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Tumor-induced osteomalacia

MedGen UID:
226893
•Concept ID:
C1274103
•
Disease or Syndrome
Synonym: Oncogenic osteomalacia
SNOMED CT: Tumor-induced osteomalacia (392559009); Oncogenic osteomalacia (392559009); Osteomalacia due to neoplastic disease (392559009); Osteomalacia due to neoplasm (392559009)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018124
Orphanet: ORPHA352540

Definition

A rare paraneoplastic syndrome characterized by renal phosphate wasting and bone demineralization due to a phosphaturic mesenchymal tumor of the mixed connective tissue variant. It causes osteomalacia in adults with bone pain and pathological fractures, and rickets in children. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor-induced osteomalacia

Professional guidelines

PubMed

Global guidance for the recognition, diagnosis, and management of tumor-induced osteomalacia.
Jan de Beur SM, Minisola S, Xia WB, Abrahamsen B, Body JJ, Brandi ML, Clifton-Bligh R, Collins M, Florenzano P, Houillier P, Imanishi Y, Imel EA, Khan AA, Zillikens MC, Fukumoto S
J Intern Med 2023 Mar;293(3):309-328. Epub 2022 Dec 13 doi: 10.1111/joim.13593. PMID: 36511653Free PMC Article
Rickets guidance: part II-management.
Haffner D, Leifheit-Nestler M, Grund A, Schnabel D
Pediatr Nephrol 2022 Oct;37(10):2289-2302. Epub 2022 Mar 29 doi: 10.1007/s00467-022-05505-5. PMID: 35352187Free PMC Article
FGF23-related hypophosphatemic rickets/osteomalacia: diagnosis and new treatment.
Fukumoto S
J Mol Endocrinol 2021 Feb;66(2):R57-R65. doi: 10.1530/JME-20-0089. PMID: 33295878

Recent clinical studies

Etiology

Diagnosis and management of tumor-induced osteomalacia: a single center experience.
Hacisahinogullari H, Tekin S, Tanrikulu S, Saribeyliler G, Yalin GY, Bilgic B, Isik EG, Salduz A, Tuncer S, Gul N, Uzum AK, Aral F, Tanakol R, Selcukbiricik OS
Endocrine 2023 Nov;82(2):427-434. Epub 2023 Jul 22 doi: 10.1007/s12020-023-03450-3. PMID: 37480497
Epidemiology of Tumor-Induced Osteomalacia in Denmark.
Abrahamsen B, Smith CD, Minisola S
Calcif Tissue Int 2021 Aug;109(2):147-156. Epub 2021 Apr 5 doi: 10.1007/s00223-021-00843-2. PMID: 33818653Free PMC Article
Nonremission and Recurrent Tumor-Induced Osteomalacia: A Retrospective Study.
Li X, Jiang Y, Huo L, Wu H, Liu Y, Jin J, Yu W, Lv W, Zhou L, Xia Y, Wang O, Li M, Xing X, Chi Y, Jiajue R, Cui L, Meng X, Xia W
J Bone Miner Res 2020 Mar;35(3):469-477. Epub 2019 Nov 15 doi: 10.1002/jbmr.3903. PMID: 31643101Free PMC Article
Tumor-Induced Osteomalacia: an Up-to-Date Review.
Hautmann AH, Hautmann MG, Kölbl O, Herr W, Fleck M
Curr Rheumatol Rep 2015 Jun;17(6):512. doi: 10.1007/s11926-015-0512-5. PMID: 25900190
Tumor localization and biochemical response to cure in tumor-induced osteomalacia.
Chong WH, Andreopoulou P, Chen CC, Reynolds J, Guthrie L, Kelly M, Gafni RI, Bhattacharyya N, Boyce AM, El-Maouche D, Crespo DO, Sherry R, Chang R, Wodajo FM, Kletter GB, Dwyer A, Collins MT
J Bone Miner Res 2013 Jun;28(6):1386-98. doi: 10.1002/jbmr.1881. PMID: 23362135Free PMC Article

Diagnosis

Global guidance for the recognition, diagnosis, and management of tumor-induced osteomalacia.
Jan de Beur SM, Minisola S, Xia WB, Abrahamsen B, Body JJ, Brandi ML, Clifton-Bligh R, Collins M, Florenzano P, Houillier P, Imanishi Y, Imel EA, Khan AA, Zillikens MC, Fukumoto S
J Intern Med 2023 Mar;293(3):309-328. Epub 2022 Dec 13 doi: 10.1111/joim.13593. PMID: 36511653Free PMC Article
Tumor-induced Osteomalacia: A Comprehensive Review.
Minisola S, Fukumoto S, Xia W, Corsi A, Colangelo L, Scillitani A, Pepe J, Cipriani C, Thakker RV
Endocr Rev 2023 Mar 4;44(2):323-353. doi: 10.1210/endrev/bnac026. PMID: 36327295
Osteomalacia Is Not a Single Disease.
Cianferotti L
Int J Mol Sci 2022 Nov 28;23(23) doi: 10.3390/ijms232314896. PMID: 36499221Free PMC Article
Burosumab for the Treatment of Tumor-Induced Osteomalacia.
Jan de Beur SM, Miller PD, Weber TJ, Peacock M, Insogna K, Kumar R, Rauch F, Luca D, Cimms T, Roberts MS, San Martin J, Carpenter TO
J Bone Miner Res 2021 Apr;36(4):627-635. Epub 2021 Jan 12 doi: 10.1002/jbmr.4233. PMID: 33338281Free PMC Article
FGF23-related hypophosphatemic rickets/osteomalacia: diagnosis and new treatment.
Fukumoto S
J Mol Endocrinol 2021 Feb;66(2):R57-R65. doi: 10.1530/JME-20-0089. PMID: 33295878

Therapy

Global guidance for the recognition, diagnosis, and management of tumor-induced osteomalacia.
Jan de Beur SM, Minisola S, Xia WB, Abrahamsen B, Body JJ, Brandi ML, Clifton-Bligh R, Collins M, Florenzano P, Houillier P, Imanishi Y, Imel EA, Khan AA, Zillikens MC, Fukumoto S
J Intern Med 2023 Mar;293(3):309-328. Epub 2022 Dec 13 doi: 10.1111/joim.13593. PMID: 36511653Free PMC Article
Rickets guidance: part II-management.
Haffner D, Leifheit-Nestler M, Grund A, Schnabel D
Pediatr Nephrol 2022 Oct;37(10):2289-2302. Epub 2022 Mar 29 doi: 10.1007/s00467-022-05505-5. PMID: 35352187Free PMC Article
Burosumab for the Treatment of Tumor-Induced Osteomalacia.
Jan de Beur SM, Miller PD, Weber TJ, Peacock M, Insogna K, Kumar R, Rauch F, Luca D, Cimms T, Roberts MS, San Martin J, Carpenter TO
J Bone Miner Res 2021 Apr;36(4):627-635. Epub 2021 Jan 12 doi: 10.1002/jbmr.4233. PMID: 33338281Free PMC Article
FGF23-related hypophosphatemic rickets/osteomalacia: diagnosis and new treatment.
Fukumoto S
J Mol Endocrinol 2021 Feb;66(2):R57-R65. doi: 10.1530/JME-20-0089. PMID: 33295878
Tumor-Induced Osteomalacia.
Florenzano P, Hartley IR, Jimenez M, Roszko K, Gafni RI, Collins MT
Calcif Tissue Int 2021 Jan;108(1):128-142. Epub 2020 Jun 5 doi: 10.1007/s00223-020-00691-6. PMID: 32504138

Prognosis

Tumor-Induced Osteomalacia: A Systematic Clinical Review of 895 Cases.
Bosman A, Palermo A, Vanderhulst J, De Beur SMJ, Fukumoto S, Minisola S, Xia W, Body JJ, Zillikens MC
Calcif Tissue Int 2022 Oct;111(4):367-379. Epub 2022 Jul 20 doi: 10.1007/s00223-022-01005-8. PMID: 35857061Free PMC Article
Epidemiology of Tumor-Induced Osteomalacia in Denmark.
Abrahamsen B, Smith CD, Minisola S
Calcif Tissue Int 2021 Aug;109(2):147-156. Epub 2021 Apr 5 doi: 10.1007/s00223-021-00843-2. PMID: 33818653Free PMC Article
Tumor-Induced Osteomalacia: an Up-to-Date Review.
Hautmann AH, Hautmann MG, Kölbl O, Herr W, Fleck M
Curr Rheumatol Rep 2015 Jun;17(6):512. doi: 10.1007/s11926-015-0512-5. PMID: 25900190
Tumor localization and biochemical response to cure in tumor-induced osteomalacia.
Chong WH, Andreopoulou P, Chen CC, Reynolds J, Guthrie L, Kelly M, Gafni RI, Bhattacharyya N, Boyce AM, El-Maouche D, Crespo DO, Sherry R, Chang R, Wodajo FM, Kletter GB, Dwyer A, Collins MT
J Bone Miner Res 2013 Jun;28(6):1386-98. doi: 10.1002/jbmr.1881. PMID: 23362135Free PMC Article
Tumor-induced osteomalacia.
Jan de Beur SM
JAMA 2005 Sep 14;294(10):1260-7. doi: 10.1001/jama.294.10.1260. PMID: 16160135

Clinical prediction guides

Burosumab Improves Patient-Reported Outcomes in Adults With Tumor-Induced Osteomalacia: Mixed-Methods Analysis.
Jan de Beur SM, Cimms T, Nixon A, Theodore-Oklota C, Luca D, Roberts MS, Egan S, Graham CA, Hribal E, Evans CJ, Wood S, Williams A
J Bone Miner Res 2023 Nov;38(11):1654-1664. Epub 2023 Sep 4 doi: 10.1002/jbmr.4900. PMID: 37578099
Hyperparathyroidism in a Large Cohort of Chinese Patients With Tumor-induced Osteomalacia.
Ni X, Liu W, Zhang D, Li X, Chi Y, Feng J, Jin C, Pang Q, Gong Y, Cui L, Jiajue R, Yu W, Wu H, Huo L, Liu Y, Jin J, Zhou X, Lv W, Zhou L, Xia Y, Wang O, Li M, Xing X, Jiang Y, Xia W
J Clin Endocrinol Metab 2023 Apr 13;108(5):1224-1235. doi: 10.1210/clinem/dgac650. PMID: 36334263
Tumor-Induced Osteomalacia: A Systematic Clinical Review of 895 Cases.
Bosman A, Palermo A, Vanderhulst J, De Beur SMJ, Fukumoto S, Minisola S, Xia W, Body JJ, Zillikens MC
Calcif Tissue Int 2022 Oct;111(4):367-379. Epub 2022 Jul 20 doi: 10.1007/s00223-022-01005-8. PMID: 35857061Free PMC Article
Epidemiology of Tumor-Induced Osteomalacia in Denmark.
Abrahamsen B, Smith CD, Minisola S
Calcif Tissue Int 2021 Aug;109(2):147-156. Epub 2021 Apr 5 doi: 10.1007/s00223-021-00843-2. PMID: 33818653Free PMC Article
Tumor localization and biochemical response to cure in tumor-induced osteomalacia.
Chong WH, Andreopoulou P, Chen CC, Reynolds J, Guthrie L, Kelly M, Gafni RI, Bhattacharyya N, Boyce AM, El-Maouche D, Crespo DO, Sherry R, Chang R, Wodajo FM, Kletter GB, Dwyer A, Collins MT
J Bone Miner Res 2013 Jun;28(6):1386-98. doi: 10.1002/jbmr.1881. PMID: 23362135Free PMC Article

Recent systematic reviews

Clinical Characteristics of Malignant Phosphaturic Mesenchymal Tumor Causing Tumor-Induced Osteomalacia.
Abate V, Vergatti A, De Filippo G, Damiano V, Menale C, D'Elia L, Rendina D
J Clin Endocrinol Metab 2024 Feb 20;109(3):e1006-e1011. doi: 10.1210/clinem/dgad690. PMID: 38006315
Tumor-Induced Osteomalacia in Patients With Malignancy: A Meta-analysis and Systematic Review of Case Reports.
Bouraima F, Sapin V, Kahouadji S, Pickering ME, Pereira B, Bouvier D, Oris C
J Clin Endocrinol Metab 2023 Oct 18;108(11):3031-3040. doi: 10.1210/clinem/dgad297. PMID: 37235783
Tumor-induced Osteomalacia: A Systematic Review and Individual Patient's Data Analysis.
Rendina D, Abate V, Cacace G, D'Elia L, De Filippo G, Del Vecchio S, Galletti F, Cuocolo A, Strazzullo P
J Clin Endocrinol Metab 2022 Jul 14;107(8):e3428-e3436. doi: 10.1210/clinem/dgac253. PMID: 35468192
Persistence and recurrence in tumor-induced osteomalacia: A systematic review of the literature and results from a national survey/case series.
Cianferotti L, Delli Poggi C, Bertoldo F, Caffarelli C, Crotti C, Gatti D, Giannini S, Gonnelli S, Mazzantini M, Ombretta V, Sella S, Setti A, Varenna M, Zucchi F, Brandi ML
Endocrine 2022 Jun;76(3):709-721. Epub 2022 Apr 5 doi: 10.1007/s12020-022-03039-2. PMID: 35381903Free PMC Article
En bloc resection for treatment of tumor-induced osteomalacia: a case presentation and a systematic review.
Meng T, Zhou W, Li B, Yin H, Li Z, Zhou L, Kong J, Yan W, Yang X, Liu T, Song D, Xiao J
World J Surg Oncol 2015 May 8;13:176. doi: 10.1186/s12957-015-0589-3. PMID: 25951872Free PMC Article

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