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Combined Lung Small Cell Carcinoma and Lung Adenocarcinoma

MedGen UID:
231029
•Concept ID:
C1332165
•
Neoplastic Process
Synonyms: Adenocarcinoma and Small Cell Carcinoma of Lung; Adenocarcinoma and Small Cell Carcinoma of the Lung; Adenocarcinoma and Small Cell Lung Carcinoma; Combined Small Cell Lung Carcinoma and Lung Adenocarcinoma

Definition

A lung carcinoma characterized by a combination of small cell carcinoma and adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCombined Lung Small Cell Carcinoma and Lung Adenocarcinoma

Professional guidelines

PubMed

PD-L1 expression in advanced NSCLC: Insights into risk stratification and treatment selection from a systematic literature review.
Brody R, Zhang Y, Ballas M, Siddiqui MK, Gupta P, Barker C, Midha A, Walker J
Lung Cancer 2017 Oct;112:200-215. Epub 2017 Aug 10 doi: 10.1016/j.lungcan.2017.08.005. PMID: 29191596
Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small-cell lung cancer.
De Leyn P, Dooms C, Kuzdzal J, Lardinois D, Passlick B, Rami-Porta R, Turna A, Van Schil P, Venuta F, Waller D, Weder W, Zielinski M
Eur J Cardiothorac Surg 2014 May;45(5):787-98. Epub 2014 Feb 26 doi: 10.1093/ejcts/ezu028. PMID: 24578407
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

T cell-related prognostic risk model and tumor immune environment modulation in lung adenocarcinoma based on single-cell and bulk RNA sequencing.
Zhang J, Liu X, Huang Z, Wu C, Zhang F, Han A, Stalin A, Lu S, Guo S, Huang J, Liu P, Shi R, Zhai Y, Chen M, Zhou W, Bai M, Wu J
Comput Biol Med 2023 Jan;152:106460. Epub 2022 Dec 21 doi: 10.1016/j.compbiomed.2022.106460. PMID: 36565482
KRAS-G12D mutation drives immune suppression and the primary resistance of anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer.
Liu C, Zheng S, Wang Z, Wang S, Wang X, Yang L, Xu H, Cao Z, Feng X, Xue Q, Wang Y, Sun N, He J
Cancer Commun (Lond) 2022 Sep;42(9):828-847. Epub 2022 Jul 11 doi: 10.1002/cac2.12327. PMID: 35811500Free PMC Article
Identification of a novel gene expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on TCGA and GEO databases.
Zhao J, Guo C, Ma Z, Liu H, Yang C, Li S
Lung Cancer 2020 Nov;149:90-96. Epub 2020 Sep 24 doi: 10.1016/j.lungcan.2020.09.014. PMID: 33002836
Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial.
Nakagawa K, Garon EB, Seto T, Nishio M, Ponce Aix S, Paz-Ares L, Chiu CH, Park K, Novello S, Nadal E, Imamura F, Yoh K, Shih JY, Au KH, Moro-Sibilot D, Enatsu S, Zimmermann A, Frimodt-Moller B, Visseren-Grul C, Reck M; RELAY Study Investigators
Lancet Oncol 2019 Dec;20(12):1655-1669. Epub 2019 Oct 4 doi: 10.1016/S1470-2045(19)30634-5. PMID: 31591063
EGFR-Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes.
Marcoux N, Gettinger SN, O'Kane G, Arbour KC, Neal JW, Husain H, Evans TL, Brahmer JR, Muzikansky A, Bonomi PD, Del Prete S, Wurtz A, Farago AF, Dias-Santagata D, Mino-Kenudson M, Reckamp KL, Yu HA, Wakelee HA, Shepherd FA, Piotrowska Z, Sequist LV
J Clin Oncol 2019 Feb 1;37(4):278-285. Epub 2018 Dec 14 doi: 10.1200/JCO.18.01585. PMID: 30550363Free PMC Article

Diagnosis

Abandoning the Notion of Non-Small Cell Lung Cancer.
Relli V, Trerotola M, Guerra E, Alberti S
Trends Mol Med 2019 Jul;25(7):585-594. Epub 2019 May 30 doi: 10.1016/j.molmed.2019.04.012. PMID: 31155338
EGFR-Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes.
Marcoux N, Gettinger SN, O'Kane G, Arbour KC, Neal JW, Husain H, Evans TL, Brahmer JR, Muzikansky A, Bonomi PD, Del Prete S, Wurtz A, Farago AF, Dias-Santagata D, Mino-Kenudson M, Reckamp KL, Yu HA, Wakelee HA, Shepherd FA, Piotrowska Z, Sequist LV
J Clin Oncol 2019 Feb 1;37(4):278-285. Epub 2018 Dec 14 doi: 10.1200/JCO.18.01585. PMID: 30550363Free PMC Article
Lung cancer.
Skřičková J, Kadlec B, Venclíček O, Merta Z
Cas Lek Cesk 2018 Fall;157(5):226-236. PMID: 30441934
Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA).
Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP
JAMA Oncol 2017 Jun 1;3(6):827-831. doi: 10.1001/jamaoncol.2016.3834. PMID: 27892978Free PMC Article
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Therapy

Liposomal irinotecan (Onivyde): Exemplifying the benefits of nanotherapeutic drugs.
Milano G, Innocenti F, Minami H
Cancer Sci 2022 Jul;113(7):2224-2231. Epub 2022 May 26 doi: 10.1111/cas.15377. PMID: 35445479Free PMC Article
Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities.
Hack SP, Zhu AX, Wang Y
Front Immunol 2020;11:598877. Epub 2020 Nov 5 doi: 10.3389/fimmu.2020.598877. PMID: 33250900Free PMC Article
Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial.
Nakagawa K, Garon EB, Seto T, Nishio M, Ponce Aix S, Paz-Ares L, Chiu CH, Park K, Novello S, Nadal E, Imamura F, Yoh K, Shih JY, Au KH, Moro-Sibilot D, Enatsu S, Zimmermann A, Frimodt-Moller B, Visseren-Grul C, Reck M; RELAY Study Investigators
Lancet Oncol 2019 Dec;20(12):1655-1669. Epub 2019 Oct 4 doi: 10.1016/S1470-2045(19)30634-5. PMID: 31591063
EGFR-Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes.
Marcoux N, Gettinger SN, O'Kane G, Arbour KC, Neal JW, Husain H, Evans TL, Brahmer JR, Muzikansky A, Bonomi PD, Del Prete S, Wurtz A, Farago AF, Dias-Santagata D, Mino-Kenudson M, Reckamp KL, Yu HA, Wakelee HA, Shepherd FA, Piotrowska Z, Sequist LV
J Clin Oncol 2019 Feb 1;37(4):278-285. Epub 2018 Dec 14 doi: 10.1200/JCO.18.01585. PMID: 30550363Free PMC Article
Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin.
Oser MG, Niederst MJ, Sequist LV, Engelman JA
Lancet Oncol 2015 Apr;16(4):e165-72. doi: 10.1016/S1470-2045(14)71180-5. PMID: 25846096Free PMC Article

Prognosis

T cell-related prognostic risk model and tumor immune environment modulation in lung adenocarcinoma based on single-cell and bulk RNA sequencing.
Zhang J, Liu X, Huang Z, Wu C, Zhang F, Han A, Stalin A, Lu S, Guo S, Huang J, Liu P, Shi R, Zhai Y, Chen M, Zhou W, Bai M, Wu J
Comput Biol Med 2023 Jan;152:106460. Epub 2022 Dec 21 doi: 10.1016/j.compbiomed.2022.106460. PMID: 36565482
Identification of a novel gene expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on TCGA and GEO databases.
Zhao J, Guo C, Ma Z, Liu H, Yang C, Li S
Lung Cancer 2020 Nov;149:90-96. Epub 2020 Sep 24 doi: 10.1016/j.lungcan.2020.09.014. PMID: 33002836
Patient-reported outcomes following pembrolizumab or placebo plus pemetrexed and platinum in patients with previously untreated, metastatic, non-squamous non-small-cell lung cancer (KEYNOTE-189): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.
Garassino MC, Gadgeel S, Esteban E, Felip E, Speranza G, Domine M, Hochmair MJ, Powell S, Cheng SY, Bischoff HG, Peled N, Reck M, Hui R, Garon EB, Boyer M, Wei Z, Burke T, Pietanza MC, Rodríguez-Abreu D
Lancet Oncol 2020 Mar;21(3):387-397. Epub 2020 Feb 6 doi: 10.1016/S1470-2045(19)30801-0. PMID: 32035514
Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial.
Nakagawa K, Garon EB, Seto T, Nishio M, Ponce Aix S, Paz-Ares L, Chiu CH, Park K, Novello S, Nadal E, Imamura F, Yoh K, Shih JY, Au KH, Moro-Sibilot D, Enatsu S, Zimmermann A, Frimodt-Moller B, Visseren-Grul C, Reck M; RELAY Study Investigators
Lancet Oncol 2019 Dec;20(12):1655-1669. Epub 2019 Oct 4 doi: 10.1016/S1470-2045(19)30634-5. PMID: 31591063
EGFR-Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes.
Marcoux N, Gettinger SN, O'Kane G, Arbour KC, Neal JW, Husain H, Evans TL, Brahmer JR, Muzikansky A, Bonomi PD, Del Prete S, Wurtz A, Farago AF, Dias-Santagata D, Mino-Kenudson M, Reckamp KL, Yu HA, Wakelee HA, Shepherd FA, Piotrowska Z, Sequist LV
J Clin Oncol 2019 Feb 1;37(4):278-285. Epub 2018 Dec 14 doi: 10.1200/JCO.18.01585. PMID: 30550363Free PMC Article

Clinical prediction guides

T cell-related prognostic risk model and tumor immune environment modulation in lung adenocarcinoma based on single-cell and bulk RNA sequencing.
Zhang J, Liu X, Huang Z, Wu C, Zhang F, Han A, Stalin A, Lu S, Guo S, Huang J, Liu P, Shi R, Zhai Y, Chen M, Zhou W, Bai M, Wu J
Comput Biol Med 2023 Jan;152:106460. Epub 2022 Dec 21 doi: 10.1016/j.compbiomed.2022.106460. PMID: 36565482
KRAS-G12D mutation drives immune suppression and the primary resistance of anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancer.
Liu C, Zheng S, Wang Z, Wang S, Wang X, Yang L, Xu H, Cao Z, Feng X, Xue Q, Wang Y, Sun N, He J
Cancer Commun (Lond) 2022 Sep;42(9):828-847. Epub 2022 Jul 11 doi: 10.1002/cac2.12327. PMID: 35811500Free PMC Article
Identification of a novel gene expression signature associated with overall survival in patients with lung adenocarcinoma: A comprehensive analysis based on TCGA and GEO databases.
Zhao J, Guo C, Ma Z, Liu H, Yang C, Li S
Lung Cancer 2020 Nov;149:90-96. Epub 2020 Sep 24 doi: 10.1016/j.lungcan.2020.09.014. PMID: 33002836
Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing.
Guo X, Zhang Y, Zheng L, Zheng C, Song J, Zhang Q, Kang B, Liu Z, Jin L, Xing R, Gao R, Zhang L, Dong M, Hu X, Ren X, Kirchhoff D, Roider HG, Yan T, Zhang Z
Nat Med 2018 Jul;24(7):978-985. Epub 2018 Jun 25 doi: 10.1038/s41591-018-0045-3. PMID: 29942094
Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin.
Oser MG, Niederst MJ, Sequist LV, Engelman JA
Lancet Oncol 2015 Apr;16(4):e165-72. doi: 10.1016/S1470-2045(14)71180-5. PMID: 25846096Free PMC Article

Recent systematic reviews

MALAT-1 Expression Correlates with Prognosis in Non-Small-Cell Lung Carcinoma: A Systematic Review and Meta-analysis.
Ran R, Jin JW, Zhang WP
Dis Markers 2021;2021:5424623. Epub 2021 Nov 23 doi: 10.1155/2021/5424623. PMID: 34858541Free PMC Article
Clinical relevance of the multidrug resistance‑associated protein 1 gene in non‑small cell lung cancer: A systematic review and meta‑analysis.
Hu P, Wong PT, Zhou Q, Sheng L, Niu W, Chen S, Xu M, Lin Y
Oncol Rep 2018 Nov;40(5):3078-3091. Epub 2018 Aug 17 doi: 10.3892/or.2018.6652. PMID: 30132569
PD-L1 expression in advanced NSCLC: Insights into risk stratification and treatment selection from a systematic literature review.
Brody R, Zhang Y, Ballas M, Siddiqui MK, Gupta P, Barker C, Midha A, Walker J
Lung Cancer 2017 Oct;112:200-215. Epub 2017 Aug 10 doi: 10.1016/j.lungcan.2017.08.005. PMID: 29191596
Lung cancer.
Neville AJ, Kuruvilla MS
BMJ Clin Evid 2010 Nov 30;2010 PMID: 21406127Free PMC Article
Lung cancer.
Neville A
BMJ Clin Evid 2009 Apr 21;2009 PMID: 19445746Free PMC Article

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