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Grade II Squamous Intraepithelial Neoplasia

MedGen UID:
226999
•Concept ID:
C1302798
•
Neoplastic Process
Synonyms: Grade 2 Squamous Intraepithelial Lesion; Grade 2 Squamous Intraepithelial Neoplasia; Grade II Squamous Intraepithelial Lesion; Squamous intraepithelial neoplasia grade 2; Squamous intraepithelial neoplasia, grade II
SNOMED CT: Squamous intraepithelial neoplasia grade 2 (400049009); Squamous intraepithelial neoplasia, grade II (400049009)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade II Squamous Intraepithelial Neoplasia

Professional guidelines

PubMed

Clinical management of cervical intraepithelial neoplasia in pregnant and postpartum women.
Wu YM, Wang T, He Y, Song F, Wang Y, Zhu L, Kong WM, Duan W, Zhang WY
Arch Gynecol Obstet 2014 May;289(5):1071-7. Epub 2013 Nov 7 doi: 10.1007/s00404-013-3076-5. PMID: 24196304
Controversies in the management of anal high-grade squamous intraepithelial lesions.
Pineda CE, Welton ML
Minerva Chir 2008 Oct;63(5):389-99. PMID: 18923350
Conservative management of adolescents with abnormal cytology and histology.
Moscicki AB
J Natl Compr Canc Netw 2008 Jan;6(1):101-6. doi: 10.6004/jnccn.2008.0010. PMID: 18267063Free PMC Article

Recent clinical studies

Etiology

The role of endocervicoscopy in women with cervical intraepithelial neoplasia: a systematic review of the literature.
Della Corte L, Mercorio A, Giampaolino P, Vitale SG, Vizzielli G, Bifulco G, Lavitola G
Updates Surg 2022 Aug;74(4):1239-1245. Epub 2021 Nov 5 doi: 10.1007/s13304-021-01193-2. PMID: 34739708
Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial.
Fonseca BO, Possati-Resende JC, Salcedo MP, Schmeler KM, Accorsi GS, Fregnani JHTG, Antoniazzi M, Pantano NP, Santana IVV, Matsushita GM, Dos Reis R
Obstet Gynecol 2021 Jun 1;137(6):1043-1053. doi: 10.1097/AOG.0000000000004384. PMID: 33957649Free PMC Article
Controversies in the management of anal high-grade squamous intraepithelial lesions.
Pineda CE, Welton ML
Minerva Chir 2008 Oct;63(5):389-99. PMID: 18923350
Cervical intraepithelial neoplasia.
Crum CP, McLachlin CM
J Cell Biochem Suppl 1995;23:71-9. doi: 10.1002/jcb.240590910. PMID: 8747380
Human papillomavirus infection and intraepithelial, in situ, and invasive carcinoma of penis.
Malek RS, Goellner JR, Smith TF, Espy MJ, Cupp MR
Urology 1993 Aug;42(2):159-70. doi: 10.1016/0090-4295(93)90640-v. PMID: 8396280

Diagnosis

The role of endocervicoscopy in women with cervical intraepithelial neoplasia: a systematic review of the literature.
Della Corte L, Mercorio A, Giampaolino P, Vitale SG, Vizzielli G, Bifulco G, Lavitola G
Updates Surg 2022 Aug;74(4):1239-1245. Epub 2021 Nov 5 doi: 10.1007/s13304-021-01193-2. PMID: 34739708
Primary squamous cell carcinoma of the ovary. Review of the literature.
Koufopoulos N, Nasi D, Goudeli C, Antoniadou F, Kokkali S, Pigadioti E, Provatas I, Maggo E, Ardavanis A, Terzakis E, Arkoumani E, J Agnantis N, Apostolikas N, Khaldi L
J BUON 2019 Sep-Oct;24(5):1776-1784. PMID: 31786837
Histology of cervical intraepithelial neoplasia and the role of biomarkers.
Martin CM, O'Leary JJ
Best Pract Res Clin Obstet Gynaecol 2011 Oct;25(5):605-15. Epub 2011 Jun 1 doi: 10.1016/j.bpobgyn.2011.04.005. PMID: 21636328
Controversies in the management of anal high-grade squamous intraepithelial lesions.
Pineda CE, Welton ML
Minerva Chir 2008 Oct;63(5):389-99. PMID: 18923350
Cervical intraepithelial neoplasia.
Crum CP, McLachlin CM
J Cell Biochem Suppl 1995;23:71-9. doi: 10.1002/jcb.240590910. PMID: 8747380

Therapy

Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy on cervical low-grade squamous intraepithelial lesions with high-risk HPV infection.
Wang X, You L, Zhang W, Ma Y, Tang Y, Xu W
Photodiagnosis Photodyn Ther 2022 Jun;38:102807. Epub 2022 Mar 11 doi: 10.1016/j.pdpdt.2022.102807. PMID: 35288319
Topical imiquimod compared with conization to treat cervical high-grade squamous intraepithelial lesions: Multicenter, randomized controlled trial.
Polterauer S, Reich O, Widschwendter A, Hadjari L, Bogner G, Reinthaller A, Joura E, Trutnovsky G, Ciresa-Koenig A, Ganhoer-Schimboeck J, Boehm I, Berger R, Langthaler E, Aberle SW, Heinze G, Gleiss A, Grimm C
Gynecol Oncol 2022 Apr;165(1):23-29. Epub 2022 Feb 15 doi: 10.1016/j.ygyno.2022.01.033. PMID: 35177279
Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial.
Fonseca BO, Possati-Resende JC, Salcedo MP, Schmeler KM, Accorsi GS, Fregnani JHTG, Antoniazzi M, Pantano NP, Santana IVV, Matsushita GM, Dos Reis R
Obstet Gynecol 2021 Jun 1;137(6):1043-1053. doi: 10.1097/AOG.0000000000004384. PMID: 33957649Free PMC Article
Controversies in the management of anal high-grade squamous intraepithelial lesions.
Pineda CE, Welton ML
Minerva Chir 2008 Oct;63(5):389-99. PMID: 18923350
Cervical intraepithelial neoplasia.
Crum CP, McLachlin CM
J Cell Biochem Suppl 1995;23:71-9. doi: 10.1002/jcb.240590910. PMID: 8747380

Prognosis

The role of endocervicoscopy in women with cervical intraepithelial neoplasia: a systematic review of the literature.
Della Corte L, Mercorio A, Giampaolino P, Vitale SG, Vizzielli G, Bifulco G, Lavitola G
Updates Surg 2022 Aug;74(4):1239-1245. Epub 2021 Nov 5 doi: 10.1007/s13304-021-01193-2. PMID: 34739708
Primary squamous cell carcinoma of the ovary. Review of the literature.
Koufopoulos N, Nasi D, Goudeli C, Antoniadou F, Kokkali S, Pigadioti E, Provatas I, Maggo E, Ardavanis A, Terzakis E, Arkoumani E, J Agnantis N, Apostolikas N, Khaldi L
J BUON 2019 Sep-Oct;24(5):1776-1784. PMID: 31786837
Histology of cervical intraepithelial neoplasia and the role of biomarkers.
Martin CM, O'Leary JJ
Best Pract Res Clin Obstet Gynaecol 2011 Oct;25(5):605-15. Epub 2011 Jun 1 doi: 10.1016/j.bpobgyn.2011.04.005. PMID: 21636328
Controversies in the management of anal high-grade squamous intraepithelial lesions.
Pineda CE, Welton ML
Minerva Chir 2008 Oct;63(5):389-99. PMID: 18923350
Human papillomavirus infection and intraepithelial, in situ, and invasive carcinoma of penis.
Malek RS, Goellner JR, Smith TF, Espy MJ, Cupp MR
Urology 1993 Aug;42(2):159-70. doi: 10.1016/0090-4295(93)90640-v. PMID: 8396280

Clinical prediction guides

Topical imiquimod compared with conization to treat cervical high-grade squamous intraepithelial lesions: Multicenter, randomized controlled trial.
Polterauer S, Reich O, Widschwendter A, Hadjari L, Bogner G, Reinthaller A, Joura E, Trutnovsky G, Ciresa-Koenig A, Ganhoer-Schimboeck J, Boehm I, Berger R, Langthaler E, Aberle SW, Heinze G, Gleiss A, Grimm C
Gynecol Oncol 2022 Apr;165(1):23-29. Epub 2022 Feb 15 doi: 10.1016/j.ygyno.2022.01.033. PMID: 35177279
The role of endocervicoscopy in women with cervical intraepithelial neoplasia: a systematic review of the literature.
Della Corte L, Mercorio A, Giampaolino P, Vitale SG, Vizzielli G, Bifulco G, Lavitola G
Updates Surg 2022 Aug;74(4):1239-1245. Epub 2021 Nov 5 doi: 10.1007/s13304-021-01193-2. PMID: 34739708
Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial.
Fonseca BO, Possati-Resende JC, Salcedo MP, Schmeler KM, Accorsi GS, Fregnani JHTG, Antoniazzi M, Pantano NP, Santana IVV, Matsushita GM, Dos Reis R
Obstet Gynecol 2021 Jun 1;137(6):1043-1053. doi: 10.1097/AOG.0000000000004384. PMID: 33957649Free PMC Article
Colposcopic patterns of vaginal intraepithelial neoplasia: a focus on low-grade lesions.
Sopracordevole F, Clemente N, Barbero M, Agarossi A, Cattani P, Garutti P, Fallani MG, Pieralli A, Boselli F, Frega A, De Piero G, Del Fabro A, Buttignol M, Ciavattini A; Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV)
Eur Rev Med Pharmacol Sci 2017 Jun;21(12):2823-2828. PMID: 28682436
Histology of cervical intraepithelial neoplasia and the role of biomarkers.
Martin CM, O'Leary JJ
Best Pract Res Clin Obstet Gynaecol 2011 Oct;25(5):605-15. Epub 2011 Jun 1 doi: 10.1016/j.bpobgyn.2011.04.005. PMID: 21636328

Recent systematic reviews

The role of endocervicoscopy in women with cervical intraepithelial neoplasia: a systematic review of the literature.
Della Corte L, Mercorio A, Giampaolino P, Vitale SG, Vizzielli G, Bifulco G, Lavitola G
Updates Surg 2022 Aug;74(4):1239-1245. Epub 2021 Nov 5 doi: 10.1007/s13304-021-01193-2. PMID: 34739708
A Meta-Analysis on Human Papillomavirus Type Distribution among Women with Cervical Neoplasia in the WHO Eastern Mediterranean Region.
Shoja Z, Farahmand M, Hosseini N, Jalilvand S
Intervirology 2019;62(3-4):101-111. Epub 2019 Sep 17 doi: 10.1159/000502824. PMID: 31527382
Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions.
Arbyn M, Roelens J, Simoens C, Buntinx F, Paraskevaidis E, Martin-Hirsch PP, Prendiville WJ
Cochrane Database Syst Rev 2013 Mar 28;2013(3):CD008054. doi: 10.1002/14651858.CD008054.pub2. PMID: 23543559Free PMC Article

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