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Altitude sickness

MedGen UID:
229
•Concept ID:
C0002351
•
Disease or Syndrome
Synonyms: Altitude anoxia; High altitude cerebral edema; Mountain sickness
SNOMED CT: Effects of high altitude (87284002); Hypobaropathy (87284002); Anoxia caused by high altitude (42883007); Illnesses due to high altitude effects (87284002); Anoxia due to high altitude (42883007); Alpine sickness (42883007)
 
Monarch Initiative: MONDO:0006625

Definition

Multiple symptoms associated with reduced oxygen at high altitude. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAltitude sickness

Professional guidelines

PubMed

Challenges in the management of high-altitude illnesses and emergencies in Bhutan and Nepal.
Dorji T, Giri S, Tshering U, LeVine S, Tshering U, Chhetri S, Dhakal N, Gaikwad SN, Flaherty GT, Lucero-Prisno DE 3rd, McIntosh S
Travel Med Infect Dis 2023 Nov-Dec;56:102660. Epub 2023 Nov 4 doi: 10.1016/j.tmaid.2023.102660. PMID: 37926372
Highland mate: Edible and functional foods in traditional medicine for the prevention and treatment of hypoxia-related symptoms.
Hou Y, Wang X, Zhang Y, Wang S, Meng X
Curr Opin Pharmacol 2021 Oct;60:306-314. Epub 2021 Sep 8 doi: 10.1016/j.coph.2021.07.018. PMID: 34508939
Travel Medicine: Clinical Updates in Women's Health Care Primary and Preventive Care Review.
Rosenbaum AJ, Stringer JSA
Obstet Gynecol 2020 Nov;136(5):1074. doi: 10.1097/AOG.0000000000004136. PMID: 33093424

Recent clinical studies

Etiology

Medical Conditions and High-Altitude Travel.
Luks AM, Hackett PH
N Engl J Med 2022 Jan 27;386(4):364-373. doi: 10.1056/NEJMra2104829. PMID: 35081281
Mountain neurology.
Dekker MCJ, Wilson MH, Howlett WP
Pract Neurol 2019 Oct;19(5):404-411. Epub 2019 Jun 8 doi: 10.1136/practneurol-2017-001783. PMID: 31177100
Acute high-altitude sickness.
Luks AM, Swenson ER, Bärtsch P
Eur Respir Rev 2017 Jan;26(143) Epub 2017 Jan 31 doi: 10.1183/16000617.0096-2016. PMID: 28143879Free PMC Article
High altitude illness.
Hartman-Ksycińska A, Kluz-Zawadzka J, Lewandowski B
Przegl Epidemiol 2016;70(3):490-499. PMID: 27888818
High-Altitude Medicine.
Johnson NJ, Luks AM
Med Clin North Am 2016 Mar;100(2):357-69. doi: 10.1016/j.mcna.2015.09.002. PMID: 26900119

Diagnosis

High-altitude mountain telemedicine.
Martinelli M, Moroni D, Bastiani L, Mrakic-Sposta S, Giardini G, Pratali L
J Telemed Telecare 2022 Feb;28(2):135-145. Epub 2020 Jun 15 doi: 10.1177/1357633X20921020. PMID: 32539486Free PMC Article
Acute high-altitude sickness.
Luks AM, Swenson ER, Bärtsch P
Eur Respir Rev 2017 Jan;26(143) Epub 2017 Jan 31 doi: 10.1183/16000617.0096-2016. PMID: 28143879Free PMC Article
High-altitude headache.
Marmura MJ, Hernandez PB
Curr Pain Headache Rep 2015 May;19(5):483. doi: 10.1007/s11916-015-0483-2. PMID: 25795155
High-altitude headache.
Serrano-Dueñas M
Expert Rev Neurother 2007 Mar;7(3):245-8. doi: 10.1586/14737175.7.3.245. PMID: 17341172
High-altitude illness.
Gallagher SA, Hackett PH
Emerg Med Clin North Am 2004 May;22(2):329-55, viii. doi: 10.1016/j.emc.2004.02.001. PMID: 15163571

Therapy

Medical Conditions and High-Altitude Travel.
Luks AM, Hackett PH
N Engl J Med 2022 Jan 27;386(4):364-373. doi: 10.1056/NEJMra2104829. PMID: 35081281
Research advances in pathogenesis and prophylactic measures of acute high altitude illness.
Li Y, Zhang Y, Zhang Y
Respir Med 2018 Dec;145:145-152. Epub 2018 Nov 8 doi: 10.1016/j.rmed.2018.11.004. PMID: 30509704
Altitude sickness.
Murdoch D
BMJ Clin Evid 2010 Mar 18;2010 PMID: 21718562Free PMC Article
Acute mountain sickness: pathophysiology, prevention, and treatment.
Imray C, Wright A, Subudhi A, Roach R
Prog Cardiovasc Dis 2010 May-Jun;52(6):467-84. doi: 10.1016/j.pcad.2010.02.003. PMID: 20417340
Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness.
Leaf DE, Goldfarb DS
J Appl Physiol (1985) 2007 Apr;102(4):1313-22. Epub 2006 Oct 5 doi: 10.1152/japplphysiol.01572.2005. PMID: 17023566

Prognosis

Comprehensive viewpoints on heart rate variability at high altitude.
Hou J, Lu K, Chen P, Wang P, Li J, Yang J, Liu Q, Xue Q, Tang Z, Pei H
Clin Exp Hypertens 2023 Dec 31;45(1):2238923. doi: 10.1080/10641963.2023.2238923. PMID: 37552638
COULD COVID-19 BE A HEMOGLOBINOPATHY?
Shakoori TA, Hafeez MM, Malik A
Acta Clin Croat 2020 Dec;59(4):740-744. doi: 10.20471/acc.2020.59.04.21. PMID: 34285445Free PMC Article
Acute high-altitude sickness.
Luks AM, Swenson ER, Bärtsch P
Eur Respir Rev 2017 Jan;26(143) Epub 2017 Jan 31 doi: 10.1183/16000617.0096-2016. PMID: 28143879Free PMC Article
Hypoxia-related altitude illnesses.
Netzer N, Strohl K, Faulhaber M, Gatterer H, Burtscher M
J Travel Med 2013 Jul-Aug;20(4):247-55. Epub 2013 Mar 11 doi: 10.1111/jtm.12017. PMID: 23809076
Altitude sickness.
Hull FM
J R Coll Gen Pract 1978 Aug;28(193):473-7. PMID: 702462Free PMC Article

Clinical prediction guides

Adaptation and altitude sickness: A 40-year bibliometric analysis and collaborative networks.
Zila-Velasque JP, Grados-Espinoza P, Morán-Mariños C, Morales Pocco KO, Capcha-Jimenez US, Ortiz-Benique ZN
Front Public Health 2023;11:1069212. Epub 2023 Mar 2 doi: 10.3389/fpubh.2023.1069212. PMID: 36935697Free PMC Article
High-altitude mountain telemedicine.
Martinelli M, Moroni D, Bastiani L, Mrakic-Sposta S, Giardini G, Pratali L
J Telemed Telecare 2022 Feb;28(2):135-145. Epub 2020 Jun 15 doi: 10.1177/1357633X20921020. PMID: 32539486Free PMC Article
The 2018 Lake Louise Acute Mountain Sickness Score.
Roach RC, Hackett PH, Oelz O, Bärtsch P, Luks AM, MacInnis MJ, Baillie JK; Lake Louise AMS Score Consensus Committee
High Alt Med Biol 2018 Mar;19(1):4-6. Epub 2018 Mar 13 doi: 10.1089/ham.2017.0164. PMID: 29583031Free PMC Article
High-altitude headache.
Serrano-Dueñas M
Expert Rev Neurother 2007 Mar;7(3):245-8. doi: 10.1586/14737175.7.3.245. PMID: 17341172
Altitude sickness.
Hull FM
J R Coll Gen Pract 1978 Aug;28(193):473-7. PMID: 702462Free PMC Article

Recent systematic reviews

High-Altitude Exposure and Cerebral Venous Thrombosis: An Updated Systematic Review.
Kharel S, Shrestha S, Pant SR, Acharya S, Sharma A, Baniya S, Bhandari SS
High Alt Med Biol 2023 Sep;24(3):167-174. Epub 2023 Aug 24 doi: 10.1089/ham.2022.0106. PMID: 37615608
A Systematic Review and Meta-Analysis of Decompression Sickness in Altitude Physiological Training.
Conkin J, Sanders RW, Koslovsky MD, Wear ML, Kozminski AG, Abercromby AFJ
Aerosp Med Hum Perform 2018 Nov 1;89(11):941-951. doi: 10.3357/AMHP.5135.2018. PMID: 30352646
Interventions for treating acute high altitude illness.
Simancas-Racines D, Arevalo-Rodriguez I, Osorio D, Franco JV, Xu Y, Hidalgo R
Cochrane Database Syst Rev 2018 Jun 30;6(6):CD009567. doi: 10.1002/14651858.CD009567.pub2. PMID: 29959871Free PMC Article
Pharmacologic prophylaxis for acute mountain sickness: a systematic shortcut review.
Seupaul RA, Welch JL, Malka ST, Emmett TW
Ann Emerg Med 2012 Apr;59(4):307-317.e1. Epub 2011 Dec 7 doi: 10.1016/j.annemergmed.2011.10.015. PMID: 22153998
Altitude sickness.
Murdoch D
BMJ Clin Evid 2010 Mar 18;2010 PMID: 21718562Free PMC Article

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