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Wasting disease

MedGen UID:
22696
Concept ID:
C0043046
Disease or Syndrome
Synonyms: Wasting Disease; Wasting Diseases; Wasting Syndrome; Wasting Syndromes
SNOMED CT: Wasting disease (288517002)

Definition

Pathologic loss of more than 10% of body weight concurrent with 30 or more days of either diarrhea or weakness and fever. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Mak RH, Iyengar A, Wang AY
Semin Nephrol 2023 Jul;43(4):151441. Epub 2023 Nov 18 doi: 10.1016/j.semnephrol.2023.151441. PMID: 37981474
Guiraud S, Davies KE
Curr Opin Pharmacol 2017 Jun;34:36-48. Epub 2017 May 6 doi: 10.1016/j.coph.2017.04.002. PMID: 28486179
Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, Franch H, Guarnieri G, Ikizler TA, Kaysen G, Lindholm B, Massy Z, Mitch W, Pineda E, Stenvinkel P, Treviño-Becerra A, Wanner C
Kidney Int 2008 Feb;73(4):391-8. Epub 2007 Dec 19 doi: 10.1038/sj.ki.5002585. PMID: 18094682

Recent clinical studies

Etiology

Birch SM, Lawlor MW, Conlon TJ, Guo LJ, Crudele JM, Hawkins EC, Nghiem PP, Ahn M, Meng H, Beatka MJ, Fickau BA, Prieto JC, Styner MA, Struharik MJ, Shanks C, Brown KJ, Golebiowski D, Bettis AK, Balog-Alvarez CJ, Clement N, Coleman KE, Corti M, Pan X, Hauschka SD, Gonzalez JP, Morris CA, Schneider JS, Duan D, Chamberlain JS, Byrne BJ, Kornegay JN
Sci Transl Med 2023 Jan 4;15(677):eabo1815. doi: 10.1126/scitranslmed.abo1815. PMID: 36599002Free PMC Article
Orge L, Lima C, Machado C, Tavares P, Mendonça P, Carvalho P, Silva J, Pinto ML, Bastos E, Pereira JC, Gonçalves-Anjo N, Gama A, Esteves A, Alves A, Matos AC, Seixas F, Silva F, Pires I, Figueira L, Vieira-Pinto M, Sargo R, Pires MDA
Biomolecules 2021 Mar 21;11(3) doi: 10.3390/biom11030466. PMID: 33801117Free PMC Article
Whitechurch BC, Welton JM, Collins SJ, Lawson VA
Adv Neurobiol 2017;15:335-364. doi: 10.1007/978-3-319-57193-5_13. PMID: 28674988
Kurt TD, Sigurdson CJ
Prion 2016;10(1):83-91. doi: 10.1080/19336896.2015.1118603. PMID: 26809254Free PMC Article
Johnson RT
Lancet Neurol 2005 Oct;4(10):635-42. doi: 10.1016/S1474-4422(05)70192-7. PMID: 16168932

Diagnosis

Duan D, Goemans N, Takeda S, Mercuri E, Aartsma-Rus A
Nat Rev Dis Primers 2021 Feb 18;7(1):13. doi: 10.1038/s41572-021-00248-3. PMID: 33602943Free PMC Article
Vilarinho S, Mistry PK
Hepatology 2019 Dec;70(6):2185-2192. doi: 10.1002/hep.30826. PMID: 31222768Free PMC Article
Mathiason CK
Prog Mol Biol Transl Sci 2017;150:267-292. Epub 2017 Aug 10 doi: 10.1016/bs.pmbts.2017.07.009. PMID: 28838664
Gilch S, Chitoor N, Taguchi Y, Stuart M, Jewell JE, Schätzl HM
Top Curr Chem 2011;305:51-77. doi: 10.1007/128_2011_159. PMID: 21598099
Dillon MJ, Leonard JV, Buckler JM, Ogilvie D, Lillystone D, Honour JW, Shackleton CH
Arch Dis Child 1980 Jun;55(6):427-34. doi: 10.1136/adc.55.6.427. PMID: 7002056Free PMC Article

Therapy

Xiang H, Yu H, Zhou Q, Wu Y, Ren J, Zhao Z, Tao X, Dong D
Pharmacol Res 2022 Nov;185:106508. Epub 2022 Oct 13 doi: 10.1016/j.phrs.2022.106508. PMID: 36243329
Elangkovan N, Dickson G
J Neuromuscul Dis 2021;8(s2):S303-S316. doi: 10.3233/JND-210678. PMID: 34511510Free PMC Article
Wisniewski T, Goñi F
Expert Rev Vaccines 2010 Dec;9(12):1441-52. doi: 10.1586/erv.10.131. PMID: 21105779Free PMC Article
Ito H
Curr Drug Targets Inflamm Allergy 2003 Jun;2(2):125-30. doi: 10.2174/1568010033484296. PMID: 14561164
Wang C, Swerdloff RS
Ann Med 1997 Oct;29(5):365-70. doi: 10.3109/07853899708999363. PMID: 9453281

Prognosis

Rodgers BD, Ward CW
Endocr Rev 2022 Mar 9;43(2):329-365. doi: 10.1210/endrev/bnab030. PMID: 34520530Free PMC Article
Osterholm MT, Anderson CJ, Zabel MD, Scheftel JM, Moore KA, Appleby BS
mBio 2019 Jul 23;10(4) doi: 10.1128/mBio.01091-19. PMID: 31337719Free PMC Article
Nance ME, Hakim CH, Yang NN, Duan D
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2018 Mar;10(2) Epub 2017 Apr 11 doi: 10.1002/wnan.1472. PMID: 28398005Free PMC Article
Johnson RT
Lancet Neurol 2005 Oct;4(10):635-42. doi: 10.1016/S1474-4422(05)70192-7. PMID: 16168932
Dillon MJ
Eur J Clin Pharmacol 1980 Jul;18(1):105-8. doi: 10.1007/BF00561486. PMID: 6249611

Clinical prediction guides

Birch SM, Lawlor MW, Conlon TJ, Guo LJ, Crudele JM, Hawkins EC, Nghiem PP, Ahn M, Meng H, Beatka MJ, Fickau BA, Prieto JC, Styner MA, Struharik MJ, Shanks C, Brown KJ, Golebiowski D, Bettis AK, Balog-Alvarez CJ, Clement N, Coleman KE, Corti M, Pan X, Hauschka SD, Gonzalez JP, Morris CA, Schneider JS, Duan D, Chamberlain JS, Byrne BJ, Kornegay JN
Sci Transl Med 2023 Jan 4;15(677):eabo1815. doi: 10.1126/scitranslmed.abo1815. PMID: 36599002Free PMC Article
Sakudo A
Curr Issues Mol Biol 2020;36:13-22. Epub 2019 Sep 9 doi: 10.21775/cimb.036.013. PMID: 31496519
Rohm M, Zeigerer A, Machado J, Herzig S
EMBO Rep 2019 Apr;20(4) Epub 2019 Mar 19 doi: 10.15252/embr.201847258. PMID: 30890538Free PMC Article
Mays CE, Soto C
Brain Res 2016 Oct 1;1648(Pt B):553-560. Epub 2016 Apr 6 doi: 10.1016/j.brainres.2016.04.009. PMID: 27060771
Johnson RT
Lancet Neurol 2005 Oct;4(10):635-42. doi: 10.1016/S1474-4422(05)70192-7. PMID: 16168932

Recent systematic reviews

Ni HJ, Hsu TF, Chen LK, Chou HL, Tung HH, Chow LH, Chen YC
Arch Gerontol Geriatr 2022 Mar-Apr;99:104605. Epub 2021 Dec 2 doi: 10.1016/j.archger.2021.104605. PMID: 34922244
Anker MS, Holcomb R, Muscaritoli M, von Haehling S, Haverkamp W, Jatoi A, Morley JE, Strasser F, Landmesser U, Coats AJS, Anker SD
J Cachexia Sarcopenia Muscle 2019 Feb;10(1):22-34. doi: 10.1002/jcsm.12402. PMID: 30920776Free PMC Article
Waddell L, Greig J, Mascarenhas M, Otten A, Corrin T, Hierlihy K
Transbound Emerg Dis 2018 Feb;65(1):37-49. Epub 2017 Jan 30 doi: 10.1111/tbed.12612. PMID: 28139079
Prousky JE
Altern Med Rev 2003 May;8(2):180-5. PMID: 12777163

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