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Adenocarcinoma of the large intestine

MedGen UID:
230816
•Concept ID:
C1319315
•
Neoplastic Process
Synonym: Colorectal adenocarcinoma
SNOMED CT: Adenocarcinoma of large intestine (408645001)
 
HPO: HP:0040275
Monarch Initiative: MONDO:0005008

Definition

A malignant epithelial tumor with a glandular organization that originates in the large intestine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma of the large intestine

Recent clinical studies

Etiology

Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study.
Separovic D, Shields AF, Philip PA, Bielawski J, Bielawska A, Pierce JS, Tarca AL
Anticancer Res 2017 Mar;37(3):1213-1218. doi: 10.21873/anticanres.11436. PMID: 28314284Free PMC Article
Primary signet-ring cell carcinoma of the colon and rectum.
Anthony T, George R, Rodriguez-Bigas M, Petrelli NJ
Ann Surg Oncol 1996 Jul;3(4):344-8. doi: 10.1007/BF02305663. PMID: 8790846
Feasibility of photodynamic therapy using endogenous photosensitization for colon cancer.
Fromm D, Kessel D, Webber J
Arch Surg 1996 Jun;131(6):667-9. doi: 10.1001/archsurg.1996.01430180093020. PMID: 8645077
Phase II evaluation of ftorafur in previously untreated colorectal cancer: a Southwest Oncology Group Study.
Buroker T, Padilla F, Groppe C, Guy G, Quagliana J, McCracken J, Vaitkevicius VK, Hoogstraten B, Heilbrun L
Cancer 1979 Jul;44(1):48-51. doi: 10.1002/1097-0142(197907)44:1<48::aid-cncr2820440109>3.0.co;2-c. PMID: 378365
The earlier diagnosis of adenocarcinoma of the large intestine. A report of 1,884 cases, including 5-year follow-up survival data, results of surgery for the disease, and effect on survival prognosis of treatment earlier in the development of the disease.
Gilbertsen VA
Cancer 1971 Jan;27(1):143-9. doi: 10.1002/1097-0142(197101)27:1<143::aid-cncr2820270122>3.0.co;2-w. PMID: 5539622

Diagnosis

Peritoneal "melanosis".
Chang ES, Bachul P, Szura M, Szpor J, Okoń K, Walocha JA
Pol J Pathol 2015 Sep;66(3):330-3. PMID: 26619112
Signet-ring cell carcinoma of the colon 7mm in size with peritonitis carcinomatosa.
Shimaoka S, Niihara T, Tashiro K, Matsuda A, Nioh T, Ohi H, Nishimata Y, Nishimata H, Fujita H, Ohkura Y, Hamada M
J Gastroenterol 2002;37(7):550-5. doi: 10.1007/s005350200085. PMID: 12162414
Primary signet-ring cell carcinoma of the colon and rectum.
Anthony T, George R, Rodriguez-Bigas M, Petrelli NJ
Ann Surg Oncol 1996 Jul;3(4):344-8. doi: 10.1007/BF02305663. PMID: 8790846
Clear-cell epithelial neoplasms of the large intestine.
Jewell LD, Barr JR, McCaughey WT, Nguyen GK, Owen DA
Arch Pathol Lab Med 1988 Feb;112(2):197-9. PMID: 3276291
Adenocarcinoma of the large intestine in young adults.
Vezzoni P, Clemente C, Gennari L
Tumori 1977 Nov-Dec;63(6):565-73. doi: 10.1177/030089167706300610. PMID: 601884

Therapy

Feasibility of photodynamic therapy using endogenous photosensitization for colon cancer.
Fromm D, Kessel D, Webber J
Arch Surg 1996 Jun;131(6):667-9. doi: 10.1001/archsurg.1996.01430180093020. PMID: 8645077
Phase II evaluation of ftorafur in previously untreated colorectal cancer: a Southwest Oncology Group Study.
Buroker T, Padilla F, Groppe C, Guy G, Quagliana J, McCracken J, Vaitkevicius VK, Hoogstraten B, Heilbrun L
Cancer 1979 Jul;44(1):48-51. doi: 10.1002/1097-0142(197907)44:1<48::aid-cncr2820440109>3.0.co;2-c. PMID: 378365
Clinical trial of rubidazone in advanced squamous cell carcinoma of the lung and adenocarcinoma of the large intestine.
Fraile RJ, Samson MK, Buroker TR, O'Bryan R, Baker LH, Vaitkevicius VK
Cancer Treat Rep 1978 Oct;62(10):1599-601. PMID: 361229
Evaluation of daunorubicin in adenocarcinoma of the large intestine.
Weiss AJ, Cantor RI
Cancer Treat Rep 1976 Nov;60(11):1667-70. PMID: 1021236

Prognosis

Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study.
Separovic D, Shields AF, Philip PA, Bielawski J, Bielawska A, Pierce JS, Tarca AL
Anticancer Res 2017 Mar;37(3):1213-1218. doi: 10.21873/anticanres.11436. PMID: 28314284Free PMC Article
Update on the serrated pathway to colorectal carcinoma.
Snover DC
Hum Pathol 2011 Jan;42(1):1-10. Epub 2010 Sep 24 doi: 10.1016/j.humpath.2010.06.002. PMID: 20869746
Primary signet-ring cell carcinoma of the colon and rectum.
Anthony T, George R, Rodriguez-Bigas M, Petrelli NJ
Ann Surg Oncol 1996 Jul;3(4):344-8. doi: 10.1007/BF02305663. PMID: 8790846
Primary linitis plastica of the colon: report of two cases and review of the literature.
Amorn Y, Knight WA Jr
Cancer 1978 Jun;41(6):2420-5. doi: 10.1002/1097-0142(197806)41:6<2420::aid-cncr2820410648>3.0.co;2-l. PMID: 207410
Adenocarcinoma of the large intestine in young adults.
Vezzoni P, Clemente C, Gennari L
Tumori 1977 Nov-Dec;63(6):565-73. doi: 10.1177/030089167706300610. PMID: 601884

Clinical prediction guides

Synchronous appearance of gastric gastrointestinal stromal tumors and colorectal adenocarcinoma:a case report.
Dragan R, Dejan S, Nebojsa M, Vinka V, Predrag S, Dragos S, Vladan Z, Dragoljub B
Hepatogastroenterology 2011 Nov-Dec;58(112):2171-4. doi: 10.5754/hge09042. PMID: 22234087
Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines.
Knutsen T, Padilla-Nash HM, Wangsa D, Barenboim-Stapleton L, Camps J, McNeil N, Difilippantonio MJ, Ried T
Genes Chromosomes Cancer 2010 Mar;49(3):204-23. doi: 10.1002/gcc.20730. PMID: 19927377Free PMC Article
Signet-ring cell carcinoma of the colon 7mm in size with peritonitis carcinomatosa.
Shimaoka S, Niihara T, Tashiro K, Matsuda A, Nioh T, Ohi H, Nishimata Y, Nishimata H, Fujita H, Ohkura Y, Hamada M
J Gastroenterol 2002;37(7):550-5. doi: 10.1007/s005350200085. PMID: 12162414
Clear-cell epithelial neoplasms of the large intestine.
Jewell LD, Barr JR, McCaughey WT, Nguyen GK, Owen DA
Arch Pathol Lab Med 1988 Feb;112(2):197-9. PMID: 3276291
Adenocarcinoma of the large intestine in young adults.
Vezzoni P, Clemente C, Gennari L
Tumori 1977 Nov-Dec;63(6):565-73. doi: 10.1177/030089167706300610. PMID: 601884

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