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Large cell medulloblastoma

MedGen UID:
226852
•Concept ID:
C1266180
•
Neoplastic Process
Synonyms: Large Cell Medulloblastoma; large cell medulloblastoma; large cell medulloblastoma (morphologic abnormality)
SNOMED CT: Large cell medulloblastoma (128790006)
 
Monarch Initiative: MONDO:0002791

Definition

A medulloblastoma composed of large cells with prominent nucleoli and a larger amount of cytoplasm in contrast with the cells of the classic medulloblastoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarge cell medulloblastoma

Professional guidelines

PubMed

SEOM clinical guideline for management of adult medulloblastoma (2020).
Luque R, Benavides M, Del Barco S, Egaña L, García-Gómez J, Martínez-García M, Pérez-Segura P, Pineda E, Sepúlveda JM, Vieito M
Clin Transl Oncol 2021 May;23(5):940-947. Epub 2021 Apr 1 doi: 10.1007/s12094-021-02581-1. PMID: 33792841Free PMC Article
Review of molecular classification and treatment implications of pediatric brain tumors.
Guerreiro Stucklin AS, Ramaswamy V, Daniels C, Taylor MD
Curr Opin Pediatr 2018 Feb;30(1):3-9. doi: 10.1097/MOP.0000000000000562. PMID: 29315108
Management of pediatric and adult patients with medulloblastoma.
Martin AM, Raabe E, Eberhart C, Cohen KJ
Curr Treat Options Oncol 2014 Dec;15(4):581-94. doi: 10.1007/s11864-014-0306-4. PMID: 25194927Free PMC Article

Recent clinical studies

Etiology

Surgical management of posterior fossa medulloblastoma in children: The Lyon experience.
Grassiot B, Beuriat PA, Di Rocco F, Leblond P, Faure-Conter C, Szathmari A, Mottolese C
Neurochirurgie 2021 Feb;67(1):52-60. Epub 2021 Jan 19 doi: 10.1016/j.neuchi.2021.01.003. PMID: 33482236
5ALA in pediatric brain tumors is not routinely beneficial.
Roth J, Constantini S
Childs Nerv Syst 2017 May;33(5):787-792. Epub 2017 Mar 14 doi: 10.1007/s00381-017-3371-8. PMID: 28293736
Histological variants of medulloblastoma are the most powerful clinical prognostic indicators.
Massimino M, Antonelli M, Gandola L, Miceli R, Pollo B, Biassoni V, Schiavello E, Buttarelli FR, Spreafico F, Collini P, Giangaspero F
Pediatr Blood Cancer 2013 Feb;60(2):210-6. Epub 2012 Jun 12 doi: 10.1002/pbc.24225. PMID: 22693015
Magnetic resonance imaging spectrum of medulloblastoma.
Fruehwald-Pallamar J, Puchner SB, Rossi A, Garre ML, Cama A, Koelblinger C, Osborn AG, Thurnher MM
Neuroradiology 2011 Jun;53(6):387-96. Epub 2011 Jan 29 doi: 10.1007/s00234-010-0829-8. PMID: 21279509
Anaplasia is rare and does not influence prognosis in adult medulloblastoma.
Giordana MT, D'Agostino C, Pollo B, Silvani A, Ferracini R, Paiolo A, Ghiglione P, Chiò A
J Neuropathol Exp Neurol 2005 Oct;64(10):869-74. doi: 10.1097/01.jnen.0000182980.64236.01. PMID: 16215458

Diagnosis

Surgical management of posterior fossa medulloblastoma in children: The Lyon experience.
Grassiot B, Beuriat PA, Di Rocco F, Leblond P, Faure-Conter C, Szathmari A, Mottolese C
Neurochirurgie 2021 Feb;67(1):52-60. Epub 2021 Jan 19 doi: 10.1016/j.neuchi.2021.01.003. PMID: 33482236
Demographics, patterns of care, and survival in pediatric medulloblastoma.
Dressler EV, Dolecek TA, Liu M, Villano JL
J Neurooncol 2017 May;132(3):497-506. Epub 2017 Mar 13 doi: 10.1007/s11060-017-2400-5. PMID: 28290003Free PMC Article
Histologic features and prognosis in pediatric medulloblastoma.
Verma S, Tavaré CJ, Gilles FH
Pediatr Dev Pathol 2008 Sep-Oct;11(5):337-43. Epub 2008 Jan 17 doi: 10.2350/07-09-0353.1. PMID: 18201118
Large-cell medulloblastoma in Aicardi syndrome. Case report and literature review.
Palmér L, Nordborg C, Steneryd K, Aman P, Kyllerman M
Neuropediatrics 2004 Oct;35(5):307-11. doi: 10.1055/s-2004-821253. PMID: 15534766
The WHO classification of tumors of the nervous system.
Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK
J Neuropathol Exp Neurol 2002 Mar;61(3):215-25; discussion 226-9. doi: 10.1093/jnen/61.3.215. PMID: 11895036

Therapy

5ALA in pediatric brain tumors is not routinely beneficial.
Roth J, Constantini S
Childs Nerv Syst 2017 May;33(5):787-792. Epub 2017 Mar 14 doi: 10.1007/s00381-017-3371-8. PMID: 28293736
Diffuse postoperative cerebellar swelling in medulloblastoma: report of two cases.
Ogiwara H, Dipatri AJ Jr, Bowman RM, Tomita T, Alden TD
Childs Nerv Syst 2011 May;27(5):743-7. Epub 2010 Nov 20 doi: 10.1007/s00381-010-1343-3. PMID: 21103880

Prognosis

Surgical management of posterior fossa medulloblastoma in children: The Lyon experience.
Grassiot B, Beuriat PA, Di Rocco F, Leblond P, Faure-Conter C, Szathmari A, Mottolese C
Neurochirurgie 2021 Feb;67(1):52-60. Epub 2021 Jan 19 doi: 10.1016/j.neuchi.2021.01.003. PMID: 33482236
Histological variants of medulloblastoma are the most powerful clinical prognostic indicators.
Massimino M, Antonelli M, Gandola L, Miceli R, Pollo B, Biassoni V, Schiavello E, Buttarelli FR, Spreafico F, Collini P, Giangaspero F
Pediatr Blood Cancer 2013 Feb;60(2):210-6. Epub 2012 Jun 12 doi: 10.1002/pbc.24225. PMID: 22693015
Histologic features and prognosis in pediatric medulloblastoma.
Verma S, Tavaré CJ, Gilles FH
Pediatr Dev Pathol 2008 Sep-Oct;11(5):337-43. Epub 2008 Jan 17 doi: 10.2350/07-09-0353.1. PMID: 18201118
Anaplasia is rare and does not influence prognosis in adult medulloblastoma.
Giordana MT, D'Agostino C, Pollo B, Silvani A, Ferracini R, Paiolo A, Ghiglione P, Chiò A
J Neuropathol Exp Neurol 2005 Oct;64(10):869-74. doi: 10.1097/01.jnen.0000182980.64236.01. PMID: 16215458
The WHO classification of tumors of the nervous system.
Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK
J Neuropathol Exp Neurol 2002 Mar;61(3):215-25; discussion 226-9. doi: 10.1093/jnen/61.3.215. PMID: 11895036

Clinical prediction guides

Demographics, patterns of care, and survival in pediatric medulloblastoma.
Dressler EV, Dolecek TA, Liu M, Villano JL
J Neurooncol 2017 May;132(3):497-506. Epub 2017 Mar 13 doi: 10.1007/s11060-017-2400-5. PMID: 28290003Free PMC Article
Aggressive large cell medulloblastoma extending to the extracranial region in brain-dead state.
Miwa T, Oi S, Nonaka Y, Tamogami R, Sasaki H, Yoshinari S, Ida H
Childs Nerv Syst 2011 Aug;27(8):1341-6. Epub 2011 Apr 28 doi: 10.1007/s00381-011-1450-9. PMID: 21533576
Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma.
Li Y, Guessous F, Johnson EB, Eberhart CG, Li XN, Shu Q, Fan S, Lal B, Laterra J, Schiff D, Abounader R
Lab Invest 2008 Feb;88(2):98-111. Epub 2007 Dec 3 doi: 10.1038/labinvest.3700702. PMID: 18059365
Anaplasia is rare and does not influence prognosis in adult medulloblastoma.
Giordana MT, D'Agostino C, Pollo B, Silvani A, Ferracini R, Paiolo A, Ghiglione P, Chiò A
J Neuropathol Exp Neurol 2005 Oct;64(10):869-74. doi: 10.1097/01.jnen.0000182980.64236.01. PMID: 16215458
The WHO classification of tumors of the nervous system.
Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK
J Neuropathol Exp Neurol 2002 Mar;61(3):215-25; discussion 226-9. doi: 10.1093/jnen/61.3.215. PMID: 11895036

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