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Anal canal neuroendocrine neoplasm

MedGen UID:
231063
Concept ID:
C1332273
Neoplastic Process
Synonyms: anal canal NET; Anal Canal Neuroendocrine Neoplasm; anal canal neuroendocrine neoplasm; anal canal neuroendocrine tumor; anal canal neuroendocrine tumor, well differentiated, low or intermediate grade; anal canal neuroendocrine tumour; Anal Neuroendocrine Neoplasm; anal neuroendocrine neoplasm; anal neuroendocrine tumor; anal neuroendocrine tumour; anus neuroendocrine neoplasm; anus neuroendocrine tumor; anus neuroendocrine tumour; neuroendocrine neoplasm of anal canal; Neuroendocrine Neoplasm of Anus; neuroendocrine neoplasm of anus; Neuroendocrine Neoplasm of the Anus; neuroendocrine neoplasm of the anus; neuroendocrine tumor of anus; neuroendocrine tumour of anus
 
Monarch Initiative: MONDO:0003504

Definition

A neoplasm with neuroendocrine differentiation that arises from the anal canal. It includes neuroendocrine tumors (well-differentiated neuroendocrine neoplasms) and neuroendocrine carcinomas (poorly differentiated neuroendocrine neoplasms). [from NCI]

Professional guidelines

PubMed

Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
Naqvi J, Lee A, Lederman A, Kavi A, Osborn VW, Schreiber D
J Gastrointest Cancer 2020 Mar;51(1):211-216. doi: 10.1007/s12029-019-00238-5. PMID: 30982929
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Recent clinical studies

Etiology

Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
Brown IS, Sokolova A, Rosty C, Graham RP
Histopathology 2023 Jan;82(2):232-241. Epub 2022 Aug 24 doi: 10.1111/his.14769. PMID: 35962741
Majbar A, Hrora A, Jahid A, Ahallat M, Raiss M
BMC Res Notes 2016 Jun 13;9:304. doi: 10.1186/s13104-016-2108-1. PMID: 27297080Free PMC Article
Matalon SA, Mamon HJ, Fuchs CS, Doyle LA, Tirumani SH, Ramaiya NH, Rosenthal MH
Radiographics 2015 Nov-Dec;35(7):2090-107. doi: 10.1148/rg.2015150037. PMID: 26562239Free PMC Article
Longacre TA, Kong CS, Welton ML
Adv Anat Pathol 2008 Sep;15(5):263-78. doi: 10.1097/PAP.0b013e318183234b. PMID: 18724100

Diagnosis

Brown IS, Sokolova A, Rosty C, Graham RP
Histopathology 2023 Jan;82(2):232-241. Epub 2022 Aug 24 doi: 10.1111/his.14769. PMID: 35962741
Hoff PM, Coudry R, Moniz CM
Surg Oncol Clin N Am 2017 Jan;26(1):57-71. doi: 10.1016/j.soc.2016.07.013. PMID: 27889037
Roy AC, Wattchow D, Astill D, Singh S, Pendlebury S, Gormly K, Segelov E
Surg Oncol Clin N Am 2017 Jan;26(1):143-161. doi: 10.1016/j.soc.2016.07.009. PMID: 27889033
Shia J
Arch Pathol Lab Med 2010 Nov;134(11):1601-11. doi: 10.5858/2009-0668-RAR.1. PMID: 21043813
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Therapy

Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
Dell'Acqua V, Surgo A, Arculeo S, Zerella MA, Bagnardi V, Frassoni S, Zampino MG, Ravenda PS, Rotundo MS, Kraja F, Kobiela J, Spychalski P, Fodor C, Gerardi MA, Cattani F, Bazani A, Petz W, Glynne-Jones R, Orecchia R, Leonardi MC, Jereczek-Fossa BA
Int J Colorectal Dis 2020 Apr;35(4):685-694. Epub 2020 Feb 8 doi: 10.1007/s00384-020-03517-x. PMID: 32036405
Voong KR, Rashid A, Crane CH, Minsky BD, Krishnan S, Yao JC, Wolff RA, Skibber JM, Feig BW, Chang GJ, Das P
Am J Clin Oncol 2017 Dec;40(6):555-560. doi: 10.1097/COC.0000000000000211. PMID: 26237193
Tutino R, Clerico G, Luc AR, Gallo G, Trompetto M
Ann Ital Chir 2016 Nov 12;87 PMID: 27857005
Klas JV, Rothenberger DA, Wong WD, Madoff RD
Cancer 1999 Apr 15;85(8):1686-93. doi: 10.1002/(sici)1097-0142(19990415)85:8<1686::aid-cncr7>3.0.co;2-7. PMID: 10223561

Prognosis

Okumura T, Noguchi T, Sekiguchi N, Kobayashi T, Kanda S, Ida K, Minagawa T, Tokumaru S, Umemura T, Koizumi T
Chemotherapy 2023;68(2):87-94. Epub 2022 Nov 3 doi: 10.1159/000527377. PMID: 36327945
Hoff PM, Coudry R, Moniz CM
Surg Oncol Clin N Am 2017 Jan;26(1):57-71. doi: 10.1016/j.soc.2016.07.013. PMID: 27889037
Roy AC, Wattchow D, Astill D, Singh S, Pendlebury S, Gormly K, Segelov E
Surg Oncol Clin N Am 2017 Jan;26(1):143-161. doi: 10.1016/j.soc.2016.07.009. PMID: 27889033
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639
Longacre TA, Kong CS, Welton ML
Adv Anat Pathol 2008 Sep;15(5):263-78. doi: 10.1097/PAP.0b013e318183234b. PMID: 18724100

Clinical prediction guides

Dell'Acqua V, Surgo A, Arculeo S, Zerella MA, Bagnardi V, Frassoni S, Zampino MG, Ravenda PS, Rotundo MS, Kraja F, Kobiela J, Spychalski P, Fodor C, Gerardi MA, Cattani F, Bazani A, Petz W, Glynne-Jones R, Orecchia R, Leonardi MC, Jereczek-Fossa BA
Int J Colorectal Dis 2020 Apr;35(4):685-694. Epub 2020 Feb 8 doi: 10.1007/s00384-020-03517-x. PMID: 32036405
Park HJ, Kim HJ, Park SH, Lee JS, Kim AY, Kim SW, Hong SM
AJR Am J Roentgenol 2018 Aug;211(2):W98-W108. Epub 2018 Jun 21 doi: 10.2214/AJR.17.18807. PMID: 29927334
Hoff PM, Coudry R, Moniz CM
Surg Oncol Clin N Am 2017 Jan;26(1):57-71. doi: 10.1016/j.soc.2016.07.013. PMID: 27889037
Longacre TA, Kong CS, Welton ML
Adv Anat Pathol 2008 Sep;15(5):263-78. doi: 10.1097/PAP.0b013e318183234b. PMID: 18724100
Fenger C
Semin Diagn Pathol 1991 Aug;8(3):190-201. PMID: 1656504

Recent systematic reviews

Temperley HC, O'Sullivan NJ, Keyes A, Kavanagh DO, Larkin JO, Mehigan BJ, McCormick PH, Kelly ME
Langenbecks Arch Surg 2022 Dec;407(8):3193-3200. Epub 2022 Nov 4 doi: 10.1007/s00423-022-02715-1. PMID: 36331615

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