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Hemorrhage of bile duct

MedGen UID:
230968
•Concept ID:
C1328491
•
Pathologic Function
Synonym: Bile Duct Hemorrhage
SNOMED CT: Hemorrhage of bile duct (721720000)

Definition

Bleeding originating from the bile duct. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemorrhage of bile duct

Professional guidelines

PubMed

Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Feb;34(2):127-140. Epub 2022 Nov 10 doi: 10.1016/j.annonc.2022.10.506. PMID: 36372281
Cholelithiasis: Presentation and Management.
Littlefield A, Lenahan C
J Midwifery Womens Health 2019 May;64(3):289-297. Epub 2019 Mar 25 doi: 10.1111/jmwh.12959. PMID: 30908805
Management of post-hepatectomy complications.
Jin S, Fu Q, Wuyun G, Wuyun T
World J Gastroenterol 2013 Nov 28;19(44):7983-91. doi: 10.3748/wjg.v19.i44.7983. PMID: 24307791Free PMC Article

Recent clinical studies

Etiology

Cholangiopathy After Severe COVID-19: Clinical Features and Prognostic Implications.
Faruqui S, Okoli FC, Olsen SK, Feldman DM, Kalia HS, Park JS, Stanca CM, Figueroa Diaz V, Yuan S, Dagher NN, Sarkar SA, Theise ND, Kim S, Shanbhogue K, Jacobson IM
Am J Gastroenterol 2021 Jul 1;116(7):1414-1425. doi: 10.14309/ajg.0000000000001264. PMID: 33993134
Biliary reconstruction and complications in living donor liver transplantation.
Jung DH, Ikegami T, Balci D, Bhangui P
Int J Surg 2020 Oct;82S:138-144. Epub 2020 May 5 doi: 10.1016/j.ijsu.2020.04.069. PMID: 32387205
Targeting cholangiocarcinoma.
Mertens JC, Rizvi S, Gores GJ
Biochim Biophys Acta Mol Basis Dis 2018 Apr;1864(4 Pt B):1454-1460. Epub 2017 Aug 24 doi: 10.1016/j.bbadis.2017.08.027. PMID: 28844952Free PMC Article
Evaluation and management of intrahepatic and extrahepatic cholangiocarcinoma.
Esnaola NF, Meyer JE, Karachristos A, Maranki JL, Camp ER, Denlinger CS
Cancer 2016 May 1;122(9):1349-69. Epub 2016 Jan 22 doi: 10.1002/cncr.29692. PMID: 26799932
Ischemic cholangiopathy.
Deltenre P, Valla DC
Semin Liver Dis 2008 Aug;28(3):235-46. Epub 2008 Sep 23 doi: 10.1055/s-0028-1085092. PMID: 18814077

Diagnosis

Infigratinib for cholangiocarcinoma.
Sadeghi S
Drugs Today (Barc) 2022 Jul;58(7):327-334. doi: 10.1358/dot.2022.58.7.3408813. PMID: 35851868
Cholangiopathy After Severe COVID-19: Clinical Features and Prognostic Implications.
Faruqui S, Okoli FC, Olsen SK, Feldman DM, Kalia HS, Park JS, Stanca CM, Figueroa Diaz V, Yuan S, Dagher NN, Sarkar SA, Theise ND, Kim S, Shanbhogue K, Jacobson IM
Am J Gastroenterol 2021 Jul 1;116(7):1414-1425. doi: 10.14309/ajg.0000000000001264. PMID: 33993134
Portal biliopathy.
Khuroo MS, Rather AA, Khuroo NS, Khuroo MS
World J Gastroenterol 2016 Sep 21;22(35):7973-82. doi: 10.3748/wjg.v22.i35.7973. PMID: 27672292Free PMC Article
Evaluation and management of intrahepatic and extrahepatic cholangiocarcinoma.
Esnaola NF, Meyer JE, Karachristos A, Maranki JL, Camp ER, Denlinger CS
Cancer 2016 May 1;122(9):1349-69. Epub 2016 Jan 22 doi: 10.1002/cncr.29692. PMID: 26799932
Hemobilia.
Chin MW, Enns R
Curr Gastroenterol Rep 2010 Apr;12(2):121-9. doi: 10.1007/s11894-010-0092-5. PMID: 20424984

Therapy

Infigratinib for cholangiocarcinoma.
Sadeghi S
Drugs Today (Barc) 2022 Jul;58(7):327-334. doi: 10.1358/dot.2022.58.7.3408813. PMID: 35851868
Molecular Characterization of Biliary Tract Cancer Predicts Chemotherapy and Programmed Death 1/Programmed Death-Ligand 1 Blockade Responses.
Yoon JG, Kim MH, Jang M, Kim H, Hwang HK, Kang CM, Lee WJ, Kang B, Lee CK, Lee MG, Chung HC, Choi HJ, Park YN
Hepatology 2021 Oct;74(4):1914-1931. Epub 2021 Jul 29 doi: 10.1002/hep.31862. PMID: 33884649
Biliary reconstruction and complications in living donor liver transplantation.
Jung DH, Ikegami T, Balci D, Bhangui P
Int J Surg 2020 Oct;82S:138-144. Epub 2020 May 5 doi: 10.1016/j.ijsu.2020.04.069. PMID: 32387205
Portal biliopathy.
Khuroo MS, Rather AA, Khuroo NS, Khuroo MS
World J Gastroenterol 2016 Sep 21;22(35):7973-82. doi: 10.3748/wjg.v22.i35.7973. PMID: 27672292Free PMC Article
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.
Tran E, Turcotte S, Gros A, Robbins PF, Lu YC, Dudley ME, Wunderlich JR, Somerville RP, Hogan K, Hinrichs CS, Parkhurst MR, Yang JC, Rosenberg SA
Science 2014 May 9;344(6184):641-5. doi: 10.1126/science.1251102. PMID: 24812403Free PMC Article

Prognosis

Infigratinib for cholangiocarcinoma.
Sadeghi S
Drugs Today (Barc) 2022 Jul;58(7):327-334. doi: 10.1358/dot.2022.58.7.3408813. PMID: 35851868
Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target.
Alvisi G, Termanini A, Soldani C, Portale F, Carriero R, Pilipow K, Costa G, Polidoro M, Franceschini B, Malenica I, Puccio S, Lise V, Galletti G, Zanon V, Colombo FS, De Simone G, Tufano M, Aghemo A, Di Tommaso L, Peano C, Cibella J, Iannacone M, Roychoudhuri R, Manzo T, Donadon M, Torzilli G, Kunderfranco P, Di Mitri D, Lugli E, Lleo A
J Hepatol 2022 Nov;77(5):1359-1372. Epub 2022 Jun 20 doi: 10.1016/j.jhep.2022.05.043. PMID: 35738508
Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells.
Zhou G, Lieshout R, van Tienderen GS, de Ruiter V, van Royen ME, Boor PPC, Magré L, Desai J, Köten K, Kan YY, Ge Z, Campos Carrascosa L, Geuijen C, Sprengers D, van der Laan LJW, Verstegen MMA, Kwekkeboom J
Br J Cancer 2022 Sep;127(4):649-660. Epub 2022 May 21 doi: 10.1038/s41416-022-01839-x. PMID: 35597867Free PMC Article
The role of tumor-infiltrating lymphocytes in cholangiocarcinoma.
Liu D, Heij LR, Czigany Z, Dahl E, Lang SA, Ulmer TF, Luedde T, Neumann UP, Bednarsch J
J Exp Clin Cancer Res 2022 Apr 7;41(1):127. doi: 10.1186/s13046-022-02340-2. PMID: 35392957Free PMC Article
Immune cell atlas of cholangiocarcinomas reveals distinct tumor microenvironments and associated prognoses.
Xia T, Li K, Niu N, Shao Y, Ding D, Thomas DL, Jing H, Fujiwara K, Hu H, Osipov A, Yuan C, Wolfgang CL, Thompson ED, Anders RA, He J, Mou Y, Murphy AG, Zheng L
J Hematol Oncol 2022 Mar 28;15(1):37. doi: 10.1186/s13045-022-01253-z. PMID: 35346322Free PMC Article

Clinical prediction guides

Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target.
Alvisi G, Termanini A, Soldani C, Portale F, Carriero R, Pilipow K, Costa G, Polidoro M, Franceschini B, Malenica I, Puccio S, Lise V, Galletti G, Zanon V, Colombo FS, De Simone G, Tufano M, Aghemo A, Di Tommaso L, Peano C, Cibella J, Iannacone M, Roychoudhuri R, Manzo T, Donadon M, Torzilli G, Kunderfranco P, Di Mitri D, Lugli E, Lleo A
J Hepatol 2022 Nov;77(5):1359-1372. Epub 2022 Jun 20 doi: 10.1016/j.jhep.2022.05.043. PMID: 35738508
Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells.
Zhou G, Lieshout R, van Tienderen GS, de Ruiter V, van Royen ME, Boor PPC, Magré L, Desai J, Köten K, Kan YY, Ge Z, Campos Carrascosa L, Geuijen C, Sprengers D, van der Laan LJW, Verstegen MMA, Kwekkeboom J
Br J Cancer 2022 Sep;127(4):649-660. Epub 2022 May 21 doi: 10.1038/s41416-022-01839-x. PMID: 35597867Free PMC Article
The role of tumor-infiltrating lymphocytes in cholangiocarcinoma.
Liu D, Heij LR, Czigany Z, Dahl E, Lang SA, Ulmer TF, Luedde T, Neumann UP, Bednarsch J
J Exp Clin Cancer Res 2022 Apr 7;41(1):127. doi: 10.1186/s13046-022-02340-2. PMID: 35392957Free PMC Article
SIRPα and PD1 expression on tumor-associated macrophage predict prognosis of intrahepatic cholangiocarcinoma.
Yang H, Yan M, Li W, Xu L
J Transl Med 2022 Mar 22;20(1):140. doi: 10.1186/s12967-022-03342-6. PMID: 35317832Free PMC Article
Progress and prospects of biomarkers in primary liver cancer (Review).
Gao YX, Yang TW, Yin JM, Yang PX, Kou BX, Chai MY, Liu XN, Chen DX
Int J Oncol 2020 Jul;57(1):54-66. Epub 2020 Apr 1 doi: 10.3892/ijo.2020.5035. PMID: 32236573

Recent systematic reviews

Common bile duct stones management: A network meta-analysis.
Mohseni S, Bass GA, Forssten MP, Casas IM, Martin M, Davis KA, Haut ER, Sugrue M, Kurihara H, Sarani B, Cao Y, Coimbra R
J Trauma Acute Care Surg 2022 Nov 1;93(5):e155-e165. Epub 2022 Aug 5 doi: 10.1097/TA.0000000000003755. PMID: 35939370
Systematic review of perioperative and oncologic outcomes of minimally-invasive surgery for hilar cholangiocarcinoma.
Cipriani F, Ratti F, Fiorentini G, Reineke R, Aldrighetti L
Updates Surg 2021 Apr;73(2):359-377. Epub 2021 Feb 22 doi: 10.1007/s13304-021-01006-6. PMID: 33615423
Progress and prospects of biomarkers in primary liver cancer (Review).
Gao YX, Yang TW, Yin JM, Yang PX, Kou BX, Chai MY, Liu XN, Chen DX
Int J Oncol 2020 Jul;57(1):54-66. Epub 2020 Apr 1 doi: 10.3892/ijo.2020.5035. PMID: 32236573
Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma.
Hüttner FJ, Fitzmaurice C, Schwarzer G, Seiler CM, Antes G, Büchler MW, Diener MK
Cochrane Database Syst Rev 2016 Feb 16;2(2):CD006053. doi: 10.1002/14651858.CD006053.pub6. PMID: 26905229Free PMC Article
Subtotal cholecystectomy for "difficult gallbladders": systematic review and meta-analysis.
Elshaer M, Gravante G, Thomas K, Sorge R, Al-Hamali S, Ebdewi H
JAMA Surg 2015 Feb;150(2):159-68. doi: 10.1001/jamasurg.2014.1219. PMID: 25548894

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