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Tumor Cell Invasion

MedGen UID:
226866
•Concept ID:
C1269955
•
Neoplastic Process
Synonyms: Invasion; Local Tumor Invasion; Tumor Invasion

Definition

The local spread of tumor cells of a malignant neoplasm through infiltration or destruction of adjacent tissue; for epithelial neoplasms, invasion signifies infiltration beneath the epithelial basement membrane. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor Cell Invasion

Professional guidelines

PubMed

Bevacizumab-Induced Hypertension in Glioblastoma Patients and Its Potential as a Modulator of Treatment Response.
Scheer KG, Ebert LM, Samuel MS, Bonder CS, Gomez GA
Hypertension 2023 Aug;80(8):1590-1597. Epub 2023 Jun 21 doi: 10.1161/HYPERTENSIONAHA.123.21119. PMID: 37340980Free PMC Article
Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment.
Pandey N, Anastasiadis P, Carney CP, Kanvinde PP, Woodworth GF, Winkles JA, Kim AJ
Adv Drug Deliv Rev 2022 Sep;188:114415. Epub 2022 Jul 3 doi: 10.1016/j.addr.2022.114415. PMID: 35787387Free PMC Article
EGFR and EGFRvIII Promote Angiogenesis and Cell Invasion in Glioblastoma: Combination Therapies for an Effective Treatment.
Keller S, Schmidt MHH
Int J Mol Sci 2017 Jun 18;18(6) doi: 10.3390/ijms18061295. PMID: 28629170Free PMC Article

Recent clinical studies

Etiology

Tumor-expressed factor VII is associated with survival and regulates tumor progression in breast cancer.
Kroone C, Tieken C, Kocatürk B, Paauwe M, Blok EJ, Ünlü B, van den Berg YW, Stanganello E, Kapteijn MY, Swier N, Zhang X, Duits DEM, Lin Y, Oostenbrink LVE, van den Akker RFP, Mosnier LO, Hawinkels LJ, van Vlijmen BJM, Ruf W, Kuppen PJ, Cannegieter SC, Buijs JT, Versteeg HH
Blood Adv 2023 Jun 13;7(11):2388-2400. doi: 10.1182/bloodadvances.2022008455. PMID: 36920782Free PMC Article
Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion.
Jeong YJ, Knutsdottir H, Shojaeian F, Lerner MG, Wissler MF, Henriet E, Ng T, Datta S, Navarro-Serer B, Chianchiano P, Kinny-Köster B, Zimmerman JW, Stein-O'Brien G, Gaida MM, Eshleman JR, Lin MT, Fertig EJ, Ewald AJ, Bader JS, Wood LD
J Clin Invest 2023 Apr 17;133(8) doi: 10.1172/JCI162054. PMID: 36881486Free PMC Article
Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review.
Wei Z, Chen J, Zuo F, Guo J, Sun X, Liu D, Liu C
J Ethnopharmacol 2023 Jan 10;300:115748. Epub 2022 Sep 24 doi: 10.1016/j.jep.2022.115748. PMID: 36162545
Cannabinoids as Anticancer Drugs.
Ramer R, Hinz B
Adv Pharmacol 2017;80:397-436. Epub 2017 Jun 12 doi: 10.1016/bs.apha.2017.04.002. PMID: 28826542
The role of tumor microenvironment in collective tumor cell invasion.
Wu JS, Sheng SR, Liang XH, Tang YL
Future Oncol 2017 May;13(11):991-1002. Epub 2017 Jan 11 doi: 10.2217/fon-2016-0501. PMID: 28075171

Diagnosis

Advances on the anti-tumor mechanisms of the carotenoid Crocin.
Bao X, Hu J, Zhao Y, Jia R, Zhang H, Xia L
PeerJ 2023;11:e15535. Epub 2023 Jun 29 doi: 10.7717/peerj.15535. PMID: 37404473Free PMC Article
Single-cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer.
Lai H, Cheng X, Liu Q, Luo W, Liu M, Zhang M, Miao J, Ji Z, Lin GN, Song W, Zhang L, Bo J, Yang G, Wang J, Gao WQ
Int J Cancer 2021 Dec 15;149(12):2099-2115. Epub 2021 Sep 16 doi: 10.1002/ijc.33794. PMID: 34480339
Tumor pH and metastasis: a malignant process beyond hypoxia.
Thews O, Riemann A
Cancer Metastasis Rev 2019 Jun;38(1-2):113-129. doi: 10.1007/s10555-018-09777-y. PMID: 30607627
Engineering Exosomes for Cancer Therapy.
Gilligan KE, Dwyer RM
Int J Mol Sci 2017 May 24;18(6) doi: 10.3390/ijms18061122. PMID: 28538671Free PMC Article
Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity.
Bakker GJ, Andresen V, Hoffman RM, Friedl P
Methods Enzymol 2012;504:109-25. doi: 10.1016/B978-0-12-391857-4.00005-7. PMID: 22264531

Therapy

Tumor microenvironment signaling and therapeutics in cancer progression.
Goenka A, Khan F, Verma B, Sinha P, Dmello CC, Jogalekar MP, Gangadaran P, Ahn BC
Cancer Commun (Lond) 2023 May;43(5):525-561. Epub 2023 Apr 2 doi: 10.1002/cac2.12416. PMID: 37005490Free PMC Article
Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review.
Wei Z, Chen J, Zuo F, Guo J, Sun X, Liu D, Liu C
J Ethnopharmacol 2023 Jan 10;300:115748. Epub 2022 Sep 24 doi: 10.1016/j.jep.2022.115748. PMID: 36162545
Berberine as a Potential Anticancer Agent: A Comprehensive Review.
Rauf A, Abu-Izneid T, Khalil AA, Imran M, Shah ZA, Emran TB, Mitra S, Khan Z, Alhumaydhi FA, Aljohani ASM, Khan I, Rahman MM, Jeandet P, Gondal TA
Molecules 2021 Dec 4;26(23) doi: 10.3390/molecules26237368. PMID: 34885950Free PMC Article
Cannabinoids as Anticancer Drugs.
Ramer R, Hinz B
Adv Pharmacol 2017;80:397-436. Epub 2017 Jun 12 doi: 10.1016/bs.apha.2017.04.002. PMID: 28826542
Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis.
Pittayapruek P, Meephansan J, Prapapan O, Komine M, Ohtsuki M
Int J Mol Sci 2016 Jun 2;17(6) doi: 10.3390/ijms17060868. PMID: 27271600Free PMC Article

Prognosis

Single-cell RNA sequencing reveals pro-invasive cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma.
Cai Z, Chen L, Chen S, Fang R, Chen X, Lei W
Cell Commun Signal 2023 Oct 18;21(1):292. doi: 10.1186/s12964-023-01312-z. PMID: 37853464Free PMC Article
Comprehensive pan-cancer analysis reveals NUSAP1 is a novel predictive biomarker for prognosis and immunotherapy response.
Zheng H, Wang M, Zhang S, Hu D, Yang Q, Chen M, Zhang X, Zhang Y, Dai J, Liou YC
Int J Biol Sci 2023;19(14):4689-4708. Epub 2023 Sep 4 doi: 10.7150/ijbs.80017. PMID: 37781040Free PMC Article
GPR87 promotes tumor cell invasion and mediates the immunogenomic landscape of lung adenocarcinoma.
Bai R, Zhang J, He F, Li Y, Dai P, Huang Z, Han L, Wang Z, Gong Y, Xie C
Commun Biol 2022 Jul 5;5(1):663. doi: 10.1038/s42003-022-03506-6. PMID: 35790819Free PMC Article
Lung cancer and epithelial-mesenchymal transition.
Menju T, Date H
Gen Thorac Cardiovasc Surg 2021 May;69(5):781-789. Epub 2021 Mar 22 doi: 10.1007/s11748-021-01595-4. PMID: 33754237
Plasticity of Cancer Cell Invasion-Mechanisms and Implications for Therapy.
Te Boekhorst V, Friedl P
Adv Cancer Res 2016;132:209-64. Epub 2016 Aug 17 doi: 10.1016/bs.acr.2016.07.005. PMID: 27613134

Clinical prediction guides

Comprehensive pan-cancer analysis reveals NUSAP1 is a novel predictive biomarker for prognosis and immunotherapy response.
Zheng H, Wang M, Zhang S, Hu D, Yang Q, Chen M, Zhang X, Zhang Y, Dai J, Liou YC
Int J Biol Sci 2023;19(14):4689-4708. Epub 2023 Sep 4 doi: 10.7150/ijbs.80017. PMID: 37781040Free PMC Article
Tumor-expressed factor VII is associated with survival and regulates tumor progression in breast cancer.
Kroone C, Tieken C, Kocatürk B, Paauwe M, Blok EJ, Ünlü B, van den Berg YW, Stanganello E, Kapteijn MY, Swier N, Zhang X, Duits DEM, Lin Y, Oostenbrink LVE, van den Akker RFP, Mosnier LO, Hawinkels LJ, van Vlijmen BJM, Ruf W, Kuppen PJ, Cannegieter SC, Buijs JT, Versteeg HH
Blood Adv 2023 Jun 13;7(11):2388-2400. doi: 10.1182/bloodadvances.2022008455. PMID: 36920782Free PMC Article
GPR87 promotes tumor cell invasion and mediates the immunogenomic landscape of lung adenocarcinoma.
Bai R, Zhang J, He F, Li Y, Dai P, Huang Z, Han L, Wang Z, Gong Y, Xie C
Commun Biol 2022 Jul 5;5(1):663. doi: 10.1038/s42003-022-03506-6. PMID: 35790819Free PMC Article
Engineering Exosomes for Cancer Therapy.
Gilligan KE, Dwyer RM
Int J Mol Sci 2017 May 24;18(6) doi: 10.3390/ijms18061122. PMID: 28538671Free PMC Article
Plasticity of Cancer Cell Invasion-Mechanisms and Implications for Therapy.
Te Boekhorst V, Friedl P
Adv Cancer Res 2016;132:209-64. Epub 2016 Aug 17 doi: 10.1016/bs.acr.2016.07.005. PMID: 27613134

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