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P(1) PHENOTYPE

MedGen UID:
226947
Concept ID:
C1292197
Finding
Synonym: P>1< phenotype
SNOMED CT: P>1< phenotype (115795001)
 
OMIM®: 111400

Professional guidelines

PubMed

Sarnowski C, Lent S, Dupuis J
BMC Genet 2018 Sep 17;19(Suppl 1):83. doi: 10.1186/s12863-018-0640-9. PMID: 30255771Free PMC Article

Recent clinical studies

Etiology

Wang C, Zhu D, Zhang D, Zuo X, Yao L, Liu T, Ge X, He C, Zhou Y, Shen Z
BMC Psychiatry 2023 Aug 15;23(1):590. doi: 10.1186/s12888-023-05081-4. PMID: 37582716Free PMC Article
Ware SM, Bhatnagar S, Dexheimer PJ, Wilkinson JD, Sridhar A, Fan X, Shen Y, Tariq M, Schubert JA, Colan SD, Shi L, Canter CE, Hsu DT, Bansal N, Webber SA, Everitt MD, Kantor PF, Rossano JW, Pahl E, Rusconi P, Lee TM, Towbin JA, Lal AK, Chung WK, Miller EM, Aronow B, Martin LJ, Lipshultz SE; Pediatric Cardiomyopathy Registry Study Group
Am J Hum Genet 2022 Feb 3;109(2):282-298. Epub 2022 Jan 12 doi: 10.1016/j.ajhg.2021.12.006. PMID: 35026164Free PMC Article
Fang J, Zhang P, Zhou Y, Chiang CW, Tan J, Hou Y, Stauffer S, Li L, Pieper AA, Cummings J, Cheng F
Nat Aging 2021 Dec;1(12):1175-1188. Epub 2021 Dec 6 doi: 10.1038/s43587-021-00138-z. PMID: 35572351Free PMC Article
Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, DePalma S, Haghighi A, Seidman JG, Seidman CE, Jacoby D, Macones G, Judge DP, Rana S, Margulies KB, Cappola TP, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Alexis JD, Boehmer J, Kamiya C, Gustafsson F, Damm P, Ersbøll AS, Goland S, Hilfiker-Kleiner D, McNamara DM; IMAC-2 and IPAC Investigators, Arany Z
Circulation 2021 May 11;143(19):1852-1862. Epub 2021 Apr 20 doi: 10.1161/CIRCULATIONAHA.120.052395. PMID: 33874732Free PMC Article
Orrù V, Steri M, Sidore C, Marongiu M, Serra V, Olla S, Sole G, Lai S, Dei M, Mulas A, Virdis F, Piras MG, Lobina M, Marongiu M, Pitzalis M, Deidda F, Loizedda A, Onano S, Zoledziewska M, Sawcer S, Devoto M, Gorospe M, Abecasis GR, Floris M, Pala M, Schlessinger D, Fiorillo E, Cucca F
Nat Genet 2020 Oct;52(10):1036-1045. Epub 2020 Sep 14 doi: 10.1038/s41588-020-0684-4. PMID: 32929287Free PMC Article

Diagnosis

Ma Z, Zhao M, Zhao H, Qu N
Front Immunol 2023;14:1338083. Epub 2024 Jan 9 doi: 10.3389/fimmu.2023.1338083. PMID: 38264647Free PMC Article
Wang C, Zhu D, Zhang D, Zuo X, Yao L, Liu T, Ge X, He C, Zhou Y, Shen Z
BMC Psychiatry 2023 Aug 15;23(1):590. doi: 10.1186/s12888-023-05081-4. PMID: 37582716Free PMC Article
Ware SM, Bhatnagar S, Dexheimer PJ, Wilkinson JD, Sridhar A, Fan X, Shen Y, Tariq M, Schubert JA, Colan SD, Shi L, Canter CE, Hsu DT, Bansal N, Webber SA, Everitt MD, Kantor PF, Rossano JW, Pahl E, Rusconi P, Lee TM, Towbin JA, Lal AK, Chung WK, Miller EM, Aronow B, Martin LJ, Lipshultz SE; Pediatric Cardiomyopathy Registry Study Group
Am J Hum Genet 2022 Feb 3;109(2):282-298. Epub 2022 Jan 12 doi: 10.1016/j.ajhg.2021.12.006. PMID: 35026164Free PMC Article
Lu Y, Xu Z, Georgakis MK, Wang Z, Lin H, Zheng L
ESC Heart Fail 2021 Jun;8(3):1954-1965. Epub 2021 Mar 3 doi: 10.1002/ehf2.13248. PMID: 33656795Free PMC Article
Otowa T, Hek K, Lee M, Byrne EM, Mirza SS, Nivard MG, Bigdeli T, Aggen SH, Adkins D, Wolen A, Fanous A, Keller MC, Castelao E, Kutalik Z, Van der Auwera S, Homuth G, Nauck M, Teumer A, Milaneschi Y, Hottenga JJ, Direk N, Hofman A, Uitterlinden A, Mulder CL, Henders AK, Medland SE, Gordon S, Heath AC, Madden PA, Pergadia ML, van der Most PJ, Nolte IM, van Oort FV, Hartman CA, Oldehinkel AJ, Preisig M, Grabe HJ, Middeldorp CM, Penninx BW, Boomsma D, Martin NG, Montgomery G, Maher BS, van den Oord EJ, Wray NR, Tiemeier H, Hettema JM
Mol Psychiatry 2016 Oct;21(10):1391-9. Epub 2016 Jan 12 doi: 10.1038/mp.2015.197. PMID: 26754954Free PMC Article

Therapy

Ma Z, Zhao M, Zhao H, Qu N
Front Immunol 2023;14:1338083. Epub 2024 Jan 9 doi: 10.3389/fimmu.2023.1338083. PMID: 38264647Free PMC Article
Wang C, Zhu D, Zhang D, Zuo X, Yao L, Liu T, Ge X, He C, Zhou Y, Shen Z
BMC Psychiatry 2023 Aug 15;23(1):590. doi: 10.1186/s12888-023-05081-4. PMID: 37582716Free PMC Article
Koller D, Pathak GA, Wendt FR, Tylee DS, Levey DF, Overstreet C, Gelernter J, Taylor HS, Polimanti R
JAMA Netw Open 2023 Jan 3;6(1):e2251214. doi: 10.1001/jamanetworkopen.2022.51214. PMID: 36652249Free PMC Article
Fang J, Zhang P, Zhou Y, Chiang CW, Tan J, Hou Y, Stauffer S, Li L, Pieper AA, Cummings J, Cheng F
Nat Aging 2021 Dec;1(12):1175-1188. Epub 2021 Dec 6 doi: 10.1038/s43587-021-00138-z. PMID: 35572351Free PMC Article
Lu Y, Xu Z, Georgakis MK, Wang Z, Lin H, Zheng L
ESC Heart Fail 2021 Jun;8(3):1954-1965. Epub 2021 Mar 3 doi: 10.1002/ehf2.13248. PMID: 33656795Free PMC Article

Prognosis

Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, DePalma S, Haghighi A, Seidman JG, Seidman CE, Jacoby D, Macones G, Judge DP, Rana S, Margulies KB, Cappola TP, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Alexis JD, Boehmer J, Kamiya C, Gustafsson F, Damm P, Ersbøll AS, Goland S, Hilfiker-Kleiner D, McNamara DM; IMAC-2 and IPAC Investigators, Arany Z
Circulation 2021 May 11;143(19):1852-1862. Epub 2021 Apr 20 doi: 10.1161/CIRCULATIONAHA.120.052395. PMID: 33874732Free PMC Article
Anstee QM, Darlay R, Cockell S, Meroni M, Govaere O, Tiniakos D, Burt AD, Bedossa P, Palmer J, Liu YL, Aithal GP, Allison M, Yki-Järvinen H, Vacca M, Dufour JF, Invernizzi P, Prati D, Ekstedt M, Kechagias S, Francque S, Petta S, Bugianesi E, Clement K, Ratziu V, Schattenberg JM, Valenti L, Day CP, Cordell HJ, Daly AK; EPoS Consortium Investigators
J Hepatol 2020 Sep;73(3):505-515. Epub 2020 Apr 13 doi: 10.1016/j.jhep.2020.04.003. PMID: 32298765
Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Gerstein HC, Paré G
Circulation 2019 Sep 9;140(10):819-830. Epub 2019 Jun 18 doi: 10.1161/CIRCULATIONAHA.119.040180. PMID: 31208196
Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG; 23andMe Research Team, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB
Nat Genet 2019 Feb;51(2):258-266. Epub 2018 Dec 31 doi: 10.1038/s41588-018-0302-x. PMID: 30598549Free PMC Article
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
Mol Psychiatry 2018 May;23(5):1181-1188. Epub 2017 Aug 1 doi: 10.1038/mp.2017.154. PMID: 28761083Free PMC Article

Clinical prediction guides

Fang J, Zhang P, Zhou Y, Chiang CW, Tan J, Hou Y, Stauffer S, Li L, Pieper AA, Cummings J, Cheng F
Nat Aging 2021 Dec;1(12):1175-1188. Epub 2021 Dec 6 doi: 10.1038/s43587-021-00138-z. PMID: 35572351Free PMC Article
Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, DePalma S, Haghighi A, Seidman JG, Seidman CE, Jacoby D, Macones G, Judge DP, Rana S, Margulies KB, Cappola TP, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Alexis JD, Boehmer J, Kamiya C, Gustafsson F, Damm P, Ersbøll AS, Goland S, Hilfiker-Kleiner D, McNamara DM; IMAC-2 and IPAC Investigators, Arany Z
Circulation 2021 May 11;143(19):1852-1862. Epub 2021 Apr 20 doi: 10.1161/CIRCULATIONAHA.120.052395. PMID: 33874732Free PMC Article
Anstee QM, Darlay R, Cockell S, Meroni M, Govaere O, Tiniakos D, Burt AD, Bedossa P, Palmer J, Liu YL, Aithal GP, Allison M, Yki-Järvinen H, Vacca M, Dufour JF, Invernizzi P, Prati D, Ekstedt M, Kechagias S, Francque S, Petta S, Bugianesi E, Clement K, Ratziu V, Schattenberg JM, Valenti L, Day CP, Cordell HJ, Daly AK; EPoS Consortium Investigators
J Hepatol 2020 Sep;73(3):505-515. Epub 2020 Apr 13 doi: 10.1016/j.jhep.2020.04.003. PMID: 32298765
Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG; 23andMe Research Team, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB
Nat Genet 2019 Feb;51(2):258-266. Epub 2018 Dec 31 doi: 10.1038/s41588-018-0302-x. PMID: 30598549Free PMC Article
Posey JE, Harel T, Liu P, Rosenfeld JA, James RA, Coban Akdemir ZH, Walkiewicz M, Bi W, Xiao R, Ding Y, Xia F, Beaudet AL, Muzny DM, Gibbs RA, Boerwinkle E, Eng CM, Sutton VR, Shaw CA, Plon SE, Yang Y, Lupski JR
N Engl J Med 2017 Jan 5;376(1):21-31. Epub 2016 Dec 7 doi: 10.1056/NEJMoa1516767. PMID: 27959697Free PMC Article

Recent systematic reviews

Casas-Recasens S, Cassim R, Mendoza N, Agusti A, Lodge C, Li S, Bui D, Martino D, Dharmage SC, Faner R
Am J Respir Crit Care Med 2024 Sep 15;210(6):766-778. doi: 10.1164/rccm.202302-0231OC. PMID: 38422471
Phadte A, Arya S, Sarathi V, Lila A, Maheshwari M, Memon SS, Rane A, Patil V, Rai K, Raghav D, Kunwar A, Bandgar T
Clin Endocrinol (Oxf) 2023 Mar;98(3):351-362. Epub 2022 Nov 17 doi: 10.1111/cen.14848. PMID: 36357326
Wittke C, Petkovic S, Dobricic V, Schaake S; MDS‐endorsed PSP Study Group, Respondek G, Weissbach A, Madoev H, Trinh J, Vollstedt EJ, Kuhnke N, Lohmann K, Dulovic Mahlow M, Marras C, König IR, Stamelou M, Bonifati V, Lill CM, Kasten M, Huppertz HJ, Höglinger G, Klein C
Mov Disord 2021 Jul;36(7):1499-1510. Epub 2021 Mar 19 doi: 10.1002/mds.28517. PMID: 34396589Free PMC Article
Hillmer A, Chawar C, Sanger S, D'Elia A, Butt M, Kapoor R, Kapczinski F, Thabane L, Samaan Z
BMC Med Genomics 2021 Aug 12;14(1):203. doi: 10.1186/s12920-021-01035-5. PMID: 34384432Free PMC Article
Singh TP, Field MA, Bown MJ, Jones GT, Golledge J
Atherosclerosis 2021 Jun;327:39-48. Epub 2021 May 12 doi: 10.1016/j.atherosclerosis.2021.05.001. PMID: 34038762

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