cell medulloblastoma; large cell medulloblastoma (morphologic abnormality)
SNOMED CT: Large cell medulloblastoma (128790006)
 
Monarch Initiative: MONDO:0002791

Definition

A medulloblastoma composed of large cells with prominent nucleoli and a larger amount of cytoplasm in contrast with the cells of the classic medulloblastoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarge cell medulloblastoma

Professional guidelines

PubMed

Luque R, Benavides M, Del Barco S, Egaña L, García-Gómez J, Martínez-García M, Pérez-Segura P, Pineda E, Sepúlveda JM, Vieito M
Clin Transl Oncol 2021 May;23(5):940-947. Epub 2021 Apr 1 doi: 10.1007/s12094-021-02581-1. PMID: 33792841Free PMC Article
Guerreiro Stucklin AS, Ramaswamy V, Daniels C, Taylor MD
Curr Opin Pediatr 2018 Feb;30(1):3-9. doi: 10.1097/MOP.0000000000000562. PMID: 29315108
Martin AM, Raabe E, Eberhart C, Cohen KJ
Curr Treat Options Oncol 2014 Dec;15(4):581-94. doi: 10.1007/s11864-014-0306-4. PMID: 25194927Free PMC Article

Recent clinical studies

Etiology

Grassiot B, Beuriat PA, Di Rocco F, Leblond P, Faure-Conter C, Szathmari A, Mottolese C
Neurochirurgie 2021 Feb;67(1):52-60. Epub 2021 Jan 19 doi: 10.1016/j.neuchi.2021.01.003. PMID: 33482236
Roth J, Constantini S
Childs Nerv Syst 2017 May;33(5):787-792. Epub 2017 Mar 14 doi: 10.1007/s00381-017-3371-8. PMID: 28293736
Massimino M, Antonelli M, Gandola L, Miceli R, Pollo B, Biassoni V, Schiavello E, Buttarelli FR, Spreafico F, Collini P, Giangaspero F
Pediatr Blood Cancer 2013 Feb;60(2):210-6. Epub 2012 Jun 12 doi: 10.1002/pbc.24225. PMID: 22693015
Fruehwald-Pallamar J, Puchner SB, Rossi A, Garre ML, Cama A, Koelblinger C, Osborn AG, Thurnher MM
Neuroradiology 2011 Jun;53(6):387-96. Epub 2011 Jan 29 doi: 10.1007/s00234-010-0829-8. PMID: 21279509
Giordana MT, D'Agostino C, Pollo B, Silvani A, Ferracini R, Paiolo A, Ghiglione P, Chiò A
J Neuropathol Exp Neurol 2005 Oct;64(10):869-74. doi: 10.1097/01.jnen.0000182980.64236.01. PMID: 16215458

Diagnosis

Grassiot B, Beuriat PA, Di Rocco F, Leblond P, Faure-Conter C, Szathmari A, Mottolese C
Neurochirurgie 2021 Feb;67(1):52-60. Epub 2021 Jan 19 doi: 10.1016/j.neuchi.2021.01.003. PMID: 33482236
Dressler EV, Dolecek TA, Liu M, Villano JL
J Neurooncol 2017 May;132(3):497-506. Epub 2017 Mar 13 doi: 10.1007/s11060-017-2400-5. PMID: 28290003Free PMC Article
Massimino M, Antonelli M, Gandola L, Miceli R, Pollo B, Biassoni V, Schiavello E, Buttarelli FR, Spreafico F, Collini P, Giangaspero F
Pediatr Blood Cancer 2013 Feb;60(2):210-6. Epub 2012 Jun 12 doi: 10.1002/pbc.24225. PMID: 22693015
Palmér L, Nordborg C, Steneryd K, Aman P, Kyllerman M
Neuropediatrics 2004 Oct;35(5):307-11. doi: 10.1055/s-2004-821253. PMID: 15534766
Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK
J Neuropathol Exp Neurol 2002 Mar;61(3):215-25; discussion 226-9. doi: 10.1093/jnen/61.3.215. PMID: 11895036

Therapy

Roth J, Constantini S
Childs Nerv Syst 2017 May;33(5):787-792. Epub 2017 Mar 14 doi: 10.1007/s00381-017-3371-8. PMID: 28293736
Ogiwara H, Dipatri AJ Jr, Bowman RM, Tomita T, Alden TD
Childs Nerv Syst 2011 May;27(5):743-7. Epub 2010 Nov 20 doi: 10.1007/s00381-010-1343-3. PMID: 21103880

Prognosis

Grassiot B, Beuriat PA, Di Rocco F, Leblond P, Faure-Conter C, Szathmari A, Mottolese C
Neurochirurgie 2021 Feb;67(1):52-60. Epub 2021 Jan 19 doi: 10.1016/j.neuchi.2021.01.003. PMID: 33482236
Massimino M, Antonelli M, Gandola L, Miceli R, Pollo B, Biassoni V, Schiavello E, Buttarelli FR, Spreafico F, Collini P, Giangaspero F
Pediatr Blood Cancer 2013 Feb;60(2):210-6. Epub 2012 Jun 12 doi: 10.1002/pbc.24225. PMID: 22693015
Verma S, Tavaré CJ, Gilles FH
Pediatr Dev Pathol 2008 Sep-Oct;11(5):337-43. Epub 2008 Jan 17 doi: 10.2350/07-09-0353.1. PMID: 18201118
Giordana MT, D'Agostino C, Pollo B, Silvani A, Ferracini R, Paiolo A, Ghiglione P, Chiò A
J Neuropathol Exp Neurol 2005 Oct;64(10):869-74. doi: 10.1097/01.jnen.0000182980.64236.01. PMID: 16215458
Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK
J Neuropathol Exp Neurol 2002 Mar;61(3):215-25; discussion 226-9. doi: 10.1093/jnen/61.3.215. PMID: 11895036

Clinical prediction guides

Dressler EV, Dolecek TA, Liu M, Villano JL
J Neurooncol 2017 May;132(3):497-506. Epub 2017 Mar 13 doi: 10.1007/s11060-017-2400-5. PMID: 28290003Free PMC Article
Miwa T, Oi S, Nonaka Y, Tamogami R, Sasaki H, Yoshinari S, Ida H
Childs Nerv Syst 2011 Aug;27(8):1341-6. Epub 2011 Apr 28 doi: 10.1007/s00381-011-1450-9. PMID: 21533576
Li Y, Guessous F, Johnson EB, Eberhart CG, Li XN, Shu Q, Fan S, Lal B, Laterra J, Schiff D, Abounader R
Lab Invest 2008 Feb;88(2):98-111. Epub 2007 Dec 3 doi: 10.1038/labinvest.3700702. PMID: 18059365
Giordana MT, D'Agostino C, Pollo B, Silvani A, Ferracini R, Paiolo A, Ghiglione P, Chiò A
J Neuropathol Exp Neurol 2005 Oct;64(10):869-74. doi: 10.1097/01.jnen.0000182980.64236.01. PMID: 16215458
Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK
J Neuropathol Exp Neurol 2002 Mar;61(3):215-25; discussion 226-9. doi: 10.1093/jnen/61.3.215. PMID: 11895036

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