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Aflatoxin-related hepatocellular carcinoma

MedGen UID:
231047
•Concept ID:
C1332222
•
Neoplastic Process
Synonyms: aflatoxin-related hepatocellular carcinoma; aflatoxins-related hepatocellular cancer; Aflatoxins-Related Hepatocellular Carcinoma; aflatoxins-related hepatocellular carcinoma
 
Monarch Initiative: MONDO:0003245

Definition

A hepatocellular carcinoma that develops following exposure to aflatoxin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAflatoxin-related hepatocellular carcinoma

Professional guidelines

PubMed

Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment.
Liu Y, Wu F
Environ Health Perspect 2010 Jun;118(6):818-24. Epub 2010 Feb 19 doi: 10.1289/ehp.0901388. PMID: 20172840Free PMC Article
Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma.
Chen CJ, Yu MW, Liaw YF, Wang LW, Chiamprasert S, Matin F, Hirvonen A, Bell DA, Santella RM
Am J Hum Genet 1996 Jul;59(1):128-34. PMID: 8659516Free PMC Article

Recent clinical studies

Etiology

Genetic polymorphisms in DNA repair genes XRCC4 and XRCC5 and aflatoxin B1-related hepatocellular carcinoma.
Long XD, Zhao D, Wang C, Huang XY, Yao JG, Ma Y, Wei ZH, Liu M, Zeng LX, Mo XQ, Zhang JJ, Xue F, Zhai B, Xia Q
Epidemiology 2013 Sep;24(5):671-81. doi: 10.1097/EDE.0b013e31829d2744. PMID: 23788213
Population attributable risk of aflatoxin-related liver cancer: systematic review and meta-analysis.
Liu Y, Chang CC, Marsh GM, Wu F
Eur J Cancer 2012 Sep;48(14):2125-36. Epub 2012 Mar 8 doi: 10.1016/j.ejca.2012.02.009. PMID: 22405700Free PMC Article
Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment.
Liu Y, Wu F
Environ Health Perspect 2010 Jun;118(6):818-24. Epub 2010 Feb 19 doi: 10.1289/ehp.0901388. PMID: 20172840Free PMC Article
Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity.
Kirk GD, Turner PC, Gong Y, Lesi OA, Mendy M, Goedert JJ, Hall AJ, Whittle H, Hainaut P, Montesano R, Wild CP
Cancer Epidemiol Biomarkers Prev 2005 Feb;14(2):373-9. doi: 10.1158/1055-9965.EPI-04-0161. PMID: 15734960
Exposure biomarkers in chemoprevention studies of liver cancer.
Wild CP, Turner PC
IARC Sci Publ 2001;154:215-22. PMID: 11220661

Diagnosis

Population attributable risk of aflatoxin-related liver cancer: systematic review and meta-analysis.
Liu Y, Chang CC, Marsh GM, Wu F
Eur J Cancer 2012 Sep;48(14):2125-36. Epub 2012 Mar 8 doi: 10.1016/j.ejca.2012.02.009. PMID: 22405700Free PMC Article
Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry.
Egner PA, Groopman JD, Wang JS, Kensler TW, Friesen MD
Chem Res Toxicol 2006 Sep;19(9):1191-5. doi: 10.1021/tx060108d. PMID: 16978023
Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: a nested case-control study in Taiwan.
Sun CA, Wang LY, Chen CJ, Lu SN, You SL, Wang LW, Wang Q, Wu DM, Santella RM
Carcinogenesis 2001 Aug;22(8):1289-94. doi: 10.1093/carcin/22.8.1289. PMID: 11470760
Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma.
Chen CJ, Yu MW, Liaw YF, Wang LW, Chiamprasert S, Matin F, Hirvonen A, Bell DA, Santella RM
Am J Hum Genet 1996 Jul;59(1):128-34. PMID: 8659516Free PMC Article

Therapy

Data-driven methods for imputing national-level incidence in global burden of disease studies.
McDonald SA, Devleesschauwer B, Speybroeck N, Hens N, Praet N, Torgerson PR, Havelaar AH, Wu F, Tremblay M, Amene EW, Döpfer D
Bull World Health Organ 2015 Apr 1;93(4):228-36. Epub 2015 Feb 27 doi: 10.2471/BLT.14.139972. PMID: 26229187Free PMC Article
Population attributable risk of aflatoxin-related liver cancer: systematic review and meta-analysis.
Liu Y, Chang CC, Marsh GM, Wu F
Eur J Cancer 2012 Sep;48(14):2125-36. Epub 2012 Mar 8 doi: 10.1016/j.ejca.2012.02.009. PMID: 22405700Free PMC Article
Is correction for protein concentration appropriate for protein adduct dosimetry? Hypothesis and clues from an aflatoxin B1-exposed population.
Peng T, Li LQ, Peng MH, Liu ZM, Liu TW, Yan LN, Shen HM, Wang L, Wang Q, Wang KB, Liang RX, Wei ZL, Ong CN, Santella RM
Cancer Sci 2007 Feb;98(2):140-6. doi: 10.1111/j.1349-7006.2006.00380.x. PMID: 17233831
Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity.
Kirk GD, Turner PC, Gong Y, Lesi OA, Mendy M, Goedert JJ, Hall AJ, Whittle H, Hainaut P, Montesano R, Wild CP
Cancer Epidemiol Biomarkers Prev 2005 Feb;14(2):373-9. doi: 10.1158/1055-9965.EPI-04-0161. PMID: 15734960
Exposure biomarkers in chemoprevention studies of liver cancer.
Wild CP, Turner PC
IARC Sci Publ 2001;154:215-22. PMID: 11220661

Prognosis

Data-driven methods for imputing national-level incidence in global burden of disease studies.
McDonald SA, Devleesschauwer B, Speybroeck N, Hens N, Praet N, Torgerson PR, Havelaar AH, Wu F, Tremblay M, Amene EW, Döpfer D
Bull World Health Organ 2015 Apr 1;93(4):228-36. Epub 2015 Feb 27 doi: 10.2471/BLT.14.139972. PMID: 26229187Free PMC Article
Genetic polymorphisms in DNA repair genes XRCC4 and XRCC5 and aflatoxin B1-related hepatocellular carcinoma.
Long XD, Zhao D, Wang C, Huang XY, Yao JG, Ma Y, Wei ZH, Liu M, Zeng LX, Mo XQ, Zhang JJ, Xue F, Zhai B, Xia Q
Epidemiology 2013 Sep;24(5):671-81. doi: 10.1097/EDE.0b013e31829d2744. PMID: 23788213
Exposure biomarkers in chemoprevention studies of liver cancer.
Wild CP, Turner PC
IARC Sci Publ 2001;154:215-22. PMID: 11220661

Clinical prediction guides

Data-driven methods for imputing national-level incidence in global burden of disease studies.
McDonald SA, Devleesschauwer B, Speybroeck N, Hens N, Praet N, Torgerson PR, Havelaar AH, Wu F, Tremblay M, Amene EW, Döpfer D
Bull World Health Organ 2015 Apr 1;93(4):228-36. Epub 2015 Feb 27 doi: 10.2471/BLT.14.139972. PMID: 26229187Free PMC Article
Genetic polymorphisms in DNA repair genes XRCC4 and XRCC5 and aflatoxin B1-related hepatocellular carcinoma.
Long XD, Zhao D, Wang C, Huang XY, Yao JG, Ma Y, Wei ZH, Liu M, Zeng LX, Mo XQ, Zhang JJ, Xue F, Zhai B, Xia Q
Epidemiology 2013 Sep;24(5):671-81. doi: 10.1097/EDE.0b013e31829d2744. PMID: 23788213
Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity.
Kirk GD, Turner PC, Gong Y, Lesi OA, Mendy M, Goedert JJ, Hall AJ, Whittle H, Hainaut P, Montesano R, Wild CP
Cancer Epidemiol Biomarkers Prev 2005 Feb;14(2):373-9. doi: 10.1158/1055-9965.EPI-04-0161. PMID: 15734960
Exposure biomarkers in chemoprevention studies of liver cancer.
Wild CP, Turner PC
IARC Sci Publ 2001;154:215-22. PMID: 11220661
Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma.
Chen CJ, Yu MW, Liaw YF, Wang LW, Chiamprasert S, Matin F, Hirvonen A, Bell DA, Santella RM
Am J Hum Genet 1996 Jul;59(1):128-34. PMID: 8659516Free PMC Article

Recent systematic reviews

Population attributable risk of aflatoxin-related liver cancer: systematic review and meta-analysis.
Liu Y, Chang CC, Marsh GM, Wu F
Eur J Cancer 2012 Sep;48(14):2125-36. Epub 2012 Mar 8 doi: 10.1016/j.ejca.2012.02.009. PMID: 22405700Free PMC Article

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