U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Wasting disease

MedGen UID:
22696
•Concept ID:
C0043046
•
Disease or Syndrome
Synonyms: Wasting Disease; Wasting Diseases; Wasting Syndrome; Wasting Syndromes
SNOMED CT: Wasting disease (288517002)

Definition

Pathologic loss of more than 10% of body weight concurrent with 30 or more days of either diarrhea or weakness and fever. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWasting disease

Professional guidelines

PubMed

Newborn screening of duchenne muscular dystrophy specifically targeting deletions amenable to exon-skipping therapy.
Beckers P, Caberg JH, Dideberg V, Dangouloff T, den Dunnen JT, Bours V, Servais L, Boemer F
Sci Rep 2021 Feb 4;11(1):3011. doi: 10.1038/s41598-021-82725-z. PMID: 33542429Free PMC Article
A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease.
Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, Franch H, Guarnieri G, Ikizler TA, Kaysen G, Lindholm B, Massy Z, Mitch W, Pineda E, Stenvinkel P, Treviño-Becerra A, Wanner C
Kidney Int 2008 Feb;73(4):391-8. Epub 2007 Dec 19 doi: 10.1038/sj.ki.5002585. PMID: 18094682
Impact of kidney bone disease and its management on survival of patients on dialysis.
Lee GH, Benner D, Regidor DL, Kalantar-Zadeh K
J Ren Nutr 2007 Jan;17(1):38-44. doi: 10.1053/j.jrn.2006.07.006. PMID: 17198930

Recent clinical studies

Etiology

Anemia Is a Strong Predictor of Wasting, Disease Severity, and Progression, in Clinical Tuberculosis (TB).
Ashenafi S, Bekele A, Aseffa G, Amogne W, Kassa E, Aderaye G, Worku A, Bergman P, Brighenti S
Nutrients 2022 Aug 12;14(16) doi: 10.3390/nu14163318. PMID: 36014824Free PMC Article
The importance of ongoing international surveillance for Creutzfeldt-Jakob disease.
Watson N, Brandel JP, Green A, Hermann P, Ladogana A, Lindsay T, Mackenzie J, Pocchiari M, Smith C, Zerr I, Pal S
Nat Rev Neurol 2021 Jun;17(6):362-379. Epub 2021 May 10 doi: 10.1038/s41582-021-00488-7. PMID: 33972773Free PMC Article
Introduction to Current Progress in Advanced Research on Prions.
Onodera T, Sakudo A
Curr Issues Mol Biol 2020;36:63-66. Epub 2019 Sep 27 doi: 10.21775/cimb.036.063. PMID: 31559970
RECENT CHANGES IN INFECTIOUS DISEASES IN EUROPEAN WILDLIFE.
Yon L, Duff JP, Ågren EO, Erdélyi K, Ferroglio E, Godfroid J, Hars J, Hestvik G, Horton D, Kuiken T, Lavazza A, Markowska-Daniel I, Martel A, Neimanis A, Pasmans F, Price SJ, Ruiz-Fons F, Ryser-Degiorgis MP, Widén F, Gavier-Widén D
J Wildl Dis 2019 Jan;55(1):3-43. Epub 2018 Oct 4 doi: 10.7589/2017-07-172. PMID: 30284963
Prion Diseases.
Whitechurch BC, Welton JM, Collins SJ, Lawson VA
Adv Neurobiol 2017;15:335-364. doi: 10.1007/978-3-319-57193-5_13. PMID: 28674988

Diagnosis

Macrophages: A rising star in immunotherapy for chronic pancreatitis.
Xiang H, Yu H, Zhou Q, Wu Y, Ren J, Zhao Z, Tao X, Dong D
Pharmacol Res 2022 Nov;185:106508. Epub 2022 Oct 13 doi: 10.1016/j.phrs.2022.106508. PMID: 36243329
Anemia Is a Strong Predictor of Wasting, Disease Severity, and Progression, in Clinical Tuberculosis (TB).
Ashenafi S, Bekele A, Aseffa G, Amogne W, Kassa E, Aderaye G, Worku A, Bergman P, Brighenti S
Nutrients 2022 Aug 12;14(16) doi: 10.3390/nu14163318. PMID: 36014824Free PMC Article
The importance of ongoing international surveillance for Creutzfeldt-Jakob disease.
Watson N, Brandel JP, Green A, Hermann P, Ladogana A, Lindsay T, Mackenzie J, Pocchiari M, Smith C, Zerr I, Pal S
Nat Rev Neurol 2021 Jun;17(6):362-379. Epub 2021 May 10 doi: 10.1038/s41582-021-00488-7. PMID: 33972773Free PMC Article
Duchenne muscular dystrophy.
Duan D, Goemans N, Takeda S, Mercuri E, Aartsma-Rus A
Nat Rev Dis Primers 2021 Feb 18;7(1):13. doi: 10.1038/s41572-021-00248-3. PMID: 33602943
From diagnosis to therapy in Duchenne muscular dystrophy.
Babbs A, Chatzopoulou M, Edwards B, Squire SE, Wilkinson IVL, Wynne GM, Russell AJ, Davies KE
Biochem Soc Trans 2020 Jun 30;48(3):813-821. doi: 10.1042/BST20190282. PMID: 32597486Free PMC Article

Therapy

Macrophages: A rising star in immunotherapy for chronic pancreatitis.
Xiang H, Yu H, Zhou Q, Wu Y, Ren J, Zhao Z, Tao X, Dong D
Pharmacol Res 2022 Nov;185:106508. Epub 2022 Oct 13 doi: 10.1016/j.phrs.2022.106508. PMID: 36243329
Anemia Is a Strong Predictor of Wasting, Disease Severity, and Progression, in Clinical Tuberculosis (TB).
Ashenafi S, Bekele A, Aseffa G, Amogne W, Kassa E, Aderaye G, Worku A, Bergman P, Brighenti S
Nutrients 2022 Aug 12;14(16) doi: 10.3390/nu14163318. PMID: 36014824Free PMC Article
Gene Therapy for Duchenne Muscular Dystrophy.
Elangkovan N, Dickson G
J Neuromuscul Dis 2021;8(s2):S303-S316. doi: 10.3233/JND-210678. PMID: 34511510Free PMC Article
IL-6 and Crohn's disease.
Ito H
Curr Drug Targets Inflamm Allergy 2003 Jun;2(2):125-30. doi: 10.2174/1568010033484296. PMID: 14561164
Androgen replacement therapy.
Wang C, Swerdloff RS
Ann Med 1997 Oct;29(5):365-70. doi: 10.3109/07853899708999363. PMID: 9453281

Prognosis

Anemia Is a Strong Predictor of Wasting, Disease Severity, and Progression, in Clinical Tuberculosis (TB).
Ashenafi S, Bekele A, Aseffa G, Amogne W, Kassa E, Aderaye G, Worku A, Bergman P, Brighenti S
Nutrients 2022 Aug 12;14(16) doi: 10.3390/nu14163318. PMID: 36014824Free PMC Article
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs.
Rodgers BD, Ward CW
Endocr Rev 2022 Mar 9;43(2):329-365. doi: 10.1210/endrev/bnab030. PMID: 34520530Free PMC Article
Nanotherapy for Duchenne muscular dystrophy.
Nance ME, Hakim CH, Yang NN, Duan D
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2018 Mar;10(2) Epub 2017 Apr 11 doi: 10.1002/wnan.1472. PMID: 28398005Free PMC Article
Prion diseases.
Johnson RT
Lancet Neurol 2005 Oct;4(10):635-42. doi: 10.1016/S1474-4422(05)70192-7. PMID: 16168932
Renin-angiotensin-aldosterone system.
Dillon MJ
Eur J Clin Pharmacol 1980 Jul;18(1):105-8. doi: 10.1007/BF00561486. PMID: 6249611

Clinical prediction guides

Assessment of systemic AAV-microdystrophin gene therapy in the GRMD model of Duchenne muscular dystrophy.
Birch SM, Lawlor MW, Conlon TJ, Guo LJ, Crudele JM, Hawkins EC, Nghiem PP, Ahn M, Meng H, Beatka MJ, Fickau BA, Prieto JC, Styner MA, Struharik MJ, Shanks C, Brown KJ, Golebiowski D, Bettis AK, Balog-Alvarez CJ, Clement N, Coleman KE, Corti M, Pan X, Hauschka SD, Gonzalez JP, Morris CA, Schneider JS, Duan D, Chamberlain JS, Byrne BJ, Kornegay JN
Sci Transl Med 2023 Jan 4;15(677):eabo1815. doi: 10.1126/scitranslmed.abo1815. PMID: 36599002
Anemia Is a Strong Predictor of Wasting, Disease Severity, and Progression, in Clinical Tuberculosis (TB).
Ashenafi S, Bekele A, Aseffa G, Amogne W, Kassa E, Aderaye G, Worku A, Bergman P, Brighenti S
Nutrients 2022 Aug 12;14(16) doi: 10.3390/nu14163318. PMID: 36014824Free PMC Article
Energy metabolism in cachexia.
Rohm M, Zeigerer A, Machado J, Herzig S
EMBO Rep 2019 Apr;20(4) Epub 2019 Mar 19 doi: 10.15252/embr.201847258. PMID: 30890538Free PMC Article
Prion diseases.
Johnson RT
Lancet Neurol 2005 Oct;4(10):635-42. doi: 10.1016/S1474-4422(05)70192-7. PMID: 16168932
Renin-angiotensin-aldosterone system.
Dillon MJ
Eur J Clin Pharmacol 1980 Jul;18(1):105-8. doi: 10.1007/BF00561486. PMID: 6249611

Recent systematic reviews

Effects of Exercise Programs in older adults with Muscle Wasting: A Systematic Review and Meta-analysis: Effects of Exercise Programs in Muscle Wasting.
Ni HJ, Hsu TF, Chen LK, Chou HL, Tung HH, Chow LH, Chen YC
Arch Gerontol Geriatr 2022 Mar-Apr;99:104605. Epub 2021 Dec 2 doi: 10.1016/j.archger.2021.104605. PMID: 34922244
Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic review.
Anker MS, Holcomb R, Muscaritoli M, von Haehling S, Haverkamp W, Jatoi A, Morley JE, Strasser F, Landmesser U, Coats AJS, Anker SD
J Cachexia Sarcopenia Muscle 2019 Feb;10(1):22-34. doi: 10.1002/jcsm.12402. PMID: 30920776Free PMC Article
Current evidence on the transmissibility of chronic wasting disease prions to humans-A systematic review.
Waddell L, Greig J, Mascarenhas M, Otten A, Corrin T, Hierlihy K
Transbound Emerg Dis 2018 Feb;65(1):37-49. Epub 2017 Jan 30 doi: 10.1111/tbed.12612. PMID: 28139079
Pellagra may be a rare secondary complication of anorexia nervosa: a systematic review of the literature.
Prousky JE
Altern Med Rev 2003 May;8(2):180-5. PMID: 12777163

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...